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Chinese Chemical Letters 2008年第3期19卷 329-332页

作者： Cai Sheng Wu bao lin guo Yu Xin Sheng Jin Lan Zhang Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100094 China

In this paper, a sensitive and specific liquid chromatography-electrospray ionisation-mass spectrometry （LC-ESI-MS） method has been developed and validated for the identification and determination of seven flavonoids, namely epimedin A, epimedin B, epimedin C, icariin, sagittatoside B, 2＂-O-rhamnosyl icariside II, and baohuoside I in Epimedium from different sources.

关键词： Flavonoids Epimedium Liquid chromatography-electrospray ionization-mass spectrometry Quantitative determination

Novel Synthesis of Sol-gel Derived Nanosized Mullite Powder

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Chinese Journal of Aeronautics 2006年第B12期19卷 71-73页

作者： LIANG Long LI Jian-bao lin Hong guo Gang-feng HE Ming-sheng State Key Lab of New Ceramics and Fine Processing Dept of Materials Science and Engineering Tsinghua University Beijing 100084 China

Using hydrous aluminum chloride （AlCl3·6H2O） and silicon ethoxide （Si （OC2H5）4） as raw materials, a kind of nano-sized mullite powder was synthesized with the sol-gel process at the medium calcination temperature. The microstructures of the alumina-silica binary aerogel and calcined nano-sized materials were investigated by means of thermogravimetry-differential thermal analysis （TG-DTA）, scanning electron microscopy （SEM） and X-ray diffractometer （XRD）. The results show that the mullitization of Al2O3-SiO2 in gel starts from about 1 000℃ and its formation ofmullite takes place in the range of 1 100℃-1 250 ℃. The size of the nano-sized mullite powder calcined at 1 250 ℃ is measured to be about 30 nm.

关键词： mullite sol-gel synthesis temperature

XAS Study of Low Dimensional Dilute Magnetic Semiconductors

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功能材料信息 2016年第4期13卷 38-39页

作者： bao-lin guo Xi'an Jiaotong University

Electrically conducting polymers induce specific cellular responses at the molecular *** of the crucial limitations of the use of conducting polymers in tissue engineering is their inability to *** incorporation of conducting polymers into degradable polymers to obtain materials that are both electroactive and degradable is therefore

关键词：英语阅读理解生物材料

CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang guo-Cui Mao Hui-lin Jiang bao-Xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： Metal hydride Ni catalysts Carbonate Metal-carbonate interface

Transient neurogenesis in ischemic cortex from Sox2^(+)astrocytes

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Neural Regeneration Research 2023年第7期18卷 1521-1526页

作者： Jia-Lei Yang Hong Fan Fan-Fan Fu bao-lin guo Ying Huang Li Sun Wen-Ting Wang Jun-ling Xing Xin-Tian Hu Yu-Qiang Ding Kun Zhang Ying-Zhou Hu Ya-Zhou Wang Department of Neurobiology and Institute of Neurosciences School of Basic MedicineFourth Military Medical UniversityXi’anShaanxi ProvinceChina China National Clinical Research Center for Neurological Diseases Department of NeurologyBeijing Tiantan HospitalBeijingChina Department of Neurology The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institute of Brain ScienceFudan UniversityShanghaiChina Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences&Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan ProvinceChina

The adult cortex has long been regarded as *** injury can induce neurogenesis in the adult cortex is still ***,we report that focal ischemia stimulates a transient wave of local *** 5′-bromo-2′-deoxyuridine labeling,we demonstrated a rapid generation of doublecortin-positive neuroblasts that died quickly in mouse cerebral cortex following ***-Cre^(ER)-based cell ablation and fate mapping showed a small contribution of neuroblasts by subventricular zone neural stem *** a mini-photothrombotic ischemia mouse model and retrovirus expressing green fluorescent protein labeling,we observed maturation of locally generated new ***,fate tracing analyses using PDGFRα-,GFAP-,and Sox2-Cre^(ER) mice showed a transient wave of neuroblast generation in mild ischemic cortex and identified that Sox2-positive astrocytes were the major neurogenic cells in adult *** addition,a similar upregulation of Sox2 and appearance of neuroblasts were observed in the focal ischemic cortex of Macaca *** findings demonstrated a transient neurogenic response of Sox2-positive astrocytes in ischemic cortex,which suggests the possibility of inducing neuronal regeneration by amplifying this intrinsic response in the future.

