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Neural Regeneration Research 2014年第24期9卷 2132-2141页

作者： Xianghai Wang Mengjie Pan Jinkun Wen Yinjuan Tang audra d.hamilton Yuanyuan Li Changhui Qian Zhongying Liu Wutian Wu Jiasong Guo department of Histology and Embryology Southern Medical University department of Histology and Embryology Xiangnan University department of Neurology Vanderbilt University department of Anatomy Li Ka Shing Faculty of Medicine The University of Hong Kong GHM Institute of CNS Regeneration Jinan University Key Laboratory of Tissue Construction and detection of Guangdong Province Institute of Bone Biology Academy of Orthopedics

In this study, we developed a novel artificial nerve graft termed self-assembling peptide nanofiber scaffold （SAPNS）-containing poly（lactic-co-glycolic acid）（PLGA） conduit （SPC） and used it to bridge a 10-mm-long sciatic nerve defect in the rat. Retrograde tracing, behavioral testing and histomorphometric analyses showed that compared with the empty PLGA conduit implantation group, the SPC implantation group had a larger number of growing and extending axons, a markedly increased diameter of regenerated axons and a greater thickness of the myelin sheath in the conduit. Furthermore, there was an increase in the size of the neuromuscular junction and myofiber diameter in the target muscle. These findings suggest that the novel artificial SPC nerve graft can promote axonal regeneration and remyelination in the transected peripheral nerve and can be used for repairing peripheral nerve injury.

关键词： nerve regeneration peripheral nerve defect artificial nerve graft poly(lactic-co-glycolic acid) self-assembling peptide nanofiber scaffold remyelination axon myelin neuromuscular junction NSFC grants neural regeneration

Targeting KRAS in pancreatic cancer

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Oncology Research 2024年第5期32卷 799-805页

作者： SANdRA STICKLER BARBARA RATH GERHARd.hamilton Institute of Pharmacology Medical University of ViennaViennaA-1090Austria

Pancreatic cancer has a dismal prognosis due to late detection and lack of efficient *** Kirsten rat sarcoma virus(KRAS)oncogene is mutated in up to 90%of all pancreatic ductal adenocarcinomas(PdACs)and constitutes an attractive target for ***,the most common KRAS mutations in PdAC are G12d(44%),G12V(34%)and G12R(20%)that are not amenable to treatment by KRAS G12C-directed cysteine-reactive KRAS inhibitors such as Sotorasib and Adagrasib that exhibit clinical efficacy in lung *** G12C mutant pancreatic cancer has been treated with Sotorasib but this mutation is detected only in 2%–3%of ***,the KRAS G12d-directed MRTX1133 inhibitor has entered clinical trials and more of such inhibitors are in *** other KRAS mutations may be targeted indirectly via inhibition of the cognate guanosine exchange factor(GEF)Son of Sevenless 1 that drives *** agents seem to provide the means to target the most frequent KRAS mutations in PdAC and to improve patient outcomes.

关键词： Pancreatic cancer PdAC KRAS SOS1 PROTAC

Agricultural impacts of longwall mine subsidence:the experience in Illinois,USA and Queensland,Australia

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International Journal of Coal Science & Technology 2014年第2期1卷 207-212页

作者： Robert G.darmody R.Bauer d.Barkley S.Clarke d.hamilton Land Reclamation division Illinois Natural Resources DepartmentIllinois Prairie Research InstituteUniversity of IllinoisChampaignUSA Bandanna Energy Limited and Agricultural Coexistence Research Committee BrisbaneAustralia

Unlike conventional room and pillar underground coal mining,where subsidence is designed to be prevented,subsidence is a planned outcome of other *** include high extraction retreat,where the roof supporting pillars are systematically removed,and longwall mining,which employs a machine that mines a continuous strip of coal,thus leaving no roof *** types result in the surface dropping -70% of the mined-out *** Illinois there was a concern that farm land thus subsided would be lost to productive ***,the possibility that planned mine subsidence would be banned in Illinois lead to the creation of the Illinois Mine Subsidence Research Program in 1985 to investigate agricultural impacts of planned mine subsidence and the possibility of mitigating its *** findings established that subsidence was not as detrimental as feared and that the impacts could be *** project was a successful collaboration of state and federal governments and local ***,in Queensland,longwall mining is opposed by some in the farming *** response,Bandanna Energy,the company planning the mining,organized the Agricultural Coexistence Research Committee to oversee research into the mitigation of longwall mining *** the soils,climate,and regulatory regimes are different,concerns of the local communities are similar.

