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Mesenchymal Stem Cells Alleviate Acute Liver Failure through Regulating Hepatocyte Apoptosis and Macrophage Polarization

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Journal of Clinical and translational Hepatology 2024年第6期12卷 571-580页

作者： Yachao tao Yonghong Wang Menglan Wang Hong tang Enqiang Chen Center of Infectious Diseases West China HospitalSichuan UniversityChengduSichuanChina Division of Infectious Diseases State Key Laboratory of BiotherapySichuan UniversityChengduSichuanChina

background and Aims:Acute liver failure(ALF)is a life-threatening clinical problem with limited treatment *** of human umbilical cord mesenchymal stem cells(hUC-MSCs)may be a promising approach for *** study aimed to explore the role of hUC-MSCs in the treat-ment of ALF and the underlying ***:A mouse model of ALF was induced by lipopolysaccharide and d-galactosamine *** therapeutic effects of hUC-MSCs were evaluated by assessing serum enzyme activity,histological appearance,and cell apoptosis in liver *** apoptosis rate was analyzed in AML12 *** levels of inflammatory cytokines and the phenotype of RAW264.7 cells co-cultured with hUC-MSCs were *** C-Jun N-terminal kinase/nuclear factor-kappa b signal-ing pathway was ***:the hUC-MSCstreatment decreased the levels of serum alanine aminotransferase and aspartate aminotransferase,reduced pathological damage,alleviated hepatocyte apoptosis,and reduced mortality in *** hUC-MSCs co-culture reduced the apoptosis rate of AML12 cells in ***,lipopolysaccharide-stimulated RAW264.7 cells had higher levels of tumor necrosis factor-α,interleukin-6,and interleukin-1β and showed more CD86-positive cells,whereas the hUC-MSCs co-culture reduced the levels of the three inflammatory cytokines and increased the ratio of CD206-positive *** hUC-MSCs treatment inhibited the activation of phosphorylated(p)-C-Jun N-terminal kinase and p-nuclear factor-kappa b not only in liver tissues but also in AML12and RAW264.7 cells co-cultured with ***:hUC-MSCs could alleviate ALF by regulating hepatocyte apoptosis and macrophage polarization,thus hUC-MSC-based cell therapy may be an alternative option for patients with ALF.

关键词： Human umbilical cord mesenchymal stem cells Acute liver failure Hepatocyte apoptosis Hepatitis Macrophage polarization LPS/D-GalN

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Delayed Fluorescence and Amplified Chirality via Modified Substitution Position for Deep-red Circularly Polarized Organic Light Emitting-diodes

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Chemical Research in Chinese Universities 2024年第4期40卷 657-663页

作者： ZHU Lixun LIU Dan WU Kaiwen XIE Guohua ZHAO Zheng tang ben Zhong School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Shenzhen518172P.R.China Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionThe Hong Kong University of Science and TechnologyHongkong999077P.R.China the Institute of Flexible Electronics(Future technologies) Xiamen UniversityXiamen361005P.R.China

Developing easily accessible deep-red/near-infrared circularly polarized emitters for practical organic light-emitting diodes remains a significant ***,a practical strategy has been proposed for developing deep-red circularly polarized delayed fluorescent emitters based on a novel chiral acceptor *** changing triphenylamine(tPA)substitution position from para to meta,R/S-M-tbbtCN demonstrated thermally activated delayed fluorescence(tADF)properties with a delayed lifetime of 6.6µs that R/S-P-tbbtCN doesn’t ***,R/S-M-tbbtCN showed a 65 nm red-shift in emission and a 10-fold enhancement in asymmetry factor(glum),compared with R/*** solution-processed nondoped circularly polarized organic light-emitting diodes(CP-OLEDs)based on R-M-tbbtCN display deep-red emission and 2.2%external quantum efficiency.

关键词： Amplified chirality Deep-red circularly polarized organic light emitting-diode binaphthol based chiral acceptor

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Generalized time-dependent generator coordinate method for induced fission dynamics

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Frontiers of physics 2024年第4期19卷 1-12页

作者： b.Li D.Vretenar t.Nikšić J.Zhao P.W.Zhao J.Meng State Key Laboratory of Nuclear Physics and technology School of PhysicsPeking UniversityBeijing 100871China Physics Department Faculty of ScienceUniversity of Zagreb10000 ZagrebCroatia Center for Circuits and Systems Peng Cheng LaboratoryShenzhen 518055China

the generalized time-dependent generator coordinate method(tD-GCM)is extended to include pairing *** correlated GCM nuclear wave function is expressed in terms of time-dependent generator states and weight *** particle–hole channel of the effective interaction is determined by a Hamiltonian derived from an energy density functional,while pairing is treated dynamically in the standard bCS approximation with time-dependent pairing tensor and single-particle occupation *** the inclusion of pairing correlations,various time-dependent phenomena in open-shell nuclei can be described more *** model is applied to the description of saddle-to-scission dynamics of induced *** generalized tD-GCM charge yields and total kinetic energy distribution for the fission of 240Pu,are compared to those obtained using the standard time-dependent density functional theory(tD-DFt)approach,and with available data.

关键词： nuclear density functional theory generator coordinate method fission dynamics

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Masses of the conjectured H-dibaryon at different temperatures

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Chinese Physics C 2024年第8期48卷 83-93页

作者： Liang-Kai Wu Han tang Ning Li Xin-Yang Wang School of Physics and Electronic Engineering Jiangsu UniversityZhenjiang 212013China Center for Fundamental Physics School of Mechanics and PhysicsAnhui University of Science and TechnologyHuainan 232001China

We present a lattice QCD determination of masses of the conjectured H-dibaryon,denoted as mH,at nine different temperatures:t/t_(c)=0.24,0.63,0.76,0.84,0.95,1.09,1.27,1.52,and *** masses of baryons N,Σ,Ξ,andΛat different temperatures were also *** simulations were performed on an anisotropic lattice with N_(f)=2+1 flavours of clover fermion at a quark mass corresponding to mπ=384(4)*** thermal ensembles were provided by the FAStSUM collaboration,whereas the zero temperature ensembles were provided by the Hadspec *** also calculated the spectral density of the correlation function of those *** spectral density distributions show a rich peak structure at the lowest temperature;at intermediate temperatures,the mass values of those particles obtained by the extrapolation method reflect a two-peak *** the spectral density for the octet baryon becomes smooth at t/t_(c)=1.27,1.52,and 1.90,the spectral density for the H-dibaryon becomes smooth at t/t_(c)=*** t/t_(c)=0.24,the mass difference of the H-dibaryon andΛpair,expressed asΔm=m_(H)−2m_(Λ),was estimated to beΔm=−14.6(6.2)MeV,which suggests the existence of a bound H-dibaryon state.

关键词： lattice QCD H-dibaryon spectral function clover fermion finite temperature

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F-doped orthorhombic Nb_(2)O_(5) exposed with 97% (100) facet for fast reversible Liþ-Intercalation

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Green Energy & Environment 2024年第4期9卷 723-731页

作者： Xiaodi Liu Yufeng tang Dan Zhang Guangyin Liu Xinwei Luo Yi Shang Xiu Li Jianmin Ma College of Chemistry and Pharmaceutical Engineering Nanyang Normal UniversityNanyang473061China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu611731China

Orthorhombic Nb_(2)O_(5)(t-Nb_(2)O_(5))is attractive for fast-charging Li-ion batteries,but it is still hard to realize rapid charge transfer kinetics for Li-ion ***,F-doped t-Nb_(2)O_(5) microﬂowers(F-Nb_(2)O_(5))are rationally synthesized through topotactic ***,F-Nb_(2)O_(5) are assembled by single-crystal nanoﬂakes with nearly 97%exposed(100)facet,which maximizes the exposure of the feasible Li^(+)transport pathways along loosely packed 4g atomic layers to the electrolytes,thus effectively enhancing the Li^(+)-intercalation ***,the band gap of F-Nb_(2)O_(5) is reduced to 2.87 eV due to the doping of F atoms,leading to enhanced electrical *** synergetic effects between tailored exposed crystal facets,F-doping,and ultrathin building blocks,speed up the Li^(+)/electron transfer kinetics and improve the pseudocapacitive properties of F-Nb_(2)O_(5).therefore,F-Nb_(2)O_(5) exhibit superior rate capability(210.8 and 164.9 mAh g^(-1) at 1 and 10 C,respectively)and good long-term 10 C cycling performance(132.7 mAh g^(-1) after 1500 cycles).

