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Journal of Environmental Sciences 2007年第10期19卷 1266-1271页

作者： XIAO Jun-ping ZHOU Qing-xiang bai hua-hua Department of Chemistry University of Science and Technology Beijing Beijing 100083 China Henan Key Laboratory for Environmental Pollution Control School of Chemistry and Environmental Sciences Henan Normal University Xinxiang 453007 China

In this study we investigated the enrichment ability of oxidized multiwalled carbon nanotubes （MWCNTs） and established a new method for the determination of trace cadmium in environment with flame atomic absorption spectrometry. The MWCNTs were oxidized by potassium permanganate under appropriate conditions before use as preconcentration packing. Parameters influencing the recoveries of target analytes were optimized. Under optimal conditions, the target analyte exhibited a good linearity （R^2=0.9992） over the concentration range 0.5-50 ng/ml. The detection limit and precision of the proposed method were 0.15 ng/ml and 2.06%, respectively. The proposed method was applied to the determination of cadmium in real-world environmental samples and the recoveries were in the range of 91.3%-108.0%. All these experimental results indicated that this new procedure could be applied to the determination of trace cadmium in environmental waters.

关键词： multiwalled carbon nanombes (MWCNTs) solid-phase extraction flame atomic absorption spectrometry

Rapid determination of phenolic compounds in water samples by alternating-current oscillopolarographic titration

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Journal of Environmental Sciences 2007年第5期19卷 622-627页

作者： XIAO Jun-ping WANG Xue-feng ZHOU Qing-xiang FAN Xiao-yuan SU Xian-fa bai hua-hua DUAN Hai-jing Department of Chemistry University of Science and Technology Beijing Beijing 100083 China Henan Key Laboratory for Environmental Pollution Control School of Chemistry and Environmental Sciences Henan Normal University Xinxiang 453007 China

A rapid, simple and sensitive method was demonstrated for the determination of phenolic compounds in water samples by alternating-current oscillopolarographic titration. With the presence of sulfuric acid, phenol could be transferred into a nitroso-compound by reacting with NaNO2. The titration end-point was obtained by the formation of a sharp cut in the oscillopolarographic with infinitesimal NaNO2 on double platinum electrodes. The results showed that phenol had an excellent linear relationship over the range of 4.82×10^-6 -9.65×10^-3 mol/L, the RSD of the proposed method was lower than 1.5%, and the spiked recoveries of three real water samples were in the range of 95.6%-106.9%.

关键词： alternating-current oscillopolarographic titration phenolic compounds

Deciphering the role of mtH2O2 in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

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Science China Chemistry 2025年第1期68卷 297-307页

作者： Bin Fang Limin Wang Haoqin Li Jiaxin Zhang Yang Ding Pan Pan Li Bo Peng hua bai Lin Li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials &Engineering Northwestern Polytechnical University Institute of Flexible Electronics (IFE Future Technologies) Xiamen University

Hepatic ischemia-reperfusion injury（HIRI） is characterized by mitochondrial dysfunction and oxidative stress. Monitoring mitochondrial hydrogen peroxide（mtH2O2） levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during HIRI. However, low-background fluorogenic probes have been overlooked in the context of super-resolution imaging. In this study, we developed a low-background fluorogenic probe（MitoWG） with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH2O2in HIRI. Activation of the desirable fluorescence properties of the probe by mtH2O2was confirmed using structural illumination microscopy（SIM）, enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH2O2levels were successfully observed in both cellular and rat models of HIRI. Furthermore, we associated the decline in mitochondrial redox homeostasis with accelerated mtH2O2production during HIRI, which triggered mitophagy deficiency and led to cell death. In conclusion, Mito-WG possesses excellent photophysical and low-background properties for SIM imaging, making it a promising tool for mtH2O2tracking in HIRI research and clinical diagnosis.

关键词： hepatic ischemia-reperfusion injury low-background mtH2O2-activatable super-resolution imaging fluorogenic probe

New exploration on pathogenesis and early diagnosis of gestational diabetes

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World Journal of Clinical Cases 2025年第1期13卷 1-5页

作者： hua bai Department of Neurology The Third Affiliated Hospital of Guizhou Medical UniversityDuyun 558099Guizhou ProvinceChina

Gestational diabetes mellitus(GDM)refers to varying degrees of abnormal glucose metabolism that occur during pregnancy and excludes patients pre-viously diagnosed with *** is a unique among the four subtypes of diabetes classified by the international World Health Organization *** GDM patients constitute a small proportion of the total number of diabetes cases,the incidence of GDM has risen significantly over the past decade,posing substantial risk to pregnant women and ***,it warrants considerable *** pathogenesis of GDM is generally considered to resemble that of type II diabetes,though it may have distinct *** blood biochemical proteins in the context of GDM can help elucidate its pathogenesis,thereby facilitating more effective prevention and management *** article reviews this critical clinical issue to enhance the medical community's sufficient understanding of GDM.

