检索结果-南通市图书馆

β-defensins and the epididymis： contrasting influences of prenatal, postnatal, and adult scenarios

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2016年第2期18卷 323-328,J0008页

作者： Camilla M Ribeiro Erick JR Silva barry t hinton Maria Christina W Avellar Section of Experime.ntaI.Endocrinology Department of Pharmacology Universidade Federal de Sao Paulo - Escola Paulista de Medicina Sao Paulo Brazil Department of Cell Biology University of Virginia School of Medicine Charlottesville Virginia USA Present address: Department of Pharmacology Institute Of Biosciences of BotucatuUniversidade Estadual Paulista 'Julio de Mesquita Filho' Botucatu Sao Paulo 186).8-970 Brazil.

β-defensins are components of host defense, with antimicrobial and pleiotropic immuno-modulatory properties. Research over the last 15 years has demonstrated abundant expression of a variety of β-defensins in the postnatal epididymis of different species. A gradient of region- and cell-specific expression of these proteins is observed in the epithelium of the postnatal epididymis. their secretion into the luminal fluid and binding to spermatozoa as they travel along the epididymis has suggested their involvement in reproduction-specific tasks. therefore, continuous attention has been given to various β-defensins for their role in sperm function and fertility. Although β-defensins are largely dependent on androgens, the underlying mechanisms regulating their expression and function in the epididymis are not well understood. Recent investigation has pointed out to a new and interesting scenario where β-defensins emerge with a different expression pattern in the Wolffian duct, the embryonic precursor of the epididymis, as opposed to the adult epididymis, thereby redefining the concept concerning the multifunctional roles of β-defensins in the developing epididymis. In this review, we summarize some current views of β-defensins in the epididymis highlighting our most recent data and speculations on their role in the developing epididymis during the prenatal-to-postnatal transition, bringing attention to the many unanswered questions in this research area that may contribute to a better understanding of epididymal biology and male fertility.

关键词： androgens embryogenesis epididymis organogenesis β-defensins

A Special Issue on the Epididymis ＆ the Proceedings of the Fourth Workshop on the Epididymis （Epid Ⅳ）

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2007年第4期9卷 I0002-I0003页

作者： Joel R. Drevet barry t. hinton trevor G. Cooper

the Fourth Epididymis （Epid Ⅳ） Workshop was held between December 4th and 7th 2006 in Chatel-Guyon, France. this was the first European venue for these workshops following Epid Ⅲ held in Charlottesville, Virginia, USA in 2002, Epid Ⅱ held in Newcastle, Australia in 1998 and a one-day meeting （later named Epid Ⅰ） in Hong Kong, China in 1992. the 2006 meeting was organised by Drs Joeol R. Drevet （Aubi6re, France） and trevor G. Cooper （Muenster, Germany） and was a satellite meeting of the Fourth European Congress of Andrology （ECA2006） which followed in toulouse （France） from December 8th to 10th.

关键词：

Intermodal Competition: Cargo Airships versus Long-Haul trucking for Perishable Commodities

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of transportation technologies 2024年第2期14卷 195-211页

作者： barry Everett Prentice transport Institute I.H. Asper School of Business University of Manitoba Winnipeg Manitoba Canada

Intermodal competition changes with changes in technology, economics, and environmental concerns. trucks and airships are generally considered not to be competitors, but this depends on the distance of haul. the tonne-kilometer cost of trucking rises much more quickly with distance than it does the cost of a cargo airship. At some distance, the two modes are direct substitutes. the costs of the Mexico-Canada refrigerated truck supply chain are compared with the costs of a 100t-lift, electrically-powered airship. the flight characteristics of the Hindenburg Zeppelin are used as a model for a modern cargo airship. the supply chain cost of trucking tomatoes is used to test the theorical proposition. the cost difference works out to about US10￠/kg (5￠/lb) advantage for trucking Mexican tomatoes to Canada. However, this cost disadvantage of the airship could be made up by their vibrationless ride, better air circulation and one-day service versus four days by truck. this alternative form of transportation could have a positive impact on worldwide north-south distribution of food. Airships can overcome trade barriers and distance to open new markets for perishable food exports. In addition, they would reduce the carbon emissions of transport. Canada imports 160,000 refrigerated truckloads of fruits and vegetables by from the southern US and Mexico. With an average driving distance of 3,000 km, these trucks emit 606,000 Mt of CO2 annually. Airships powered by hydrogen fuel cells would have zero-carbon emissions. Markets are not yet incorporating the environmental advantage of airships in any freight comparison, but inevitably this will be important.

