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Synthesis and Characterization of TiO2 Nanoreservoirs Supported with Platinum II and Sodium Bicarbonate Solution

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材料科学与工程（中英文A版） 2015年第1期5卷 100-108页

作者： Jose Albino Moreno Rodriguez Genaro Carmona Gutierrez Marco-Antonio Gonzalez Coronell Efrain Rubio Rosas Lilian-aurora Moreno Rodrlguez Fernando Moreno Rodriguez Chemistry Department Faculty of Chemistry Science Academic Entailment Center and Technology Transfer Physics Institute C. U. Colonia San Manuel. Puebla Puebla. C. P. 72570. Mexico Tapia's Chiautla Hospital S/N C.P. Puebla 74730. Mexico

In the past 10 years, the nanoreservoirs to based on TiO2 have taken the lead to develop new and better ways to control and possible "removal" of diseases that have bewildered mankind since its existence. In seeking to contribute to these expectations, at this early stage we synthesized nanoreservoirs of TiO2 with sodium bicarbonate solution to 15% (NaHCO3-15/TiO2), with salt of platinum(II) to 0.1% (Pt-0.1/TiO2) and with the NaHCO3 15% and the platinum(II) 0.1% "in situ" (Pt-0.1-NaHCO3-15/TiO2) by sol-gel. We show that TiO2 and Pt-0.1/TiO2 nanoreservoirs are amorphous. While the NaHCO3-15/TiO2 and the Pt-0.1-NaHCO3-15/TiO2 nanoreservoirs are crystalline. The NaHCO3-15/TiO2 and Pt-0.1-NaCO3-15/TiO2 nanoreservoirs are crystalline because to transformation of the sodium bicarbonate (NaHCO3) to trona phase. The trona phase increases the average particle size of the Pt-0.1-NaCO3-15/TiO2 nanoreservoirs of 180 nm to 130 nm (NaHCO3-15/TiO2). The nanoreservoirs doped with platinum decreases the particle size to 50 nm (Pt-0.1/TiO2).

关键词：二氧化钛碳酸氢钠溶液合成 TiO2 二代白金表征

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超强记忆源自大脑异常？

环球科学 2014年第3期 74-79页

作者：詹姆斯·L·麦高(James L. McGangh) 奥萝拉·勒波尔(aurora LePort) 邱天(翻译) 毛利华(审校)

神经科学家发现，有些人对20年前发生事情的细节，仍能记忆犹新，仿佛那一切就发生在昨天。

关键词：记忆大脑科学家

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影响奶牛休息时间的因素

广东奶业 2011年第1期 33-33页

作者： aurora Villarroel Ben Krahn 熊倩（译者）赵尊阳（审阅）美国Hoard’SDairyman公司不详

之前的相关研究均表示奶牛的休息时间越长产奶越多，但想要诱使奶牛休息更长却非常困难。通过提高牧场条件进而增加奶牛的休息时间，大家进行了许多尝试和努力，从改善卧床到降低牛群密度等等。

关键词：休息时间奶牛产奶牧场牛群

芬顿试剂与腐植酸联用去除污染水中全氟辛酸(PFOA)的研究

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腐植酸 2018年第5期 46-46页

作者： aurora Santos Sergio Rodríguez Fernando Pardo 矫威中国腐植酸工业协会

全氟化合物(PFCs)因它的分布全球性、高持久性和生物蓄积性而受到广泛关注。其中,全氟辛酸(PFOA)是环境中最常见的一种。本研究采用了化学氧化法、腐植酸吸附法以及芬顿试剂(FR)和腐植酸组合法对PFOA的消除进行研究。PFOA中的强键C-F很... 详细信息

全氟化合物(PFCs)因它的分布全球性、高持久性和生物蓄积性而受到广泛关注。其中,全氟辛酸(PFOA)是环境中最常见的一种。本研究采用了化学氧化法、腐植酸吸附法以及芬顿试剂(FR)和腐植酸组合法对PFOA的消除进行研究。PFOA中的强键C-F很难降解,因此,正如在25℃下使用FR或过硫酸盐(PS)所证实的那样,室温和常压下的高级氧化过程(AOPS)不能氧化它们。相反,用加热的过硫酸盐(100 mmol/L,

关键词：腐植酸过硫酸盐

Advances in cellular technology in the hematology field: What have we learned so far?

