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Acquired hepatocerebral degeneration in a metastatic neuroendocrine tumor long-term survivor——an update on neuroendocrine neoplasm’s treatment:A case report

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World Journal of Hepatology 2021年第5期13卷 611-619页

作者： Oriol Mirallas Nadia Saoudi Diego gómez-Puerto Mar Riveiro-Barciela Xavier Merino Cristina auger Stefania Landolfi Laia Blanco Amparo garcia-Burillo Xavier Molero Maria Teresa Salcedo-Allende Jaume Capdevila Medical Oncology Department Vall d'Hebron University HospitalVall Hebron Institute of OncologyBarcelona 08035CatalunyaSpain Liver Unit Department of Internal MedicineCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y DigestivasHospital Universitari Vall d'HebronUniversitat Autònoma de BarcelonaBarcelona 08035CatalunyaSpain Radiodiagnostic Department Vall d’Hebron University HospitalBarcelona 08035CatalunyaSpain Pathology Department Vall d'Hebron University HospitalBarcelona 08035CatalunyaSpain Hepatobiliopancreatic Surgery and Transplantation Department Vall d'Hebron University HospitalBarcelona 08034CatalunyaSpain Nuclear Medicine Department Vall d'Hebron University HospitalBarcelona 08035CatalunyaSpain

BACKgROUND Metastatic small bowel low-grade neuroendocrine tumors(NETs)have a good *** is the only curative treatment;however,this may induce advanced liver disease,particularly in long-term survivor *** hepatocerebral degeneration or Parkinsonism in cirrhosis is characterized by rapidly progressive extrapyramidal symptoms in patients with advanced liver *** SUMMARY A 70-year-old man presented to the emergency department with diminished consciousness and disorientation,and was diagnosed with hepatic *** patient was diagnosed in 1993 with a metastatic small bowel NET,for which he twice underwent hepatic surgery,with metastatic resection in 1993 and a right hepatectomy in 2002 to remove two hepatic *** 2003,the patient started first-line chemotherapy and in 2004 started the first of three consecutive biological treatments,followed by radio-molecular therapy,achieving stable disease for 14 *** progression was identified and he underwent an endoscopic retrograde ***,in 2019 advanced liver disease was *** diagnosed the development of acquired hepatocerebral degeneration,an unusual long-term side effect after multiple hepatic *** The importance of regular and ongoing surveillance in long-term NET survivors who undergo hepatic procedures should be integrated into the therapeutic management plan,as some of these negative outcomes could be prevented.

关键词： Neuroendocrine tumors Hepatocerebral degeneration Parkinsonism Somatostatin analogues Everolimus Hepatic metastases Peptide radionuclide receptor therapy Encephalopathy Paramagnetic deposits Case report

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单核吞噬细胞

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国外医学（免疫学分册） 1990年第5期13卷 267-268页

作者： MARTIN J auger 尹金本

单核吞噬细胞系统(MPS)包括周围血内的单核细胞(mon)、骨髓内前mon和组织内巨噬细胞(Mφ)。mon 和Mφ曾被视为仅是一种吞噬细胞,但现在发现它们有许多不同的重要功能,如诱导急性期应答、调节生血作用、激活免疫和凝固系统。

关键词：单核吞噬细胞单核细胞

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基于改进微分进化算法的风光互补系统发电容量优化配置

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电力科学与技术学报 2017年第3期32卷 22-28页

作者：陈天蔡泽祥谢鹏 Francois auger Salvy BOURgUET 华南理工大学电力学院广东广州510640 Institut de Recherche en Energie Electrique de Nantes Atlantique Université de Nantes

为有效兼顾风光互补发电系统的可靠性与经济性,以年缺电负荷率最小及微网系统投资建设成本最低为目标函数,以储能电池充放电次数、微网功率平衡以及电池充放电上下限等为约束条件,搭建风光互补系统发电容量优化模型。针对缺电负荷率、... 详细信息