关键词： Airship Refrigerated trucks Mexico tomatoes Carbon-emissions Perishables

Investigation of HCAR2 antagonists as a potential strategy to modulate bovine leukocytes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2024年第4期15卷 1567-1577页

作者： Laman K.Mamedova Kirby C.Krogstad Paiton O.McDonald Laxman Pokhrel Duy H.Hua Evan C.titgemeyer barry J.Bradford Department of Animal Science Michigan State UniversityEast LansingMichigan 48824USA Department of Animal Sciences and Industry Kansas State UniversityManhattanKS 66506USA Comparative Medicine and Integrative Biology East LansingMI 48824USA Department of Chemistry Kansas State UniversityManhattanKS 66506USA

Background Dairy cows experiencing ketosis after calving suffer greater disease incidence and are at greater risk of leaving the herd. In vitro administration of beta-hydroxybutyric acid(BHBA;the primary blood ketone) has inhibitory effects on the function of bovine leukocytes. BHBA is a ligand of HCAR2 and the activation of these receptors promotes an anti-inflammatory response which may be related with immunosuppression observed in transition dairy cattle. the objective of this study was to identify and test antagonists for HCAR2 in bovine immune cells cultured with *** We observed expression of HCAR2 at the protein level within lymphocytes, monocytes, and granulocytes. the proportion of cells expressing HCAR2 tended to be greater in mid-lactation compared to early lactation cows;the increase was a result of increased proportion of t and B cells expressing HCAR2. Stimulation of HCAR2 with niacin or BHBA promoted Ca^(2+) mobilization in neutrophils and mononuclear cells. Mononuclear cells treated with BHBA had diminished intracellular Ca^(2+) responses when HCAR2 was knocked down by si RNA silencing, indicating Ca^(2+) mobilization was mediated by HCAR2 signaling. two candidate antagonists for HCAR2, synthesized from niacin(NA-1 and NA-5), were tested;monocytes and neutrophils pre-treated with NA-1 and NA-5 had reduced Ca^(2+) mobilization after incubation with BHBA. Furthermore, NA-5 but not NA-1 prevented BHBA-associated reductions in cyclic *** We demonstrated that HCAR2 is present on bovine leukocytes and has greater expression later in lactation. We confirmed that BHBA and niacin derived HCAR2 antagonists alter bovine leukocyte activity. Our results demonstrate that both BHBA and niacin affect bovine leukocyte Ca^(2+) mobilization in a HCAR2-dependent manner.

关键词： Flow cytometry GPR109A HM74A Ketosis

Cell-cell interactions and communication dynamics in lung fibrosis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第2期2卷 63-71页

作者： ting Xie Jiurong Liang barry Stripp Paul W.Noble Division of Pulmonary and Critical Care Medicine Department of MedicineWomen’s Guild Lung InstituteCedars-Sinai Medical CenterLos AngelesCA 90048USA

Cell-cell interactions are essential components of coordinated cell function in lung *** diseases involve altered cell-cell interactions and communication between different cell types,as well as between subsets of cells of the same *** identification and understanding of intercellular signaling in lung fibrosis offer insights into the molecular mechanisms underlying these interactions and their implications in the development and progression of lung fibrosis.A comprehensive cell atlas of the human lung,established with the facilita-tion of single-cell RNA transcriptomic analysis,has enabled the inference of intercellular communications using ligand-receptor *** this review,we provide a comprehensive overview of the modified cell-cell commu-nications in lung *** highlight the intricate interactions among the major cell types within the lung and their contributions to *** insights presented in this review will contribute to a better understand-ing of the molecular mechanisms underlying lung fibrosis and may guide future research efforts in developing targeted therapies for this debilitating disease.

关键词： Cell–cell interaction Lung fibrosis Lung homeostasis targeted therapies

Manufacture of Industrial Refractory Crucibles Based on Clays from Burkina Faso

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Minerals and Materials Characterization and Engineering 2024年第2期12卷 79-90页

作者： Kassoum barry Youssouf Sawadogo Moustapha Sawadogo Brahima Sorgho Mohamed Seynou Boubié Guel Philippe Blanchart Lamine Zerbo Laboratory of Molecular Chemistry and Materials (LC2M) University Joseph KI-ZERBO Ouagadougou Burkina Faso Institute of Research for Ceramic (IRCER) European Ceramic Centre (CEC) Limoges France

In Burkina Faso, one of the three largest gold producers in West Africa, foundry activity is often paralyzed when basic equipment such as crucibles and cups are not available or should be imported. However, previous studies have shown the availability of kaolinite-rich clay resources that could be used for the local manufacture of silico-aluminous ceramic crucibles. this work allowed to manufacture industrial ceramic crucibles with local clays and then they were tested in foundry industry. the materials were manufactured from three (03) raw materials including two clays (SAB and ROU) and sand. the chemical and mineral analysis has shown that the raw materials are suitable for the formulation of refractory materials. the results of characterization of the materials formulated showed that the properties of use are appreciable. the porosity of the materials is relatively low (23 - 28 vol%) with a diametral compressive strength between 0.61 and 1.34 MPa. Crucibles sintered at 1250˚C with a stay of 2 hours have a mechanical strength capable of supporting the weight of the ores contained. these crucibles have a refractoriness under load (t0.5) above 1141˚C and resist chemical attacks. tests were carried out in the industry at 1100˚C, and the results were satisfactory.