关键词： Gestational diabetes mellitus Pathogenesis Proteomics RBP4 ANGPTL8

Searching for new drugs to treat Alzheimer’s disease dementia through multiple pathways

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World Journal of Clinical Cases 2025年第1期13卷 22-28页

作者： hua bai Xiao-Feng Feng Department of Neurology The Third Affiliated Hospital of Guizhou Medical UniversityDuyun 558099Guizhou ProvinceChina Department of Neurology Wulong Branch of the People's Hospital Affiliated to Chongqing UniversityWulong 408500ChongqingChina Department of Neurology Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina

Dementia is a group of diseases,including Alzheimer's disease(AD),vascular dementia,Lewy body dementia,frontotemporal dementia,Parkinson's disease dementia,metabolic dementia and toxic *** treatment of dementia mainly includes symptomatic treatment by controlling the primary disease and accompanying symptoms,nutritional support therapy for repairing nerve cells,psychological auxiliary treatment,and treatment that improves cognitive function through *** them,drug therapy to improve cognitive function is *** review focuses on introducing and commenting on some recent progress in exploring drugs to improve cognitive function,especially the new progress in drug treatment for *** mainly discuss the opportunities and challenges in finding and developing new therapeutic drugs from the aspects of acetylcholinesterase,N-methyl-D-aspartate glutamate receptor,amyloid protein,tau protein and chronic immune inflammation.

关键词： Alzheimer's disease Dementia Cholinesterase inhibitor Beta amyloid Tau protein

油烟净化器对餐饮VOCs排放和光化学特征的影响

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中国环境科学 2021年第5期41卷 2040-2047页

作者：蒋宝孙成一白画画陈雪何万清聂磊石爱军李国傲北京市环境保护科学研究院国家城市环境污染控制工程技术研究中心城市大气挥发性有机物污染防治技术与应用北京市重点实验室北京100037

选取了北京市21家餐饮企业,检测了净化器前端和后端的挥发性有机污染物(VOCs)的浓度水平,经油烟净化器净化后,烷烃类、烯烃类、含氧VOCs类和苯系物类污染物的排放平均浓度分别为(714.62±212.17),(264.88±94.58),(374.72±57.48)和(174... 详细信息

选取了北京市21家餐饮企业,检测了净化器前端和后端的挥发性有机污染物(VOCs)的浓度水平,经油烟净化器净化后,烷烃类、烯烃类、含氧VOCs类和苯系物类污染物的排放平均浓度分别为(714.62±212.17),(264.88±94.58),(374.72±57.48)和(174.93±55.19)μg/m^(3),烯烃类污染物中仅对四氯乙烯有明显的浓度降低效果.根据净化器对VOCs污染物的去除效果,有35.7%的净化器净化效率为负值.烯烃类污染物是餐饮油烟污染中臭氧生成的最重要的前体物,占总臭氧生成潜势的48.2%~50.7%.苯系物成为餐饮业排放污染物中二次有机气溶胶(SOA)的主要前体物,占总SOA生成潜势的95%以上.

关键词：餐饮业挥发性有机污染物臭氧生成潜势二次有机气溶胶

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北京市餐饮业大气污染物排放特征

环境科学 2020年第6期41卷 2596-2601页

作者：孙成一白画画陈雪翟翼飞高启天何万清聂磊石爱军李国傲北京市环境保护科学研究院国家城市环境污染工程技术研究中心城市大气挥发性有机物污染防治技术与应用北京市重点实验室北京100037 北京市通州区生态环境局北京101101

餐饮业是中国大型城市大气环境污染源之一.为了解餐饮业大气污染物的产生能力,本研究以北京为研究对象,选取41家不同菜系的餐饮企业,现场实地检测了净化设备前端的油烟、颗粒物和非甲烷总烃(NMHC)的产生浓度水平.结果表明,净化前油烟、... 详细信息

餐饮业是中国大型城市大气环境污染源之一.为了解餐饮业大气污染物的产生能力,本研究以北京为研究对象,选取41家不同菜系的餐饮企业,现场实地检测了净化设备前端的油烟、颗粒物和非甲烷总烃(NMHC)的产生浓度水平.结果表明,净化前油烟、颗粒物和NMHC的初始平均浓度约为1.93、6.6和10.9 mg·m^-3.提出了一种基于工作日与非工作日的估算污染物排放总量的计算方法.并基于北京市餐饮企业数量和本研究测得的排放因子,初步估算了2019年全市餐饮源主要污染物的初始产生总量,油烟、颗粒物和NMHC的年排放总量分别为5512、18849和6169 t.川湘菜、烧烤、烤鸭与家常菜产生的油烟与颗粒物浓度的Pearson系数均>0.6,具有强相关性;其中川湘菜和烤鸭排放的Pearson系数均>0.8,呈现极强相关性.

