检索结果-南通市图书馆

Leptin Modulates the Differentiation of Keratinocytes via Autophagy in Psoriasis Patients with Metabolic Syndrome

International j.urnal of Dermatology and Venereology 2024年第3期7卷 121-130页

作者： Song C.-H. Wang R. Zhao Z.-K. Zhang Y. Sun j. Zhang X. Ding X.-Y. bai j. Liang X.-Q. Wei X.-j. Liu X.-L. Yang T. Liang X.-L. Li C.-X. Lin B.-W. Department of Dermatology PLA General Hospital Beijing 100853 China Department of Clinical Laboratory PLA General Hospital Beijing 100853 China Department of Dermatology Southern Medical University Guangdong Guangzhou 510515 China

Obj.ctive: Psoriasis is associated with a high prevalence of metabolic syndrome (MS), and patients with concomitant psoriasis and MS are more severely affected and less responsive to treatment. However, the molecular mechanisms behind these effects are unknown. Recent studies have shown that leptin may serve as a molecular link between psoriasis and MS, suggesting that high leptin concentrations may exacerbate psoriasis. However, the molecular mechanism of this effect is still unclear. We aimed to investigate the effect of leptin on autophagy in patients with psoriasis. Methods: From j.nuary 2021 to j.ne 2022 in PLA General Hospital, we enrolled 51 patients with psoriasis, including 21 patients with MS and 30 without MS, and 30 healthy controls who had undergone nevus surgery. We measured the epidermal leptin, P62, and LC3B concentrations of patients by immunohistochemistry, and measured the serum leptin concentration by enzyme-linked immunosorbent assay. We then performed correlation analyses to compare these proteins' concentrations between patients with concomitant psoriasis and MS, patients with psoriasis alone, and healthy control groups. Additionally, we performed western blotting after in vitro culture of HaCaT cells with different concentrations of leptin and measured the expression levels of the autophagy markers Beclin1, LC3B, and P62; the differentiation markers K10, K16, and K17; and PI3K/AKT/mTOR signaling pathway-related proteins of HaCat cells. Next, we transfected ATG5 into HaCaT cells to revert autophagy and used the specific PI3K inhibitor LY294002 to block PI3K/AKT/mTOR signaling. The expression levels of K10, K16, and K17 of HaCat cells were again measured. One-way analysis of variance was used for the comparison of means of multiple samples, and LSD-t post hoc test was used for comparison between the 2 groups. The counting data were analyzed by the chi-square test. Correlations were evaluated by Pearson correlation analysis. Results: The serum l

关键词： autophagy keratinocyte differentiation leptin metabolic syndrome PI3K/AKT/mTOR psoriasis signal pathway

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Electrical stimulation with polypyrrole-coated polycaprolactone/silk fibroin scaffold promotes sacral nerve regeneration by modulating macrophage polarisation

引用

Biomaterials Translational 2024年第2期5卷 157-174页

作者： Cheng H. bai j. Zhou X. Chen N. j.ang Q. Ren Z. Li X. Su T. Liang L. j.ang W. Wang Y. Peng j. Shang A. School of Medicine Nankai University Tianjin China Department of Neurosurgery Chinese PLA General Hospital Beijing China Institute of Orthopedics Chinese PLA General Hospital Beijing Key Lab of Regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma and War Injuries PLA Beijing China Co-innovation Center of Neuroregeneration Nantong University Jiangsu Province Nantong China Graduate School of Chinese PLA General Hospital Beijing China Department of Ultrasound Chinese PLA General Hospital Beijing China