关键词： Exposed facets Orthorhombic Nb_(2)O_(5) F-doping Pseudocapacitive intercalation anode Li-ion storage

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(m,n)-Igusa-todorov Algebras,It-Dimensions and triangular Matrix Algebras

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Journal of Mathematical Research with Applications 2024年第3期44卷 337-343页

作者： Jiyuan tang Yuanfeng ZHANG Hanpeng GAO School of Mathematical Sciences Anhui University

Let t,U be two Artin algebras andUMtbe a *** this paper,we get a necessary and sufficient condition such that the formal triangular matrix algebra■ is（m,n）-Igusa-todorov whenUM,Mtare *** also study the Igusa-todorov dimension ofΛ.More specifically,it is proved that max{*** t,*** U}≤***Λ≤min{max{*** t,*** U},max{*** U,*** t}}.

关键词： Igusa-todorov algebras It-dimensions triangular matrix algebras

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blautia producta displays potential probiotic properties against dextran sulfate sodium-induced colitis in mice

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Food Science and Human Wellness 2024年第2期13卷 709-720页

作者： bingyong Mao Weiling Guo Shumao Cui Qiuxiang Zhang Jianxin Zhao Xin tang Hao Zhang State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China

blautia has attracted attention because of its potential efficacy in ameliorating host energy metabolism and *** study aims to investigate the influences of blautia producta D4 on colitis induced by dextran sulfate sodium(DSS)and to reveal the underlying *** showed that *** D4 intervention significantly relieved body weight loss,and suppressed the elevation of pro-inflammatory cytokines(including interleukin-6(IL-6),tumor necrosis factor-α(tNF-α),and interleukin-1β(IL-1β))and excessive oxidative stress(myeloperoxidease(MPO)activity,superoxide dismutase(SOD)activity,glutathione peroxidase(GSH-Px)activity,and malondialdehyde(MDA)level)in colitis ***,the concentrations of tight junction proteins(occludin,claudin-1,and ZO-1)related to the intestinal barrier were obviously elevated,and colitis-related tLR4/NF-κb pathway activation was remarkably inhibited after *** D4 *** intestinal microbial disorder was evidently ameliorated by increasing the relative abundance of Clostridium sensu stricto 1,bifidobacterium,GCA-900066225,Enterorhabdus,and reducing the relative abundance of Lachnospiraceae NK4A136 *** conclusion,oral administration of *** D4 could ameliorate DSS-induced colitis by suppressing inflammatory responses,maintaining the intestinal barrier,inhibiting tLR4/NF-κb pathway,and regulating intestinal microbiota *** results are conducive to accelerate the development of *** D4 as a functional probiotic for colitis.

关键词： blautia producta D4 Colitis Intestinal mechanical barrier tLR4/NF-κb pathway Intestinal microbiot

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On the low cycle fatigue behaviour of an Al-Zn-Mg-Cu alloy processed via non-isothermal ageing

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Journal of Materials Science & technology 2024年第1期168卷 227-238页

作者： Guangyi Guo Guofu Xu Yuan tang Zhihao Zhao Zhihao Yi Haoran Li Ruohan Wang Xiaoyan Peng School of Materials Science and Engineering Central South UniversityChangsha 410083China Key Laboratory of Nonferrous Materials Science and Engineering of Ministry of Education Changsha 410083China

the low cycle fatigue behaviour of an Al-Zn-Mg-Cu alloy processed via non-isothermal ageing(NIA)was examined at different strain *** showed that NIA improved the low cycle fatigue life(more than 7000 cycles)by optimising the precipitate configuration within 5.5 h while maintaining comparable mechanical properties(570 MPa for tensile strength)and conductivity(nearly 39%IACS)to conventional isothermal ageing,*** observation combined with molecular dynamic simula-tion revealed that precipitation configuration manipulated by NIA had a crucial effect on fatigue resis-tance.A great number of repeatedly sheared and locally destructed GP zones enhanced co-planar slip and slip localisation in the under-aged alloy during the early stage of NIA,responsible for the dramatic displacement steps on the surface and resultant poor fatigue *** the NIA further proceeded,moderately coarsened precipitates with an average dimension of 6.0 nm and elevated number density ef-fectively impeded the dislocation movement and weaken the slip localisation to a great extent,improving the fatigue performance within a few hours.