关键词： adult astrocyte cortex fate-mapping ischemia local neurogenesis neural stem cells Sox2

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芍药属丹皮酚类化合物的化学分类学意义再探

植物分类学报 2008年第5期46卷 724-729页

作者：郭宝林洪德元肖培根中国医学科学院北京协和医学院药用植物研究所北京100094 系统与进化植物学国家重点实验室中国科学院植物研究所北京100093

本文在对芍药属Paeonia3个组14种及2亚种植物根皮中丹皮酚类和芍药苷类成分进行分析的基础上,探讨了这些成分在牡丹组***、芍药组***和北美芍药组***中的存在和含量情况。***中,丹皮酚类化合物是所有种类的高含量成分;***有4个类群即芍... 详细信息

本文在对芍药属Paeonia3个组14种及2亚种植物根皮中丹皮酚类和芍药苷类成分进行分析的基础上,探讨了这些成分在牡丹组***、芍药组***和北美芍药组***中的存在和含量情况。***中,丹皮酚类化合物是所有种类的高含量成分;***有4个类群即芍药***、川赤芍*** ***、美丽芍药***和块根芍药***检测出微量的丹皮酚类成分,北美芍药组中不含有丹皮酚类成分。丹皮酚是结构简单和在植物中比较常见的化合物,该化合物的减少和缺失可能是进化的结果。可推测芍药属三个组的关系为木本类型的牡丹组最为原始,最先从芍药属的祖先类型中衍生出来,而草本类型为次生类群。在草本类型中,与牡丹组关系较近的是芍药组。在牡丹组中,肉质花盘亚组***的种类较革质花盘亚组***种类的丹皮酚类成分为少,表现出较后者更进化一些。牡丹组中,含微量丹皮酚类成分的几个类群除美丽芍药外均是分布于中国的二倍体种,特别是芍药和川赤芍形态上属于芍药属的原始类群,而芍药组中形态特化的种类均未发现含有丹皮酚类。

关键词：化学分类芍药属丹皮酚类化合物

Neuron progenitors in the leptomeninges derived from the ventricular zone during development

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Neuron progenitors in the leptomeninges derived from the ven...

中国神经科学学会第十二届全国学术会议

作者： Jing Chen Jing Huang Fei-Fei Wu bao-lin guo guo-Hong Cai Nobuaki Tamamaki Sheng-Xi Wu Department of Anatomy and K.K.Leung Brain Research Centre Fourth Military Medical University Department of Neurobiology and Collaborative Innovation Centre for Brain Science Fourth Military Medical University Department of Morphological Neural Science Graduate School of Medical SciencesKumamoto University

Objective Meninges which surround the center nerve system consist of pia mater, arachnoid membrane and dura mater. Pervious research showed that these membranes work not only for a simple protection but also to keep the brain condition. It is reported that neural progenitors can be activated in the cortical surface adjacent to the injured region and leptomeninges（include the pia mater and arachnoid membrane）, and the cells sorted from the leptomeninges can form neurosphere-like clusters with selfrenewal activity in vitro. All these studies indicated that leptomeninges may be a novel stem cell niche. Some researchers thought that the microvascular pericytes may be the potential sources of neural progenitors. However, here we report that the neural progenitors may be derived from the ventricular zone as other nevour system. Methods The existence of potential neural progenitors in the leptomeninges was identified by different progenitor makers and Brd U label. And the origin of these neural progenitors was shown by in utero electroporation. Results（1） The ENKergic neurons born at E11.5 can be found near the leptomeninges of spinal cord during development stages;（2） Granule cells in the leptomeninges express or transcient express PV, GAD67 and Tbr2 during development;（3） 24 h after electroporation, the GFP-positive cells mainly located near the SVZ, but near the surface of the neocortex, there are also some GFP-positive cells. Conclusion Neural progenitors in the leptomeninges derived from the ventricular zone during development.

