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Impact of sodium glucose cotransporter-2 inhibitors on liver steatosis/fibrosis/inflammation and redox balance in non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2022年第26期28卷 3243-3257页

作者： Francesco Bellanti aurelio Lo Buglio MichałDobrakowski Aleksandra Kasperczyk Sławomir Kasperczyk Palok Aich Shivaram P Singh Gaetano Serviddio Gianluigi Vendemiale Department of Medical and Surgical Sciences University of FoggiaFoggia 71122Italy Department of Biochemistry Medical University of Silesia in KatowiceZabrze 41-808Poland School of Biological Sciences National Institute of Science Education and ResearchKhurdha 752050India Department of Gastroenterology SCB Medical CollegeCuttack 753007India

BACKGROUND Sodium glucose cotransporter-2 inhibitors(SGLT2-I)are the most recently approved drugs for type 2 diabetes(T2D).Recent clinical trials of these compounds reported beneficial cardiovascular(CV)and renal outcomes.A major cause of vascular dysfunction and CV disease in diabetes is hyperglycemia associated with inflammation and oxidative ***-clinical studies demonstrated that SGLT2-I reduce glucotoxicity and promote anti-inflammatory effects by lowering oxidative *** To investigate the effects of SGLT2-I on markers of oxidative stress,inflammation,liver steatosis,and fibrosis in patients of T2D with non-alcoholic fatty liver disease(NAFLD).METHODS We referred fifty-two consecutive outpatients treated with metformin monotherapy and exhibiting poor glycemic control to our *** introduced the outpatients to an SGLT2-I(dapagliflozin,empagliflozin,or canagliflozin;n=26)or a different hypoglycemic drug[other glucose-lowering drugs(OTHER),n=26].We evaluated circulating interleukins and serum hydroxynonenal(HNE)-or malondialdehyde(MDA)-protein adducts,fatty liver index(FLI),NAFLD fibrosis score,aspartate aminotransferase(AST)/alanine aminotransferase(ALT)ratio,AST-to-platelet-ratio index(APRI),and fibrosis-4 on the day before(T0)and following treatment for six months(T1).We also performed transient elastography at T0 and *** Add-on therapy resulted in improved glycemic control and reduced fasting blood glucose in both *** note,following treatment for six months,a reduction of FLI and APRI,as well as of the FibroScan result,was reported in patients treated with SGLT2-I,but not in the OTHER group;furthermore,in the SGLT2-I group,we reported lower circulating levels of interleukin(IL)-1β,IL-6,tumor necrosis factor,vascular endothelial growth factor,and monocyte chemoattractant protein-1,and higher levels of IL-4 and *** did not observe any modification in circulating interleukins in the OTHER ***,serum HNE-and MDA-protein a

关键词： Sodium glucose cotransporter-2 inhibitors Non-alcoholic fatty liver disease Oxidative stress Type 2 diabetes Liver fibrosis Inflammation

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Identification of an extracellular infection-induced glyceraldehyde-3-phosphate dehydrogenase of the phytopathogenic proteobacterium <i>Pseudomonas syringae</i>pv tomato DC3000

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Advances in Bioscience and Biotechnology 2014年第3期5卷 201-208页

作者： Bouchra Elkhalfi aurelio Serrano Abdelaziz Soukri Institute for Plant Biochemistry and Photosynthesis (IBVF) CSIC-Universidad de Sevilla Seville Spain Laboratory of Physiology & Genetics Molecular Faculty of Sci-ences Ain Chock Casablanca Morocco

According to molecular biology, genomic and proteomic data, the phytopathogenic gamma-proteobacterium Pseudomonas syringae pv. tomato DC3000 produces a number of proteins that may promote infection and draw nutrients from plants. Remarkably, P. syringae DC3000 strain possesses three paralogous gap genes encoding glyceraldehyde-3-phosphate dehydrogenase (GAPDH) enzymes with different predicted molecular sizes and metabolic functions. As GAPDH was shown to be a virulence factor in other microbial pathogens, in the current study, we analyzed the expression levels of each paralogous gap gene by realtime PCR to understand the actual impact of their protein products on P. syringae virulence. We found that all of them were strongly induced during the infection process. Nevertheless, proteomic analysis of culture supernatants revealed that only Class I GAPDH1 encoded by the gap1 gene was identified as an extracellular protein in infective cells. These results strongly suggest that this GAPDH should play a role in the infective process, including its well-know enzymatic function in the glycolytic metabolic pathway.

关键词： GAPDH Secretome MALDI-TOF Gene Expression Infective State Bacterial Speak RNA

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青少年的性节制:生活史的观点(英文)

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心理学报 2007年第3期39卷 481-488页

作者： Barbara Hagenah Brumbach Michele Walsh aurelio José Figueredo University of Arizona

生活史是研究身体发育与后代繁衍时间表的一种进化方法。本研究根据生活史理论调查与分析了 13000余名“婚前节欲”性教育规划中青少年的性态度、性信念与性行为关系。因子分析结果显示,多种性信念和性态度可以整合成一个一般因子,性节... 详细信息

生活史是研究身体发育与后代繁衍时间表的一种进化方法。本研究根据生活史理论调查与分析了 13000余名“婚前节欲”性教育规划中青少年的性态度、性信念与性行为关系。因子分析结果显示,多种性信念和性态度可以整合成一个一般因子,性节制。可以假设,性节制是生活史策略的一个维度。性节制的表现主要包括:性自我克制的意愿、承认性抑制的个人和社会原因、积极肯定青少年的节欲行为、否认性行为的积极影响、回绝性行为的技能、以健康为由赞同性抑制,以及对宗教的虔诚与笃信等。研究结果显示,性节制因子上的低分与更频繁性行为有关,年龄与性别变量对二者关系没有影响。本文还探讨了性态度、性行为以及人类生活史间的关系。

关键词：生活史方法性节制性行为性态度

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Erosion problem in tool steel using cold box core-making process

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China Foundry 2019年第3期16卷 204-210页

作者： Eduardo Rodríguez Alberto Pérez Rafael David Mercado-Solis Velasco-Téllez Abraham Omar Jimenez Martin Flores Marco aurelio Gonzalez Jesus Ibarra Universidad de Guadalajara Departamento de Ingeniería de Proyectos/CUCEI CONACyT México Facultad de Ingeniería Mecánica y Eléctrica UANL México Nemak México S.A. García México Instituto Tecnológico José Mario Molina Pasquel y Henríquez Unidad Zapopan México

This paper presents the erosion results of the AISI H13 steel impinged by resin-bonded silica sand, using a testing rig that closely simulates the real blowing conditions during industrial core-making. Steel specimens were heat treated to obtain hardness of 294, 445 and 595 HV200 (29, 45 and 55 HRC). Erosion tests were carried out at impingement angles from 20° to 90° and air drag pressures of 1.38, 2.07 and 2.76 bar (20, 30 and 40 psi). The main results are summarized as follows:(i) The harder material, the lower erosion;(ii) the maximum erosion rate is at 30°;(iii) Little difference in erosion rate at impact angle of 60° and 90° for a constant pressure tested regardless of the hardness level;(iv) As the pressure increases, so does the erosion rate, being more sensitive for low impact angles. Finally, a differential form of the general erosion equation is applied on a practical core-making case to evaluate the erosion rate of the H13 steel at 30° and 90° impingement angles.

关键词： erosion cold box core-making H13 tool steel resin coated silica sand

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Gradient Step Method to Predict the Ozone Solubility in Water

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Journal of Environmental Science and Engineering(A) 2012年第2期1卷 256-260页

作者： Marco aurelio Cremasco Vanessa Trevizan Mochi Chemical Engineering School University of Campinas Campinas 13083-852 SP Brazil

In this work it presents a strategy to obtain the ozone solubility in water by gradient step method. In this methodology, the ozone in mixture with oxygen is bubbling in a reactor with distilled water at 21℃ and pH 7. The ozone concentration on gas phase is continually increased after the saturation is reached. The method proposed is faster than conventional method （isocratic method）. The solubility from the gradient method is compared with that values obtained from correlations founded in the literature.

关键词： Ozone solubility gradient step method isocratic method.

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Predispatch of Hydroelectric Power Systems with Modifications in Network Topologies

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Applied Mathematics 2014年第15期5卷 2271-2283页

作者： Silvia M. S. Carvalho aurelio Oliveira Federal University of Sao Carlos Sao Carlos Brazil University of Campinas Campinas Brazil

In this article, the primal-dual interior-point methods are used to minimize costs and losses in a predispatch model for the generation and transmission of direct current (DC) power flow in a hydroelectric system with pre-programmed manipulations;i.e., in cases of preventive maintenance, within a period of twenty-four hours. From the computational standpoint, the effort required to solve a problem with and without manipulations is similar, and the reasons why will be also discussed in this study. Computational results prove these findings.