关键词：餐饮业油烟颗粒物非甲烷总烃(NMHC) 相关性初始产生总量

浊点萃取-火焰原子吸收光谱法测定环境水样中痕量铅

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河南师范大学学报（自然科学版） 2007年第2期35卷 115-118页

作者：周庆祥白画画代文华丁玉杰汪卫东赵新宁河南师范大学化学与环境科学学院河南省环境污染控制重点实验室河南新乡453007

采用浊点萃取技术-火焰原子吸收光谱法联用开发了分析环境水样中痕量铅的新方法．方法的检测限为58．7ng·mL^-1，线性范围为200～400ng·mL^-1，实际水样分析结果令人满意．所建立的方法可应用于铅的例行分析，为环境监测部门提供了便... 详细信息

采用浊点萃取技术-火焰原子吸收光谱法联用开发了分析环境水样中痕量铅的新方法．方法的检测限为58．7ng·mL^-1，线性范围为200～400ng·mL^-1，实际水样分析结果令人满意．所建立的方法可应用于铅的例行分析，为环境监测部门提供了便捷的检测工具，对铅的环境安全性评价具有非常重要的意义．

关键词：浊点萃取铅火焰原子吸收光谱法

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平均指标在统计分析中的应用

信阳农业高等专科学校学报 2004年第1期14卷 93-94页

作者：申斯董新华柏华信阳农业高等专科学校河南信阳464000

平均指标应用广泛,在统计工作中具有非常重要的作用。熟练掌握平均指标的计算与应用,有利于提高统计分析质量及统计工作效率。

关键词：平均指标统计分析应用

Meta-analysis of 5, 10-methylenetetrahydrofolate reductase gene polymorphism as a risk factor for ischemic cerebrovascular disease in a Chinese Han population

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Neural Regeneration Research 2011年第5期6卷 360-365页

作者： hua bai Department of Neurology First Affiliated Hospital of Chengdu Medical College Chengdu 610500 Sichuan Province China

OBJECTIVE： To assess whether 5, 10-methylenetetrahydrofolate reductase （MTHFR） gene polymorphism （TT genotype or T allele） is a risk factor for ischemic cerebrovascular disease （ICVD）. DATA SOURCES： MEDLINE and PubMed databases from September 1997 to December 2009 were searched for case-control studies that examined MTHFR genotype in human ICVD using ＂MTHFR, gene, polymorphism, and ischemic cerebrovascular disease＂ as search key words. STUDY SELECTION： Eighteen associated studies were identified. The methods used to collect relevant information factors were similar between case and control groups, and diagnosis of ischemic cerebrovascular disease was in accordance with Trial of ORG 10172 in Acute Stroke Treatment criteria classification, with some referring to European Stroke Diagnostic Criteria. Quality of all included studies was evaluated, and meta-analysis was conducted using RevMan4.2 software （Cochrane Collaboration, http：//***） following strict screening. MAIN OUTCOME MEASURES： The correlation between MTHFR gene TT genotype or T allele and ICVD was determined. RESULTS： Eighteen studies involving 4 295 patients with ICVD and 6 169 control subjects were included for this meta-analysis. There was a significant difference in MTHFR gene TT genotype or T allele frequency （x^2 = 15.737, 9.186, P 〈 0.01） between ICVD cases and controls. In addition, six Chinese Han population studies were specially reviewed by meta-analysis. Results showed no significant difference between ICVD and control groups with regard to frequency of MTHFR gene TT genotype and T allele （x^2 = 1.076, 2.434, P 〉 0.05） in the Chinese Han population. CONCLUSION： Results from the present meta-analysis suggested that the MTHFR gene TT genotype or T allele is a risk factor for ICVD. However, the TT genotype or T allele is not a risk factor for ICVD in the Chinese Han population.

关键词： ischemic cerebrovascular disease methylenetetrahydrofolate gene polymorphism