为有效兼顾风光互补发电系统的可靠性与经济性,以年缺电负荷率最小及微网系统投资建设成本最低为目标函数,以储能电池充放电次数、微网功率平衡以及电池充放电上下限等为约束条件,搭建风光互补系统发电容量优化模型。针对缺电负荷率、系统成本2个目标函数相悖的特点,考虑将帕累托非劣排序操作引入至常规微分进化算法,并对常规算法中的变异策略进行了相应改进,使得改进后的算法在具备多目标寻优能力的同时,寻优速度也得到了较为显著的提升。最后,应用所提改进多目标微分进化算法对风光互补系统发电容量优化模型进行求解,算例结果验证了该文模型的合理性和所提算法的有效性。

关键词：风光互补系统容量优化微分进化算法多目标优化

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膜受体糖脂成分的结构和动态-~2H核磁共振为在体观察提供了途径

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中国药理学通报 1991年第6期7卷 478-481页

作者： Smith ICP auger M Jarrell HC 黄河胜 Laboratory for Medical Biosciences Division of Biologieal SciencesBuilding M54 National Research Council of Canada Montreal RodOttawaOntarioCanada KIA OR6

糖脂类普遍存在于大自然中,大脑中同样具有相当的数量。由于以往偏重于研究更引人注目的磷脂酰胆碱、乙醇氨及丝氨酸,人们相当程度上忽视了糖脂,现在我们终于认识到糖脂很可能在功能上比其它脂质具有更大的意义。在已知几个重要的过程中... 详细信息

糖脂类普遍存在于大自然中,大脑中同样具有相当的数量。由于以往偏重于研究更引人注目的磷脂酰胆碱、乙醇氨及丝氨酸,人们相当程度上忽视了糖脂,现在我们终于认识到糖脂很可能在功能上比其它脂质具有更大的意义。在已知几个重要的过程中,它们关联到免疫应答、细胞间识别和激素接受。大脑中信号肽及调节蛋白质的受体无疑与这类糖脂或糖蛋白相当。

关键词：糖脂类核磁共振核自旋共振葡萄糖基乳糖脂糖残基脂质脂类麻醉剂半乳糖己糖碳水化合物糖类板层位相

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Human sperm quality and lipid content after migration into normal ovulatory human cervical mucus containing low numbers of leukocytes

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Asian Journal of Andrology 2009年第3期11卷 308-316页

作者： Nozha Chakroun-Feki Patrice Therond Martine Couturier Florence Eustache gerard Limea Alain Legrand Pierre Jouannet Jacques auger Laboratory of Reproductive Biology/CECOS （Center of Study and Conservation of human Eggs and Sperm） Cochin Hospital Rend Descartes University Paris 75014 France Laboratory of Clinical and Metabolic Biochemistry EA 3617 Rend Descartes University Paris 75270 Cedex 06 France INSERM U551 La Pitie Hospital 75651 Paris Cedex 13 France

The aim of this study was to investigate whether a relationship exists between the presence of low numbers of leukocytes in normal ovulatory cervical mucus and sperm quality and lipid content after migration. The percentages of live, motile and morphologically normal spermatozoa, movement parameters assessed by computer-aided sperm analysis （CASA）, and ionophore-induced acrosome reaction measured by flow cytometry were determined before and after migration. High-performance liquid chromatography with ultraviolet detection was used to measure the sperm lipid content, including the various diacyl subspecies. The number of leukocytes found in solubilized mucus samples was counted using a haemocytometric method. Overall, the presence of leukocytes in the cervical mucus samples did not significantly influence sperm motility and morphology, sperm kinematic parameters, or the sperm content in sphingomyelin or cholesterol. In contrast, after migration, the decrease in various sperm diacyls and the level of induced acrosome reaction was significantly less pronounced in mucus samples containing ≥10^4 leukocytes than in mucus samples with no or rare leukocytes whereas the level of induced acrosome reaction was higher. The present data suggest that the low level of leukocytes found in normal ovulatory cervical mucus could influence the process of sperm lipid remodelling/capacitation.