关键词： Predispatch of Hydroelectric Systems Interior-Point Methods Hydroelectric Systems Power Systems

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Impact of senescence on the transdifferentiation process of human hepatic progenitor-like cells

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World Journal of Stem Cells 2021年第10期13卷 1595-1609页

作者： Francesco Bellanti Giorgia di Bello Rosanna Tamborra Marco Amatruda aurelio Lo Buglio MichałDobrakowski Aleksandra Kasperczyk Sławomir Kasperczyk Gaetano Serviddio Gianluigi Vendemiale Department of Medical and Surgical Sciences University of FoggiaFoggia 71122Italy Department of Biochemistry Medical University of SilesiaZabrze 41-808Poland

BACKGROUND Senescence is characterized by a decline in hepatocyte function,with impairment of metabolism and regenerative *** models that duplicate liver functions in vitro are essential tools for studying drug metabolism,liver diseases,and organ *** human HepaRG cell line represents an effective model for the study of liver metabolism and hepatic ***,the impact of senescence on HepaRG cells is not yet *** To characterize the effects of senescence on the transdifferentiation capacity and mitochondrial metabolism of human HepaRG *** We compared the transdifferentiation capacity of cells over 10(passage 10[P10])vs *** was evaluated by senescence-associated(SA)beta-galactosidase activity and the comet *** transdifferentiation was analyzed by confocal microscopy and flow cytometry(expression of cluster of differentiation 49a[CD49a],CD49f,CD184,epithelial cell adhesion molecule[EpCAM],and cytokeratin 19[CK19]),quantitative PCR analysis(expression of albumin,cytochrome P4503A4[CYP3A4],γ-glutamyl transpeptidase[γ-GT],and carcinoembryonic antigen[CEA]),and functional analyses(albumin secretion,CYP3A4,andγ-GT).Mitochondrial respiration and the ATP and nicotinamide adenine dinucleotide(NAD^(+))/NAD with hydrogen(NADH)content were also *** SAβ-galactosidase staining was higher in P20 than P10 HepaRG cells;in parallel,the comet assay showed consistent DNA damage in P20 HepaRG *** respect to P10,P20 HepaRG cells exhibited a reduction of CD49a,CD49f,CD184,EpCAM,and CK19 after the induction of ***,lower gene expression of albumin,CYP3A4,andγ-GT,as well as reduced albumin secretion capacity,CYP3A4,andγ-GT activity were reported in transdifferentiated P20 compared to P10 *** contrast,the gene expression level of CEA was not reduced by transdifferentiation in P20 *** note,both cellular and mitochondrial oxygen consumption was lower in P20 than in P10 tra

关键词： Senescence HepaRG cells Transdifferentiation Mitochondria Regeneration Nicotinamide adenine dinucleotide

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Antibacterial activity of plant methanolic extracts on a field isolate of <i>Pseudomonas syringae</i>pvtomato from the Casablanca region (Morocco)

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Advances in Bioscience and Biotechnology 2013年第7期4卷 1-9页

作者： Bouchra Elkhalfi Abderrazak Essari aurelio Serrano Abdelaziz Soukri Ibn Rochd University Hospital Casablanca Morocco Institute for Plant Biochemistry and Photosynthesis (IBVF) CSIC-Universidad de Sevilla Seville Spain Laboratory of Physiology & Molecular Genetics Faculty of Sciences Ain Chock Casablanca Morocco

A bacterial field isolate recovered from infected tomato plants in a green-house at Sidi Rehal, a region near Casablanca city (Morocco), was identified as the gammaproteobacterium Pseudomonas syringae pv. tomato DC3000 strain, the causal agent of bacterial speck. The bacterial isolate was characterized by morphological, biochemical and molecular biological tests, its growth curves carried out in various culture media, and its phytopathogenicity verified by infection tests. A screening was performed to evaluate the antibacterial activity of methanolic extracts of 12 selected Moroccan plants against the P. syringae pv. tomato DC3000 isolate, and Agar-well diffusion and Broth microdilution methods were used to determine minimum inhibitory and minimum bactericidal concentrations. Among the methanolic extracts tested, only those of Nigella sativa, Geranuim robertianum, Aizoon canariense and Rubia peregrine showed clear inhibitory and bactericidal activities, although the highest values were achieved with N. sativa, a plant used in Morocco as a spice, condiment and medicinal treatment.

