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Janus-faced Mitofusin 2 (MFN2): mitochondria-endoplasmic reticulum shaping and tethering functions unveiled

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Signal Transduction and Targeted Therapy 2024年第2期9卷 341-342页

作者： Camilla aurora Franchino Elisa Motori Matteo Bergami Institute for Biochemistry University of Cologne50674 CologneGermany Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases(CECAD) Faculty of Medicine and University Hospital CologneUniversity of Cologne50931 CologneGermany Center for Molecular Medicine 50931 CologneGermany

In a recently published study in Science,Naòn et *** two uncharacterized splice variants of Mitofusin 2(MFN2)that specifically shape and tether the endoplasmic reticulum(ER)to mitochondria.1 This work sheds new light on the pleiotropic effects previously ascribed to MFN2 loss-of-function mutations,and has important implications for associated metabolic and neurological diseases.

关键词： MFN2 reticulum

Hydrogeochemical and isotopic assessment of the origin of NO_(3)^(−)and N-NH_(3)contents in the aquifer located in a closed lacustrine volcano-sedimentary basin in the metropolitan area of Mexico City

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Acta Geochimica 2024年第4期43卷 719-736页

作者： Jose Ivan Morales-Arredondo Maria aurora Armienta Hernandez Joel Edmundo Ortega-Gutierrez Elisa Cuellar Ramirez Natural Resources Department Institute of GeophysicsNational Autonomous University of MexicoCiudad Universitaria No.3000Col.Copilco UniversidadCoyoacán Delegation04360 MexicoCDMXMexico Instituto Politecnico Nacional ***án 55La Laguna Ticoman07340 MexicoCDMXMexico Benemérita Universidad Autónoma de Puebla Ciudad Universitaria Col.San ManuelPueblaPueMexico

To explain the presence and spatial distribution of NO_(3)^(−)and N-NH_(3)in the Aquifer of the Metropolitan Area of Mexico City(AMAMC),a hydrogeochemical and isotopic analysis using^(13)C DIC(as well as the stable isotopes^(18)O and^(2)H)in groundwater was *** aquifer is located in an old closed lacustrine volcano-sedimentary basin;some wells hosted in the semi-confined zone contain high N-NH_(3)concentrations,while others present NO_(3)^(−)contents in the recharge zones(hosted in an oxidizing environment).In this study,a change in the isotopic signature(primarily in^(18)O and^(2)H)was observed from the recharge zones to the basin center in some of the wells with high NO_(3)^(−)concentrations,this behavior can be attributed to evaporation during the incorporation of recently infiltrated *** addition,the results for^(13)C(along with ^(2) H)in wells with the highest N-NH_(3)concentrations exhibited an atypically broad range of *** indicated the occurrence of hydrogeochemical and/or biochemical processes in the aquifer(in an oxidizing or reducing environment),such as organic degradation,bacterial decomposition(primarily in the ancient Lake Texcoco and which acts as a natural sink for carbon,nitrogen,sulfur,and phosphorus),besides rock weathering and dissolution,which may be responsible for a very marked isotopic modification of the^(13)C(and,to a lesser extent,2 H).Methanotrophic bacterial activity and methanogenic activity may be related to N-NH_(3)removal processes by oxidation and residual water incorporation respectively,whereas the increase in the NO_(3)^(−)content in some wells is due to the recent contribution of poor-quality water due to contamination.

关键词： 18 O and^(13)C isotopes Iron Hydrogeochemical processes Nitrate Nitrogen species

Near Infrared Spectroscopy (NIRS) Model-Based Prediction for Protein Content in Cowpea

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American Journal of Plant Sciences 2024年第3期15卷 145-160页

作者： Kavera Biradar Waltram Ravelombola aurora Manley Caroline Ruhl Texas A&M AgriLife Research Vernon TX USA University of Agricultural Sciences Dharwad India Department of Soil and Crop Sciences Texas A&M University College Station TX USA