关键词： cervical mucus leukocyte lipid spermatozoa

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Platelet-Activating Factor Induces Du-al-Specificity Phosphatase 1 and 5 gene Expression

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Pharmacology & Pharmacy 2015年第9期6卷 442-450页

作者： Fanny Lapointe Michael Stiffel Jean-Philippe auger Marek Rola-Pleszczynski Jana Stankova Division of Immunology and Allergy Department of Pediatrics Faculty of Medicine and Health Sciences Université de Sherbrooke Sherbrooke Canada

Platelet-activating factor (PAF) is a potent inflammatory phospholipid mediator that is known to play a role in early-phase responses in asthma and other diseases. Through its high affinity receptor, PAFR, PAF is known to activate multiple signalling pathways contributing to its proinflammatory effects. Of these pathways, the mitogen-activated protein kinase (MAPK) cascade is initiated upon PAF stimulation, leading to the activation of the conventional MAPKs ERK1/2, p38 and JNK. Since dual-specificity phosphatases (DUSP) downregulated MAPK activity, we postulated that PAF could also enhance DUSP expression and thus induced an autoregulatory loop. In this report, we studied the effect of PAF on DUSP mRNA expression in human monocytes. Our results demonstrate that PAF induces DUSP1 and DUSP5 gene expression in a time- and concentration-dependent manner, with maximal effects at PAF 100 nM and at 20 - 30 min of stimulation. In contrast, DUSP2 and DUSP6 gene expression was not enhanced by PAF. Moreover, leukotriene D4, another lipid mediator of inflammation, was unable to modulate DUSP expression. PAF-induced DUSP expression was prevented by the PAFR antagonist WEB2170 and by pretreatment with the transcriptional inhibitor Actinomycin D. Moreover, enhanced DUSP5, but not DUSP1 expression was prevented by pretreatment with the ERK inhibitor PD98059 or the PI3K inhibitor Wortmannin. Taken together, our results indicate that PAF selectively enhances DUSP1 and DUSP5 gene expressions through PAFR activation, and suggest that PAF may have an active role in the resolution of inflammation by its ability to upregulate the two DUSPs and thus provide a negative auto-regulatory signalling mechanism.

关键词： Inflammation Asthma PAF Dual-Specificity Phosphatase MAPK PI3K

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Stable and accurate schemes for smoothed dissipative particle dynamics

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Applied Mathematics and Mechanics(English Edition) 2018年第1期39卷 83-102页

作者： g. FAURE g. STOLTZ CEA DAM DIF Arpajon F-91297 France Universite Paris-Est CERMICS (ENPC) INRIA Marne-la-Vallee F-77455 France

Smoothed dissipative particle dynamics （SDPD） is a mesoscopic particle method that allows to select the level of resolution at which a fluid is simulated. The numerical integration of its equations of motion still suffers from the lack of numerical schemes satisfying all the desired properties such as energy conservation and stability. Similarities between SDPD and dissipative particle dynamics with energy （DPDE） con- servation, which is another coarse-grained model, enable adaptation of recent numerical schemes developed for DPDE to the SDPD setting. In this article, a Metropolis step in the integration of the fluctuation/dissipation part of SDPD is introduced to improve its stability.

关键词： smoothed dissipative particle dynamics (SDPD) numerical integration Metropolis algorithm

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Challenges and opportunities in the production of magnesium parts by directed energy deposition processes

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Journal of Magnesium and Alloys 2024年第5期12卷 1663-1686页

作者： gürel Cam Ali günen Iskenderun Technical University Faculty of Engineering and Natural SciencesDepartment of Mechanical Engineering31200 Iskenderun-HatayTurkey Iskenderun Technical University Faculty of Engineering and Natural SciencesDepartment of Metallurgy and Materials Engineering31200 Iskenderun-HatayTurkey

Mg-alloys have gained considerable attention in recent years for their outstanding properties such as lightweight,high specific strength,and corrosion resistance,making them attractive for applications in medical,aerospace,automotive,and other transport ***,their widespread application is hindered by their low formability at room temperature due to limited slip *** Mg-alloys have low mechanical properties due to the presence of casting defects such as porosity and anisotropy in addition to the high *** casting methods benefit from established process optimization techniques for these problems,additive manufacturing methods are increasingly replacing casting methods in Mg alloys as they provide more precise control over the microstructure and allow specific grain orientations,potentially enabling easier optimization of anisotropy properties in certain *** metal additive manufacturing(MAM)technology also results in some manufacturing defects such as inhomogeneous microstructural evolution and porosity and additively manufactured Mg alloy parts exhibit lower properties than the wrought parts,they in general exhibit superior properties than the cast ***,MAM is a promising technique to produce Mg alloy *** energy deposition processes,particularly wire arc directed energy deposition(WA-DED),have emerged as an advantageous additive manufacturing(AM)technique for metallic materials including magnesium alloys,offering advantages such as high deposition rates,improved material efficiency,and reduced production costs compared to subtractive ***,the inherent challenges associated with magnesium,such as its high reactivity and susceptibility to oxidation,pose unique hurdles in the application of this *** review paper delves into the progress made in the application of DED technology to Mg-alloys,its challenges,and ***,the predominant imperfections,notably inhomo