关键词： Neural progenitors leptomeninges development ventricular zone

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淫羊藿属植物黄酮类化合物的分类学意义再探

植物分类学报 2008年第6期46卷 874-885页

作者：郭宝林裴利宽肖培根中国医学科学院中国协和医科大学药用植物研究所北京100094

利用HPLC方法,对中国淫羊藿属Epimedium,主要是Epimedium亚属Diphyllon组的35种1变种129个植物叶片样品进行了淫羊藿苷类黄酮化合物的HPLC指纹图谱特征分析。主要依据样品图谱中的第二组峰'ABCI'组峰特征将所有图谱归为4大类9亚类,通过... 详细信息

利用HPLC方法,对中国淫羊藿属Epimedium,主要是Epimedium亚属Diphyllon组的35种1变种129个植物叶片样品进行了淫羊藿苷类黄酮化合物的HPLC指纹图谱特征分析。主要依据样品图谱中的第二组峰'ABCI'组峰特征将所有图谱归为4大类9亚类,通过与花形态性状的关联分析,确定不同类型图谱以及包含色谱峰的演化关系,并且提出:II-3是最原始的类型,II-1、IV、I-3为原始类型直接衍生的类型;I-1为基本类型,I-2、I-4、III、II-2为进化或者是特化类型。HPLC图谱类型的划分与***2002年发表的淫羊藿属分类系统Diphyllon组下4个系的划分具有较好的相关性。

关键词：化学分类淫羊藿属黄酮类化合物 HPLC色谱指纹图谱

Significant changes in mitochondrial distribution in different pain models of mice

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Significant changes in mitochondrial distribution in differe...

Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

中国神经科学学会第十届全国学术会议

作者： bao-lin guo Bing-Dong Sui Xue-Ying Wang Yan-Yan Wei Jing Huang Jing Chen Sheng-Xi Wu Yun-Qing Li Ya-Yun Wang Yan-ling Yang Department of Anatomy and K.K.Leung Brain Research Centre Fourth Military Medical University Department of Hepatobilliary Surgery The Fourth Military Medical University

Mitochondria play an important role in pathophysiology of inflammatory and neuropathic pain but the mechanisms *** far no comprehensive study exists that evaluates the changes of mitochondrial dynamics following the *** this study,we detected the mitochondrial distribution and subcellular morphology by using intrathecal injection of mitochondrial marker,Mitotracker Red（?） CM-H2XRox（Mito-Red） and confocal microscopic analysis in models of formalin-induced acute inflammatory pain,Complete Freund’s Adjuvant（CFA）-induced persistent pain and spared nerve injury（SNI）-induced neuropathic *** results demonstrated that subcutaneous formalin injection did not affect the number of Mito-Red cells within the spinal dorsal horn at both acute and tonic phases,but significantly increased the number of cluster type mitochondria in superficial spinal dorsal horn（laminas Ⅰ-Ⅱ） at tonic ***,the number of Mito-Red cells significantly increased in superficial and deep spinal dorsal horn（laminas Ⅲ-Ⅴ） following persistent CFA and SNI neuropathic ***,bom CFA and SNI remarkably increased the number of cluster type mitochondria and decreased the number of granule type mitochondria,in both superficial and deep spinal dorsal *** we concluded that abnormal mitochondrial distribution contributes to neuropathic and some forms of inflammatory pain.

关键词： mitochondrial dynamics inflammatory pain neuropathic pain mitochondrial marker

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Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang Chen Zhifeng Chen Menghua Li Weiwei guo Shuolong Yuan Liangwei Xu Chang lin Xi Shi Wei Chen Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine