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Cultivated hawthorn(Crataegus pinnatifida ***)genome sheds light on the evolution of Maleae(apple tribe)

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Journal of Integrative Plant Biology 2022年第8期64卷 1487-1501页

作者： Ticao Zhang Qin Qiao Xiao Du Xiao Zhang Yali Hou Xin Wei Chao Sun Rengang Zhang Quanzheng Yun MJames CCrabbe Yves van de Peer Wenxuan Dong College of Chinese Material Medica Yunnan University of Chinese MedicineKunming 650500China School of Agriculture Yunnan UniversityKunming 650091China College of Horticulture Shenyang Agricultural UniversityShenyang 110866China Key Laboratory of Beibu Gulf Environment Change and Resources Utilization of Ministry of Education Nanning Normal UniversityGuangxiNanning 530001China Beijing Ori‐Gene Science and Technology Co.Ltd Beijing 102206China Wolfson College Oxford UniversityOxfordUK Institute of Biomedical and Environmental Science&Technology School of Life SciencesUniversity of BedfordshirePark SquareLutonUK School of Life Sciences Shanxi UniversityTaiyuan 030006China department of Plant Biotechnology and Bioinformatics Center for Plant Systems BiologyGhent UniversityVIB9052GhentBelgium department of Biochemistry Genetics and MicrobiologyUniversity of PretoriaPretoria 0028South Africa College of Horticulture Nanjing Agricultural UniversityNanjing 210095China

Cultivated hawthorn(Crataegus pinnatifida ***)is an important medicinal and edible plant with a long history of use for health protection in ***,we provide a de novo chromosomelevel genome sequence of the hawthorn cultivar“Qiu Jinxing.”We assembled an 823.41 Mb genome encoding 40571 genes and further anchored the779.24 Mb sequence into 17 pseudo-chromosomes,which account for 94.64%of the assembled *** analyses revealed that cultivated hawthorn diverged from other species within the Maleae(apple tribe)at approximately 35.4 ***,genes involved in the flavonoid and triterpenoid biosynthetic pathways have been significantly amplified in the hawthorn *** addition,our results indicated that the Maleae share a unique ancient tetraploidization event;however,no recent independent whole-genome duplication event was specifically detected in *** amplification of non-specific long terminal repeat retrotransposons contributed the most to the expansion of the hawthorn ***,we identified two paleo-sub-genomes in extant species of Maleae and found that these two sub-genomes showed different rearrangement *** also reconstructed the ancestral chromosomes of Rosaceae and discussed two possible paleopolyploid origin patterns(autopolyploidization or allopolyploidization)of ***,our study provides an improved context for understanding the evolution of Maleae species,and this new highquality reference genome provides a useful resource for the horticultural improvement of hawthorn.

关键词： ancestral chromosome reconstruction hawthorn(Crataegus spp.) long terminal repeat retrotransposons(LTR-RTs) medicinal and edible plants sub-genome

“Winter Is Coming” : How did Polyploid Plants Survive?

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Molecular Plant 2020年第1期13卷 4-5页

作者： Zhen Li Yves van de Peer department of Plant Biotechnology and Bioinformatics Ghent University9052 GhentBelgium VIB Center for Plant Systems Biology 9052 GhentBelgium Centre for Microbial Ecology and Genomics Department of BiochemistryGenetics and MicrobiologyUniversity of PretoriaPretoria 0028South Africa.

Cold and dark periods have descended on Earth several times in geological history. One such period characterized the Cretaceous-Paleogene (K-Pg) boundary, following a meteor impact near Chicxulub in Mexico, about 66 million years ago, which caused dust, sulfate aerosols, and soot particles to be ejected into the atmosphere. This in turn led to a so-called “impact winter,” inhibiting photosynthesis and causing a global collapse of terrestrial and marine food webs, leading to the extinction of 60%–70% of plants and animals ( Alvarez et al., 1980 ). Different from animals that might still be able to find shelter and detritus food in a harsh environment, plants are sessile and require (lots of) light for photosynthesis. How did they survive in a time of prolonged darkness and decreasing temperatures ( Vellekoop et al., 2016 )?

