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Topical Calendula officinalis *** inflammatory pain through antioxidant,anti-inflammatory and peripheral opioid mechanisms

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Journal of Integrative Medicine 2023年第1期21卷 34-46页

作者： bárbara b.Garrido-Suárez Gabino Garrido Addis bellma Menéndez Nelson Merino Odalys Valdés Nilia de la Paz Aylema Romero Livan Delgado Miguel D.Fernández Octavio Piñeros RenéDelgado-Hernández Pharmacology and Toxicology Chemical Analytic and Pharmaceutical Technology LaboratoriesCenter for Pharmaceutical Research and Development(CIDEM)Havana 10600Cuba Department of Pharmacology Institute of Marine Science(ICIMAR)Havana 10300Cuba Department of Pharmaceutical Sciences Faculty of SciencesCatholic University of the NorthAntofagasta 1240000Chile Research Department University of Santiago de CaliCali 760032Colombia Center for Research and biological Evaluations Institute of Pharmacy and FoodUniversity of HavanaHavana 17100Cuba

Objective The present study evaluated the antinociceptive activity of Calendula officinalis L.(Ca)cream on inflammatory *** Creams with different Ca concentrations were tested for their ability to ameliorate pain-related behavior and edema in rats using formalin test,carrageenan(Cg)-induced acute inflammation model,bradykinin(bK)-induced acute inflammation model,and complete Freund’s adjuvant(CFA)-induced chronic inflammation *** the formalin test,we also examined the implication of peripheral opioid receptors in the antinociceptive mechanisms of Ca cream,by means of Q-naloxone,a peripherally acting nonselective opioid ***,the effects of Ca cream compared with diclofenac on bK-induced edema were examined when the kininase II in tissue was preserved or inhibited by *** local production of redox biomarkers in formalin model,tumor necrosis factor-α(TNF-α)in Cg model and histopathological changes in CFA model were also *** A single application of Ca cream at a dose of 10%or 30%(w/w)decreased the formalin-induced licking/biting behavior during both phases of this test in a Q-naloxone-sensitive *** effect was associated with the reduction of oxidative stress in the injured paw and the edema associated with the later phase of formalin-induced pain.A single application of Ca cream(10%or 30%)reduced paw edema and thermal hypernociception in Cg-induced acute inflammation,corresponding with a local decrease in TNF-α.Ca cream also inhibited bK-induced spontaneous nociceptive behavior and paw inflammation in both paradigms *** applications of Ca cream also decreased CFA-induced chronic inflammation,mechanical hypernociception and histopathological changes in the *** These results reveal the topical antinociceptive and antiedematogenic effects of Ca cream.A modulatory action on peripheral opioid receptors associated with its antioxidant mechanism may be involved,at least in par

关键词： Calendulaofficinalis L. Formalintest Pain Hyperalgesia Inflammation

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Fe-Al金属间化合物的第一性原理研究综述

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材料保护 2024年第7期57卷 142-153页

作者：陈维铅喇培清李亚明许世鹏兰州理工大学省部共建有色金属先进加工与再利用重点实验室甘肃兰州730050 酒泉职业技术学院甘肃省太阳能发电系统重点实验室甘肃酒泉735000

Fe-Al金属间化合物具有密度低、比强度高、抗高温氧化和耐腐蚀性良好等优点,且成本低廉,成为镍基高温合金潜在的替代结构材料。综述了利用第一性原理计算研究元素掺杂/微合金化对Fe-Al金属间化合物及涂层的室温脆性、高温强度、界面结... 详细信息

Fe-Al金属间化合物具有密度低、比强度高、抗高温氧化和耐腐蚀性良好等优点,且成本低廉,成为镍基高温合金潜在的替代结构材料。综述了利用第一性原理计算研究元素掺杂/微合金化对Fe-Al金属间化合物及涂层的室温脆性、高温强度、界面结合、抗高温氧化及耐腐蚀性能影响的研究进展,设计了第一性原理研究b2型Fe-Al合金耐氯化盐腐蚀机理的理论计算方案,展望了第一性原理计算应用于Fe-Al合金及涂层材料研究的发展方向。

关键词：第一性原理 Fe-Al金属间化合物力学性能耐腐蚀性界面强度

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GLObAL SOLUTIONS TO A HYDRODYNAMIC MODEL FOR SEMICONDUCTORS WITH VELOCITY RElaXATION

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Acta Mathematica Scientia 2023年第2期43卷 975-980页

作者：王先婷陆云光 Richard De la cruz 尤国桥 Department of Mathematics Wuxi Institute of TechnologyWuxi 214121China School of Mathematics Hangzhou Normal UniversityHangzhou 311121China Escuela de Matematicas y Estadistica Universidad Pedagógica y Tecnológica de Colombia 999076Colombia School of Mathematics Nanjing Audit UniversityNanjing 210000China

In this paper,we apply the method given in the paper“Zero relaxation time limits to a hydrodynamic model of two carrier types for semiconductors”(Mathematische Annalen,2022,382:1031–1046)to study the Cauchy problem for a one dimensional inhomogeneous hydrodynamic model of two-carrier types for semiconductors with the velocity relaxation.