Cowpea (Vigna unguiculata L. Walp) is a multi-purpose legume with high quality protein for human consumption and livestock. The objective of this work was to develop near-infrared spectroscopy (NIRS) prediction models to estimate protein content in cowpea. A total of 116 cowpea breeding lines with a wide range of protein contents (19.28 % to 32.04%) were selected to build the model using whole seed and ground seed samples. Partial least-squares discriminant analysis (PLS-DA) regression technique with different pre-treatments (derivatives, standard normal variate, and multiplicative scatter correction) were carried out to develop the protein prediction model. Results showed: 1) spectral plots of both the whole seed and ground seed showed higher spectral scatter at higher wavelengths (>1450 nm), 2) data pre-processing affects prediction accuracy for bot whole seed and ground seed samples, 3) prediction using ground seed samples (0.64 R2 0.85) is better than the whole seed (0.33 R2 0.78), and 4) the data pre-processing second derivative with standard normal variate has the best prediction (R2_whole seed = 0.78, R2_ground seed = 0.85). The results will be of interest in cowpea breeding programs aimed at improving total seed protein content.

关键词： Cowpea Germplasm Protein Near-Infrared Spectroscopy (NIRS) Partial Least Squares (PLS)

Development of donor specific antibodies after SARS-CoV-2 vaccination:What do we know so far?

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World Journal of Meta-Analysis 2024年第2期12卷 1-4页

作者： Ahmed Daoud Karim Soliman Maria aurora Posadas Salas Sakshi Vaishnav Genta Uehara AhmedAbdelkader Tibor Fulop Michael J Casey Department of Medicine Division of NephrologyMedical University of South CarolinaCharlestonSC 29425United States Department of Medicine Cairo University Medical SchoolCairo 11211Egypt Department of Medicine Medical ServicesRalph H.Johnson VA Medical CenterCharlestonSC 29425United States Department of Medicine Division of NephrologyMedical ServicesRalph H.Johnson VA Medical CenterCharlestonSC 29425United States

Vaccination against Coronavirus disease-19(COVID-19)was pivotal to limit spread,morbidity and *** aim is to find out whether vaccines against COVID-19 lead to an immunological response stimulating the production of de novo donor specific antibodies(DSAs)or increase in mean fluorescence intensity(MFI)of pre-existing DSAs in kidney transplant recipients(KTRs).This study involved a detailed literature search through December 2nd,2023 using PubMed as the primary *** search strategy incorporated a combination of relevant Medical Subject Headings terms and keywords:"COVID-19","SARS-CoV-2 Vaccination","Kidney,Renal Transplant",and"Donor specific antibodies".The results from related studies were collated and analyzed.A total of 6 studies were identified,encompassing 460 KTRs vaccinated against *** responses were detected in 8 KTRs of which 5 had increased MFIs,1 had de novo DSA,and 2 were categorized as either having de novo DSA or increased *** were 48 KTRs with pre-existing DSAs prior to vaccination,but one study(Massa et al)did not report whether pre-existing DSAs were associated with post vaccination *** the remaining 5 studies,35 KTRs with pre-existing DSAs were identified of which 7 KTRs(20%)developed de novo DSAs or increased ***,no immunological response was detected in 452(98.3%)*** study affirms prior reports that COVID-19 vaccination is safe for KTRs,especially if there are no pre-existing ***,if KTRs have pre-existing DSAs,then an increased immunological risk may be *** findings need to be taken cautiously as they are based on a limited number of patients so further studies are still needed for confirmation.

关键词： COVID-19 SARS-CoV-2 vaccination Kidney Renal transplant Donor specific antibodies

Parking Availability Prediction with Coarse-Grained Human Mobility Data

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Computers, Materials & Continua 2022年第6期71卷 4355-4375页

作者： aurora Gonzalez-Vidal Fernando Terroso-Sáenz Antonio Skarmeta University of Murcia Murcia30003Spain Universidad Católica de Murcia(UCAM) Murcia30107Spain

Nowadays,the anticipation of parking-space demand is an instrumental service in order to reduce traffic congestion levels in urban *** purpose of our work is to study,design and develop a parking-availability predictor that extracts the knowledge from human mobility data,based on the anonymized human displacements of an urban area,and also from weather *** of the existing solutions for this prediction take as contextual data the current road-traffic state defined at very high temporal or spatial ***,access to this type of fine-grained location data is usually quite limited due to several economic or privacy-related *** overcome this limitation,our proposal uses urban areas that are defined at very low spatial and temporal *** conducted several experiments using three Artificial Neural Networks:Multilayer Perceptron,Gated Recurrent Units and bidirectional Long Short Term Memory networks and we tested their suitability using different combinations of *** metrics are provided for the sake of comparison within our study and between other *** solution has been evaluated in a real-world testbed in the city of Murcia(Spain)integrating an open human-mobility dataset showing high accuracy.A MAPE between 4%and 10%was reported in horizons of 1 to 3 h.

