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Participation of CD45,NKR-P1A and ANK61 antigen in rat hepatic NK cell(pit cell)-mediated target cell cytotoxicity

World Journal of Gastroenterology 2000年第4期6卷 546-552页

作者： David Vermiilen bülent ahishali Vasilis Triantis Karin Vanderkerken Peter J. K.Kuppen Eddie Wisse Laboratory for Cell biology and Histology. Department of Hematology and immunology Free University of Brussels(VUB)Brussels-JetteBelgium K Vanderkerken is a postdoctoral researcher of the Fund for Scientific Research Flanders. Department of Surgery and Pathology Leiden University Medical CenterLeidenThe Netherlands

AIM Several triggering receptors have beendescribed to be involved in natural killer（NK）cell-mediated target *** these studies,NKcells derived from blood or spleen were *** are liver-specific NK cells that possess ahigher level of natural cytotoxicity and a differentmorphology when compared to blood NK *** aim of this study was to characterize the roleof the NK-triggering molecules NKR-P1A,ANK61antigen,and CD45 in pit cell-mediated killing oftarget *** 51Cr-release and DNA fragmentationwere used to quantify target cell lysis andapoptosis,*** Flow cytometric analysis showed thatpit cells expressed CD45,NKR-P1A,and *** of pit cells with monoclonalantibody（mAb）to CD45（ANK74）not onlyinhibited CC531s or YAC-1 target lysis but alsoapoptosis induced by pit *** mAbs to NKR-P1A（3.2.3）and ANK61 antigen（ANK61）had no effect on pit cell-mediated CC531s or YAC-1 targetcytolysis or apoptosis,while they did increase theFcγ receptor positive（FcγR+）P815 cytolysis *** enhanced cytotoxicity could beinhibited by 3,4-dichloroisocoumarin,an inhibitorof *** These results indicate that CD45participates in pit cell-mediated CC531s and YAC-1target cytolysis and ***-P1A andANK61 antigen on pit cells function as activationstructures against FcγR+ P815 cells,which wasmediated by the perforin/granzyme pathway.

关键词： hepatic NK cells pit cells cytolysis apoptosis perforin/granzyme pathway

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On the cell biology of pit cells,the liver-specific NK cells

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World Journal of Gastroenterology 2000年第1期6卷 1-11页

作者： Luo DZ Vermijlen D ahishali b Triantis V Plakoutsi G braet F Vanderkerken K Wisse E Laboratory for Cell biology and Histology Free University of Brussels(VUB)Brussels-JetteBelgium Department of Pathology Guangxi Medical University NanningChina Laboratory for Cell biology and Histology Free University of Brussels(VUB)Brussels-JetteBelgium Department of Hematology and Immunology Free University of Brussels(VUB)Brussels-JetteBelgium

INTRODUCTION Natural killer (NK) cells are functionally defined by their ability to kill certain tumor cells and virus-infected cells without prior

关键词： Subject headings pit cells hepatic natural killer cells large granular lymphocytes

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