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Identifying changes in punitive transcriptional factor binding sites from regulatory single nucleotide polymorphisms that are significantly associated with disease or sickness

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World Journal of Hematology 2016年第4期5卷 75-87页

作者： norman E Buroker Department of Pediatrics University of Washington

AIM To identify punitive transcriptional factor binding sites(TFBS) from regulatory single nucleotide polymorphisms(rS NPs) that are significantly associated with *** The genome-wide association studies have provided us with nearly 6500 disease or trait-predisposing SNPs where 93% are located within non-coding regions such as gene regulatory or intergenic areas of the genome. In the regulatory region of a gene, a SNP can change the DNA sequence of a transcriptional factor(TF) motif and in turn may affect the process of gene regulation. SNP changes that affect gene expression and impact gene regulatory sequences such as promoters, enhancers, and silencers are known as rS NPs. Computational tools can be used to identify unique punitive TFBS created by rS NPs that are associated with disease or sickness. Computational analysis was used to identify punitive TFBS generated by the alleles of these rS *** r SNPs within nine genes that have been significantly associated with disease or sickness were used to illustrate the tremendous diversity of punitive unique TFBS that can be generated by their alleles. The genes studied are the adrenergic, beta, receptor kinase 1, the v-akt murine thymoma viral oncogene homolog 3, the activating transcription factor 3, the type 2 demodkinase gene, the endothetal Per-Arnt-Sim domain protein 1, the lysosomal acid lipase A, the signal Transducer and Activator of Transcription 4, the thromboxane A2 receptor and the vascular endothelial growth factor A. From this sampling of SNPs among the nine genes, there are 73 potential unique TFBS generated by the common alleles comparedto 124 generated by the minor alleles indicating the tremendous diversity of potential TFs that are capable of regulating these *** From the diversity of unique punitive binding sites for TFs, it was found that some TFs play a role in the disease or sickness being studied.

关键词： Regulatory single nucleotide polymorphisms Alleles Transcriptional factors Transcriptional factor binding sites Linkage disequilibrium Disease or sickness

Thyroidectomy for Massive Goiter Weighing more than 500 Grams. Technical Difficulties, Complications and Management. Review

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Surgical Science 2011年第5期2卷 278-284页

作者： norman Oneil Machado 不详

Background: Multinodular goiter is a relatively common thyroid disorder with a marked female preponderance. Most of these goiters weigh less than 100 grams with those weighing more than 500 grams being exceptional. The massively expanding goiter due to the strategic anatomic location of thyroid gland, in addition to being cosmetically disfiguring can seriously compromise the patency of the trachea and oesophagus. Thyroidectomy for such goiters is a surgical challenge due to the possible association of tracheomalacia, retrosternal extension, skin involvement and the difficulty in intubation and dissection of the thyroid gland due to distorted and displaced anatomy. Material and methods: While presenting 2 patients who underwent thyroidectomy for glands weighing more than 500 grams, the literature is reviewed to analyze the technical difficulties and approach in such patients and the frequently encountered complications in them and their management. Results: A review of the literature revealed an additional 7 cases of patients who had undergone thyroidectomy for glands weighing more than 500 grams. Massively enlarged goiter was often associated with tracheomalacia, tracheal stenosis and retrosternal extension. Difficulty during surgery was most often encountered in establishing the airway and in exposure of the gland particularly when the skin was involved. The predominant postoperative complications were related to respiratory distress as a consequence of tracheomalacia and tracheal stenosis. Conclusion: In spite of the technical challenge related to the airway, and thyroidectomy, surgery continues to be the best option in experienced hands due to its distinct advantage of its immediate effect and complete resolution of compressive symptoms.

关键词： Thyroidectomy Massive Goiters Tracheomalacia Retrosternal Goiter

Recurrent Giant Phyllodes Tumour of the Breast Pathological Considerations and Management Approach for Recurrence and Metastasis

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Surgical Science 2012年第4期3卷 220-225页

作者： norman Oneil Machado Department of Surgery Sultan Qaboos University Hospital Muscat Oman