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World Journal of Stem Cells 2015年第1期7卷 106-115页

作者： Gustavo Torres de Souza Claudineia Pereira Maranduba Camila Maurmann de Souza Danielle Luciana aurora Soares do Amaral Francisco Carlos da Guia Rafaella de Souza Salomao Zanette Joao Vitor Paes Rettore Natana Chaves Rabelo Lucas Mendes Nascimento Icaro Franca Navarro Pinto Julia Boechat Farani Abrahao Elias Hallack Neto Fernando de Sa Silva Carlos Magno da Costa Maranduba Angelo Atalla Laboratory of Human Genetics and Cell Therapy Biology Department Biological Sciences Institute Federal University of Juiz de Fora Juiz de Fora 36036-900Brazil Haematology and Bone Marrow Transplantation Service Medical Clinic Department University Hospital Federal University of Juiz de Fora Juiz de Fora 36036-900 Brazil

Despite the advances in the hematology field, blood transfusion-related iatrogenesis is still a major issue to be considered during such procedures due to blood antigenic incompatibility. This places pluripotent stem cells as a possible ally in the production of more suitable blood products. The present review article aims to provide a comprehensive summary of the state-of-theart concerning the differentiation of both embryonic stem cells and induced pluripotent stem cells to hematopoietic cell lines. Here, we review the most recently published protocols to achieve the production of blood cells for future application in hemotherapy, cancer therapy and basic research.

关键词： Hematopoietic stem cells Progenitor Induced pluripotent stem cells Reprogramming Embryonic stem cells

Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

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Cellular & Molecular Immunology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez E Clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of Medical Biochemistry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biomedicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Medico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Emergencies Virgen del Rocío University HospitalSevilleSpain Intensive Care Unit Virgen del Rocío University HospitalSevilleSpain Department of Medicine University of SevilleSevilleSpain Cardiology and Cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumatology Unit Virgen del Rocío University HospitalSevilleSpain Internal Medicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain Neurology and Clinical Neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and Nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and Nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Investigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity *** cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease *** this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory ***,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 ***,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were *** findings contribute to a better understanding of the immunological sequelae of COVID-19.

关键词： SARS-CoV-2 COVID-19 Dendritic cell Long-COVID

分子谱与生存率的MR成像预测:TCGA胶质母细胞瘤数据组的多中心研究

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国际医学放射学杂志 2013年第4期 373-373页

作者： D.A. Gutman L.A.D. Cooper S.N. Hwang C.A. Holder J.J. Gao T.D. aurora 施逸兴 Department of Biomedical Informatics 36 Eagle Row Room 572 PAIS Emory University Hospital Atlanta GA 30322

目的由于胶质母细胞瘤(GBM)的MR所见表现与基因改变、基因表达以及病人生存率有关,应用公认的MRI术语,对GBM的肿瘤大小、成分进行全面的影像评估分析。材料与方法因为所有参与本研究的病人均已被癌症基因组计划匿名化,而且应用的是不包... 详细信息

