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Impact of age on transcatheter aortic valve implantation outcomes：a comparison of patients aged≤ 80 years versus patients ＆gt; 80 years

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journal of Geriatric Cardiology 2016年第1期13卷 31-36页

作者： Frank van der Kley Philippe j van Rosendael Spyridon Katsanos Vasileios Kamperidis Nina A Marsan Ioannis Karalis Arend de Weger Meindert Palmen jeroen j bax Martin j Schalij Victoria Delgado Heart Lung Center Leiden University Medical Center Leiden the Netherlands

ObjectiveTo investigate the procedural outcomes and the long-term survival of patients undergoing transcatheter aortic valve implantation （TAVI） and compare study results of patients≤ 80 years and patients ＆gt; 80 years *** total of 240 patients treated with TAVI were divided into two groups according to age≤ 80 years （n = 105; 43.8%） and ＆gt; 80 years （n= 135; 56.2%）. The baseline characteristics and the pro-cedural outcomes were compared between these two groups of *** the exception of peripheral artery disease and hypercho-lesterolemia, which were more frequently observed in the older age group, baseline characteristics were comparable between groups. Complica-tion rates did not differ significantly between patients≤ 80 years and patients ＆gt; 80 years. There were no differences in 30-day mortality rates be-tween patients aged≤ 80 years and patients ＆gt; 80 years old （9.5%vs. 7.4%, respectively;P = 0.557）. After a median follow-up of 28 months （in-terquartile range： 16-42 months）, 50 （47.6%） patients aged≤ 80 years died compared to 57 （42%） deaths in the group of patients ＆gt; 80 years old （P= 0.404）.ConclusionThe results of the present single center study showed that age did not significantly impact the outcomes of TAVI.

关键词： Age Survival rate Transcatheter aortic valve implantation

Collagen scaffolds functionalized with triple-helical peptides support 3D HUVEC culture

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Regenerative Biomaterials 2020年第5期7卷 471-482页

作者： jean-Daniel Malcor Emma j.Hunter Natalia Davidenko Daniel V.bax Ruth Cameron Serena Best Sanjay Sinha Richard W.Farndale Department of Biochemistry University of CambridgeCambridge CB21QWUK Department of Materials Science and Metallurgy University of CambridgeCambridge CB30FSUK Division of Medicine and Wellcome Trust Medical Research Council Cambridge Stem Cell InstituteUniversity of CambridgeCambridge CB20AWUK Present address:CambCol Laboratories Ltd Oak Lane Business ParkLittleportElyCambridgeshireCB79RPUK

Porous biomaterials which provide a structural and biological support for cells have immense potential in tissue engineering and cell-based therapies for tissue *** biomaterials that can host endothelial cells represent promising tools for the vascularization of engineered ***-dimensional collagen scaffolds possessing controlled architecture and mechanical stiffness are obtained through freeze–drying of collagen suspensions,followed by chemical cross-linking which maintains their ***,cross-linking scaffolds renders their biological activity suboptimal for many cell types,including human umbilical vein endothelial cells(HUVECs),by inhibiting cell–collagen ***,we have improved crucial HUVEC interactions with such cross-linked collagen biomaterials by covalently coupling combinations of triple-helical peptides(THPs).These are ligands for collagen-binding cell-surface receptors(integrins or discoidin domain receptors)or secreted proteins(SPARC and von Willebrand factor).THPs enhanced HUVEC adhesion,spreading and proliferation on 2D collagen *** grafted to 3D-cross-linked collagen scaffolds promoted cell survival over seven *** study demonstrates that THP-functionalized collagen scaffolds are promising candidates for hosting endothelial cells with potential for the production of vascularized engineered tissues in regenerative medicine applications.

关键词： collagen biomaterial endothelial cells 3D cell scaffold collagen-mimetic peptides

64层CT冠状动脉造影评价支架内再狭窄的效果

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世界核心医学期刊文摘(心脏病学分册) 2007年第9期 59-60页

作者： Cademartiri F. Schuijf j.D. Pugliese F. j.j. bax 赵君 Department of Radiology and Cardiology Leiden University Medical Center Leiden Netherlands

目的:旨在分析64层多层CT(MSCT)冠状动脉造影在对曾行冠状动脉支架置入患者的随访中的诊断准确性。背景:近来的研究表明,与前一代的MSCT相比,64层MSCT无创性冠状动脉造影的图像质量和诊断准

关键词：支架内再狭窄冠状动脉造影冠脉造影心血管造影 CT

Characterization of a Liquid Crystal Stabilized Pharmaceutical Oil-in-Water Emulsion Optimized for Skin Delivery