关键词： Parking space human mobility mining recurrent neural networks prediction

BK viral infection: A review of management and treatment

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World Journal of Transplantation 2023年第6期13卷 309-320页

作者： June Hayrelle Gorriceta Amy Lopez Otbo Genta Uehara Maria aurora Posadas Salas Department of Medicine St Francis Hospital-BartlettBartlettTN 38133United States Department of Medicine St.Luke’s Medical CenterQuezon 1112Philippines Department of Medicine Division of NephrologyMedical University of South CarolinaCharlestonSC 29425United States

BK viral infection remains to be a challenging post-transplant infection,which can result in kidney *** mainstay approach to BK infection is reduction of *** in immunosuppressive regimen with minimization of calcineurin inhibitors,use of mechanistic target of rapamycin inhibitors,and leflunomide have been attempted with variable *** the past few years,investigators have explored potential therapeutic options for BK *** prophylaxis and treatment was found to have no benefit in kidney transplant *** utility of cidofovir is limited by its *** immunoglobulin is becoming a popular option for treatment and prophylaxis for BK infection,as it increases the neutralizing antibody titers against the most common BK virus ***-specific T cell therapy is an emerging treatment option for BK *** this review,we will explore management and therapeutic options for BK infection and recent evidence available in literature.

关键词： BK infection Kidney transplant Treatment Management

Morphofunctional characterization of hemocytes in black soldier fly larvae

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Insect Science 2023年第4期30卷 912-932页

作者： Daniele Bruno aurora Montali Marzia Gariboldi Anna Katarzyna Wronska Agata Kaczmarek Amr Mohamed Ling Tian Morena Casarteli Gianluca Tettamanti Department of Biotechnology and Life Sciences University of InsubriaVareseItaly Host Parasites Molecular Interaction Research Unit Witold Stefanski Institute of ParasitologyPolish Academy of SciencesWarsawPoland Department of Entomology Faculty of ScienceCairo UniversityGizaEgypt Guangdong Provincial Key Laboratory of Agro-animal Genomics and Molecular Breeding Guangdong Provincial Sericulture and Mulberry Engineering Research CenterCollege of Animal ScienceSouth China Agricultural UniversityGuangzhouChina Department of Biosciences University of MilanoMilanoItaly Interuniversity Centerfor Studies on Bioinspired Agro-environmental Technology(BAT Center) University of Napoli Federico llPorticiItaly

In insects,the cell-mediated immune response involves an active role of hemo-cytes in phagocytosis,nodulation,and *** these processes have been well documented in multiple species belonging to different insect orders,information con-cerning the immune response,particularly the hemocyte types and their specific function in the black soldier fly Hermetia illucens,is still *** is a serious gap in knowledge given the high economic relevance of *** larvae in waste management strategies and considering that the saprophagous feeding habits of this dipteran species have likely shaped its immune system to efficiently respond to *** present study repre-sents the first detailed characterization of black soldier fly hemocytes and provides new insights into the cell-mediated immune response of this *** particular,in addition to prohemocytes,we identified five hemocyte types that mount the immune response in the larva,and analyzed their behavior,role,and morphofunctional changes in response to bac-terial infection and injection of chromatographic *** results demonstrate that the circulating phagocytes in black soldier fly larvae are *** cells also take part in nodulation and encapsulation with granulocytes and lamellocyte-like cells,devel-oping a starting core for nodule/capsule formation to remove/encapsulate large bacterial aggregates/pathogens from the hemolymph,*** processes are supported by the release of melanin precursors from crystal cells and likely by mobilizing nutrient reserves in newly circulating adipohemocytes,which could thus trophically support other hemocytes during the immune ***,the regulation of the cell-mediated im-mune response by eicosanoids was investigated.