关键词： Agricultural impact Longwall mine subsidence Coal mining subsidence Subsidence mitigation

Humanitarian action in academic institutions:a case study in the ethical stewardship of unidentified forensic cases

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Forensic Sciences Research 2022年第3期7卷 358-365页

作者： Justin Z.Goldstein Mariah E.Moe Emilie L.Wiedenmeyer Petra M.Banks Sophia R.Mavroudas Michelle d.hamilton department of Anthropology Texas State UniversitySan MarcosTXUS

Forensic anthropologists are often responsible for the management of long-term unidentified *** have contextualised these decedents—many of whom likely belonged to socially,politically,and/or economically marginalised groups in life—as part of a larger identification crisis in the ***,there has been little discussion surrounding how this humanitarian crisis has manifested in academic institutions,where anthropologists often provide medicolegal consultation and act as long-term stewards of the *** Identification&Repatriation Initiative was created at the Forensic Anthropology Centre at Texas State University(FACTS)to recognise and investigate unidentified human remains in long-term *** paper outlines common challenges that were encountered during our initial reassessment of unidentified cases at FACTS,emphasising the detrimental impacts of inconsistent procedures,loss of context,and case *** is likely that other academic institutions face similar challenges,and by highlighting these issues we hope to help initiate a larger conversation concerning ethical stewardship of human remains in these *** incorporating humanitarian perspectives into forensic casework,anthropologists in academia can better advocate for the long-term unidentified.

关键词： Forensic sciences forensic anthropology unidentified persons long-term unidentified identification academic institutions standardisation humanitarian action

The China tuberculosis clinical trials consortium network:a model for international TB clinical trials capacity building

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Infectious diseases of Poverty 2020年第3期9卷 148-149页

作者： Yu-Hong Liu Shu Chen Jing-Tao Gao Yao Zhang Kimberly Booher Xiao-Fen ding Wei Shu Jian du Jing Bao Richard Hafner Carol d.hamilton Liang Li Beijing Chest Hospital Capital Medical University/Beijing Tuberculosis and Thoracic Tumor InstituteNo.9Beiguan AveTongzhou DistrictBeijing 101149China 不详

Background:With the second largest tuberculosis(TB)burden globally,China is committed to actively engage in international TB clinical trials to contribute to global TB ***,lack of research capacity among local sites has been identified as a *** text:The China Tuberculosis Clinical Trials Consortium(CTCTC)was initiated by Beijing Chest Hospital with investment from the US National Institutes of Health and technical support from Family Health International 360 in 2013,as a nationwide collaborative clinical trial network to strengthen selected clinical site research capacity and attract TB clinical *** program aims to:1)recruit leading hospitals that care for TB patients;2)conduct on-site assessment to identify capacity gaps and needs for improvement;3)design and deliver capacity building activities;4)attract and deliver high quality results for TB clinical trials.A total of 24 sites have joined CTCTC,covering 20 provinces in ***-two sites have been accredited by the National Medical Products Administration(NMPA)to be qualified to conduct TB clinical *** onsite assessment,extensive trainings among the CTCTC sites and young investigators have resulted in better understanding and improvement of the site capacity in conducting TB clinical *** establishment and growth of the CTCTC network has benefited from the good leadership,effective international cooperation and local *** in human resources,regulatory environment and sustainability have been challenging the network from continuing *** researchers have full-time clinical responsibilities in China and it is thus important to build a cadre of other human resources to *** regulatory environment is becoming friendlier in China to introduce international clinical trials to the CTCTC ***:The CTCTC,with mature management structure and sustainable development model,which are distilled five key lessons for other developing countr

关键词： Clinical trial consortium Tuberculosis Capacity building China

Risk factors for long COVId in children and adolescents:a systematic review and meta-analysis

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World Journal of Pediatrics 2024年第2期20卷 133-142页

作者： daniel G.Rayner Elaine Wang Cloris Su Om d.Patel Stephanie Aleluya Alessandra Giglia Evelyn Zhu Maha Siddique department of Health Research Methods Evidenceand ImpactFaculty of Health SciencesMcMaster University1280 Main St WHamiltonONL8S 4K1Canada Faculty of Health Sciences McMaster University1280 Main St WHamiltonON L8S 4K1Canada Faculty of Science McMaster University1280 Main St WHamiltonONL8S 4K1Canada