Phyllodes tumours are rare and account for 0.4% of all breast tumours. The majority of them tend to be less than 5 cms in size with giant tumours larger than 10 cms being about 20% of these cases. They display a broad range of clinical and pathological behavior and are regarded as falling within the spectrum of fibroepithelial neoplasms. Surgery has been the primary modality of treatment. However the extent of resection and the role of adjuvant radiotherapy and chemotherapy are still controversial. The risk of recurrence is (4.7% - 30%) for benign phyllodes tumour and (30% - 65%) for borderline and malignant phyllodes tumour. A case of giant phyllodes tumour measuring 36 × 30 cm and weighing 6.8 kg is presented, which had recurred following a previous resection 5 years back. The literature is reviewed with regards to pathology, the role of investigations, nature of resection and the risk factors for recurrence and

关键词： Phyllodes Tumour Mastectomy Giant Tumour Recurrence

Science Skill-Based Activities for Senior High School Students

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Journal of Contemporary Educational Research 2024年第12期8卷 291-298页

作者： norman Ruelo Marquez Senior High School Bauan Technical High SchoolPedro Munoz StreetBauanBatangasPhilippines Kauai High School Lualima St.Lihue Hawaii 96766United States

Science enables students to seek knowledge and practice relevant scientific processes to provide meaningful solutions or information that can contribute to the development of *** study aimed to create a science learning activity for senior high school students that integrates learning skills in science such as information retrieval,scientific reading,data representation,scientific writing,and knowledge *** subjects of this study,which was employed through purposive sampling,were Grade 12 STEM students and Science teachers from Batangas’2nd Congressional District-Area *** analysis was used to analyze the least mastered competencies in earth science,general biology,general chemistry,and general *** interview was also used to reinforce the data collection and *** content’s relevancy influences the students’attitudes and interests,the teachers’teaching tactics,and the opportunity to learn *** student’s learning skills in science were honed by the learning activities provided by their ***,the students’data representation and knowledge presentation skills must be *** pedagogical considerations may be emphasized in developing a learning activity to boost student engagement and achieve a better learning experience.

关键词： Science learning competencies Attitudes and interest of STEM Learning skills in science Pedagogical consideration

Duodenal injury post laparoscopic cholecystectomy: Incidence, mechanism, management and outcome

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World Journal of Gastrointestinal Surgery 2016年第4期8卷 335-344页

作者： norman Oneil Machado Department of Surgery Sultan Qaboos University Hospital

AIM: To study the etiopathogenesis, management and outcome of duodenal injury post laparoscopic cholecystectomy(LC).METHODS: A Medline search was carried out for all articles in English, on duodenal injury post LC, using the search word duodenal injury and LC. The cross references in these articles were further searched, for potential articles on duodenal injury, which when found was studied. Inclusion criteria included, case reports, case series, and reviews. Articles even with lack of details with some of the parameters studied, were also analyzed. The study period included all the cases published till January 2015. The data extracted were demographic details, the nature and day of presentation, potential cause for duodenal injury, site of duodenal injury, investigations, management and outcome. The model(fixed or random effect) for meta analyses was selected, based on Q and I2 statistics. STATA software was used to draw the forest plot and to compute the overall estimate and the 95%CI for the time of detection of injury and its outcome on mortality. The association between time of detection of injury and mortality was estimated using χ2 test with Yate's correction. Based on Kaplan Meier survival curve concept, the cumulative survival probabilities at various days of injury was estimated. RESULTS: Literature review detected 74 cases of duodenal injury, post LC. The mean age of the patients was 58 years(23-80 years) with 46% of them being males. The cause of injury was due to cautery(46%), dissection(39%) and due to retraction(14%). The injury was noted on table in 46% of the cases. The common site of injury was to the 2nd part of the duodenum with 46% above the papilla and 15% below papilla and in 31% to the 1st part of duodenum. Duodenorapphy(primary closure) was the predominant surgical intervention in 63% with 21% of these being carried out laparoscopically. Other procedures included, percutaneous drainage, tube duodenostomy, gastric resection, Whipple resectio

关键词： Laparoscopic cholecystectomy Duodenal injury Duodenorapphy

Zhonggu Zhongguo yu Sute wenming （Medieval China and Sogdian Culture）

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Frontiers of History in China 2015年第3期10卷 525-530页

作者： norman Harry Rothschild University of North Florida

Rong Xinjiang＇s new work Zhonggu Zhongguo yu Sute wenming, with origins going back to the author＇s work with historian Zhang Guangda in the late 1980s, is a continuation of its ambitious predecessor, Zhonggu Zhonggu...

