检索结果-南通市图书馆

RIP140 regulates POLK gene expression and the response to alkylating drugs in colon cancer cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Drug Resistance 2022年第2期5卷 401-414页

作者： Pascale Palassin Marion Lapierre Sandrine Bonnet Marie-Jeanne Pillaire balázs győrffy Catherine Teyssier Stéphan Jalaguier Jean-Sébastien Hoffmann Vincent Cavaillès Audrey Castet-Nicolas IRCM Institut de Recherche en Cancérologie de MontpellierINSERMU1194Institut Régional du Cancer de MontpellierUniversitéde MontpellierMontpellier 34298France Institut de Pharmacologie et de Biologie Structurale IPBSUniversitéde ToulouseCNRSUPSToulouse 31077France. Department of Bioinformatics Semmelweis University and TTK Lendület Cancer Biomarker Research GroupBudapest H-1117Hungary Laboratoire de pathologie Laboratoire d’excellence Toulouse CancerInstitut Universitaire du Cancer-ToulouseOncopoleToulouse 31059France Département de Pharmacie Clinique Centre Hospitalo-Universitaire MontpellierMontpellier 34295France. Unitéde Formation et de Recherche des Sciences Pharmaceutiques et Biologiques Montpellier 34090France.

Aim:The transcription factor RIP140(receptor interacting protein of 140 kDa)is involved in intestinal *** plays a role in the control of microsatellite instability(MSI),through the regulation of MSH2 and MSH6 gene *** aim of this study was to explore its effect on the expression of POLK,the gene encoding the specialized translesion synthesis(TLS)DNA polymeraseκknown to perform accurate DNA synthesis at ***:Different mouse models and engineered human colorectal cancer(CRC)cell lines were used to analyze by RT-qPCR,while Western blotting and luciferase assays were used to elucidate the role of RIP140 on POLK gene *** DNA microarray datasets were *** in vitro sensitivity of CRC cells to methyl methane sulfonate and cisplatin was ***:RIP140 positively regulates,at the transcriptional level,the expression of the POLK gene,and this effect involves,at least partly,the p53 tumor *** different cohorts of CRC biopsies(with or without MSI),a strong positive correlation was observed between RIP140 and POLK gene *** connection with its effect on POLK levels and the TLS function of this polymerase,the cellular response to methyl methane sulfonate was increased in cells lacking the Rip140 ***,the association of RIP140 expression with better overall survival of CRC patients was observed only when the corresponding tumors exhibited low levels of POLK,thus strengthening the functional link between the two genes in human ***:The regulation of POLK gene expression by RIP140 could thus contribute to the maintenance of microsatellite stability,and more generally to the control of genome integrity.

关键词： Colorectal cancer genome stability translesion DNA synthesis polymerase Pol Kappa RIP140

免疫检查点相关分子在基底样乳腺癌中的预后价值分析

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

标记免疫分析与临床 2019年第9期26卷 1542-1546页

作者：艾超唐婧冀召帅宋微微闫旭 balázs gy?rffy 清华大学附属北京清华长庚医院清华大学临床医学院匈牙利科学院酶学研究所动量癌症生物标志物研究小组塞梅维什大学儿科二系

目的系统总结并全面探讨免疫检查点相关分子与基底样乳腺癌预后的相关性。方法从Gene Expression Omnibus(GEO)数据库下载、合并基于Affymetrix检测平台的乳腺癌全基因组表达谱数据集,并筛选出基底样乳腺癌基因表达谱及预后数据。根据... 详细信息

目的系统总结并全面探讨免疫检查点相关分子与基底样乳腺癌预后的相关性。方法从Gene Expression Omnibus(GEO)数据库下载、合并基于Affymetrix检测平台的乳腺癌全基因组表达谱数据集,并筛选出基底样乳腺癌基因表达谱及预后数据。根据最新文献全面总结免疫检查点基因及免疫检查点抑制剂疗效相关基因,全面分析这些基因的表达在基底样乳腺癌中的预后价值。结果本研究共筛选出618例基底样乳腺癌全基因组表达谱数据及预后信息,并总结了37个免疫检查点基因及免疫检查点抑制剂疗效相关基因。通过全面分析37个免疫检查点相关分子与无进展生存(PFS)的相关性,结果发现,乳酸脱氢酶A(LDHA)与PFS呈负相关(P0.05)。结论37个免疫检查点相关分子中,有34个基因与PFS呈正相关,1个基因与PFS呈负相关,2个基因与PFS无统计学相关性。