Background The long-term sequelae of COVId-19 in children and adolescents remain poorly understood and *** systematic review and meta-analysis sought to summarize the risk factors for long COVId in the pediatric *** We searched six databases from January 2020 to May 2023 for observational studies reporting on risk factors for long COVId or persistent symptoms those were present 12 or more weeks post-infection using multivariable regression *** registries,reference lists of included studies,and preprint servers were hand-searched for relevant ***-effects meta-analyses were conducted to pool odds ratios for each risk *** study risk of bias was rated using QUIPS,and the GRAdE framework was used to assess the certainty of evidence for each unique *** Sixteen observational studies(N=46,262)were included,and 19 risk factors were amenable to *** moderate certainty in the evidence,age(per 2-year increase),allergic rhinitis,obesity,previous respiratory diseases,hospitalization,severe acute COVId-19,and symptomatic acute COVId-19 are probably associated with an increased risk of long *** sex,asthma,comorbidity,and heart diseases may be associated with an increased risk of long COVId,and Asian and Black races may be associated with a decreased risk of long *** did not observe any credible subgroup effects for any risk *** The current body of literature presents several compelling risk factors for the development of long COVId in the pediatric *** research is necessary to elucidate the pathophysiology of long COVId.

关键词： COVId-19 Long COVId Post-acute COVId-19 syndrome Pediatrics Risk factors

The association of physical activity duration and intensity on emotional intelligence in 10-13 year-old Children

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Sports Medicine and Health Science 2024年第4期6卷 331-337页

作者： Marie C.Gabour Tongjian You Richard Fleming Paul d.McNicholas Philimon N.Gona department of Health Sciences Regis College235 Wellesley StreetWestonMA02493USA department of Exercise and Health Sciences University of Massachusetts Boston100 Morrissey BlvdBostonMA02125USA department of Mathematics&Statistics McMaster UniversityHamiltonOntarioCanada L8S 4L8

Previous studies have shown that Physical Activity(PA)has a positive association with emotional health and intelligence in adolescents but none have focused on the relationship of PA duration and intensity on Emotional Intelligence(EI).The purpose of this study was to cross-sectionally assess the association of PA measures on overall EI and its domains in a cohort of 2029 adolescents aged 10-13 years of age in the National Longitudinal Survey for Children and Youth(NLSCY)from *** linear regression analysis of EI was adjusted for age,sex,annual household income,and health ***-way analysis of variance(ANOVA)was used to relate PA duration measured in minutes,frequency,and intensity categories with continuous GEI scores and also the corresponding scores for domains of *** mean GEI scores were(28.3±6.6)for 0-30 minute(min)PA duration,(30.0±6.5)for 30 tod(30.1±6.5)for≥121 *** was a statistically significant linear trend across PA duration categories,p?***-hoc pairwise comparison revealed that compared to the referent category(d 60-120 min),both p-valuesd Health Organization(WHO)guidelines for duration and vigorous intensity were positively associated with the higher overall EI and its domains except for Stress Management.

关键词： Physical activity duration Intensity Emotional Intelligence Adolescents

Role of circulating tumor cell spheroids in drug resistance

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Cancer drug Resistance 2019年第3期2卷 762-772页

作者： Gerhard.hamilton Barbara Rath department of Surgery Medical University of ViennaVienna A-1090Austria

Cancer cell spheroids are used for drug screening as these three-dimensional(3d)assemblies recapitulate tumors more realistic than the widely employed 2d in vitro *** drug diffusion and gradients of oxygen and nutrients in spheroids represent avascular tumor regions containing quiescent and hypoxic tumor cells with high drug *** tumor cells(CTCs)effect metastatic spread and are present in high numbers in malignant diseases such as small-cell lung cancer(SCLC)and in other cancer patients with high tumor *** are heterogeneous and only a small fraction of these cells survive in the circulation and cause distal *** may circulate as single cells but small CTC clusters or CTC spheroids have been detected in cancer patients and demonstrated to possess increased metastatic *** our lab we have obtained 9 permanent SCLC CTC cell lines(BHGc7,BHGc10,BHGc16,BHGc26,BHGc27,BHGc50,BHGc59,BHGc71,and UHGc5)of distinct patients exhibiting similar characteristics and spontaneous formation of large spheroids,termed *** aggregates were shown to exhibit high drug resistance compared to the corresponding single cell *** increased metastatic capability of small circulating tumor clusters/spheroids may be explained by their role as putative precursors of tumorospheres eventually trapped in *** drug penetration and the presence of hypoxic/quiescent cells can readily account for the global drug resistance of advanced SCLC which has resulted in clinical failure of a wide range of chemotherapeutics and low ***,we have detected such tumorospheres in non-small-cell lung cancer(NSCLC)patients progressing under EGFR-directed tyrosine kinase inhibitor therapy which had undergone NSCLC-SCLC transformation.

