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SusMat 2022年第4期2卷 476-486页

作者： Arnar Sveinbjörnsson Anna bergljót Gunnarsdóttir Erin b.Creel Camila Pía Canales b.rr zulevi Xiang Lyu Charl J.Jafta Egill Skúlason Alexey Serov Helga Dögg Flosadóttir Atmonia ehf. ReykjavíkIceland Faculty of Industrial Engineering Mechanical Engineering and Computer ScienceUniversity of IcelandVR-IIIReykjavíkIceland Electrification and Energy Infrastructures Division Oak Ridge National LaboratoryOak RidgeTennesseeUSA Pajarito Powder LLC(PPC)AlbuquerqueNew MexicoUSA Science Institute University of IcelandVR-IIIReykjavíkIceland

Ammonia(NH3)production via the electrochemical nitrogen reduction reaction(Nrr)is a promising method for sustainable generation of this important *** are ongoing in finding an efficient,stable,and selective catalyst that will enable the ***,progress is hindered in the field due to lack of reproducibility,most likely a consequence of reports of false-positive results due to improper measurement control and *** this study,we explore the Nrr activity of a promising class of single atom catalysts,transition metal-nitrogen-carbon(M-N-C)*** a state-of-the-art in-line ammonia quantification methodology,with detection limit as low as 1 ppb for ammonia,we show that single atom Nb and Fe embedded in a stable carbon and nitrogen framework do not electrochemically reduce N_(2) to NH_(3).Critically,this demonstrates that our experimental setup with in-line sequential injection analysis successfully excludes ammonia contamination from the gas supply and atmospheric sources,allowing for thorough and high-throughput examination of potential Nrr catalysts.

关键词： ammonia synthesis electrocatalysis nitrogen electroreduction Nrr single atom catalyst

Antidiabetic effect of combination of fractionated-extracts of Andrographis paniculata and Centella asiatica: In vitro study

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Asian Pacific Journal of Tropical biomedicine 2018年第11期8卷 527-532页

作者： LOM.Fitrawan R.Ariastuti rr.TjANDrawinata AE.Nugroho S.Pramono Master Program of Pharmaceutical Sciences of Faculty of Pharmacy Universitas Gadjah Mada Faculty of Pharmacy Universitas Halu Oleo Dexa Laboratories of biomolecular Sciences Department of Pharmacology and Clinical Pharmacy Faculty of Pharmacy Universitas Gadjah Mada Department of Pharmaceutical biology Faculty of Pharmacy Universitas Gadjah Mada

Objective: To examine the effect of combination of Andrographis paniculata herb fraction(AHF) and Centella asiatica herb fraction(CHF) on PPAR γ and GLUT4 mRNA expression in 3 T3-L1 adipocyte, and its effect on insulin-stimulated glucose uptake. Methods: 3 T3 L1 adipocyte cells were used to investigate gene expression of PPARy reverse transcription-polymerase chain reaction method. The γ and GLUT4 protein b adipocyte cells were differentiated by using insulin, dexamethasone and 3-isobutyl-1-methylxanthine from 3 T3-L1 cells. Pioglitazone, AHF, CHF and the combination of both herbs were evaluated on glucose uptake activity, PPAR γ and GLUT4 mRNA expressions in 3 T3-L1 adipocyte. Results: The results showed that combination of AHF at 30 μg/mL and CHF at 10 μg/mL could enhance insulin-stimulated glucose uptake. The combination also increased PPAR γ and GLUT4 mR NA expressions significantly in comparison to those of negative control(DMSO). These effects were equal in comparison to those of pioglitazone(0.02 μM) and its single extracts Conclusions: The combination of AHF and CHF can increase glucose uptake and insulin sensitivity through up-regulation of PPAR γ and GLUT4 mRNA expressions in 3 T3-L1 adipocyte.