关键词： Bacterial Speck Bacterial Field Isolate LOPAT Pathogenicity Tests Antibacterial Activity Methanolic Plant Extracts Nigella sativa

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Seasonal and Spatial Variation in the Monitoring Parameters of Zomar Stream, Palestine during 2010

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Journal of Environmental Science and Engineering(A) 2013年第1期2卷 1-14页

作者： Saleh Sulaiman Laura Scrano Sabino aurelio Bufo Rafik Karaman Department of Science University of Basilicata Potenza 85100 Italy Institute of Environmental and Water Studies Birzeit University West Bank Palestine Department of European Culture University of Basilicata Potenza 85100 Italy Department of Bioorganic Chemistry Faculty of Pharmacy Al-Quds University Jerusalem 20002 Palestine

Levels of pollutants at Zomar stream, the only recreational area for the inhabitants of the northern part of the West Bank, Palestine, were recently determined, and have shown to be relatively high. Three bathing sites along the Zomar stream area were monitored for one year （fortnightly）. Wastewater samples were subjected to microbiological analysis （fecal coliforms, Escherichia coli, Pseudomonas, Enterococcus and Klebsiella）, physico-chemical analyses （water temperature, pH, electroconductivity and DO （dissolved oxygen））, biochemical oxygen demand, total Kjeldahl nitrogen and ammonia. The study results demonstrated seasonal and locational variations in all parameters studied. The highest levels of pollution were detected during summer, especially before a rainfall or after a discharge from onsite cesspits. Locations associated with sewage discharge were found to have the highest fecal indicator levels.

关键词： Wastewater pollution seasonal variations Zomar stream microbiological contamination BOD (biochemical oxygen demand).

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Distal femur complex fractures in elderly patients treated with megaprosthesis:Results in a case series of 11 patients

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World Journal of Orthopedics 2022年第5期13卷 454-464页

作者： Fabio Zanchini Antonio Piscopo Valerio Cipolloni Federico Fusini Stefano Cacciapuoti Davide Piscopo Charlotte Pripp Luigi aurelio Nasto Enrico Pola Orthopaedics and Traumatology Division Multidisciplinary Department of Medical-Surgical and Dental SpecialtiesUniversity of Campania"Luigi Vanvitelli"School of MedicineNaples 80138Italy Department of Orthopedics and Traumatology Sacro Cuore di GesùFatebenefratelli HospitalBenevento 82100Italy Spine Division Department of Orthopaedics and TraumatologyA.Gemelli IRCCS University HospitalCatholic University of RomeRome 00168Italy Department of Orthopaedic and Traumatology Regina Montis Regalis HospitalMondovì12084Italy Service de Geriatrie et réaaptation HUG H?pital de Bellerive ChemGenève 1205Switzerland

BACKGROUND Surgical treatment of complex fractures of the distal femur in the elderly is *** and pre-existent osteoarthritis are common comorbidities in the elderly which add to the need for early walking and rapid restoration of function and also pose significant obstacles to achievement of satisfactory results with standard fixation ***,several authors have suggested that primary arthroplasty could be a viable alternative option to standard fixation techniques in selected patients with complex distal femur *** To present our experience with 11 cases of distal femur fractures treated with knee arthroplasty and large femoral resection in a population of patients over the age of *** Data from 11 consecutive patients(10 females,1 male)presenting with acute intra-articular supracondylar or intercondylar distal femur fractures and with pre-existent primary osteoarthritis who were treated with primary knee arthroplasty were *** collected standard demographic data,comorbidities and patient reported outcomes including Visual Analogical Scale(VAS),Oxford Knee Score(OKS)and Barthel’s ***-operative joint range of motion(ROM)and standard radiographic data were also *** At a mean follow-up of 23.2 mo,all of the implants were well-positioned and ***,all the patients were alive and walking either independently or with walking *** was a marked improvement in pain(VAS 4.5 postop vs 1.9 at the last follow-up),OKS score(29.5 postop vs 36.81 at the last follow-up),ROM(96.2°postop vs 102°at the last follow-up)and restoration of pre-injury ambulatory status(average Barthel Index 77.3).The radiographic evaluations showed good restoration of the articular *** deaths and no complications were *** In conclusion,we believe that knee megaprosthesis in the case of complex fractures of the distal femur is a valid surgical *** is particularly true in

关键词： Knee Joint replacement Megaprosthesis Elderly Distal femur fracture

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