关键词： Additive manufacturing DED processes Arc-DED Wire arc additive manufacturing(WAAM) 3-D printing High deposition rate

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Catalytic-kinetic spectrophotometric determination of vanadium (V) based on the Celestine blue-bromate-vanadium (V)-citric acid reaction

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Rare Metals 2011年第4期30卷 348-358页

作者： Ramazan gürkan Olcay gürkan Department of Chemistry Faculty of Sciences University of Cumhuriyet Sivas Fen Lisesi Emek mah. 64. Basari Sok. TR-58010 Merkez Sivas TURKEY

A novel sensitive and relatively selective kinetic method is presented for the determination of V（V） based on its catalytic effect on the oxidation reaction of Celestine blue by potassium bromate in the presence of citric acid as an activator. The reaction was monitored spectropho- tometrically by measuring the decrease in absorbance of Celestine blue at a maximum absorption wavelength of 540 nm between 0.5 and 9 min （the fixed-time method） in an H3PO4 medium at 45℃. The effect of various parameters such as concentrations of H3PO4, citric acid, potassium bromate and Celestine blue, ionic strength, reaction temperature and time on the rate of V（V） catalyzed reaction was studied. The method is free from the most interferences, especially from large amounts of V（IV）. The decrease in absorbance is proportional to the concentration of V（V） over the entire concentration range tested （0.025-1.25 ***^-1） with a detection limit of 6.80 tag.L^-1 （according to statistical 3Sblank/k criterion） and a coefficient of variation （CV） of 1.78% （for ten replicate measurements at 95% confidence level）. The proposed method suffers from a few interferences such as Cr（VI） and Hg（Ⅱ） ions. The method was successfully applied to the determination of V（V） in river water, lake water, tap water, natural drinking water samples and a certified standard reference material such as SRM-1640 with satis- factory results. The vanadium contents of natural water samples were detected by using both linear calibration curve and standard addition curve methods. The recoveries of spiked vanadium （V） into the certified standard water sample were found to be quantitative, and the reproducibility was satisfactory. It was observed that the results of the SRM 1640 were in good agreement with the certified value.

关键词： catalytic effect vanadium spectrophotometry bromates Celestine blue citric acid

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Influence of earthquake direction on the seismic response of irregular plan RC frame buildings

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Earthquake Engineering and Engineering Vibration 2014年第2期13卷 243-256页

作者： Magliulo g Maddaloni g Petrone C University of Naples Federico II Department of Structures for Engineering and Architecture University of Naples Parthenope Department of Engineering

The nonlinear response of structures is usually evaluated by considering two accelerograms acting simultaneously along the orthogonal directions. In this study, the infl uence of the earthquake direction on the seismic response of building structures is examined. Three multi-story RC buildings, representing a very common structural typology in Italy, are used as case studies for the evaluation. They are, respectively, a rectangular plan shape, an L plan shape and a rectangular plan shape with courtyard buildings. Nonlinear static and dynamic analyses are performed by considering different seismic levels, characterized by peak ground acceleration on stiff soil equal to 0.35 g, 0.25 g and 0.15 g. Nonlinear dynamic analyses are carried out by considering twelve different earthquake directions, and rotating the direction of both the orthogonal components by 30° for each analysis(from 0° to 330°). The survey is carried out on the L plan shape structure. The results show that the angle of the seismic input motion signifi cantly infl uences the response of RC structures; the critical seismic angle, i.e., the incidence angle that produces the maximum demand, provides an increase of up to 37% in terms of both roof displacements and plastic hinge rotations.

关键词： plan irregularity nonlinear analyses reinforced concrete buildings seismic performance ground motion directionality

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