关键词： global L solution hydrodynamic model two-carrier types velocity relaxation

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The interaction of versican with its binding partners

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Cell Research 2005年第7期15卷 483-494页

作者： David P. la PIERRE,Albert J. YEE,burton b. YANG Sunnybrook & Women’s College Health Sciences Centre 2075 bayview Avenue Toronto M4N 3M5 Canada Department of laboratory Medicine and Pathobiology University of Toronto Canada Sunnybrook & Women’s College Health Sciences Centre 2075 bayview Avenue Toronto M4N 3M5 Canada Sunnybrook & Women’s College Health Sciences Centre 2075 bayview Avenue Toronto M4N 3M5 Canada Department of laboratory Medicine and Pathobiology University of Toronto Canada

Versican belongs to the family of the large aggregating chondroitin sulfate proteoglycans located primarily within theextracellular matrix (ECM). Versican, like other members of its family, has unique N- and C-terminal glob.lar regions,each with multiple motifs. A large glycosaminoglycan-binding region lies between them. This review will begin byoutlining these structures, in the context of ECM proteoglycans. The diverse binding partners afforded to versican byvirtue of its modular design will then be examined. These include ECM components, such as hyaluronan, type Icollagen, tenascin-R, fibulin-1, and -2, fibrillin-1, fibronectin, P- and L-selectins, and chemokines. Versican also binds tothe cell surface proteins CD44, integrin β1, epidermal growth factor receptor, and P-selectin glycoprotein *** multiple interactors play important roles in cell behaviour, and the roles of versican in modulating such processesare discussed.

关键词： extracellular matrix proteoglycan G3 domain glycosaminoglycan interaction.

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AIM在炎症反应和脂质代谢疾病中的作用

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中国比较医学杂志 2024年第3期34卷 142-148页

作者：张帆田春雨王景存喇孝瑾付茜茹李洁付文浩华北理工大学河北唐山063210 河北省中西医结合防治糖尿病及其并发症重点实验室河北唐山063210

巨噬细胞凋亡抑制因子(apoptosis inhibitor of macrophage,AIM),是清道夫受体富含半胱氨酸残基超家族(scavenger receptor cysteine rich-super family,SRCR-SF)b组的成员之一。AIM为巨噬细胞分泌的一种可溶性蛋白,该蛋白的表达受肝X受体(liver X receptor,LXR)控制,且在机体的免疫反应中起重要作用。AIM作为巨噬细胞的一种分泌蛋白,发挥着广泛的作用,不仅对巨噬细胞的凋亡具有抑制作用,并且可参与调控巨噬细胞极化。还有相关研究发现,AIM参与炎症、肥胖、动脉粥样硬化和癌症等多种生理、病理过程;可以作为结核病和肝硬化等疾病的生物诊断标志物;可以通过抑制脂肪酸合成酶(fatty acid synthase,FAS)活性从而促进脂肪细胞的脂解,在调节脂质内稳态平衡、脂质代谢与自身免疫疾病中发挥着重要的作用。该文论述了AIM的分子特征及其在炎症反应和脂质代谢等相关疾病方面的作用,展示AIM的多种功能特点,为相关的医学研究提供依据。

关键词： AIM 炎症反应脂质代谢

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Confirmation of a Sub-Saturn-size Transiting Exoplanet Orbiting a G Dwarf:TOI-1194 b and a Very Low Mass Companion Star: TOI-1251 b from TESS

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Research in Astronomy and Astrophysics 2024年第3期24卷 129-143页

