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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1518-1520页

作者： Ugur Yilmaz Mumcu Ibrahim Kocer orhan Ates H.Hakan Alp Department of Ophthalmology Haydarpasa Training and Research Hospital Department of Ophthalmology Faculty of MedicineAtatürk University Department of Biochemistry Atatürk University

To investigate the malondialdehyde（MDA） levels,paraoxonase1（PON1） activity and 8-hydroxy 2-deoxyguanosine（8-OHd G） levels in the primary open angle glaucoma（POAG） *** samples from 52 healthy individuals and 53 patients with POAG were analyzed for MDA and 8-OHd G by high-performance liquid chromatography（HPLC） and PON1 by *** data obtained were analyzed *** levels were 10.46±8.4 and 4.70±1.79 μmol; PON1 levels were 121 ±39.55 and 161.62 ±60.22 U/m L; and 8-OHd G values were1.32 ±0.53/10~6 d G and 0.47 ±0.27/10~6 d G in the POAG patients and the control group,*** difference was significant in MDA levels,8-OHd G levels and PON1 activity in POAG patients in comparison with controls（P 〈0.001）.We concluded that the observed increase in MDA and 8-OHd G levels may be correlated with decreased PON1 *** stress plays an important role in glaucoma development.

关键词： glaucoma paraoxonase 8-hydroxy2-deoxy guanosine

Natural Products as Potential Leads Against Coronaviruses: Could They be Encouraging Structural Models Against SARS-CoV-2?

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Natural Products and Bioprospecting 2020年第4期10卷 171-186页

作者： Ilkay Erdogan orhan F.Sezer Senol Deniz Department of Pharmacognosy Faculty of PharmacyGazi University06330 AnkaraTurkey

New coronavirus referred to SARS-CoV-2 has caused a worldwide pandemic(COVID-19)declared by *** disease 2019(COVID-19)is an infectious disease with severe acute respiratory syndrome caused by coronavirus-2(SARS-CoV-2).SARS-CoV-2 is akin to SARS-CoV,which was the causative agent of severe acute respiratory syndrome(SARS)in 2002 as well as to that of Middle East respiratory syndrome(MERS)in ***-CoV-2 has been revealed to belong to Coronaviridiae family as a member ofβ-*** has a positive-sense single-stranded RNA with the largest RNA *** its genomic sequence has a notable similarity to that of SARS-CoV,antiviral drugs used to treat SARS and MERS are now being also applied for COVID-19 *** order to combat SARS-CoV-2,many drug and vaccine development studies at experimental and clinical levels are currently conducted *** this sense,medicinal plants and the pure natural molecules isolated from plants have been reported to exhibit significant inhibitory antiviral activity against SARS-CoV and other types of *** the present review,plant extracts and natural molecules with the mentioned activity are discussed in order to give inspiration to researchers to take these molecules into consideration against SARS-CoV-2.

关键词： Coronavirus SARS-CoV Medicinal plants Natural products Antiviral

Clinical and impression cytology findings of amniotic membrane and oral mucosal membrane transplantation for the management of socket contracture

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International Journal of Ophthalmology(English edition) 2014年第2期7卷 340-344页

作者： Bengi Ece Kurtul Ugur Erdener Mehmet Cem Mocan Murat Irkec Mehmet orhan Department of Ophthalmology Hacettepe University

AIM:To investigate and compare the cytopathological and clinical effects of amniotic membrane transplantation(AMT)and oral mucosal membrane transplantation(OMMT)in socket ***:Twelve patients who could not be fitted with ocular prosthesis due to socket contracture were included in this *** patients underwent AMT and 5 patients underwent *** patients who had healthy sockets were included as control *** of inferior fornix,degree of inflammation,extent of the socket contracture and socket volume were measured in the preoperative period and at sixth and twelfth weeks *** cytology of conjunctival fornices and tear transforming growth factor beta-1(TGFβ1)levels were ***:In the AMT group,socket volume and lower fornix depth values were significantly higher(P=0.030and P=0.004 respectively)and inflammation levels and impression cytology stages(P=0.037 and P=0.022respectively)were significantly lower in postoperative period compared to preoperative *** the OMMT group,no statistical differences were found in terms of clinical parameters,inflammation levels and impression cytology stages of preoperative versus postoperative *** tear TGFβ1 levels were higher in AMT and OMMT groups compared to the control group(25.5 ng/mL,26.3 ng/mL and 21.7 ng/mL respectively).Decreased tear TGFβ1 levels were observed in both the AMT and OMMT groups postoperatively(median decrease value=2.1 ng/mL and 2.7 ng/mL respectively).CONCLUSION:AMT is associated with postoperative improvement in inferior fornix depth,socket volume,inflammation and impression cytology levels and may bea more proper alternative method than OMMT in the management of socket contracture.

