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Effect of glaucoma on identification of bottle cap color in ophthalmic medications

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International Journal of Ophthalmology(English edition) 2019年第1期12卷 169-171页

作者： Jonathan Paul Jon David Hammer Roozbeh Akhtari brede Skillings Daniel b.moore Department of Ophthalmology University of Kentucky Northwell Health Department of Ophthalmology Krieger Eye Institute

A prospective, nonrandomized, observational trial of 60 glaucoma patients to correlate visual acuity and visual field with ability to distinguish bottle cap color of commonly used ophthalmic medications was conducted. A total of 103 eyes from 60 patients(30 women) were evaluated. The mean logMAR acuity was 0.34±0.54(approximately 20/45 Snellen acuity), average Humphrey Visual Field(HVF) mean deviation was-8.58±8.69 db, mean Ishihara plates(out of 14) were 11.78±4.15, and bottle cap color score(out of 10) was 8.56±2.51. Multiple linear regression analysis revealed an independent correlation of visual acuity(P=0.0137) and Ishihara score(Pbut no significant effect with visual field mean deviation(P>0.05). Glaucoma patients with poor visual acuity, but not necessarily advanced visual field loss, are likely to have difficultly identifying the color of their bottle caps. Physicians should be cognizant of this potential issue when reviewing medications with patients.

关键词： glaucoma color vision compliance medication patient communication

Connexins in neurons and glia: targets for intervention in disease and injury

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Neural Regeneration Research 2015年第7期10卷 1013-1017页

作者： Keith b.moore John O'brien Richard S.Ruiz M.D.Department of Ophthalmology & Visual Science The University of Texas Health Science Center at Houston The University of Texas Graduate School of biomedical Sciences

both neurons and glia throughout the central nervous system are organized into networks by gap junctions. Among glia, gap junctions facilitate metabolic homeostasis and intercellular communication. Among neurons, gap junctions form electrical synapses that function primarily for communication. However, in neurodegenerative states due to disease or injury gap junctions may be detrimental to survival. Electrical synapses may facilitate hyperactivity and bystander killing among neurons, while gap junction hemichannels in glia may facilitate inflammatory signaling and scar formation. Advances in understanding mechanisms of plasticity of electrical synapses and development of molecular therapeutics to target glial gap junctions and hemichannels offer new hope to pharmacologically limit neuronal degeneration and enhance recovery.

关键词： ischemia retinal degeneration amacrine cells astrocytes dopamine receptors adenosine receptors NMDA receptors connexin mimetic peptides

Finding the perfect recipe for success

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Pediatric Investigation 2018年第4期2卷 222-222页

作者： Theodore b.moore Department of Pediatrics David Geffen School of Medicine at UCLADivision of Pediatric Hematology/OncologyLos AngelesCAUSA

Familial hemophagocytic lymphohistiocytosis (FHLH) is a rare genetic disease for which optimal therapy includes consolidation with a hematopoietic stem cell transplant (HSCT). The HLH-1994 study demonstrated a 3-year survival of 62% in patients who received HSCT.1 The conditioning regimen was myeloablative carrying with it significant morbidity and mortality from the resulting organ toxicity. As several studies have shown that 20%–30%donor chimerism is sufficient in most cases to eliminate the clinical manifestations of FHLH, an attempt was made to reduce the toxicity of the conditioning regimen by reducing the myeloablative aspects and replacing them with more immunoablative components. Several single institution reports demonstrated the effectiveness of this approach2,3 achieving overall survival rates of 80%–100%, although this was accompanied by significant issues with mixed chimerism and nonengraftment. In the bone Marrow Transplant Clinical Trials Network (bMT-CTN) protocol 1204 multi-institutional trial similar results were obtained with only a third of patients achieving sustained donor engraftment with the initial transplant, and the remainder requiring subsequent transplants to achieve this.4 Although the 1-year survival achieved 80%, this dropped to 67% by 18 months. Although significant progress was made in reducing transplant related mortality, clearly additional changes to the conditioning regimen are needed to achieve improved engraftment.