作者： Jia-Qi Wang Xiao-Jun Jiang Jie Zheng Hanna Kellermann Arno Riffeser Liang Wang Karen A.Collins Allyson bieryla lars A.buchhave Steve b.Howell Elise Furlan Eric Girardin Joao Gregorio Eric Jensen Felipe Murgas Mesut Yilmaz Sam Quinn Xing Gao Ruo-Yu Zhou Frank Grupp Hui-Juan Wang CAS Key laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy Of SciencesBeijing 10010China University of Chinese Academy of Sciences Beijing 100049China University Observatory Munich Scheinertrsse 1.D-81679 MunichGemany Max Planck Institute for Extraterrestrial Physics Giessenbachstr.1D-85748 GarchingGermany National Astronomical Observatories/Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing210042China CAS Key laboratory of Astronomical Optics&Technology Nanjing Institute of Astronomical Optics&TechnologyNanjing 210042China Center for Astrophysics Harvard&Smithsonian60 Garden Street.CambridgeMA 02138USA National Space Institute Technical University of DenmarkElektrovejDK-2800 KgsLyngbyDenmark NASA Ames Research Center Moffett FieldCA 94035USA NASA Exoplanet Science Institute Caltech/IPACMail Code 100-221200 E.California Blvd.PasadenaCA91125USA Grand Pra Observatory Switzerland Department of Physics Washington UniversitySt.LouisMO 63130.USA Department of Physics and Astronomy Swarthmore CollegeSwarthmorePA 19081USA Instituto de Astrofísica de Canarias(IAC) E-38205 La Laguna.TenerifeSpain Departamento de Astrofísica Universidad de La LagunaSpain Dept.of Astronomy and Space Sciences Ankara UniversityTandogan 06100AnkaraTurkey Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Urumqi No.1 Senior High School Urumqi 830002China Lijiang Gemini Observatory Lijiang 674199China

We report the confirmation of a sub-Saturn-size exoplanet,TOI-1194 b,with a mass of about 0.456+0.055-0.051M_(J),and a very low mass companion star with a mass of about 96.5±1.5 MJ,TOI-1251 *** candidates provided by the Transiting Exoplanet Survey Satellite(TESS)are suitable for further follow-up observations by ground-based telescopes with small and medium *** analysis is performed based on data from several telescopes worldwide,including telescopes in the Sino-German multiband photometric campaign,which aimed at confirming TESS Objects of Interest(TOIs)using ground-based small-aperture and medium-aperture telescopes,especially for long-period ***-1194 b is confirmed based on the consistent periodic transit depths from the multiband photometric *** measure an orbital period of 2.310644±0.000001 days,the radius is 0.767+0.045-0.041RJ and the amplitude of the RV curve is 69.4_(-7.3)^(+7.9)m s^(-1).TOI-1251 b is confirmed based on the multiband photometric and high-resolution spectroscopic data,whose orbital period is 5.963054+0.000002-0.000001days,radius is 0.947+0.035-0.033 R_(J) and amplitude of the RV curve is 9849_(-40)^(+42)ms^(-1).

关键词： planets and satellites fundamental parameters-planets and satellites gaseous planets-stars fundamental parameters-stars low-mass-methods data analysis-techniques photometric-techniques spectroscopic

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Sustainable transit vehicle tracking service,using intelligent transportation system services and emerging communication technologies:A review

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第6期7卷 729-747页

作者： Ricardo Salazar-Cabrera álvaro Pachón de la Cruz Juan Manuel Madrid Molina Telematics Engineering Research Group(GIT) Telematics DepartmentUniversidad del CaucaPopayanColombia Information Technology and Telecommunications Research Group(I2T) ICT DepartmentUniuersidad IcesiCaliColombia

The most salient problems of transit vehicle service in latin American intermediate cities include:the high number of passengers involved in traffic accidents;traffic congestion caused by transit vehicles,and pollution generated by these vehicles,which increases in high congestion *** improve upon this situation,a research was conducted on the transit vehicle tracking service,which is a basic service for implementing mobility solutions for the aforementioned problems,the most relevant characteristics of this service for the context of latin American intermediate cities were identified,and an implementation was *** paper presents the four stages of the study:(a)a review of the state-of-the-art of services or systems related to vehicle tracking,including wireless communications technologies,implemented sustainability approaches,usage of special algorithms for efficiency improvement,and the intelligent transportation system(ITS)architecture used as a basis;(b)the process of identifying relevant characteristics of the service for a given context;(c)proposal of an ITS architecture for this service in an intermediate city,its requirements and the suggested technologies;and(d)development of experiments for validating usage of the key suggested *** review allowed to identify the main service characteristics,with regard to vehicle positioning technologies,the recommended wireless communication technology(long range,LoRa),energy consumption considerations,and use of artificial intelligence(AI)to calculate waiting time of users at bus ***,an ITS architecture for the city of Popayan(Colombian city)considering the aforementioned characteristics is proposed,and the experiments related to the use of these technologies are described in detail.