关键词： socket reconstruction amniotic membrane oral mucosal membrane

Plasma coenzyme Q10 levels in type 2 diabetic patients with retinopathy

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International Journal of Ophthalmology(English edition) 2013年第5期6卷 675-679页

作者： orhan Ates Habip Bilen Sadullah Keles H.Hakan Alp Mevlüt Sait Keles Kenan Yildirim Osman ndas L.Can Pinar Mustafa Civelekler orhan Baykal Department of Ophthalmology Medical School of Ataturk University Department of Internal Medicine Division of Endocrinology and MetabolismSchool Medical of Ataturk University Department of Biochemistry Medical School of Ataturk University Department of Ophthalmology Etimesgut Military Hospital

AIMTo determine the relationship between proliferative diabetic retinopathy (PDRP) and plasma coenzyme Q10(CoQ10) concentration.

关键词： coenzyme Q10 diabetic retinopathy

Synthesis and Crystal Structure of Trans-bis(acesulfamato-O)tetraaquazinc(Ⅱ)

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Chinese Journal of Structural Chemistry 2010年第7期29卷 1047-1050页

作者： SAHIN Onur ICBUDAK Hasan B(U|¨)Y(U|¨)KG(U|¨)NG(O|¨)R orhan Department of Physics Faculty of Arts and SciencesOndokuz Mayis UniversitySamsunTurkey Department of Chemistry Faculty of Arts and SciencesOndokuz Mayis UniversitySamsunTurkey

The title compound, trans-bis（acesulfamato-O）tetraaquazinc（Ⅱ）（I, C8H16N2O12S2Zn）, crystallizes in the triclinic system, space group P1 with a = 5.1638（5）, b = 8.5338（9）, c = 9.9583（9）A, α = 74.325（8）, β = 81.112（7）, γ = 75.800（8）°, V= 407.77（7） A3, Z = 1, F（000） = 236, Rint = 0.085, T= 296 K, the final R = 0.029 and wR = 0.078 for 1832 observed reflections with I〉 2σ（0. The ZnⅡcentre resides on a centre of symmetry and has a distorted octahedral geometry. The basal plane is defined by two carbonyl O atoms of two monodentate trans-oriented acesulfamato ligands and two trans-aqua ligands. The axial positions in the octahedron are occupied by two trans-aqua ligands. Intermolecular O-H…O hydrogen bonds produce R22（8） and R22（16） rings, which lead to two- dimensional polymeric chains.

关键词： crystal structure zinc(Ⅱ) octahedral complex hydrogen bonds

Revisiting the Bjerrum's correction factor:Use of the liquidity index for assessing the effect of soil plasticity on undrained shear strength

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Journal of Rock Mechanics and Geotechnical Engineering 2015年第6期7卷 716-721页

作者： Kamil Kayabali Ozgur Akturk Mustafa Fener orhan Dikmen Furkan Hamza Harputlugil Department of Geological Engineering Ankara University Department of Geological Engineering Akdeniz University

The undrained shear strength （su） of fine-grained soils that can be measured in situ and in laboratory isone of the key geotechnical parameters. The unconfined compression test （UCT） is widely used in laboratoryto measure this parameter due to its simplicity; however, it is severely affected by sampledisturbance. The vane shear test （VST） technique that is less sensitive to sample disturbance involves acorrection factor against the soil plasticity, commonly known as the Bjerrum＇s correction factor, m. Thisstudy aims to reevaluate the Bjerrum＇s correction factor in consideration of a different approach and arelatively new method of testing. Atterberg limits test, miniature VST, and reverse extrusion test （RET）were conducted on 120 remolded samples. The effect of soil plasticity on undrained shear strength wasexamined using the liquidity index instead of Bjerrum＇s correction factor. In comparison with the resultobatined using the Bjerrum＇s correction factor, the undrained shear strength was better representedwhen su values were correlated with the liquidity index. The results were validated by the RET, whichwas proven to take into account soil plasticity with a reliable degree of accuracy. This study also showsthat the RET has strong promise as a new tool for testing undrained shear strength of fine-grained soils.