关键词： Andrographis paniculata Centella asiatica GLUT4 PPAR γ 3T3-L1

A new heparin fragment decreases liver ischemia-reperfusion injury

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 190-192页

作者： Enio R Vasques Estela rr Figueira Joel A Rocha-Filho Cinthia Lanchotte Jorge LS Ximenes Helena b Nader Ivarne LS Tersariol Marcelo A Lima Tiago Rodrigues JoséEM Cunha Eleazar Chaib Luiz AC D’Albuquerque Flávio HF Galvão Laboratorio de Investigaçao Medica 37 Departamento de GastroenterologiaHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de São PauloSão Paulo 01246-903Brazil Departamento de Gastroenterologia Hospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de São PauloSão PauloBrazil Disciplina de Anestesiologia Hospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de São PauloSão PauloBrazil Departamento de bioquimica Universidade Federal de São PauloSão PauloBrazil Universidade Federal do AbC Santo AndreSão PauloBrazil Serviço de Transplante de Figado e Orgaos do Aparelho Digestivo Departamento de GastroenterologiaHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de São PauloSão PauloBrazil

To the Editor:Ischemia-reperfusion injury following surgery and transplantation can lead to irreversible multiorgan *** calcium overload is associated to cellular death during ischemiareperfusion.A recently discovered heparin fragment (HF),trisulfated disaccharide (TD),that acts on sodium-calcium exchanger(NCX) decreasing intracellular Ca^(2+),showed effectiveness on protecting hepatocytes from ischemia-reperfusion injury [1].

关键词： irreversible heparin injury

Commonly used caspase inhibitors designed based on substrate specificity profiles lack selectivity

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Cell Research 2006年第12期16卷 961-963页

作者： Alicia b berger Kelly b Sexton Matthew bogyo Department of Pathology Stanford University School of Medicine300 Pasteur Dr.StanfordCA 94305USA2 Cancer BiologyGraduate Program.Stanford University School of Medicine300 Pasteur Dr.StanfordCA 94305USA Department of Pathology Stanford University School of Medicine300 Pasteur Dr.StanfordCA 94305USA

Dear Editor:Caspase regulation and activation have been extensivelystudied since the discovery of this class of proteases almosttwo decades ago, yet surprisingly few tools are availablethat can be used to monitor individual caspase activities[1]. The most commonly used tools include caspase-specificanti-sera as well as fluorogenic substrates and ***, antibody reagents often do not provide anaccurate measure of caspase activity since several caspasefamily members (caspases 8/10 and 9) do not require pro-teolytic processing for activation [2,3].Furthermore,recentevidence suggests that caspase-7(an executioner caspase)activation occurs via a catalytically active full-length inter-mediate that cannot be differentiated from the non-cleavedinactive zymogen using antibodies[4,5].As an alternative to antibody-based reagents,smallmolecule substrates and inhibitors can be used to directlymonitor caspase activity and a relatively large number ofcaspase substrates,inhibitors,and activity-based probes arenow commercially *** reagents have begunto find widespread use in cell biological and biochemicalstudies of caspase *** most cases,these tools areused as selective reagents to assess the contribution ofspecific caspases to a given apoptotic pathway.

关键词： Commonly used caspase inhibitors designed based on substrate specificity profiles lack selectivity

ADA与EASD对2型糖尿病高血糖处理：治疗启动与评定的新共识方案

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中国糖尿病杂志 2009年第1期17卷 75-77页

作者： Nathan DM[美] buse Jb[美] Davidson Mb[美] Ferrannini E[意大利] Holman rr[英] Sherwin R[美] Zinman b[加拿大] 钱荣立(摘译) 哈佛大学医学院、麻省总医院糖尿病中心北卡罗林大学医学院加州洛杉矶Drew大学比莎大学牛津大学牛津糖尿病中心耶鲁大学多伦多大学不详

在不到一年时间由同一批专家代表ADA和EASD先后起草和发布了两次关于"2型糖尿病高血糖处理的共识声明"同时发表在2008年1月和12月的《Diabetes Care》和《Diabetologia》上。第一次共识声明内容主要围绕TZDs药物的安全性,本刊作了摘译转... 详细信息