关键词： Transportation engineering Intelligent transportation systems Transit vehicle ITS architecture Tracking Long range

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环保型家具用重组竹的制备及性能研究

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林产工业 2024年第9期61卷 5-12页

作者：李腊梅马红霞谢桂军李怡欣李万菊广东省森林培育与保护利用重点实验室广东省林业科学研究院广东广州510520

本研究采用低温固化环保型酚醛树脂为胶黏剂制备重组竹板材,探索热压温度、施胶量和板材密度对重组竹物理力学性能的影响。结果表明:当热压温度为125℃时,板材芯层温度即能达到胶黏剂的固化温度范围,且此条件下的板材密度均匀性、理化... 详细信息

本研究采用低温固化环保型酚醛树脂为胶黏剂制备重组竹板材,探索热压温度、施胶量和板材密度对重组竹物理力学性能的影响。结果表明:当热压温度为125℃时,板材芯层温度即能达到胶黏剂的固化温度范围,且此条件下的板材密度均匀性、理化力学性能以及各项性能的稳定性更优。然而,热压温度升高对性能的改善不明显。当施胶量达到8.6%以上时,重组竹的密度可达到1.00 g/cm^(3),物理力学性能较优。

关键词：重组竹低温固化环保型酚醛树脂施胶量制备工艺力学性能

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Ex situ echo sounder target strengths of ice krill Euphausia crystallorophias

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Chinese Journal of Oceanology and Limnology 2015年第3期33卷 802-808页

作者： Hyoung Sul la Hyungbeen LEE Donhyug KANG SangHoon LEE Hyoung Chul SHIN Division of Polar Ocean Environment Research Korea Polar Research Institute Korea Institute of Ocean Science and Technology Maritime Security Research Center Korea Institute of Ocean Science and Technology

Ice krill is the keystone species in the neritic ecosystem in the Southern Ocean, where it replaces the more oceanic Antarctic krill. It is essential to understand the variation of target strength （TS in db re l m^2） with the different body size to accurately estimate ice krill stocks. However, there is comparatively little knowledge of the acoustic backscatter of ice krill. The TS of individual, formalin-preserved, tethered ice krill was measured in a freshwater test tank at 38, 120, and 200 kHz with a calibrated split-beam echo sounder system. Mean TS was obtained from 21 individual ice krill with a broad range of body lengths （L： 13-36 iron）. The length （L, mm） to wet weight （W; mg） relationship for ice krill was 11/=0.001 21g^103~L35s （R2=0.96）. The mean TS-to-length relationship were TS38kHz=-177.4＋57log10（L）, （R^2=0.86）; TS120kHz= -129.9＋31.561ogf0（L）, （R2=0.87）; and TS200kHz=-117.6＋24.661ogre（L）, （R2=0.84）. Empirical estimates of the relationship between the TS and body length of ice krill were established at 38, 120, and 200 kHz and compared with predictions obtained from both the linear regression model of Greene et al. （1991） and the Stochastic Distorted Wave born Approximation （SDWbA） model. This result might be applied to improve acoustic detection and density estimation of ice krill in the Southern Ocean. Further comparative studies are needed with in situ target strength including various body lengths of ice krill.

关键词： ice krill Euphausia crystallorophias ex situ target strength split-beam echo sounder

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The impact of Pinus halepensis afforestation on Mediterranean spontaneous vegetation:do soil treatment and canopy cover matter?

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Journal of Forestry Research 2012年第4期23卷 517-528页

作者： Pasta Salvatore Tommaso la Mantia Juliane Rühl Dipartimento DEMETRA Università di PalermoViale delle ScienzeEd.4Ingr H90128 PalermoItaly.

We investigated central Mediterranean Pinus halepensis plantations under semi-arid climate in order to evaluate the combined effect of soil treatment and afforestation practices on spontaneous plant species composition, richness and evenness, and on the trend and speed of vegetation dynamics. Phytosociological releves of three different plot typologies, i.e. （1） soil-treatment and plantation, （2） only soil-treatment, （3） no soil-treatment and no plantation, were compared by （a） multivari- ate analysis and （b） with reference to species richness and evenness. Moreover, in order to compare vegetation dynamics within the planta- tions with those ones ongoing in semi-natural garrigue communities, we compared life form and syntaxonomic spectra between phytosociological relev6s taken at 8 years of distance. DCA showed that floristic species composition and similarity are influenced by the canopy cover of Pine trees as well as by soil-treatment practices. Although species richness and evenness are not clearly related to neither soil treatment nor Pine afforestation, canopy cover clearly plays a major role： in fact, the highest Ph cover rates correspond to the lowest values of understory species richness. This is true also if only species of biogeographical/conservation interest are considered. Regarding vegetation dynamics, sites with dense Pine canopy cover evolve much slower than the adjacent garrigue communities. The same factors invoqued to explain the patterns of floristic composition and similarity （i.e. allelopathy and competition for light, water and nutrients） may also explain the lowering of diversity of therophytes and the strong decline of the cover perfomed by both therophytes and hemicryptophytes underneath the canopy of dense Ph plantations. Thus, in sites where Ph cover exceeds about 80%, thinning is recommended not only in order to accelerate succession, but also to give a natural ＇shape＇ to afforestations.

关键词： plant diversity understory vegetation dynamics plantation

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