关键词： Soil plasticity Undrained shear strength Bjerrum's correction factor Vane shear test(VST) Reverse extrusion test(RET)

Laser-assisted dacryocystorhinostomy in nasolacrimal duct obstruction：5-year follow-up

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International Journal of Ophthalmology(English edition) 2018年第10期11卷 1616-1620页

作者： Mustafa Dogan Anar Alizada Güliz Fatma Yavas orhan Kemal Kahveci Osman Bakan Department of Ophthalmology Faculty of Medicine AfyonKocatepe University Afyonkarahisar 03200 Turkey Department of Ophthalmology Faculty of MedicineHacettepe Univerisity Ankara 06100 Turkey Department of Otolarhinoaryngology Faculty of MedicineAfyon Kocatepe University Afyonkarahisar 03200 Turkey Medlife Hospital istanbul 34500 Turkey

AIM：To evaluate the long-term sucess rate of laserassisted dacryocystorhinostomy （L-DCR） in patients with nasolacrimal duct obstruction （NDO）.METHODS：Forty-one eyes of forty patients aged between 21-85y （mean 56.7y） who underwent L-DCR for the treatment of NDO were included in this retrospective,non-randomized study. The follow-up time was *** sucess was defined as the disappearance of epiphora under normal conditions and the presence of a patent ostium on lacrimal irrigation. Anatomical success was defined as a patent lacrimal passage on syringing besides continuing epiphora. Surgical failure was defined as persistent epiphora and closed ***：Twenty-seven of 40 patients （67.5%） were female and 13 of 40 patients （32.5%） were male. The NDO was right-sided in 17 （42.5%） patients and left-sided in 22（55%） patients whereas 1 （2.5%） patient had undergone bilateral surgery. In 11 （27.5%） patients there were additional nasal abnormalities requiring simultaneous surgical approach. The average time for L-DCR was 26.50±4.9min（16-39min） and the average total amount of laser energy used was 287±27.9 J （239-367 J）. At the 5y follow-up, anatomical sucess rate was 75.0%（30 patients） and functional success rate was 65.0%（26 patients）, whereas surgical failure was seen in 25%（10 patients）. Revision of surgery was performed in 10 cases （25.0%）; failure of revision surgery was seen in 2 cases（5.0%）.CONCLUSION： Transcanalicular L-DCR is a reliable and fast procedure in the treatment of NDO. It can be alternative to external DCR which is accepted as the gold standard currently. The functional and anatomical success rate is higher in the first months and years, but still satisfactory at fifth year.

关键词： nasolacrimal duct obstruction laser-assisted dacryocystorhinostomy 5-year follow-up

Endoscopic retrograde cholangiopancreatography during pregnancy without radiation

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World Journal of Gastroenterology 2009年第29期15卷 3649-3652页

作者： Adem Akcakaya orhan Veli Ozkan Ismail Okan orhan Kocaman Mustafa Sahin 1st Department of General Surgery Vakif Gureba Research and Training Hospital 34093 Istanbul Turkey Department of General Surgery Faculty of Medicine Mustafa Kemal University 31100 Hatay Turkey Gastroenterology Division of Medical Faculty Hospital Kocaeli University 41380 Kocaeli Turkey