在不到一年时间由同一批专家代表ADA和EASD先后起草和发布了两次关于"2型糖尿病高血糖处理的共识声明"同时发表在2008年1月和12月的《Diabetes Care》和《Diabetologia》上。第一次共识声明内容主要围绕TZDs药物的安全性,本刊作了摘译转载(参阅《中国糖尿病杂志》2008年第7期)。第二次修订的共识声明,关注点为降糖药的新分级,论据及观点比较清晰,故仍摘译供读者参考。

关键词： 2型糖尿病 EASD 高血糖 ADA 治疗 TZDs 安全性降糖药

2型糖尿病高血糖处理：对启动治疗与判定的共识方案--ADA与EASD关于噻唑烷二酮类药的新共识

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中国糖尿病杂志 2008年第7期16卷 389-390页

作者： Nathan DM[美] buse JL[美] Davidson Mb[美] Ferrannini E[意] Holman rr[英] Sherwin R[美] Einman b[加] 钱荣立(译) 哈佛大学医学院麻省总医院糖尿病中心北卡罗林大学医学院加州洛杉矶Drew大学比莎大学牛津大学牛津糖尿病中心耶鲁大学多伦多大学不详

自2006年新英格兰杂志发表Nissen等的荟萃分析,提出罗格列酮(RSG)可增加心肌梗塞风险以来,国内外已发表了很多意见相左的文章和共识声明,但迄无定论,致使临床医师们在应用TZDs药物时无所适从。今年1月Diabetes Care与Diabetologia同时... 详细信息

自2006年新英格兰杂志发表Nissen等的荟萃分析,提出罗格列酮(RSG)可增加心肌梗塞风险以来,国内外已发表了很多意见相左的文章和共识声明,但迄无定论,致使临床医师们在应用TZDs药物时无所适从。今年1月Diabetes Care与Diabetologia同时刊出了由美国麻省总院糖尿病中心Nathan医师执笔代表ADA和EASD专家意见关于噻唑烷二酮类药的最新共识声明。现节译如下,供读者参考。

关键词：噻唑烷二酮类药 EASD ADA 2型糖尿病高血糖治疗 Nissen 临床医师

The initial research about the mutation of the ramie degumming microbe treated by the Ar plasma jet and the repeated experiment3

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The initial research about the mutation of the ramie degummi...

第十三届全国核物理大会暨第八届会员代表大会

作者： WU Yu~(a2) XU Mingyao~a CHEN Feiming~a HU Yuhua~a WANG Shouguo~b a Department of Mathematics and Physics,The Institute of Technical Physics,Wuhan University of Science and Engineering(Wuhan Keji Xxueyuan),Wuhan,rr.China,430073 b Academy of Opto-electronics,Chinese Academy of Science,P.O.box 650,beijing,rr.China,100010

The plant fibre is recyclable in nature,and will firstly be chosen as the cheap resource in the production of compound *** ramie fibre is strong,with good property and full of cellulose among the species of plant *** ... 详细信息

关键词： plasma jet mutation ramie degumming microbe

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感染免疫的分子基础

医学分子生物学杂志 1980年第5期 242-243页

作者： Porter rr 高昌烈英国牛津大学生物化学系教授

第一讲免疫球蛋白结构动物对外来物质(抗原)的反应是通过淋巴细胞致敏,并在适当条件下,一些b淋巴细胞分化成合成和分泌抗体的浆细胞。抗体属于免疫球蛋白,它能特异地结合抗原。抗体也是b淋巴细胞上的特异受体,因而它既是参与特异性免疫... 详细信息

第一讲免疫球蛋白结构动物对外来物质(抗原)的反应是通过淋巴细胞致敏,并在适当条件下,一些b淋巴细胞分化成合成和分泌抗体的浆细胞。抗体属于免疫球蛋白,它能特异地结合抗原。抗体也是b淋巴细胞上的特异受体,因而它既是参与特异性免疫反应,也是与抗原结合的主要组分。在补体参与下,抗原抗体反

