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Aims and First Assessments of the French Hydrogen Pathways Project HyFrance3

Journal of Energy and Power Engineering 2012年第1期6卷 34-40页

作者： Alain Le Duigou Marie-Marguerite Quemere Pierre Marion Philippe Menanteau Pascal Houel LaureSinegre Lionel Nadau Aline Rastetter aude Cuni Philippe Mulard Loic Antoine Thierry Alleau I-Tese CEA Gif-Sur-Yvette Cedex 91191 France Departement EPI-ECUELLES EDF R＆D Moret Sur Loing Cedex 77818 France IFP Energies nouvelles 1 et 4 avenue de Bois Preau Rueil Malmaison Cedex 92852 France LEPII Universit# de Grenoble - CNRS Grenoble Cedex 9 BP 47 38040 France DRI GDF SUEZ 361 av du pdt WILSON Saint Denis La Plaine Cedex BP 33 93211 France ALPHEA EURODEV CENTER 4 rue Jules Verne Eurozone Forbach 57600 France AIR LIQUIDE 1 chemin de la porte des loges Jouy-en-Josas BP 126 78354 France TOTAL RAFFINAGE MARKETING La Defense 10 Paris la Defense Cedex 92069 France ADEME 20 avenue du Gresille Angers Cedex 01 BP 90406 49004 France AFH2 28 rue Saint Dominique Paris 75007 France

The HyFrance Group was originally formed in France to support the European project HyWays, by providing (former projects HyFrance1 and HyFrance2) the French data and possible hydrogen pathways according to national specificities. HyFrance3 is a new project that focuses on the economic competitiveness of different steps of the hydrogen chain, from the production to end usage, at the time horizon of 2030 in France. The project is coordinated by CEA with the other partners being: ADEME (co-funding), AFH2, CNRS, IFP, Air Liquide, EdF, GdF Suez, TOTAL, ALPHEA. The project is divided into 4 sub-projects, that address present and future French hydrogen industrial markets for chemical & refinery uses, the analysis of the interplay between wind energy production and storage of hydrogen for different automotive requirements (refuelling stations, BtL plants, H2/NG mix), massive hydrogen storage to balance various offer and demand characteristics, and the supply network (pipeline option competitiveness vs. trucked in supply) to distribute hydrogen in a French region for automotive applications. Technical and economical issues, as well as GHG emissions, are addressed.

关键词：法国氢链温室气体排放量评估经济竞争力时间跨度合作伙伴科学研究

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Screening and diagnosis of endometrial cancer in Lynch syndrome

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World Journal of Obstetrics and Gynecology 2016年第4期5卷 218-225页

作者： Caroline Cornou Anne Sophie Bats Charlotte Ngo Léa Rossi Perrine Capmas Pierre Laurent-Puig Chérazade Bensaid Claude Nos Marie aude Lefrère-Belda Fabrice Lécuru Department of Gynecologic Oncology European Hospital Georges Pompidou University of Paris Descartes

Lynch syndrome(LS) is an autosomal dominant inherited cancer predisposition syndrome caused by a mismatch of DNA repair(MMR system). Lifetime risk of developing endometrial and ovarian cancer in LS is higher than in the general population and gynecologic screening appears interesting. Screening is based on several tests: pelvic ultrasound, endometrial biopsy and hysteroscopy for endometrial cancer, pelvic ultrasound and CA125 for ovarian cancer. Those tests appear efficient for the diagnosis of gynecologic cancers in LS. Nevertheless, screening tests have not proved clinical benefit until now, and potential problems of compliance, risk of false negative cases, and interval cancer associated with screening do justify offering prophylactic surgery to patients. Women with LS should be informed of the potential benefits and risks of screening and the importance of evaluation in case of gynecologic symptoms or abnormal bleeding. Chemoprevention by progestincontaining oral contraceptives and the treatment of premalignant lesion are available options for reducing the risk of endometrial cancer in LS population.

关键词： DNA修复染色体治疗方法临床分析

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Ethnobotanical Survey of Two Medicinal Plants(Heliotropium indicum L.,Abrus precatorius L.,)Used in Traditional Medicine in West Africa

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Journal of Botanical Research 2021年第3期3卷 12-18页

作者： Farid T.Badé Durand Dah-Nouvlessounon Sina Haziz CisséHama aude Kelomey Assogba Sylvestre OladéléGautier Roko Adjanohoun Adolphe Savadogo Aly Baba-Moussa Lamine Laboratory of Biology and Molecular Typing in Microbiology Faculty of Science and Technology/University of Abomey-CalaviCotonouBenin Laboratory of Biochemistry and Applied Immunology(LABIA) UFR in Life and Earth SciencesDoctoral School of Sciences and TechnologiesJoseph KI-ZERBO UniversityOuagadougouBurkina Faso South Agricultural Research Center National Agricultural Research Institute of BeninAttogonBenin

Since the time of our ancestors,natural products issued from plant play a therapeutic crucial *** 25-30%of all medicines(drugs)available for the treatment of diseases are derived from natural products(from plants,animals,bacteria and fungi)or are derivatives of natural *** aim of this research was to scientifically identify and supply tangible documentation on these two plants employed in the traditional *** November 2020 to February 2021,an ethnobotanical survey was conducted within four markets at the south of Benin,employing a semi-structured *** hundred respondents including 80%of females and 20%of males were *** 2 studied plants are mainly used for different types of sickness related to ***’herbalists are the most *** this research,it appears that the 2 plants are widely used for the treatment of severe *** the market,95%of the leafy steam are sold against 5%of the roots for both *** main preparation way is *** use is reported to be common in all *** value of samples sold varies from 200F CFA(Financial Cooperation of Africa)to 1000F *** decoctions are usually obtained through one of a mix of different types of *** knowledge is transmitted from one generation to another by oral *** today there was no record *** our study,we did no record prohibition or side effect related to these plants’*** medicinal plants occupy a crucial place within the therapeutic arsenal of west *** results constitute a vital tool to determine the true potentials of these *** results could lead to new improved traditional medicine.