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精神疾病与躯体疾病共病:21世纪医学的重大挑战(英文)

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上海精神医学 2013年第2期25卷 68-69页

作者： norman SARTORIOUS University of Geneva

Over the past two decades the prevalence of comorbid mental and physical diseases has increased dramatically,reaching epidemic proportions in many *** persons over the age of sixty the simultaneous presence of two or ... 详细信息

关键词：疾病身体精神医药患病率合并症流行病

中国金丝桃属金丝桃组(藤黄科)新分类群(英文)

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植物分类学报 2005年第3期43卷 271-277页

作者： norman K.B.ROBSON Department of Botany The Natural History Museum Cromwell Road London SW7 5BD

描述了中国云南北部的金丝桃属Hypericum L.(藤黄科)两个新种,即楚雄金丝桃H. fosteri N. Robson和漾濞金丝桃H. wardianum N. Robson。二者均与短柱金丝桃H. hookerianum Wight & Arn.相近。楚雄金丝桃为一地方特有种,目前仅在模式地... 详细信息

描述了中国云南北部的金丝桃属Hypericum L.(藤黄科)两个新种,即楚雄金丝桃H. fosteri N. Robson和漾濞金丝桃H. wardianum N. Robson。二者均与短柱金丝桃H. hookerianum Wight & Arn.相近。楚雄金丝桃为一地方特有种,目前仅在模式地点发现;漾濞金丝桃在缅甸东北部还有分布。二者主要以蒴果伸长,非卵状近球形,萼片无中脉而有别于短柱金丝桃。此外,将宽萼金丝桃H. latisepalum (N. Robson) N. Robson从亚种提升为种;将变异较大的纤枝金丝桃H. lagarocladum N. Robson划分为两个亚种,即叶较宽、具有开张习性的原亚种纤枝金丝桃H. lagarocladum ssp. lagarocladum和叶较窄、更为直立的新亚种狭叶金丝桃H. lagarocladum ssp. angustifolium N. Robson。

关键词：中国金丝桃属金丝桃组藤黄科新分类群新种楚雄金丝桃漾濞金丝桃

Current landscape in motoneuron regeneration and reconstruction for motor cranial nerve injuries

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Neural Regeneration Research 2020年第9期15卷 1639-1649页

作者： Yanjun Xie Kevin J.Schneider Syed A.Ali norman D.Hogikyan Eva L.Feldman Michael J.Brenner Department of Otolaryngology-Head and Neck Surgery University of Michigan Medical SchoolAnn ArborMIUSA Department of Neurology University of Michigan Medical SchoolAnn ArborMIUSA

The intricate anatomy and physiology of cranial nerves have inspired clinicians and scientists to study their roles in the nervous system. Damage to motor cranial nerves may result from a variety of organic or iatrogenic insults and causes devastating functional impairment and disfigurement. Surgical innovations directed towards restoring function to injured motor cranial nerves and their associated organs have evolved to include nerve repair, grafting, substitution, and muscle transposition. In parallel with this progress, research on tissue-engineered constructs, development of bioelectrical interfaces, and modulation of the regenerative milieu through cellular, immunomodulatory, or neurotrophic mechanisms has proliferated to enhance the available repertoire of clinically applicable reconstructive options. Despite these advances, patients continue to suffer from functional limitations relating to inadequate cranial nerve regeneration, aberrant reinnervation, or incomplete recovery of neuromuscular function. These shortfalls have profound quality of life ramifications and provide an impetus to further elucidate mechanisms underlying cranial nerve denervation and to improve repair. In this review, we summarize the literature on reconstruction and regeneration of motor cranial nerves following various injury patterns. We focus on seven cranial nerves with predominantly efferent functions and highlight shared patterns of injuries and clinical manifestations. We also present an overview of the existing reconstructive approaches, from facial reanimation, laryngeal reinnervation, to variations of interposition nerve grafts for reconstruction. We discuss ongoing endeavors to promote nerve regeneration and to suppress aberrant reinnervation and the development of synkinesis. Insights from these studies will shed light on recent progress and new horizons in understanding the biomechanics of peripheral nerve neurobiology, with emphasis on promising strategies for optimizing

关键词： axon degeneration cranial neuropathy facial nerve facial paralysis motoneuron nerve regeneration peripheral nerve recurrent laryngeal nerve synkinesis vocal fold paralysis