关键词： perfect recipe success Familial hemophagocytic lymphohistiocytosis

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中国农田的温室气体排放

第四纪研究 2003年第5期23卷 493-503页

作者：李长生肖向明 S.Frolking b.moore ⅲ W.Salas 邱建军张宇庄亚辉王效科戴昭华刘纪远秦小光廖柏寒 R.Sass 新罕布舍大学地球海洋与空间研究所美国DurhamNH 03824 中国农业科学院农业资源和农业区划研究所北京100081 中国气象科学院农业气象研究所北京100081 中国科学院生态环境研究中心北京100085 中国科学院地理科学与资源研究所北京100101 中国科学院地质与地球物理研究所北京100029 湖南农业大学农业环境科学学院长沙410128 莱斯大学生命和进化科学系美国HoustonTexas 77252-1892

中国是一个农业大国 ,拥有约 1 .33百万平方公里的农田。这些田地的种植、翻耕、施肥、灌溉等管理措施不仅长期改变着农田生态系统中的化学元素循环 ,而且给全球气候变化带来影响。农业生态系统对全球变化的影响主要是通过改变 3种温室... 详细信息

中国是一个农业大国 ,拥有约 1 .33百万平方公里的农田。这些田地的种植、翻耕、施肥、灌溉等管理措施不仅长期改变着农田生态系统中的化学元素循环 ,而且给全球气候变化带来影响。农业生态系统对全球变化的影响主要是通过改变 3种温室气体 ,即二氧化碳(CO2 )、甲烷 (CH4)和氧化亚氮 (N2 O)在土壤 -大气界面的交换而实现的。为了分析多种因素(如气候、土壤质地、农作物品种及各种农田经营管理措施等 )对农业土壤释放CO2 ,CH4和N2 O的综合影响 ,一个生物地球化学过程模型 (DNDC)近年发展起来 ,用于预测这一复杂系统的动态。DNDC模型可对农业生态系统中的碳 (C)、氮 (N)循环进行计算机模拟 ,并计算农田温室气体的释放量。通过与一个地理信息系统数据库的连接 ,DNDC完成了对中国农田 1 990年温室气体排放的估算。结果表明中国农业生态系统的CO2 净排放量约 95百万吨C/年、CH4约 9.2百万吨C/年、N2 O约 1 .3百万吨N/年。根据全球增温潜势 (GWP)计算 ,中国农田释放的N2 O对全球增温的影响高于CO2 和CH4。模拟结果还发现中国农业对减缓全球温室效应的最大贡献发生在 1 980～ 2 0 0 0年间 ,在这 2 0年中 ,全国水稻田的灌溉方法由持续淹灌逐渐改为晒田间灌 ,DNDC计算的中国农田CH4的年排放量由 1 980年的 1 2百?

关键词：中国农业农田温室气体生物地球化学 DNDC 地理信息系统数据库

Association of Hypertension and Plant-based Dietary Patterns on Cognitive Impairment: A Nationwide Cohort Study in China

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Food Science and Human Wellness 2024年

作者： Fang Liang Jialin Fu Gabrielle Turner-McGrievy Yechuang Wang Kai Ding Jing Zeng Justin b.moore Rui Li Chengdu High-tech Zone Center for Diseases Control and Prevention School of Public Health， Wuhan University Department of Implementation Science， Division of Public Health Sciences， Wake Forest School of Medicine Department of Health Promotion， Education， and behavior Arnold School of Public Health， University of South Carolina Columbia， SC USA School of Nursing， Wuhan University