Peripheral nerve inj.ry poses a great threat to neurosurgery and limits the regenerative potential of sacral nerves in the neurogenic bladder. It remains unknown whether electrical stimulation can facilitate sacral nerve regeneration in addition to modulate bladder function. The obj.ctive of this study was to utilise electrical stimulation in sacra nerve crush inj.ry with newly constructed electroconductive scaffold and explore the role of macrophages in electrical stimulation with crushed nerves. As a result, we generated a polypyrrole-coated polycaprolactone/silk fibroin scaffold through which we applied electrical stimulation. The electrical stimulation boosted nerve regeneration and polarised the macrophages towards the M2 phenotype. An in vitro test using bone marrow derived macrophages revealed that the pro-regenerative polarisation of M2 were significantly enhanced by electrical stimulation. Bioinformatics analysis showed that the expression of signal transducer and activator of transcriptions (STATs) was differentially regulated in a way that promoted M2-related genes expression. Our work indicated the feasibility of electricals stimulation used for sacral nerve regeneration and provided a firm demonstration of a pivotal role which macrophages played in electrical stimulation. © 2024, Chinese Medical Multimedia Press Co Ltd. All rights reserved.

关键词： electrical stimulation j.K-STAT signalling pathway macrophage polarisation peripheral nerve regeneration polypyrrole sacral nerve inj.ry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microphysical Insights into a Tornadic Supercell from Dual-Polarization Radar Observations in j.angsu, China on 14 May 2021

引用

j.urnal of Meteorological Research 2024年第2期38卷 303-320页

作者： Chao YUAN Yang bai Pengfei SUN Hua bai Lu XIA China Meteorological Administration Tornado Key Laboratory Foshan 528315 Institute of Atmospheric Environment China Meteorological AdministrationShenyang 110166 Panj.n National Climate Observatory Panjin 124010 Yangzhou Meteorological Bureau of j.angsu Province Yangzhou 225100 Yichun Meteorological Bureau of Heilongj.ang Province Yichun 153000

Tornadoes are incredibly powerful and destructive natural events,yet the microphysical characteristics of the parent storm and its effects on tornadogenesis remain *** study analyzed polarization radar data of a tornadic supercell that occurred in j.angsu Province of China on 14 May 2021,in comparison with another tornadic supercell and two non-tornadic supercells that occurred in the same region in *** two tornadic supercells exhibited lower differential reflectivity(ZDR)in the hook echo region compared with the non-tornadic supercells,indicating smaller median drop sizes.A distinct increase in ZDR from the melting of frozen hydrometeors,observed between2.5-and 4.0-km altitude in the non-tornadic storms,was absent in the tornadic *** non-tornadic supercells also displayed substantially higher specific differential phase(KDP)below the melting level,likely aroused from enhanced melting and *** findings suggest fundamental microphysical contrasts between tornadic and nontornadic ***,tornadic supercells have smaller droplets and may reduce melting in hook ***,greater separation between the ZDR arc and the KDP foot was observed during *** vertical gradient of KDP related to the cooling pool strength of the hook echo,regulating rear-flank downdraft *** the limited number of cases investigated,the findings of this study indicate that monitoring ZDR,KDP,and drop size distribution trends could assist with tornado prediction and warnings.

关键词： tornado polarimetric radar supercell hook echo drop size distribution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Free-moving-state microscopic imaging of cerebral oxygenation and hemodynamics with a photoacoustic fiberscope

引用

Light(Science & Applications) 2024年第1期13卷 33-46页

作者： Xiaoxuan Zhong Yizhi Liang Xiaoyu Wang Haoying Lan Xue bai Long j.n bai-Ou Guan Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications Institute of Photonics TechnologyJinan UniversityGuangzhou510632China

We report the development of a head-mounted photoacoustic fiberscope for cerebral imaging in a freely behaving *** 4.5-gram imaging probe has a 9-µm lateral resolution and 0.2-Hz frame rate over a 1.2-mm wide *** probe can continuously monitor cerebral oxygenation and hemodynamic responses at single-vessel resolution,showing significantly different cerebrovascular responses to external stimuli under anesthesia and in the freely moving *** example,when subj.cted to high-concentration CO_(2) respiration,enhanced oxygenation to compensate for hypercapnia can be visualized due to cerebral regulation in the freely moving *** studies exhibit significantly weakened compensation capabilities in obese *** new imaging modality can be used for investigating both normal and pathological cerebrovascular functions and shows great promise for studying cerebral activity,disorders and their treatments.