AIM： To present our experience with pregnant patients who underwent endoscopic retrograde cholangiopancreatography （ERCP） without using radiation, and to evaluate the acceptability of this alternative therapeutic pathway for ERCP during pregnancy. METHODS： Between 2000 and 2008, six pregnant women underwent seven ERCP procedures. ERCP was performed under mild sedoanalgesia induced with pethidine HCI and midazolam. The bile duct was cannulated with a guidewire through the papilla. A catheter was slid over the guidewire and bile aspiration and/or visualization of the bile oozing around the guidewire was used to confirm correct cannulation. Following sphincterotomy, the bile duct was cleared by balloon sweeping. When indicated, stents were placed. Confirmation of successful biliary cannulation and stone extraction was made by laboratory, radiological and clinical improvement. Neither fluoroscopy nor spot radiography was used during the procedure. RESULTS： The mean age of the patients was 28 years （range, 21-33 years）. The mean gestational age for the fetus was 23 wk （range, 14-34 wk）. Five patients underwent ERCP because of choledocholithiasis and/or choledocholithiasis-induced acute cholangitis. In one case, a stone was extracted after precut papillotomy with a needle-knife, since the stone was impacted. One patient had ERCP because of persistent biliary fistula after hepatic hydatid disease surgery. Following sphincterotomy, scoleces were removed from the common bile duct. Two weeks later, because of the absence of fistula closure, repeat ERCP was performed and a stent was placed. The fistula was closed after stent placement. Neither post-ERCP complications nor premature birth or abortion was seen. CONCLUSION： Non-radiation ERCP in experienced hands can be performed during pregnancy. Stent placement should be considered in cases for which complete common bile duct clearance is dubious because of a lack of visualization of the biliary tree.

关键词： Cholangitis Choledocholithiasis Endoscopic retrograde cholangiopancreatography Jaundice Pregnancy

Synthesis, Crystal and Molecular Structure and Biological Activity of Dimethyl Trans-3-(2-bromophenyl)-2-methylisoxazolidine-4,5-dicarboxylate

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Chinese Journal of Structural Chemistry 2012年第9期31卷 1251-1262页

作者： YÜKSEKTEPE Çigdem ÖZKAN Hamdi YAVUZ Serkan YANMAZ Volkan DISLI Ali BÜYÜKGÜNGÖR orhan Department of Physics Faculty of ScienceCankiri Karatekin University Department of Chemistry Faculty of ScienceCankiri Karatekin University Department of Chemistry Faculty of Arts and SciencesGazi University Department of Physics Faculty of Arts and SciencesOndokuz Mayis University

The compound of dimethyl trans-3-（2-bromophenyl）-2-methylisoxazolidine-4,5-dicarboxylate has been synthesized and characterized by IR, 1H-NMR, 13C-NMR, 2D-NMR （COSY, NOESY, HMQC, HMBC） and UV-vis. spectroscopy techniques and single-crystal X-ray diffraction （XRD）. The biological activities of the title compound have been investigated in detail. The new compound crystallizes in monoclinic, space group C2/c with a = 26.9263（10）, b = 7.0970（2）, c = 19.8554（7）？, and β = 126.630（2）. In addition to the single crystal structure, the molecular geometry, vibrational frequencies, chemical shifts, molecular electrostatic potential and frontier molecular orbital analysis of the title compound in the ground state have been calculated by Density Functional Theory （DFT） method.

关键词： ab initio calculations isoxazolidine spectroscopy X-ray structure determination

QT interval dispersion in the patients with central serous chorioretinopathy

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International Journal of Ophthalmology(English edition) 2015年第1期8卷 61-65页

作者： Necati Dagli Burak Turgut Rumeysa Tanyildizi Sabiha Kobat Mehmet Ali Kobat orhan Dogdu Department of Cardiology School of MedicineFirat University Department of Ophthalmology School of MedicineFirat University Elazig Education and Research Hospital

AIM: To evaluate QT dispersion(QTD) in patients with central serous chorioretinopathy(CSC).METHODS: This clinical, comperative, case-control study included 30 patients with CSC at acute phase(Group 1) and 30 age- and sex-matched healthy subjects(Group 2, the control group). From all subjects, a 12-lead surface electrocardiography was obtained. The heart rate(HR), QT maximum(QT max), QT minimum(QT min), QT corrected(QT c), QTD and T mean were manually measured and analyzed. Student’s t-test and Pearson’s method of correlation were used for statistical analysis.· RESULTS: The patient and control groups were matched for age, smoking status(rate and duration) and gender. There were no significant differences with regard to these among the groups(P >0.05). The participants included 19 men(63.3%) and 11 women(36.7%) in Group1, 20 men(66.7%) and 10 women(33.3%) in Group *** max, QTD and QT c were significantly higher than those of healthy controls(P 0.05 for HR). No significant correlation was found between duration of the disorder and QTD values(r =0.13, P >0.05).CONCLUSION: These findings suggest that CSC may be associated with an increase in QTD and that the patients might be at risk for ventricular arrhythmia.

关键词： central serous chorioretinopathy electrocardiography QT dispersion ventricular arrhythmia