This study investigated the association of hypertension with cognitive impairment and determined whether better adherence to plant-based diet (PbD) patterns may modify the association. We analyzed 4485 elderly individuals with normal cognition at baseline from the Chinese Longitudinal Healthy Longevity Survey (2011-2018). Cognitive function was assessed by the Mini-mental State Examination (MMSE)， and cognitive impairment was defined as an MMSE score below 18 points. Diet patterns were assessed using the overall plant-based diet index (PDI)， healthful plant-based diet index (hPDI)， and unhealthful plant-based diet index (uPDI) derived from a simplified food frequency questionnaire (FFQ). blood pressure was measured through physical examination. Cox proportional hazard regression and restricted cubic spline were performed. Participants with hypertension had an increased risk of cognitive impairment compared with normal group. The associations between hypertension and cognitive impairment were more pronounced among participants with lower PDI than those with higher PDI， among participants with lower hPDI than those with higher hPDI， and among participants with higher uPDI than those with lower uPDI. A healthful PbD pattern may attenuate hypertension-induced cognitive impairment， while an unhealthful PbD pattern may exacerbate hypertension-induced cognitive impairment in elderly. Adherence to healthful PbD pattern could be used to prevent or mitigate adverse neurological effects in the hypertensive population.

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Does the scent of a potential mate prevent the resorption of oocytes by apoptosis in Nauphoeta cinerea？

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Insect Science 2009年第5期16卷 393-398页

作者： Emma L. b. barrett Allen J. moore Patricia J. moore Centre for Ecology and Conservation School of Biosciences University of Exeter Cornwall Campus Penryn Cornwall UK

We expect organisms to have evolved mechanisms to gather and use the information available within their environments, to steer resource investment decisions toward the traits that will give the greatest fitness returns. Pheromones are social signals, a common purpose of which is to act as indicators of mate presence. Consequently, pheromones have the potential to act as signals to increase or maintain reproductive investment over that of competing life-history traits. In the cockroach, Nauphoeta cinerea （Oliver）, females pay costs of maintaining investment in reproduction when there are no males, and males produce pheromones that are known to effect female reproductive outcomes. Whether the pheromones have an influence on resource physiology is unknown. We subjected newly eclosed females to either a synthetic blend of male pheromones or control. We dissected females at 7, 12, 17 or 22 days. We measured apoptosis levels and size of all oocytes within the vitellerium, and measured dry fat body mass. Synthetic male pheromone blend did not have an effect on any measure of female reproductive or somatic resource physiology. Although negative results are always problematic, the success of the synthetic pheromone method in the past suggests that females may be insensitive to male pheromones in the pre-oviposition period, and may rely on mating stimulus rather than pheromone as the cue for oocyte maintenance and growth. Previous studies reporting effects of male pheromones on female reproduction suggest that the period of pheromone sensitivity may be between mating and birth.

关键词： apoptosis environment oocyte ovary pheromone predictable trade-off

Expression of octopaminergic receptor genes in 4 nonneural tissues in female Nicrophorus vespilloides beetles

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Insect Science 2015年第4期22卷 495-502页

作者： Christopher b. Cunningham Mary K. Douthit Allen J. moore Department of Genetics University of Georgia Athens GA 30602 USA

Octopamine regulates the function of many tissues and physiological processes in invertebrates. The expression of octopamine receptor genes has been examined in multiple tissue types in several different insect orders. However, little work has addressed this issue in Coleoptera. Most studies characterize individual genes in different tissue types, but here we describe the expression of 6 octopamine receptor genes in thoracic musculature, oviducts, Malpighian tubules, and fat body of female Nicrophorus vespilloides beetles to characterize both different genes and different tissues within a single study. We then compare the gene expression profiles found in this beetle to other insects to examine the extent to which expression profiles are conserved across insects. We also examine the relative involvement of octopamine verses octopamine/tyramine receptors based on receptor gene expression in each tissue to help elucidate if tyramine plays a role in the regulation of these tissues. We find a high degree of overlap in the expression profile of the 6 genes examined in the thoracic muscula^tre, a moderate amount for the oviducts, and divergent profiles for Malpighian tubules and fat body. based on expression difference in receptor subtypes, our results also support the suggestion that tyramine is a biogenic amine with physiological actions separate from octopamine.