关键词： Non-isothermal ageing Fatigue Al-Zn-Mg-Cu alloy Precipitate manipulation Slip localization

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Microstructure Evolution and Mechanical Properties of Friction Stir Welded Al-Cu-Li Alloy

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Acta Metallurgica Sinica(English Letters) 2024年第5期37卷 855-871页

作者： Peng Chen Wenhao Chen Jiaxin Chen Zhiyu Chen Yang tang Ge Liu bensheng Huang Zhiqing Zhang School of New Energy and Materials Southwest Petroleum UniversityChengdu 610500China Sichuan Provincial Engineering Research Center of Advanced Materials Manufacturing technology for Shale Gas High-Efficient Exploitation Southwest Petroleum UniversityChengdu 610500China College of Materials Science and Engineering Chongqing UniversityChongqing 400045China School of Mechatronic Engineering Southwest Petroleum UniversityChengdu 610500China School of Robot Engineering Yangtze Normal UniversityChongqing 408100China

the investigation concentrates on friction stir welded(FSW)Al-Cu-Li alloy concerning its local microstructural evolution and mechanical *** grain features were characterized by electron back scattered diffraction(EbSD)technology,while precipitate characterization was conducted by using transmission electron microscopy(tEM)aligned along[011]Al and[001]Al zone *** mechanical properties are evaluated through micro-hardness and tensile *** can be found that nugget zones exhibit finely equiaxed grains evolved through complete dynamic recrystallization(DRX),primarily occurring in continuous dynamic recrystallization(CDRX)and discontinuous dynamic recrystallization(DDRX).In the thermal-mechanically affected zone(tMAZ),numerous sub-structured grains,exhibiting an elongated morphology,were created due to partial DRX,signifying the dominance of CDRX,DDRX,and geometric dynamic recrystallization(GDRX)in this region.t_(1)completely dissolves in the nugget zone(NZ)leading to the formation of Guinier-Preston zones and increase ofδ′,β′and S′.Conversely,t_(1)partially solubilizes in tMAZ,the lowest hardness zone(LHZ)and heat affected zone(HAZ),and the residual t_(1)undergoes marked coarsening,revealing various t_(1)*** solubilization and coarsening of t_(1)are primary contributors to the degradation of hardness and strength.θ′primarily dissolves and coarsens in NZ and tMAZ,whilst this precipitate largely coarsens in HAZ and LHZ.σ,tb,grain boundary phases(GbPs)and precipitate-free zone(PFZ)are newly generated during FSW.σexists in the tMAZ,LHZ and HAZ,whereas tb nucleates in *** and PFZ mostly develop in LHZ and HAZ,which can cause strain localization during tensile deformation,potentially leading to LHZ joint fracture.

关键词： Al-Cu-Li alloy Friction stir welding Microstructure evolution Mechanical properties

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Highly efficient CO_(2) capture using 2-methylimidazole aqueous solution on laboratory and pilot-scale

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Chinese Journal of Chemical Engineering 2024年第3期67卷 148-156页

作者： Kun Li Han tang Shuangshuang Li Zixuan Huang bei Liu Chun Deng Changyu Sun Guangjin Chen State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing 102249China Zhejiang tiandi Environmental Protection technology Co. Ltd.Hangzhou 310012China

to date,the primary industrial carbon capture approach is still absorption using aqueous solutions of ***,to pursue a substitute for the amine-based approach to improve the CO_(2) capture efficiency and decrease the energy cost further,we report a new carbon capture approach using a 2-methylimidazole(mIm)aqueous *** properties and sorption behaviors of this approach have been experimentally *** results show that the mIm solution has higher CO_(2) absorption capacity under relatively higher equilibrium pressure(>130 kPa)and lower desorption heat than the methyldiethanolamine solution.91.6%sorption capacity of mIm solution can be recovered at 353.15 K and 80 *** selectivity for CO_(2)/N_(2) and CO_(2)/CH_(4) can reach an exceptional 7609 and 4324,***,the pilot-scale tests were also performed,and the results demonstrate that more than 98%of CO_(2) in the feed gas could be removed and cyclic absorption capacity can reach 1 mol·L^(-1).this work indicates that mIm is an excellent alternative to alkanolamines for carbon capture in the industry.

关键词： CO_(2) capture Absorption 2-Methylimidazole Separation Pilot-scale tests

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