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journal of Cosmetics, Dermatological Sciences and Applications 2018年第4期8卷 207-217页

作者： Melinda j. Sutton David W. Osborne Kevin Dahl Victoria bax G. Alan Schick Department of Chemistry Missouri State University Springfield MO USA Dow Development Institute Petaluma CA USA KBI Biopharma Boulder CO USA

A moisturizing cream containing 25 wt% of an organic solvent, diethylene glycol monoethyl ether (DEGEE), is observed to be stabilized by an emulsifying wax blend of cetearyl alcohol, dicetyl phosphate, and ceteth-10 phosphate (tradename Crodafos CES). Polarized light microscopy indicates that the Crodafos CES helps to produce a liquid-crystal stabilized oil-in-water emulsion, which is physically stable for months under accelerated aging conditions and chemically stable over the full topical pH range of 3.5 to 9. Emulsion globule size in the cream is observed to be dependent on the degree of emulsifying wax neutralization, with the globule size decreasing with increasing cream pH. The superior solubilizing properties of DEGEE combined with the full pH range and liquid-crystal stabilizing properties of the Crodafos CES give this formulation the potential for a wide range of applications in the topical delivery of active pharmaceutical ingredients.

关键词： Pharmaceutical Emulsion Skin Delivery Liquid Crystal Stabilized Emulsion Polarized Light Microscopy Topical Formulation

右室起搏可导致心房颤动患者在房室结消融后的心室不同步

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世界核心医学期刊文摘（心脏病学分册） 2007年第4期3卷 51-52页

作者： Tops L.F. Schalij M.j. Holman E.R. j.j.bax 郭俊 Department of Cardiology Leiden University Medical CenterLeidenNetherlands Dr.

目的:本研究旨在评估长期右室(RV)起搏对左室(LV)不同步、LV功能和心力衰竭症状的影响。背景:房室(AV)结消融及随后的长期RV起搏是心房颤动(AF)患者的极佳治疗选择。

关键词：心房颤动患者房室结消融心力衰竭症状药物难治性射血分数舒张期末容积心脏协会超声心动图组

PEPE HEYKOOP:旧物翻新从零开始

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设计 2012年第11期25卷 118-123页

作者： Yxiang Annemarijne bax

荷兰埃园霍芬设计学院（DESIGN ACADEMY EINDHOVEN）出7很多人才，比如当年还没毕业就出名的VIAARTE NBAAS，那一系列烧的黑呼呼的家具，让人摸不清头脑j却也迅速让他成为画廊和拍卖行的明星。现在同门师弟PEPEHEYKOOP同样迅速崛起，但... 详细信息

荷兰埃园霍芬设计学院（DESIGN ACADEMY EINDHOVEN）出7很多人才，比如当年还没毕业就出名的VIAARTE NBAAS，那一系列烧的黑呼呼的家具，让人摸不清头脑j却也迅速让他成为画廊和拍卖行的明星。现在同门师弟PEPEHEYKOOP同样迅速崛起，但他可不是“破坏者”，而是介“拯救家”。

关键词：翻新设计学院拍卖行

利用16层CT对冠状动脉搭桥术后患者的综合评价

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世界核心医学期刊文摘(心脏病学分册) 2006年第2期 34-35页

作者： Salm L. P. bax j. j. jukema j. W. 韩瑞娟 Department of Cardiology(C5-P) Leiden University Medical Center PO Box 9600 2300 RC Leiden Netherlands Dr.

Background: Multidetector-row computed tomography(MDCT) is a versatile modality to evaluate stenoses in native coronary arteries and bypass grafts. Acquired MDCT data can additionally be used to assess left ventricular ejection fraction(LVEF). The purpose was to use MDCT for the assessment of bypass graft and coronary artery disease combined with evaluation of LVEF. Methods: Twenty-five patients underwent 16-detector-row CT examination and coronary angiography. Bypass grafts and nongrafted coronary artery segments at MDCT were evaluated on eligibility, patency, and ≥ 50% stenosis. The MDCT data set was used to calculate LVEF and was divided into patients with no/subendocardial/transmural myocardial infarctions(MIs). Results: Ninety vessels were evaluated: 14 arterial grafts/53 vein grafts/23 nongrafted vessels. Of 225 segments, 17 were ineligible for evaluation because of metal clips. With MDCT, patency in segments of arterial grafts/vein grafts/nongrafted vessels could be evaluated with high accuracy in 100% /100% /97% of segments. In arterial grafts, stenoses ≥ 50% did not occur at angiography,which was for all eligible segments correctly diagnosed at MDCT. Stenosis ≥ 50% could be correctly detected by MDCT with a sensitivity/ specificity of 100% /94% for vein grafts and 100% /89% for nongrafted vessels. Negative predictive value was 100% for vein grafts and nongrafted vessels. In patients with transmural MI, MDCT revealed a significant lower LVEF as compared with patients without or with subendocardial MI(P< .05). Conclusion: Comprehensive assessment of bypass grafts, nongrafted vessels, and LVEF is feasible with MDCT. Owing to the high negative predictive value this noninvasive approach may be used as gatekeeper before coronary angiography.