关键词： biogenic amines Coleoptera G-protein coupled receptors quantitative real-time PCR

Microbiological safety of spices and their interaction with antibiotics:implications for antimicrobial resistance and their role as potential antibiotic adjuncts

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Food Quality and Safety 2019年第2期3卷 93-97页

作者： Rachel E.moore b.Cherie Millar Jayachandran R.Panickar John E.moore Department of bacteriology Northern Ireland Public Health LaboratoryBelfast City HospitalLisburn RoadBelfastNorthern IrelandBT97ADUK School of biomedical Sciences Ulster UniversityCromore RoadColeraineBT521SANorthern IrelandUK Centre for Experimental Medicine Queen’s University97 Lisburn RoadBelfast BT97BLNorthern IrelandUK Department of Paediatrics Sheikh Khalifa Medical CityAbu DhabiUnited Arab Emirates

Objectives:A study was undertaken to:*** contaminating bacteria on a variety of spices purchased at retail market;*** if spice bacterial enrichments alter the phenotype of 13 bacterial foodborne and clinical pathogens and 1 probiotic organism;and *** if spices can alter antimicrobial activity of seven clinical antibiotics against 16 bacterial foodborne/clinical *** and Methods:Microbiological examination was undertaken employing 27 spice varieties with four antibiotics and 15 bacterial ***:bacteriological contamination levels varied amongst spice varieties,ranging from Kasmin chilli powder(7.5×10^(6)cfu/g;log10^(6).88 cfu/g)to ginger(1.5×10^(4)cfu/g;log_(10)4.18 cfu/g);mean contamination was 1.38×10^(6)cfu/g(log_(10)6.14 cfu/g).Four species within the genus bacillus were identified(bacillus megaterium,bacillus subtilis,bacillus licheniformis,and bacillus cereus).There was no phenotypic difference with the 14 bacteria,with bacterial colony growth/proliferation,pigment production,or with adhesin and mucoid *** of the spice cultures inhibited any of the 14 bacterial species *** the case of doxycycline,amoxicillin,colistin,erythromycin,and piperacillin/tazobactam,the zone of inhibition increased with the inclusion of the 26 spice varieties,suggesting that the spices were interacting synergistically with the antibiotic,thus making the antibiotic more potent against the bacteria ***:This study demonstrates a positive interaction between spices and conventional *** the burden of antimicrobial resistance(AMR)worldwide,but particularly in South Asian countries(India and Pakistan),any food-related innovation that can help maximize the potency of existing antibiotics is to be encouraged and *** specific mechanism as to how spices increase the potency of antibiotics needs to be elucidated,as well as novel food(spice)delivery modalities including novel medicinal foo

关键词： antibiotic resistance antimicrobial resistance bacillus foodborne pathogen microbiology Pseudomonas aeruginosa spice

Regulation of Pain and Itch by TRP Channels

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Neuroscience bulletin 2018年第1期34卷 120-142页

作者： Carlene moore Rupali Gupta Sven-Eric Jordt Yong Chen Wolfgang b.Liedtke Department of Neurology Duke University Medical Center Department of Anesthesiology Duke University Medical Center

Nociception is an important physiological process that detects harmful signals and results in pain perception. In this review, we discuss important experimental evidence involving some TRP ion channels as molecular sensors of chemical, thermal, and mechanical noxious stimuli to evoke the pain and itch sensations. Among them are the TRPA1 channel, members of the vanilloid subfamily （TRPV1, TRPV3, and TRPV4）, and finally members of the melastatin group （TRPM2, TRPM3, and TRPMS）. Given that pain and itch are pro-survival, evolutionarily-honed protective mechanisms, care has to be exercised when developing inhibitory/modulatory com- pounds targeting specific pain/itch-TRPs so that physio- logical protective mechanisms are not disabled to a degree that stimulus-mediated injury can occur. Such events have impeded the development of safe and effective TRPV1- modulating compounds and have diverted substantial resources. A beneficial outcome can be readily accom- plished via simple dosing strategies, and also by incorpo- rating medicinal chemistry design features during compound design and synthesis. beyond clinical use, where compounds that target more than one channel might have a place and possibly have advantageous features, highly specific and high-potency compounds will be helpful in mechanistic discovery at the structure-function level.

关键词： TRP channels Pain Itch Nociceptors - Inflammation Lipids Temperature Hyperalgesia Nerve damage Neuropathic pain Mechanotransduction Allodynia