关键词： winter Cretaceous terrestrial

Analysis of Pulmonary Arteries Growth after Initial Shunt Palliation in Neonates and Infants

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Congenital Heart Disease 2023年第5期18卷 525-537页

作者： François-Xavier van Vyve Karlien Carbonez Geoffroy de Beco Stéphane Moniotte Jean ERubay Mona Momeni Laurent Houtekie Alain J.Poncelet department of Cardiovascular and Thoracic Surgery Universitécatholique de Louvain(UCLouvain)—Cliniques Universitaires Saint-LucBrusselsB-1200Belgium department of Pediatric Cardiology Universitécatholique de Louvain(UCLouvain)—Cliniques Universitaires Saint-LucBrusselsB-1200Belgium department of Anesthesiology Universitécatholique de Louvain(UCLouvain)—Cliniques Universitaires Saint-LucBrusselsB-1200Belgium department of Pediatric Intensive Care Universitécatholique de Louvain(UCLouvain)—Cliniques Universitaires Saint-LucBrusselsB-1200Belgium

Objective:despite increasing enthusiasm for neonatal repair,patients with ductal-dependent circulation(pulmonary/systemic)or restrictive pulmonary blood flow still require initial *** stenting has emerged as an endovascular approach whereas modified-Blalock-Taussig and central shunt remain surgical *** this study,we analyzed the relationship between pulmonary artery growth,sites of shunt connection,or antegrade pulmonary blood flow in surgically placed *** need for secondary catheter-based interventions or pulmonary arterioplasty was also ***:A retrospective single-center study analyzing 175 patients undergoing surgery for a central or modified-Blalock-Taussig *** growth variables were right pulmonary artery/left pulmonary artery diameters/Z scores,the indexed sum area(right pulmonary artery+left pulmonary artery),and the pulmonary symmetry *** imaging modalities were used:angiography,computed tomography,and ***:At baseline,pulmonary arteries were larger in patients with antegrade pulmonary blood flow(Nakata index 137 vs.114,p=0.047)as well as in patients receiving a modified-Blalock-Taussig shunt(Nakata index 138 vs.84,pdex increased from 134 to 233 mm^(2)/m^(2)(pdex remained stable(0.86)over *** the inter-stage period,shunt-related pulmonary artery stenosis and juxta-ductal stenosis were diagnosed in 16(10%)and 17 patients(11%),***:Surgical shunt palliation allows normal pulmonary artery *** artery stenosis was either shunt-related(10%)or secondary to juxta-ductal stenosis(11%).Close echographic follow-up allows early diagnosis and treatment of juxta-ductal stenosis.

关键词： Congenital heart disease cyanosis palliation neonates outcome

A Stochastic Model Approach for Optimisation of Lowland River Restoration Works

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Journal of Earth Science 2016年第1期27卷 55-67页

作者： Saskia van Vuren Huib de Vriend Hermjan Barneveld Section of Hydraulic Engineering Delft University of Technology 2600 AA Delft the Netherlands HKV Consultants Lelystad the Netherlands

Over the course of centuries, river systems have been heavily trained for the purpose of safe discharge of water, sediment and ice, and improves navigation. Traditionally, dikes are used to be reinforced and heightened to protect countries from ever higher flood levels. Other types of solutions than technical engineering solutions, such as measures to increase the flood conveyance capacity（e.g., lowering of groynes and floodplains, setting back dikes） become more popular. These solutions may however increase the river bed dynamics and thus impact negatively navigation, maintenance dredging and flood safety. A variety of numerical models are available to predict the impact of river restoration works on river processes. Often little attention is paid to the assessment of uncertainties. In this paper, we show how we can make uncertainty explicit using a stochastic approach. This approach helps identifying uncertainty sources and assessing their contribution to the overall uncertainty in river processes. The approach gives engineers a better understanding of system behaviour and enables them to intervene with the river system, so as to avoid undesired situations. We illustrate the merits of this stochastic approach for optimising lowland river restoration works in the Rhine in the Netherlands.

关键词： river restoration flood protection dredging navigation stochastic approach Room forthe River program.

Investigation of operational parameters for an industrial CFB combustor of coal,biomass and sludge

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China Particuology 2007年第4期5卷 247-254页

作者： Manon van de Velden Jan Baeyens Bill Dougan Alan McMurdo department of Chemical Engineering University of Birmingham B15 2TT Birmingham United Kingdom UPM-Kymmene Caledonian Paper Ltd.AyrUnited Kingdom

The combustion of coal and/or biomass （sludge, wood waste, RDF, etc.） in a circulating fluidized bed has been a commercial topper for over 20 years, and references to principles and applications are numerous and widespread although few data are presented concerning the operation of large scale CFB-units. The authors studied the CFB-combustion at UPM-Kymmene （Ayr）, a major paper mill relying for its steam production upon the combustion of coal （80-85 %）, wood bark （5-10%） and wastewater treatment sludge （5-10%）. The maximum capacity of the CFB is 58 MWth. A complete diagnostic of the operation was made, and additional tests were performed to assess the operating mode. The plant schematics, relevant dimensions and process data are given. To assess the operation of the UPM-CFB, it is important to review essential design parameters and principles of CFB combustors, which will be discussed in detail to include required data, heat balance and flowrates, operating versus transport velocity, kinetics and conversion （including the possible effect of the Bouduard reaction if carbon is present）. Since the residence time in the riser and the cyclone efficiency determine the burnout of circulating fuel-particles, the UPM-CFB was subjected to a stimulus response technique using nickel oxide as tracer. Results illustrate the efficiency of the cyclone separation and the number of recycle loops for particles of a given size. Results will also be used to assess the cyclone operation and efficiency and to comment upon expected and measured carbon conversion.