关键词： cerebral anesthesia moving

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The 2024 M_(j. 7.6 Noto Peninsula, j.pan earthquake caused by the fluid flow in the crust

引用

Earthquake Research Advances 2024年第3期4卷 1-6页

作者： Yuzo Ishikawa Ling bai Center for Integrated Research and Education of Natural Hazards Shizuoka UniversityShizuoka422-8529Japan State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing100101China University of Chinese Academy of Sciences Beijing100049China

On j.nuary 1, 2024 at 16:10:09 j.T, an M_(j. 7.6 earthquake struck the Noto Peninsula in the southern part of the Sea of j.pan. This location has been experiencing an earthquake swarm for more than three years. Here, we provide an overview of this earthquake, focusing on the slip distribution of the mainshock and its relationship with the preceding swarm. We also reexamined the source areas of other large earthquakes that occurred around the Sea of j.pan in the past and compared them with the Matsushiro earthquake swarm in central j.pan from1964 to 1968. The difference between the Matsushiro earthquake swarm and the Noto earthquake swarm is the surrounding stress field. The Matsushiro earthquake swarm was a strike-slip stress field, so the cracks in the crust were oriented vertically. This allowed fluids seeped from the depths to rise and flow out to the surface. On the other hand, the Noto area was a reverse fault stress field. Therefore, the cracks in the earth's crust were oriented horizontally. Fluids flowing underground in deep areas could not rise and spread over a wide area in the horizontal plane. This may have caused a large amount of fluid to accumulate underground, triggering a large earthquake. Although our proposed mechanism does not take into account other complex geological conditions into consideration, it may provide a simple way to explain why the Noto swarm is followed by a large earthquake while other swarms are not.

关键词： The M 7.6 Noto Peninsular earthquake Earthquake swarm Fluid triggering Strike-slip fault Reverse fault

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Knowledge and data j.intly driven aeroengine gas path performance assessment method

引用

Chinese j.urnal of Aeronautics 2024年第5期37卷 533-557页

作者： Zhe WANG Xuyun FU Rui ZHANG Zhengfeng bai Xiangzhao XIA Wei j.ANG Department of Mechanical Engineering Harbin Institute of TechnologyWeihai 264209China Weihai Key Laboratory of Intelligent Operation and Maintenance Harbin Institute of TechnologyWeihai 264209China Control System Design Laboratory AECC ShenYang Engine Research InstituteShenyang 110015China

Aeroengines,as the sole power source for aircraft,play a vital role in ensuring flight *** gas path,which represents the fundamental pathway for airflow within an aeroengine,directly impacts the aeroengine's performance,fuel efficiency,and ***,timely and accurate evaluation of gas path performance is of paramount *** paper proposes a knowledge and data j.intly driven aeroengine gas path performance assessment method,combining Fingerprint and gas path parameter deviation ***,Fingerprint is used to correct gas path parameter deviation values,eliminating parameter shifts caused by non-component performance ***,coarse errors are removed using the Romanovsky criterion for short-term data divided by an equal-length overlapping sliding ***,an Ensemble Empirical Mode Decomposition and Non-Local Means(EEMD-NLM)filtering method is designed to“clean”data noise,completing the preprocessing for gas path parameter deviation ***,based on the characteristics of gas path parameter deviation values,a Dynamic Temporary Blended Network(DTBN)model is built to extract its temporal features,cascaded with Multi-Layer Perceptron(MLP),and combined with Fingerprint to construct a Dynamic Temporary Blended AutoEncoder(DTB-AutoEncoder).Eventually,by training this improved autoencoder,the aeroengine gas path multi-component performance assessment model is formed,which can sufficiently decouple the nonlinear mapping relationship between aeroengine gas path multi-component performance degradation and gas path parameter deviation values,thereby achieving the performance assessment of engine gas path *** practical application cases,the effectiveness of this model in assessing the aeroengine gas path multi-component performance is verified.