关键词：基底样乳腺癌免疫检查点分子预后

Spectral Test Instrument for Color Vision Measurement

在线全文

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2005年第2期2卷 75-79页

作者： balázs Vince Nagy gyrgy brahám Department of Mechatronics Optics and Instrumentation Budapest University of Technology and Economics Muegyetem rkp. 1-3 Budapest HUNGARY-1111Department of Mechatronics Optics and Instrumentation Budapest University of Technology and Economics Muegyetem rkp. 1-3 Budapest HUNGARY-1111

Common displays such as CRT or LCD screens have limited capabilities in displaying most color spectra correctly. The main disadvantage of these devices is that they work with three primaries and the colors displayed are the mixture of these three colours. Consequently these devices can be confusing in testing human color identification, because the spectral distribution of the colors displayed is the combined spectrum of the three primaries. We have developed a new instrument for spectrally correct color vision measurement. This instrument uses light emitting diodes (LEDs) and is capable of producing all spectra of perceivable colors, thus with appropriate test methods this instrument can be a reliable and useful tool in test~ing human color vision and in verifying color vision correction.

关键词： human color vision color vision measurement color spectrum LED instrument

Characteristics of allergic colitis in breast-fed infants in the absence of cow's milk allergy

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第24期19卷 3824-3830页

作者： Kriszta Molnár Petra Pintér Hajnalka gyrffy ron Cseh Katalin Eszter Müller András Arató Gábor Veres 1~(st) Department of Pediatrics Semmelweis University 2~(nd) Department of Pathology Semmelweis University

AIM: To investigate the characteristics of mucosal le-sions and their relation to laboratory data and long-term follow up in breast-fed infants with allergic colitis. METHODS: In this study 31 breast-fed infants were prospectively evaluated (mean age, 17.4 wk) whose rectal bleeding had not ceased after a maternal elimi-nation diet for cow's milk. Thirty-four age-matched and breast-fed infants (mean age, 16.9 wk) with no rectal bleeding were enrolled for laboratory testing as con-trols. Laboratory findings, colonoscopic and histological characteristics were prospectively evaluated in infants with rectal bleeding. Long-term follow-up with differ-ent nutritional regimes (L-amino-acid based formula or breastfeeding) was also included. RESULTS: Iron deficiency, peripheral eosinophilia andthrombocytosis were significantly higher in patients with allergic colitis in comparison to controls (8.4±3.2 μmol/L vs 13.7±4.7 μmol/L, Pgy exclusion, is generally a benign and probably self-limiting disorder despite marked mucosal abnor-mality. Formula feeding results in shorter time to cessa-tion of rectal bleeding; however, breast-feeding should not be discouraged in long-lasting

关键词： Rectal bleeding Breast-feeding Allergic colitis Colonoscopy Amino-acid formula

Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第25期18卷 3254-3259页

作者： Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres First Department of Pediatrics Semmelweis UniversityH-1083 BudapestHungary Research Group for Pediatrics and Nephrology Semmelweis University and Hungarian Academy of SciencesH-1083 BudapestHungary SE-MTA "Lendulet" Diabetes Research Group H-1083 BudapestHungary Second Department of Pathology Semmelweis UniversityH-1091 BudapestHungary First Department of Medicine Semmelweis UniversityH-1083 BudapestHungary Second Department of Medicine University of Debrecen H-4032 Debrecen Hungary

AIM： To investigate intestinal alkaline phosphatase （iAP） in the intestinal mucosa of children with inflammatory bowel disease （IBD）. METHODS： Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls. In IBD patients, specimens were obtainedboth from inflamed and non-inflamed areas. The lAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis, respectively. Tissue localiza- tion of lAP and Toll-like receptor （TLR） 4 was investi- gated by immunofluorescent staining. RESULTS： The lAP protein level in the inflamed muco- sa of children with Crohn＇s disease （CD） and ulcerative colitis （UC） was significantly decreased when compared with controls （both P 〈 0.05）. Similarly, we found a significantly decreased level of lAP protein in the in- flamed mucosa in CD compared with non-inflamed mucosa in CD （P 〈 0.05）. In addition, the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD （P 〈 0.05）. lAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls, lAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significant- ly different from that in non-inflamed colonic mucosa with CD. Expression of lAP mRNA in patients with non- inflamed mucosa and in controls were similar. Co-local- ization of lAP with TLR4 showed intense staining with a dotted-like pattern, lAP was present in the inflamed and non-inflamed mucosa of patients with CD, UC, and in control biopsy specimens, irrespective of whether it was present in the terminal ileum or in the colon. However, the fluorescent signal of TLR4 was more pro- nounced in the colon compared with the terminal ileum in all groups studied. CONCLUSION： Lower than normal lAP protein levels in inflamed mucosa of IBD patients may indicate a role for lAP in inflammatory lesions in IBD. Based on our r

关键词： Intestinal alkaline phosphatase Toll-like recep-tor Colonic biopsy Children Inflammatory bowel disease

Comparison study of several numerical integration schemes used in calculations of density functional theory

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 1996年第4期14卷 289-296页

作者： Hong, gy Li, LM BEIJING UNIV COLL CHEM & MOL ENGNSTATE KEY LAB RARE EARTH MAT CHEM & APPLICATBEIJING 100871PEOPLES R CHINA

Several numerical integration schemes for the evaluation of matrix elements in density functional theory calculations have been studied and compared by computational practice. The best scheme was found to be the combination of the atomic partition function proposed by Becke with the scaled generalized Gauss-Laguerre quadrature formula for radial integration suggested by Yang, which achieve the highest convergence rate to the numerical integration. With the same number of integration points, the accuracy of the calculated results by this scheme is higher by 1 to 2 orders of magnitudes than that by other schemes. The reason for achieving higher accuracy by this scheme has been proposed preliminarily.

关键词： density functional theory partition function numerical integration Gaussian quadrature numerical error

Schistosomiasis:progress and problems

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2000年第1期6卷 12-19页

作者： Wu gy Halim MH Department of Medicine Division of Gastroenterology-Hepatology-University of Connecticut Health CenterFarmingtonCT USA Department of Biochemistry National Research CentreCairoDokkiEgypt

INTRODUCTIONSchistosomiasis,also commonly known asbilharziasis,is one of the most significant parasiticdiseases of humans.A report of World HealthOrganization in 1996 estimated that over 200 millionpeople were infeste... 详细信息

关键词： Subject headings schistosomiasis development immune response diagnosis treatment

Almost Everywhere Convergence of Sequences of Cesàro and Riesz Means of Integrable Functions with Respect to the Multidimensional Walsh System

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2014年第2期30卷 311-322页

作者： gyrgy GT Institute of Mathematics and Computer Science College of Nyíregyhza

The aim of this paper is to prove the *** of sequences of the Cesaro and Riesz means of the Walsh–Fourier series of d variable integrable *** is,let a=（a1,...,ad）：N→Nd（d∈P）such that aj（n＋1）≥δsupk≤n aj（k）（j=1,...,d,n∈N）for someδ〉0 and a1（＋∞）=···=ad（＋∞）=＋∞.Then,for each integrable function f∈L1（Id）,we have the *** for the Cesaro means limn→∞σαa（n）f=f and for the Riesz means limn→∞σα,γa（n）f=f for any 0〈αj≤1≤γj（j=1,...,d）.A straightforward consequence of our result is the so-called cone restricted *** of the multidimensional Cesaro and Riesz means of integrable functions,which was proved earlier by Weisz.

关键词： Walsh system d-dimensional Fejer and Riesz means subsequence almost everywhereconvergence

Almost Everywhere Convergence of Fejér Means of L^1 Functions on Rarely Unbounded Vilenkin Groups

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2007年第12期23卷 2269-2294页

作者： gyrgy GT College of Nyíregyháza Institute of Mathematics and Computer Science

A highly celebrated problem in dyadic harmonic analysis is the pointwise convergence of the Fejér （or （C, 1）） means of functions on unbounded Vilenkin groups. There are several papers of the author of this paper concerning this. That is, we know the a.e. convergence σnf → f （n → ∞） for functions f ∈ L^p, where p 〉 1 （Journal of Approximation Theory, 101（1）, 1-36, （1999）） and also the a.e. convergence σMnf → f （n → ∞） for functions f ∈ L^1 （Journal of Approximation Theory, 124（1）, 25-43, （2003））. The aim of this paper is to prove the a.e. relation limn→∞ σnf = f for each integrable function f on any rarely unbounded Vilenkin group. The concept of the rarely unbounded Vilenkin group is discussed in the paper. Basically, it means that the generating sequence m may be an unbounded one, but its ＂big elements＂ are not ＂too dense＂.

关键词： rarely unbounded Vilenkin groups Vilenkin series Fejér means a.e. convergence