目的由于胶质母细胞瘤(GBM)的MR所见表现与基因改变、基因表达以及病人生存率有关,应用公认的MRI术语,对GBM的肿瘤大小、成分进行全面的影像评估分析。材料与方法因为所有参与本研究的病人均已被癌症基因组计划匿名化,而且应用的是不包括病人标符、HIPAA所允许的数据集,所以不再需要机构审查委员会的批准。应用标准化特征集,3位神经放射学医师对75例基因信息已录入TCGA门户网站的GBM病人根据MR影像中肿瘤的大小、位置及形态进行分级。应用Krippendorff α统计以及组内相关系数对观察者间一致性进行分析。应用多变量Cox回归模型确定生存率、肿瘤大小与肿瘤形态之间的相关性;应用Fisher确切检验研究影像特征与基因组学之间的相关性。结果就肿瘤强化区、无强化区、坏死、水肿及肿瘤大小等变量而言,观察者间具有显著一致性。肿瘤强化体积及最大长径与较差的生存率高度相关(风险率分别为:8.84,P=0.0253;1.02,P=0.00973),甚至在卡氏评分校正后亦如此(P=0.0208)。原神经型GBM的强化水平明显低于其他亚型(P=0.02),而间质型GBM无强化肿瘤的水平较低(P<0.01)。结论分析显示,此方法能够可重复地描述脑肿瘤的影像特征;本研究显示,对影像特征的影像学肉眼评估可与基因改变、基因表达亚型结合,以更深入地观察GBM亚型潜在的生物学属性。

关键词：胶质母细胞瘤 GBM TCGA 生存率 MR

Nat Genet:科学家设计新方法找到抑制癌症发育的新基因

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现代生物医学进展 2017年第15期17卷 I0004-I0004页

作者： Jorge de la Rosa, Mathias Josef Friedrich, Yilong Li, Lena Rad, Hannes Ponstingl, Qi Liang, Sandra Bernaldo de Quirós, Imran Noorani, Emmanouil Metzakopian, Alexander Strong, Meng Amy Li, Gary J Hoffman, Rocío Fuente, George S Vassiliou, Roland Rad, Allan Bradley Juan Cadiñanos Jorge de la Rosa Juan Cadiñanos Jorge de la Rosa Carlos López-Otín Julia Weber Roland Rad Julia Weber Roland Rad aurora Astudillo María Teresa Fernández-García María Soledad Fernández-García Gary J Hoffman Carlos López-Otín The Wellcome Trust Sanger Institute Wellcome Trust Genome Campus Hinxton UK Instituto de Medicina Oncológica y Molecular de Asturias (IMOMA) Oviedo Spain Departamento de Bioquímica y Biología Molecular Facultad de Medicina Instituto Universitario de Oncología (IUOPA) Universidad de Oviedo Oviedo Spain Department of Internal Medicine II Klinikum rechts der Isar Technische Universität München München Germany German Cancer Consortium (DKTK) German Cancer Research Center (DKFZ) Heidelberg Germany Servicio de Anatomía Patológica Hospital Universitario Central de Asturias Oviedo Spain Unidad de Histopatología Molecular Facultad de Medicina IUOPA Universidad de Oviedo Oviedo Spain School of Medicine University of Western Australia Crawley Western Australia Australia Centro de Investigación Biomédica en Red de Cáncer Spain.

英国桑格研究院的研究人员和他们的合作者们最近发现了帮助阻止前列腺癌、皮肤癌和乳腺癌发育的新基因。这些基因能够与众所周知的肿瘤抑制基因PTEN配合发挥作用，该研究还发现这些基因与人类前列腺肿瘤存在相关性。相关研究结果发表在... 详细信息

英国桑格研究院的研究人员和他们的合作者们最近发现了帮助阻止前列腺癌、皮肤癌和乳腺癌发育的新基因。这些基因能够与众所周知的肿瘤抑制基因PTEN配合发挥作用，该研究还发现这些基因与人类前列腺肿瘤存在相关性。相关研究结果发表在国际学术期刊Nature Genetics上。该研究揭示了一些参与癌症发育的新途径，这些基因有望成为治疗PTEN突变癌症的新药物靶点。这项研究开发的一些方法也可以用于发现其他协同抑制癌症生长的基因。

关键词：新基因癌症发育 Nat 科学家设计肿瘤抑制基因国际学术期刊