关键词：蛋白酶抗原蛋白水解酶感染免疫经典途径免疫球蛋白抗体补体系统结合部位恒定区淋巴细胞白细胞 Fab 残基晶体结构结晶构造固体结构转化酶蔗糖酶复合物生物活性

Toward three-dimensional in vitro models to study neurovascular unit functions in health and disease

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Neural Regeneration Research 2021年第11期16卷 2132-2140页

作者： Tara M.Caffrey Emily b.button Jerome Robert Djavad Mowafaghian Center for brain Health University of British ColumbiaVancouverBCCanada Department of Pathology University of British ColumbiaVancouverBCCanada Institute of Clinical Chemistry University Hospital of ZurichZurichSwitzerland

The high metabolic demands of the brain require an efficient vascular system to be coupled with neural activity to supply adequate nutrients and *** supply is coordinated by the action of neurons,glial and vascular cells,known collectively as the neurovascular unit,which temporally and spatially regulate local cerebral blood flow through a process known as neurovascular *** many neurodegenerative diseases,changes in functions of the neurovascular unit not only impair neurovascular coupling but also permeability of the blood-brain b.rrier,cerebral blood flow and clearance of waste from the *** order to study disease mechanisms,we need improved physiologicallyrelevant human models of the neurovascular *** towards modeling the cellular complexity of the neurovascular unit in vitro have been made using stem-cell derived organoids and more recently,vascularized organoids,enabling intricate studies of non-cell autonomous *** and design innovations in microfluidic devices and tissue engineering are progressing our ability to interrogate the *** advanced models are being used to gain a better understanding of neurodegenerative disease processes and potential *** innovation is required to build more physiologically-relevant models of the neurovascular unit encompassing both the cellular complexity and designed features to interrogate neurovascular unit functionality.

关键词： Alzheimer’s disease cerebrovasculature in vitro model neurodegeneration neurovascular unit

Design and validation of a handheld capnography device for cardiopulmonary assessment based on the Arduino platform

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Journal of Innovative Optical Health Sciences 2021年第6期4卷 42-54页

作者： Om Prakash Singh Ismail M.El-badawy M.b.Malarvili bio-signal Processing Research Group(bSPRG)School of biosciences and Medical Engineering Universiti Teknologi Malaysia(UTM) 81310 SkudaiJohorMalaysia Electronics and Communication Engineering Department Arab Academy for Science and Technology CairoEgypt School of Electrical Engineering Universiti Teknologi Malaysia(UTM)81310 SkudaiJohorMalaysia bio-Signal Processing Research Group(bSPRG)School of biosciences and Medical Engineering Universiti Teknologi Malaysia(UTM) 81310 SkudaiJohorMalaysia

The design of a handheld capnography device is in great demand because of its effective and practical uses in all cardiac arrest resuscitations,according to the recommendation of the American Heart ***,a handheld capnography device that can be used in clinical settings and the home environment is *** proposed device was developed by using an infrared CO_(2)sensor,Arduino Mega2560,and a high-resolution display(2.8").Furthermore,two rechargeable batteries(7.6 V,0.99 A)and a secure digital card with a capacity of 16 Gb were incorporated to increase the portability and usability of the *** were implemented to measure standard features,namely,inspired CO_(2)(ICO_(2)),end-tidal CO_(2)(EtCO_(2)),and re-spiratory rate(rr).The features of 15 healthy subjects were recorded by using the developed prototype and the standard capnography device(Capnostream^(TM)20 Model CS08798).Validation was performed with bland-Altman *** revealed that mean differences±standard deviations for the set limits of ICO_(2),EtCO_(2)and rr were 0.29±1.30 millimeters of mercury(mmHg),0.15±1.77 mmHg and 0.40±0.97 breaths per minute(bpm),*** of the differences among device measurements across all features fell within the 95%limits of ***,the developed device may help manage respiratory distress conditions in and outside of a hospital setting.

关键词： Arduino board capnogram carbon dioxide sensor cardiorespiratory monitoring system