关键词： Circulating fluidized bed Combustion Coal Biomass Operation Cyclone

NANOWIRES WITH deFINITE RADII FORMED IN OPERATING LIQUID METAL ION SOURCES （LMIS）

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NANOWIRES WITH DEFINITE RADII FORMED IN OPERATING LIQUID MET...

Short-term nitisinone discontinuation of hereditary tyrosinemia type 1 mice causes metabolic alterations in glutathione metabolism/biosynthesis and multiple amino acid degradation pathways

Ⅻ International Symposium on Small Particles and Inorganic Clusters

作者： Pierre Joyes Jean van de walle René-Jean Tarento Laboratoire de Physique des Solides Université Paris-SudBt.510 91405 Orsay（France） Laboratoire de Physique des Solides Université Paris-SudBt.510 91405 Orsay（France） Laboratoire de Physique des Solides Université Paris-SudBt.510 91405 Orsay（France）

＜正＞ For some elements such as germanium or tin, the mass spectra of ions emitted by liquid metal ion sources （LMIS） exhibit periodicities, i.e. series of equidistant peaks with an increase, v, in the number of atoms between two peaks. We attribute it to the existence of jets inoperating LMIS, the upper part of them being cylinders with v-atom sections. The Ge6m+3+1

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Genes & Diseases 2023年第5期10卷 1759-1762页

作者： Colemonts-Vroninks Haaike Norman P.Brendan van Laere Sven Davison S.Andrew Marcélis Lionel Casimir Georges Goyens Philippe Claes Paul de Bundel Dimitri Martens Geert Ranganath Lakshminarayan Rao vanhaecke Tamara Gallagher James A de Kock Joery Vrije Universiteit Brussel Liver Therapy&Evolution TeamIn Vitro Toxicology and Dermato-Cosmetology(IVTD)Research GroupFaculty of Medicine and PharmacyLaarbeeklaan 103Brussels B-1090Belgium Vrije Universiteit Brussel Experimental Pharmacology(EFAR)Research GroupFaculty of Medicine and PharmacyLaarbeeklaan 103Brussels B-1090Belgium University of Liverpool Dept.of Musculoskeletal&Ageing ScienceInstitute of Life Course&Medical SciencesLiverpool L78TXUnited Kingdom Vrije Universiteit Brussel Interfaculty Center Data Processing and StatisticsFaculty of Medicine and PharmacyLaarbeeklaan 103Brussels B-1090Belgium Liverpool University Hospitals NHS Foundation Trust Clinical Biochemistry and Metabolic MedicineLiverpool L35PSUnited Kingdom UniversitéLibre de Bruxelles Laboratoire de PédiatrieBrussels B-1050Belgium Vrije Universiteit Brussel In Vitro Liver Disease Modelling TeamIn Vitro Toxicology and Dermato-Cosmetology(IVTD)Research GroupFaculty of Medicine and PharmacyLaarbeeklaan 103Brussels B-1090Belgium AZ delta General Hospital Department of Laboratory MedicineRoeselare 8800Belgium Ghent University Department of Biomolecular MedicineGhent 9052Belgium

Hereditary tyrosinemia type 1(HT1)is a life-threatening disease caused by the patient's inability to break down tyrosine due to loss-of-function mutations in the fumarylacetoacetate hydrolase(FAH)enzyme(Fig.S1).Currently,the only available life-saving treatment is nitisinone(NTBC).However,nitisinone therapy comes with debilitating side effects and requires a strict drug regime combined with a tyrosine-and phenylalanine-restricted ***,therapy adherence is often experienced as an additional *** this study,transcriptional profiling was conducted parallel to high-resolution metabolomics on,respectively,liver tissue and serum samples of Fah-deficient *** experimental workflow of our study is shown in Figure *** pathway analyses showed manifest activation of the NRF2-stress response,associated with hepatocellular damage and mainly driven by a markedly increased oxidative *** altered canonical pathways were primarily a downstream consequence of the ***,we observed an overall aminoacidemia and changes related to aminoacyl-tRNA biosynthesis,which postulates that short-term nitisinone discontinuation can already put the patient at risk for hepatocellular carcinoma ***,we did not only identify changes in numerous pathways,directly and indirectly,related to the metabolism of tyrosine and glutathione but also the presence of“side-chain”metabolites,such as y-glutamyl-and N-acetyl-coupled amino acids,indicating that non-directly related pathways like phase II biotransformation reactions are also affected.

关键词： continuation Figure hereditary

Dual-functional porous and cisplatin-loaded polymethylmethacrylate cement for reconstruction of load-bearing bone defect kills bone tumor cells

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Bioactive Materials 2022年第9期7卷 120-130页

作者： Zhule Wang Liebert Parreiras Nogueira Håvard Jostein Haugen Ingrid CM.van der Geest Patricia Caetano de Almeida Rodrigues dennis Janssen Thom Bitter Jeroen J.J.P.van den Beucken Sander CG.Leeuwenburgh Radboud University Medical Center Department of Dentistry-Regenerative BiomaterialsRadboud Institute for Molecular Life SciencesNijmegenthe Netherlands University of Oslo Department of BiomaterialsInstitute of Clinical DentistryFaculty of DentistryOsloNorway Radboud University Medical Center Department of OrthopedicsRadboud Institute for Health SciencesNijmegenthe Netherlands

Malignant bone tumors are usually treated by resection of tumor tissue followed by filling of the bone defect with bone graft ***(PMMA)cement is the most commonly used bone substitute in clinical orthopedics in view of its ***,the dense nature of PMMA renders this biomaterial unsuitable for local delivery of chemotherapeutic drugs to limit the recurrence of bone ***,we introduce porosity into PMMA cement by adding carboxymethylcellulose(CMC)to facilitate such local delivery of chemotherapeutic drugs,while retaining sufficient mechanical properties for bone reconstruction in load-bearing *** results show that the mechanical strength of PMMA-based cements gradually decreases with increasing CMC *** incorporation of≥3%CMC,the PMMA-based cements released up to 18%of the loaded cisplatin,in contrast to cements containing lower amounts of CMC which only released less than 2%of the cisplatin over 28 *** release of cisplatin efficiently killed osteosarcoma cells in vitro and the fraction of dead cells increased to 91.3%at day 7,which confirms the retained chemotherapeutic activity of released cisplatin from these PMMA-based ***,tibias filled with PMMA-based cements containing up to 3%of CMC exhibit comparable compressive strengths as compared to intact *** conclusion,we demonstrate that PMMA cements can be rendered therapeutically active by introducing porosity using CMC to allow for release of cisplatin without compromising mechanical properties beyond critical *** such,these data suggest that our dual-functional PMMA-based cements represent a viable treatment option for filling bone defects after bone tumor resection in load-bearing sites.

关键词： Porous polymethylmethacrylate cement Bone tumor treatment Local drug delivery Chemotherapeutic drug Ex vivo biomechanical assessment

Surface charging activated mechanism change: A computational study of O, CO, and CO2 interactions on Ag electrodes

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Journal of Energy Chemistry 2020年第11期29卷 307-313页

作者： Ilker Tezsevin Mauritius C.M.van de Sanden Suleyman Er DIFFER-Dutch Institute for Fundamental Energy Research De Zaale 20Eindhoven 5612 AJThe Netherlands CCER-Center for Computational Energy Research DIFFER-Dutch Institute for Fundamental Energy ResearchDe Zaale 20Eindhoven 5612 AJThe Netherlands department of Applied Physics Eindhoven University of TechnologyEindhoven 5600 MBThe Netherlands

Electrocatalytic and plasma-activated processes receive increasing attention in catalysis. density functional theory(DFT) calculations are state-of-the-art tools for the fundamental study of reaction mechanisms and predicting the performance of catalytic materials. Proper application of DFT-based methods is crucial when investigating charge-doped electrode surfaces during electrocatalytic and plasma-activated reactions. Here, as a model electrode for plasma-activated CO2 splitting, we studied the interactions of O, CO, and CO2 with the neutral and progressively charged Ag(111) metal surfaces. We show that the application of correction procedures is necessary to obtain accurate adsorption energy profiles of O atoms,CO and CO2 molecules on Ag surfaces that are under the influence of additional electrons. Interestingly,the oxidation of CO is found to shift from a Langmuir–Hinshelwood mechanism on a neutral electrode to an Eley–Rideal mechanism on charged electrodes. Furthermore, we show that the surface charging of Ag(111) electrodes increase their CO2 reduction performance by enhancing the adsorption of O atoms and desorption of CO molecules. A further increase in the absolute charge-state of the electrode surface is expected to waive the thermodynamic barriers for the CO2 splitting reaction.

关键词： density functional theory CO2 reduction Silver electrode Surface charge