关键词： Refractory Foundry Activity Compressive Strength Chemical Resistance

Sustainable Management of Biodegradable Waste in Guinea: Effect of Compost on Eggplant and Chilli Crop Yields Pepper

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Agricultural Sciences 2024年第9期15卷 1009-1017页

作者： Mamadou Yaya Baldé Mamadou Aliou Diallo Mariama barry Dian Foula Diallo Mamadouba Bangaly Camara Nyankoï Soropogui Institut de Recherche Environnementale de Guine (IREG) Conakry Guinea Department of Chemistry Gamal Abdel Nasser University of Conakry Conakry Guinea

the fight against insalubrity in large urban and peri-urban agglomerations is a major challenge in developing countries. this problem is compounded by that of sustainable waste management mechanisms. Indeed, the current waste collection system in Guinea has proved inadequate, as moving garbage from point “A” to point “B” is tantamount to “moving the problem”. the aim of this experimental work is to demonstrate the cost-effectiveness and benefits of sustainable waste management. As part of this drive to valorize biodegradable waste, the Waste Management Research Center has undertaken a series of activities ranging from composting organic waste to testing compost on certain crop varieties. An experimental field of 8024 m2 was laid out and treated with 1500 Kg of fine compost in doses ranging from 2.5 to 5 t/ha. two crop varieties, eggplant and chili, were tested. Compost application increased production yields: 15 to 21 tonnes of eggplant and 10.4 to 11.1 tonnes of chili per hectare. Growth rates compared with usual yields varied from 50% to 64% and from 11% to 17% for eggplant and chili, respectively. this study resulted in an optimum compost dose of 2.5 t/ha for this phase.

关键词： Sustainable Waste Management Compost Eggplant Chilli Yield IREG CREGED

Osgood Schlatter Disease: Study of 2 Observations in Conakry, Guinea

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Rheumatology and Autoimmune Diseases 2024年第2期14卷 77-83页

作者： Adama Bah Laetitia Cynthia Abandazegoue Andjembe Abdoulaye barry Mamadou Lamine Diallo Moustapha Niasse Aly Badra Kamissoko Rheumatology Department Ignace Deen Hospital Conakry Conakry Guin&#233e Rheumatology Department CHU Aristide Le Dantec of Dakar Dakar S&#233n&#233gal Department of Rhumatology Sylvanus Olypio University Hospital Lom&#233 Lom&#233 Togo

Introduction: OSD is a growth osteochondrosis affecting the apophyseal cartilage of the anterior tibial tuberosity of the knee, 20 to 30% of young growing athletes suffer from this pathology, described by Osgood and Schlatter in 1903. Objective: to report 2 observations and review the literature. Observation 1: this was a 14-year-old Guinean teenager, Halpoular, living in Conakry, a right-handed footballer who presented with a painful swelling of the right knee that looked mechanical, whose father had HLA B27 positive ankylosing spondylitis. X-ray of the right knee showed fragmentation of the anterior tibial tuberosities, and ossicle with edema of the patellar tendons at stage 4 according to Ehrenbord and Lagergren (1961). thus, the disease of OSD is retained, He received 120 mg of diclofenac, 20 mg omeprazole for 1 month and the cessation of sports activity, the evolution was favorably marked by the regression of pain. Observation 2: A 16-year-old girl, initials M.L.t, Guinean, residing in Coyah (Republic of Guinea), a handball player, consulted for intense pain (VAS: 8/10) in her knees after a violent shock received when she hit the post. the physical examination found a painful, soft swelling at the anterior tibial tuberosity of the right knee, the rest of the examination was normal. the X-ray of the right knee shows fragmentation of the anterior tibial tuberosity, and ossicle with edema of the patellar tendon at stage 4 according to Ehrenbord and Lagergren 1961, thus the OSD disease is retained, the treatment instituted was 120 mg of diclofenac, the cessation of sports activity which gives a good evolution (EVA at 2/10). Conclusion: OSD is a growth osteochondrosis affecting the apophyseal cartilage of the anterior tibial tuberosity of the knee in young growing athletes, resolving at rest.

关键词： Osgood Shlatter Disease Young Athlete

miR-31: a key player in CD8 t-cell exhaustion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2017年第12期14卷 954-956页

作者： Siddheshvar Bhela barry t Rouse Department of Biomedical and Diagnostic Sciences College of Veterinary MedicineUniversity of TennesseeKnoxvilleKnoxvilleTN 37996USA

Over the past decade,miRNAs have emerged as genetic factors that can influence immune functions.1 they act by post-transcriptionally downregulating gene expression either by degrading target mRNAs or by repressing their translation.2 Linking miRNA expression to disease was first accomplished by comparing outcomes in normal animals with those in miR-155 knockout animals.3 Our group also used a viral pathogen to show that knocking out miR-155 resulted in less severe inflammatory lesions caused by herpes simplex virus infection,yet animals without miR-155 became more susceptible to developing viral encephalitis.

关键词： encephalitis infection simplex