Cell-cell interactions and communication dynamics in lung fibrosis
Cell-cell interactions and communication dynamics in lung fibrosis作者机构：Division of Pulmonary and Critical Care MedicineDepartment of MedicineWomen’s Guild Lung InstituteCedars-Sinai Medical CenterLos AngelesCA 90048USA
出 版 物：《Chinese Medical Journal Pulmonary and Critical Care Medicine》 (呼吸与危重症医学（英文）)
年 卷 期：2024年第2卷第2期
页 面：63-71页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：supported by the American Heart Association Career Development Award#19CDA34660211(to T.X.) the Cedars-Sinai Med-ical Center CSRI-Clinical Scholars Award(to T.X.) P01 HL108793(to P.W.N.and B.R.S.) R01 HL151160(to B.R.S.) R35 HL150829(to P.W.N.) National Institute on Aging Grant R01 AG078655(to J.L.and P.W.N.) P01-HL108793(to P.W.N.)
主 题：Cell–cell interaction Lung fibrosis Lung homeostasis Targeted therapies
摘 要：Cell-cell interactions are essential components of coordinated cell function in lung *** diseases involve altered cell-cell interactions and communication between different cell types,as well as between subsets of cells of the same *** identification and understanding of intercellular signaling in lung fibrosis offer insights into the molecular mechanisms underlying these interactions and their implications in the development and progression of lung fibrosis.A comprehensive cell atlas of the human lung,established with the facilita-tion of single-cell RNA transcriptomic analysis,has enabled the inference of intercellular communications using ligand-receptor *** this review,we provide a comprehensive overview of the modified cell-cell commu-nications in lung *** highlight the intricate interactions among the major cell types within the lung and their contributions to *** insights presented in this review will contribute to a better understand-ing of the molecular mechanisms underlying lung fibrosis and may guide future research efforts in developing targeted therapies for this debilitating disease.
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