关键词： Performance assessment Aeroengine Fingerprint Gas path parameter deviation values j.intly drive

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Oxygen tension modulates cell function in an in vitro three-dimensional glioblastoma tumor model

引用

Bio-Design and Manufacturing 2024年第3期7卷 307-319页

作者： Sen Wang Siqi Yao Na Pei Luge bai Zhiyan Hao Dichen Li j.ankang He j.Miguel Oliveira Xiaoyan Xue Ling Wang Xinggang Mao State Key Laboratory for Manufacturing System Engineering Xi’an Jiaotong UniversityXi’an 710054China School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710054China NMPA Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices Xi’an Jiaotong UniversityXi’an 710054China 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-PT Government Associate Laboratory 4806-909 Braga/Guimar˜aesPortugal Department of Pharmacology School of PharmacyFourth Military Medical UniversityXi’an 710032China Department of Neurosurgery Xijing HospitalFourth Military Medical UniversityXi’an 710032China

Hypoxia is a typical feature of the tumor microenvironment,one of the most critical factors affecting cell behavior and tumor ***,the lack of tumor models able to precisely emulate natural brain tumor tissue has impeded the study of the effects of hypoxia on the progression and growth of tumor *** study reports a three-dimensional(3D)brain tumor model obtained by encapsulating U87MG(U87)cells in a hydrogel containing type I *** also documents the effect of various oxygen concentrations(1%,7%,and 21%)in the culture environment on U87 cell morphology,proliferation,viability,cell cycle,apoptosis rate,and ***,it compares two-dimensional(2D)and 3D *** comparison purposes,cells cultured in flat culture dishes were used as the control(2D model).Cells cultured in the 3D model proliferated more slowly but had a higher apoptosis rate and proportion of cells in the resting phase(G0 phase)/gap I phase(G1 phase)than those cultured in the 2D ***,the two models yielded significantly different cell ***,hypoxia(e.g.,1%O2)affected cell morphology,slowed cell growth,reduced cell viability,and increased the apoptosis rate in the 3D *** results indicate that the constructed 3D model is effective for investigating the effects of biological and chemical factors on cell morphology and function,and can be more representative of the tumor microenvironment than 2D culture *** developed 3D glioblastoma tumor model is equally applicable to other studies in pharmacology and pathology.

关键词： Hypoxia Glioma Three-dimensional glioma model In vitro

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Simplified Method for the Stress Analysis of Underground Transfer Structures Crossing Multiple Subway Tunnels

引用

Computer Modeling in Engineering & Sciences 2024年第6期139卷 2893-2915页

作者： Shen Yan Daj.ang Geng Ning Dai Mingj.an Long Zhicheng bai College of Civil Engineering Tongji UniversityShanghai200092China China Construction 4th Engineering Bureau 6th Corp. Ltd.Shanghai201199China Department of Civil and Architecture Engineering Hubei Polytechnic UniversityHuangshi435003China

According to the design specifications,the construction of extended piles involves traversing the tunnel’s upper region and extending to the underlying rock *** address this challenge,a subterranean transfer structure spanning multiple subway tunnels was *** on the function of piles in the transfer structure as springs with axial and bending stiffness,and taking into account the force balance and deformation coordination conditions of beams and plates within the transfer structure,we established a simplified mechanical model that incorporates soil stratification by combining it with the Winkler elastic foundation beam *** resolved established simplifiedmechanicalmodel employed finite difference technology and the Newton-Simpsonmethod,elucidating the mechanical mechanism of the transfer *** research findings suggest that the load carried by the upper structural columns can be transferred to the pile foundation beneath the beams through the transfer structure,subsequently reaching the deep soil layer and ensuring minimal impact on adj.cent *** established simplified analysis method can be used for stress analysis of the transfer structure,concurrently considering soil stratification,pile foundation behavior,and plate *** pile length,pile section size,and beam section size within the transfer structure should account for the characteristics of the upper load,ensuring an even distribution of the beam bending moment.

关键词： Crossing tunnels transfer structure force mechanism simplify analysis layered soil mass

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Surface decoration of mesocarbon microbeads with multifunctional TiNbO_(4-x)@C coating layer as high rate and stable anode of Li-ion batteries

引用

Rare Metals 2024年第5期43卷 2053-2066页

作者： j.a-Mei Lai Zhi-Min Zou Yu bai Yu-Tao Xing Chun-Hai j.ang Fuj.an Provincial Key Laboratory of Functional Materials and Applications Institute of Advanced Energy MaterialsSchool of Materials Science and EngineeringXiamen University of TechnologyXiamen 361024China Shanghai XFH Science and Technology Development Co. Ltd.Shanghai 200949China Fuj.an XFH New Energy Materials Co. Ltd.Yong'an 366000China Shenzhen XFH Science and Technology Co. Ltd.Shenzhen 518071China Laboratorio de Microscopia Eletronica de Alta Resolucao Centro de Caracterizagao Avangada Para a Industria de Petroleo(LaMAR/CAIPE)Universidade Federal FluminenseNiteroiRJ 24210-346Brazil

Surface modification of graphite anode with electroactive matters has been proven of a more practical strategy in enhancing the performance of Li-ion batteries than exploring alternative novel anode ***,rutile TiNbO_(4-x) nanoparticles with a tunnel structure are employed as multifunctional decoration substances in combination with a carbon coating layer to improve the rate and cycle properties of mesocarbon microbeads(MCMBs).As compared to pristine MCMB,the Li^(+)diffusion coefficients of the composite anodes are enhanced due to the synergistic effect of TiNbO_(4-x)@***,the overcharge and voltage polarization of the composite anodes at high rate are obviously minimized due to the current sharing effect of the high-potential TiNbO_(4-x).Moreover,the amorphous Li_(y)TiNbO_(4-x) converted from TiNbO_(4-x) in the initial lithiation process can deliver pseudocapacitive capacity to the composite anodes from the second *** of these functions of TiNbO_(4-x)@Ccoating layer have directly contributed to the improved rate and cycle performance of the MCMB/TiNbO_(4-x)@C composite *** one containing 12.0 wt%TiNbO_(4-x) exhibits a high reversible specific capacity of 118 m Ah·g^(-1)at 10C(1C=372 m A·g^(-1)),together with a high capacity retention of 90.9%after 300 cycles at 3C,which are all much superior to those of pristine MCMB.

关键词： Li-ion batteries MCMB TiNbO_(4-x)@C Surface decoration Rate capability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Genome editing toward biofortified soybean with minimal trade-off between low phytic acid and yield

引用

aBIOTECH 2024年第2期5卷 196-201页

作者： Wenxin Lin Mengyan bai Chunyan Peng Huaqin Kuang Fanj.ang Kong Yuefeng Guan Sanya Institute of China Agricultural University Sanya 572000China College of Agronomy China Agricultural UniversityBeijing 100193China Guangdong Provincial Key Laboratory of Plant Adaptation and Molecular Design Innovative Center of Molecular Genetics and EvolutionSchool of Life SciencesGuangzhou UniversityGuangzhou 510006China College of Life Sciences Fujian Agriculture and Forestry UniversityFuzhou 350002China

Phytic acid(PA)in grain seeds reduces the bioavailability of nutrient elements in monogastric animals,and an important obj.ctive for crop seed biofortification is to decrease the seed PA ***,we employed CRISPR/Cas9 to generate a PA mutant population targeting PA biosynthesis and transport genes,including two multi-drug-resistant protein 5(MRP5)and three inositol pentose-phosphate kinases(IPK1).We characterized a variety of lines containing mutations on multiple IPK and MRP5 *** seed PA was more significantly decreased in higher-order mutant lines with multiplex ***,such mutants also exhibited poor agronomic *** the population,we identified two lines carrying single mutations in ipk1b and ipk1c,*** mutants exhibited moderately reduced PA content,and regular agronomic performance compared to the wild *** study indicates that moderately decreasing PA by targeting single GmIPK1 genes,rather than multiplex mutagenesis toward ultra-low PA,is an optimal strategy for low-PA soybean with a minimal trade-off in yield performance.

关键词： Genome editing Phytic acid Soybean Agronomic traits CRISPR/Cas9

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：