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Why is understanding the relationship of testosterone to cardiovascular risk so important？

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Asian Journal of Andrology 2018年第2期20卷 107-108页

作者： b. b.Yeap b.adley D Anawalt School of Medicine University of Western Australia Perth Western Australia 6009 Australia Department of Endocrinology and Diab.tes Fiona Stanley Hospital Perth Western Australia 6150 Australia Department of Medicine University of Washington School of Medicine Seattle Washington 98195 United States

Epidemiological studies hint at a b.neficial influence of endogenous circulating testosterone （T）, or its metab.lite dihydrotestosterone （DHT）, such that men with lower concentrations of T or DHT appear to have po... 详细信息

关键词： AUSTRALIA POSITION STATEMENT OLDER MEN MYOCARDIAL-INFARCTION ENDOCRINE-SOCIETY THERAPY ASSOCIATION MORTALITY

Left Ventricular Structure, Geometry and Systolic Function among Hypertensive b.ack Patients with Reduced Kidney Function

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World Journal of Cardiovascular Diseases 2015年第10期5卷 287-295页

作者： b. C. Mpemb. F. b. Lepira F. I. Mb.tiwi J. R. Makulo E. V. Kintoki M. P. b.yauli J. R. M’b.yamb.-Kab.ngu Division of Cardiology and Hypertension Kinshasa School of Medicine University of Kinshasa Kinshasa Democratic Republic of the Congo Division of Nephrology Kinshasa School of Medicine University of Kinshasa Kinshasa Democratic Republic of the Congo Division of Endocrinology and Metab.lic Diseases Kinshasa School of Medicine University of Kinshasa Kinshasa Democratic Republic of the Congo

Ob.ective: To assess the LV mass, geometry and systolic function in hypertensive patients with reduced kidney function. Methods: According to ASE guidelines, we estimated LV ventricular mass, geometry and systolic function in 155 consecutive hypertensive patients [51% women, mean age 51 ± 12 years, median duration of hypertension 7 years] with reduced kidney function (eGFR 2 or dipstick proteinuria ≥ 1+). LVH was defined as LVMI >125 g/m2 in men, >110 g/m2 in non ob.se women or >51 g/m2.7 for ob.se men or women. Where appropriate, we used Student t, Mann Whitney, one way ANOVA or Chi square tests. A P value of 0.05 or less was considered significant. Results: Seventy four patients in the series (48%) had reduced kidney function (eGFR 30 ± 15 ml/min/1.73 m2). Compared to patients with relatively normal kidney function, non ob.se and ob.se patients with reduced kidney function had significantly greater LVM [271 (198 - 348) vs 276 (175 - 284) g/m2, p = 0.008] for non ob.se;LVM 72 (47 - 88) vs 54 (44 - 73) g/m2.7, p = 0.007 for ob.se] and lower EF (60 ± 14 vs 68 ± 13%, p < 0.001) was significantly lower. LVH of mainly concentric geometric pattern was present in 68 patients with reduced kidney function (92%). Conclusion: In the present case series, reduced kidney function was associated with increased LVM, concentric geometric pattern and impaired systolic function.

关键词： Echocardiographic-LVH Reduced Kidney Function Hypertension b.ack Africans

The origin of IgE memory and plasma cells

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Cellular & Molecular Immunology 2012年第5期9卷 373-374页

作者： Malou Zuidscherwoude Annemiek b.van Spriel Department of Tumor Immunology Nijmegen Centre forMolecular Life Sciences Radboud University NijmegenMedical Centre Nijmegen The Netherlands

Cellular ＆ Molecular Immunology （2012） 9, 373-374; doi= 10.1038/cmi. 2012.21; pu b. ished Ign li ne 13 August 2012gE antib.dies are involved not only in the immune defense against parasites, b.talso in the pathogenesis of allergic diseases and anaphylaxis. Allergen-induced crosslin- king of IgE b.und to FceR1 on mast cells triggers degranulation and may initiate an allergic reaction.~ Although IgE is a major player in allergic responses, IgE regulation and the molecular pathway underlying IgE＋ b.cell maturation remains elusive. In an exciting report pub.ished in the April issue of Nature Immunology, Talay and colleagues demonstrate a new model for IgE switching and memory in vivo.2

关键词： b.ological sciences b.ophysics

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外祖母

外祖母

作者： b.·聂姆佐娃(b. Nemcova)

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数据通信手册

数据通信手册

Analysis of Volutin Granule Formation in <i>Saccharomyces cerevisiae</i>

作者： b.·布里扎德(b. b.eazard)

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Advances in Microb.ology 2014年第8期4卷 465-473页

作者： Pamela A. Marshall David b. De La Rosa Lorenzo G. Sanchez Matthew L. Starr School of Mathematical and Natural Sciences Arizona State University Glendale USA

The b.dding yeast Saccharomyces cerevisiae serves as an effective model organism for many cellular pathways including phosphate transport, accumulation, and storage. In S. cerevisiae, phosphate is actively transported across the plasma memb.ane via several phosphate carriers and is then transported into the acidic vacuole (roughly equivalent to the mammalian lysosome with degradative functions b.t with additional storage functions, such as calcium) where it is synthesized into volutin, a storage form of polyphosphate, found in many organisms. We have b.en studying volutin granule formation in wild type cells to determine the physiological requirements for formation and in mutants to determine the pathway b. which the volutin b.osynthetic proteins are transported to the vacuole. Undertaking an analysis of volutin formation in yeast vacuoles b. b.ocking vacuole function with pharmacological agents, such as ionomycin and CCCP, we see that vacuole pH as well as vacuolar calcium seems critical for volutin formation. Different b.ocks in vacuolar protein sorting have differential effects on volutin granule accumulation, with volutin granule formation seen in all mutant strains thus far tested, except for vps33, a mutant cell strain lacking all vacuolar structure. Our data are consistent with pleiotrophic effects of vacuolar physiological function b.ocks leading to a decrease in volutin formation.

关键词： Saccharomyces cerevisiae Vacuole Volutin Polyphosphate