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Assessment of Exposure to Toxic Metals through Food with Reference to Some Towns in Russia

Journal of Environmental Science and Engineering 2010年第4期4卷 53-61页

作者： b.a. katsnelson S.V. Kuzmin T.V. Mazhayeva A.N. Lavrentyev L.I. Privalova V.b. Gurvich O.L. Malykh Ural Regional Center for Environmental Epidemiology Ekaterinburg Russia Sverdlovsk Regional Office of the Federal Service on Surveillance in the Sphere of Consumer Rights Protection and Human Well-being in the Russian Federation Ekaterinburg Russia

In big countries, nutrition profiles and foodstuffs chemical contamination may differ significantly between different regions and even between areas within a region. Thus one should assess toxic exposure through food on not only national but also local level. We have developed and distributed a personal questionnaire for estimating average daily consumption of 44 types of foodstuffs, and for 12 of them-the percentage contribution of the main sources of supply. Depending on data analysis results, we choose the most important foodstuffs for determining their chemical contamination. We tested this approach in 7 industrial towns and found differences among them, as well as among children and adults, with regard to toxic exposure through food. People with a relatively high income consume more milk, cheese, meat, fish, poultry and fruit but less bread and potatoes than those with medium or low income. About 80% of consumed potatoes are grown locally and thus depend on each area＇s contamination. Although daily intakes of toxicants do not exceed WHO tolerable levels, their contribution to the total environmentally dependent dose is important. The approach developed by us can be used in epidemiological and risk assessment studies when they are performed on regional or local level.

关键词： Nutrition profiles toxic metals risk assessment.

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Looking for biological Protectors against Adverse Health Effects of Some Nanoparticles that Can Pollute Workplace and Ambient Air (A Summary of Authors’ Experimental Results)

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Journal of Environmental Protection 2017年第8期8卷 844-866页

作者： Larisa I. Privalova boris A. katsnelson Marina P. Sutunkova Ilzira A. Minigalieva Vladimir b. Gurvich Oleg H. Makeyev Vladimir Ya. Shur Irene E. Valamina Svetlana V. Klinova Ekaterina V. Shishkina Ilya V. Zubarev The Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers Ekaterinburg Russia The Institute of Natural Sciences The Ural Federal University Yekaterinburg Russia The Ural State Medical University Ekaterinburg Russia The Ural State Medical University Ekaterinburg Russia

Especially high health risks associated with impacts of metallic nanoparticles (Me-NPs) and their presence in the workplace and ambient air of not only the nano-industry but also of some long-existing traditional technologies make it necessary, along with keeping respective dangerous exposures as low as possible, to look for ways of increasing the organism’s resistance to them. based on theoretical premises of such beneficial interference with toxicokinetics and toxicodynamics of Me-NPs developed by our research team and on understanding general and specific key mechanisms of different Me-NPs’ toxic action, we proposed several bioprotective complexes (bPCs) comprising mainly pectin, some vitamins, glutamate, glycine, N-acetylcysteine, omega-3 PUFA, and different essential trace elements. Results of our animal experiments with different Me-NPs showed that, against the background of such bPCs’ oral administration, the integral and specific toxicity of Me-NPs and even their genotoxicity can be markedly attenuated. Therefore we would recommend to further develop this vector of nano-toxicological research.

关键词： Nanoparticles Toxic metals bioptotectors

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Enhancing Population’s Resistance to Toxic Exposures as an Auxilliary Tool of Decreasing Environmental and Occupational Health Risks (a Self-Overview)

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Journal of Environmental Protection 2014年第14期5卷 1435-1449页

作者： boris A. katsnelson Larisa I. Privalova Vladimir b. Gurvich Sergey V. Kuzmin Ekaterina P. Kireyeva Ilzira A. Minigalieva Marina P. Sutunkova Nadezhda V. Loginova Olga L. Malykh Sergey V. Yarushin Julia I. Soloboyeva Natalia I. Kochneva Medical Research Center for Prophylaxis and Health Protection in Industrial Workers Ekaterinburg Russian Federation Sverdlovsk Regional Office of the Federal Service on Supervision in Sphere of Protection of the Consumers’ Rights and Well-being of a Person (Rospotreb.a.zor) Ekaterinburg Russian Federation

Environment chemical pollution can be persistent, and even virtually irremovable. For some chemicals in the workplace environment reliably safe low exposure levels are technically unattainable or presumably nonexistent. As a supplement to decreasing harmful exposures to as low levels as possible, the “biological prophylaxis” aims at enhancing host’s protective mechanisms. During over 30 years in animal experiments modeling isolated or combined chronic or subchronic exposures to silica, asbestos, monazite, lead, chromium, arsenic, manganese, nickel, vanadium, nanosilver, nanocopper, formaldehyde, phenol, naphthalene, benzo(a)pyrene we tested so-called “bioprophylatic complexes” (bPCs) comprising innocuous substances with theoretically expected beneficial influence on the toxicokinetics and/or toxicodynamics of those toxics. The bPCs proved protectively effective in animal experiments were then subjected to controlled field trials on restricted groups of volunteers. Once the effectiveness and safety of a bPC was established, it was recommended for practical use, first of all, in the most vulnerable population groups (children, pregnant women) and in the most harmful occupations. At each stage of this work the effectiveness of the bioprophylactic approach to chemical risks management was successfully demonstrated. The bPCs tested up to now proved capable of mitigating systemic toxicity, cytotoxicity, fibrogenicity, and mutagenicity of the above-listed chemicals.

关键词： Environmental Pollution Health Risks bio-Protectors

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脑缺氧是影响严重颅脑创伤患者短期预后的独立危险因素(英文)

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中华神经外科疾病研究杂志 2011年第5期10卷 452-452页

作者： Oddo M Levine JM Mackenzie L Frangos S Feihl F Kasner SE katsnelson M Pukenas b Macmurtrie E Maloney-Wilensky E Kofke WA Leroux PD

background:b.a.n hypoxia(bH)can aggravate outcome after severe traumatic b.a.n injury(TbI).Whether bH or reduced b.a.n oxygen(Pbto2)is an independent outcome predictor or a marker of disease severity is not fully *** To analyze the relationship between Pbto2,intracranial pressure(ICP),and cereb.a. perfusion pressure(CPP)and to examine whether bH correlates with worse outcome independently of ICP and *** We studied103patients

关键词：脑缺氧颅脑创伤短期预后危险因素

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