关键词： eicosanoids encapsulation hemocytes Hermetia illucens immunity phagocytosis

Evaluation on the corrosion resistance, antibacterial property and osteogenic activity of biodegradable Mg-Ca and Mg-Ca-Zn-Ag alloys

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Journal of Magnesium and Alloys 2022年第12期10卷 3380-3396页

作者： Hewei Chen Bo Yuan Rui Zhao Xiao Yang Zhanwen Xiao Antoniac aurora Bita Ana Iulia Xiangdong Zhu Antoniac Vasile Iulian Xingdong Zhang National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China Faculty of Materials Science and Engineering University Politehnica of BucharestBucharest 060042Romania Academy of Romanian Scientists Bucharest 050094Romania

The rapid degradation of magnesium(Mg)-based implants in physiological environment limits its clinical applications, and alloying treatment is an effective way to regulate the degradation rate of Mg-based materials. In the present study, three Mg alloys, including Mg-0.8Ca(denoted as ZQ), Mg-0.8Ca-5Zn-1.5Ag(denoted as ZQ71) and Mg-0.8Ca-5Zn-2.5Ag(denoted as ZQ63), were fabricated by alloying with calcium(Ca), zinc(Zn) and silver(Ag). The results obtained from electrochemical corrosion tests and in vitro degradation evaluation demonstrated that the three Mg alloys exhibited distinct corrosion resistance, and ZQ71 exhibited the lowest degradation rate in vitro among them. After addition of Zn and Ag, the antibacterial potential of Mg alloys was also enhanced. The in vitro cell experiments showed that all the three Mg alloys had good biocompatibility. After implantation in a rat femoral defect, ZQ71 showed significantly higher osteogenic activity and bone substitution rate than ZQ63 and ZQ, due to its higher corrosion resistance as well as the stimulatory effects of the released metallic ions. In addition, the average daily degradation rate of each Mg alloy in vivo was significantly higher than that in vitro, as could be due to the implantation site located in the highly vascularized trabecular region. Importantly, the correlations between the in vitro and in vivo degradation parameters of the Mg alloys were systematically analyzed to find out the potential predictors of the in vivo degradation performance of the materials. The current work not only evaluated the clinical potential of the three biodegradable Mg alloys as bone grafts but also provided a feasible approach for predicting the in vivo degradation behavior of biodegradable materials.

关键词： Mg alloys Degradability Antibacterial property Osteogenic ability Bone defect repair

Calcitriol induces post-thawed bovine sperm capacitation

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BIOCELL 2023年第5期47卷 1135-1143页

作者： ANA CECILIA LIAUDAT FRANCISCA EBEL BIANCA ANA OPIZZO MARINA aurora GONZALEZ DAMIÁN BLOIS PABLO BOSCH NANCY RODRIGUEZ Departamento de Biología Molecular Instituto de Biotecnología Ambiental y Salud(INBIAS)Río Cuarto5800Argentina

Background:Capacitation is a set of physiological changes sperms undergo to acquire fertilizing *** vivo,this process is directly associated with high calcium levels in sperm ***,the vitamin D hypercalcemic metabolite,is related to human sperm motility,capacitation,and acrosome *** work aimed to study the effect of calcitriol on bull sperm quality parameters and ***:One million freezethawed spermatozoa were obtained from different bulls and treated with 20 nM of calcitriol for 30 *** cells(negative control)and treated ones with calcitriol or heparin(100μg/mL,positive capacitation control)were evaluated for motility,viability,and functional ***(70μM,30 min)treatment was included as a reactive oxygen species(ROS)positive sperm ***:The results elucidated that sperm exposed to 20 nM calcitriol showed higher viability,vigor,and capacitation than their positive and negative *** percentage of sperm with intact plasma and acrosome membranes,mitochondrial membrane potential(ΔΨm),and phosphatidylserine externalization was similar in all the conditions evaluated,while ROS production was higher with heparin and menadione-treated groups than the calcitriol group or negative ***:Our results indicate that calcitriol induces the capacitation of thawed bull spermatozoa and maintains acceptable values of progressive motility,viability,and vigor without altering key biological parameters such as redox status,ΔΨm,and cell death.

关键词： Bovine Sperm capacitation Calcitriol Cell viability Plasma membrane integrity Reactive oxygen species