关键词： Cancer spheroid circulating tumor cells small cell lung cancer non-small-cell lung cancer transformation dormancy

Maintaining Resources for Traditional Medicine: A Global Overview and a Case Study from Buganda (Uganda)

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植物分类与资源学报 2013年第4期35卷 407-423页

作者： Alan hamilton Yildiz Aumeeruddy-Thomas Kunming Institute of Botany Chinese Academy of Sciences Centre d' Ecologie Fonctionnelle et Evolutive

Presentations at a session of the 13 th Congress of the International Society for Ethnobiology ( ISE,May 2012) provided a global overview of'maintaining resources for traditional medicine'. Two themes received special attention,transmission of traditional medical knowledge and conservation of medicinal plants. The consensus at the well-attended session was that traditional medicine can play a useful role in primary healthcare,including for chronic complaints and spiritual problems. However,the use of traditional medicine is declining in many places. Some practical efforts at maintaining resources for traditional medicine are described. A case study for Buganda ( Uganda) , given in greater detail,shows that progress in maintaining resources for traditional medicine can be impeded by forces not directly related to its intrinsic merits. The value of making efforts to maintain resources for traditional medicine is discussed in relation to its contribution to biocultural conservation,much needed today to counter-balance the homogenising and ecologically destabilising influences of globalisation.

关键词：植物学植物分类植物演化植物生理学生物因素

Effects of N on Plant Response to Heat-wave:A Field Study with Prairie Vegetation

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Journal of Integrative Plant Biology 2008年第11期50卷 1416-1425页

作者： dan Wang Scott A. Heckathorn Kumar Mainali E. William hamilton department of Environmental Sciences University of Toledo Toledo Ohio 43606 USA department of Biology Washington and Lee University Lexington Virginia 24450 USA

More intense, more frequent, and longer heat-waves are expected in the future due to global warming, which could have dramatic ecological impacts. Increasing nitrogen （N） availability and its dynamics will likely impact plant responses to heat stress and carbon （C） sequestration in terrestrial ecosystems. This field study examined the effects of N availability on plant response to heat-stress （HS） treatment in naturally-occurring vegetation. HS （5 d at ambient or 40.5 ℃） and N treatments （±N） were applied to 16 1 m^2 plots in restored prairie vegetation dominated by Andropogon gerardii （warm-season C4 grass） and Solidago canadensis （warm-season C3 forb）. Before, during, and after HS, air, canopy, and soil temperature were monitored; net CO2 assimilation （Pn）, quantum yield of photosystem Ⅱ （ФpsⅡ）, stomatal conductance （gs）, and leaf water potential （ψw） of the dominant species and soil respiration （Rsoll） of each plot were measured daily during HS. One week after HS, plots were harvested, and C% and N% were determined for rhizosphere and bulk soil, and above-ground tissue （green/senescent leaf, stem, and flower）. Photosynthetic N-use efficiency （PNUE） and N resorption rate （NRR） were calculated. HS decreased Pn, gs, ψw, and PNUE for both species, and ＋N treatment generally increased these variables （±HS）, but often slowed their post-HS recovery. Aboveground biomass tended to decrease with HS in both species （and for green leaf mass in S. canadensis）, but decrease with ＋N for A. gerardii and increase with ＋N for S. canadensis. For A. gerardii, HS tended to decrease N% in green tissues with ＋N, whereas in S. canadensis, HS increased N% in green leaves. Added N decreased NRR for A. gerardii and HS increased NRR for S. canadensis. These results suggest that heat waves, though transient, could have significant effects on plants, communities, and ecosystem N cycling, and N can influence the effect of heat waves.

关键词： global climate change heat stress N resorption rate photosynthesis photosynthetic N-use efficiency.