关键词： CT 血管桥静脉桥

左室不同步性可预示心脏再同步化治疗的效果和预后

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世界核心医学期刊文摘（心脏病学分册） 2005年第4期1卷 49-50页

作者： bax j. j. Bleeker G. B. Marwick T. H. 尚福军

This study was designed to predict the response and prognosis after cardiac re synchronization therapy(CRT) in patients with end-stage heart failure(HF). Card iac resynchronization therapy improves HF symptoms, exercise capacity, and left ventricular(LV) function. Because not all patients respond, preimplantation iden tification of responders is needed. In the present study, response to CRT was pr edicted by the presence of LV dyssynchrony assessed by tissue Doppler imaging. M oreover, the prognostic value of LV dyssynchrony in patients undergoing CRT was assessed. Eighty-five patients with end-stage HF, QRS duration >120 ms, and le ft bundle-branch block were evaluated by tissue Doppler imaging before CRT. At baseline and six months follow-up, New York Heart Association functional class, quality of life and 6-min walking distance, LV volumes, and LV ejection fracti on were determined. Events (death, hospitalization for decompensated HF) were ob tained during one-year follow-up. Responders(74%) and nonresponders(26%) had comparable baseline characteristics, except for a larger dyssynchrony in respon ders (87±49 ms vs. 35±20 ms, p< 0.01). Receiver-operator characteristic curve analysis demonstrated that an optimal cutoff value of 65 ms for LV dyssynchrony yielded a sensitivity and specificity of 80%to predict clinical improvement an d of 92%to predict LV reverse remodeling. Patients with dyssynchrony ≥65 ms ha d an excellent prognosis(6%event rate) after CRT as compared with a 50%event r ate in patients with dyssynchrony< 65 ms(p< 0.001). Patients with LV dyssynchron y< 65 ms respond to CRT and have an excellent prognosis after CRT.

关键词：心脏再同步化组织多普勒显像再同步预测意义心功能级别射血分数左束支传导阻滞终点事件心脏协会步行距离

Associations between testicular development and fetal size in the pig

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journal of Animal Science and Biotechnology 2022年第5期13卷 1340-1350页

作者： Claire Stenhouse Yennifer Cortes-Araya F.Xavier Donadeu Cheryl j.Ashworth Functional Genetics and Development Division The Roslin Institute and Royal(Dick)School of Veterinary StudiesUniversity of EdinburghMidlothianUK Department of Animal Science Texas A&M University440 Kleberg CenterCollege StationTX 77843-2471USA

Background:Impaired reproductive performance is the largest contributing factor for the removal of boars from commercial *** growth restricted piglets represent 25%of the total number of piglets born and have impaired reproductive *** study aimed to improve the understanding of temporal changes in testicular gene expression during testes development in fetuses of different *** lightest and closest to mean litter weight(CTMLW)male Large White×Landrace littermates were collected at gestational days(GD)45,60 and 90(n=5-6 litters/GD).Results:Testes weight and testes weight as a percentage of fetal weight were not associated with fetal size at GD60 or *** plasma testosterone was not associated with fetal size at *** was no association between fetal size and seminiferous tubule area and number,number of germ or Sertoli cells per *** lightest fetuses tended to have wider seminiferous tubules compared to the CTMLW fetuses at GD90(P=0.077).The testicular expression of KI67(P≤0.01)and bax:BCL2 ratio(P=0.058)mRNAs decreased as gestation *** SPP1 mRNA expression was observed at GD60 when compared with GD45 and 90(P≤0.05).Lower expression of DMRT1 and SPP1(P<0.01)mRNAs was observed in testes associated with the lightest fetuses compared to the CTMLW fetuses at ***:These findings provide novel insights into the expression profiles of genes associated with testicular development and ***,these data suggest that programming of reproductive potential in IUGR boars occurs late in gestation,providing a platform for further mechanistic investigation.

关键词： Fetal growth Intrauterine growth restriction(IUGR) Porcine Pregnancy Testes