关键词： Therapeutic Ethnobotanical Decoction Medicine West Africa

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通过“生活实验室”和多中心治理设计韧性水景

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景观设计学（中英文） 2019年第3期7卷 12-31页

作者：奥德·赞格拉夫-哈梅德朱丽叶·马丁格尔德·鲁普乔安妮·林内鲁斯-拜耳史蒂文·鲍莱特李慧彦(译) 田晓劼(译) 德国慕尼黑工业大学策略性景观规划与管理系法国图尔大学人文科学学院国际应用系统分析研究所(IIASA) 不详

多中心治理和"生活实验室"概念均基于去中心化的参与式规划、协同设计和决策而建立。尽管"生活实验室"的概念在近几年才刚刚兴起,但于2000~2011年施行的伊萨河计划既已对其进行了开拓性探索。该计划沿德国慕尼黑市伊萨河对多种基于自然... 详细信息

多中心治理和"生活实验室"概念均基于去中心化的参与式规划、协同设计和决策而建立。尽管"生活实验室"的概念在近几年才刚刚兴起,但于2000~2011年施行的伊萨河计划既已对其进行了开拓性探索。该计划沿德国慕尼黑市伊萨河对多种基于自然的解决方案进行了选择、协同设计并予以实施。虽然多个管理部门参与了伊萨河计划的决策过程,但时至今日尚缺乏对促成该项目的多中心治理的研究分析。本文以利益相关者访谈及文献综述为基础,对伊萨河计划的修复规划流程进行了分析。文章阐述了伊萨河计划治理架构的演变,论述了"生活实验室"的协同治理方法,并分析呈现了多中心治理如何增进信任和相互交流,以及韧性水景的协同设计。最终,本文认为,当各具自主权的多层级决策者共同参与政策方案制定时,"生活实验室"可以成为一种实施多中心治理的方法,反之亦然。

关键词：参与式过程社会-生态修复城市研究河流管理水资源治理生活实验室多中心治理

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EGFR Expression Is Unreliable to Decide for Cetuximab Treatment in Patients with Metastatic Colorectal Cancer: Results from “ERBITUX-OUEST”

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Open Journal of Internal Medicine 2016年第2期6卷 56-67页

作者： Jean-Philippe Metges Erick Gamelin Alain Volant Olivier Capitain Jean-François Ramée Jean-Luc Raoul Jean-Yves Douillard Pierre-Luc Etienne Isabelle Cumin Olivier Dupuis Roger Faroux Marie-aude Coulon Philippe Deguiral Karine Bideau Nacr Eddine Achour Alain Gourlaouen Corinne Alleaume Annie Wdowik Laurent Miglianico Yann Touchefeu Vincent Klein Alain Penchet Ludovic Rosenfeld Daniel Martin Claire Stampfli Jean-Jacques Auger Alain Bargain Murielle Broyer-Petit Jérome Chettrit Louis-Rémi De Ybarlucea Serge Eloit Pierre Marie Girardot Nathalie Heresbach Christian Laboisse Eric Lavoine Gilles Lemasson Claire Magois Sophie Michalak Norbert Padilla Joseph Politis Frédéric Staroz Bruno Turlin Arnaud Uguen Viorel Vasiliu Véronique Verriele Fanny Marhuenda Delphine Déniel Lagadec Christian Riché Françoise Grudé Observatoire dédié au Cancer des régions Bretagne et Pays de la Loire France Centre Hospitalier Régional Universitaire (CHRU) Brest France Institut de Cancérologie de l’Ouest (ICO) Paul Papin Angers France Centre Catherine de Sienne Nantes France CRLCC Eugène Marquis Rennes France ICO René Gauducheau Nantes France Centre CARIO-HCPA Plérin France Centre Hospitalier Bretagne Sud (CHBS) Lorient France Clinique Victor Hugo Le Mans France Centre Hospitalier Départemental (CHD) La Roche-sur-Yon France CH Le Mans France Clinique Mutualiste de l’Estuaire Saint-Nazaire France CHIC Quimper France Clinique Pasteur Lanroze Brest France CH MORLAIX France CH Saint-Brieuc France CHBA Vannes France CHP Saint-Grégoire France CHU Nantes France Hopital Privé Océane Vannes France Clinique Saint-Michel et Sainte-Anne Quimper France Pole Santé Sarthe et Loire La Flèche France Polyclinique du Maine Laval France Polyclinique Sud Quimper France CH Laval France Polyclinique Cesson Sévigné France Laboratoire d’anatomie et de cytologie pathologiques Cholet France Cabinet d’anatomie et de cytologie pathologiques Saint-Malo France Laboratoire d’anatomie et de cytologie pathologiques Lorient France Institut d’histopathologie Nantes France Laboratoire de Pathologie Médicale Laval France ARMOR Pathologie Plérin France Laboratoire d’anatomie et de cytologie pathologiques Rennes France Laboratoire d’anatomie et de cytologie pathologiques Angers France Laboratoire Analyses Biologie Glasgow Brest France CHU Angers France Centre d’anatomie et de cytologie pathologiques Le Mans France Cabinet d’anatomie et de cytologie pathologiques Vannes France Laboratoire d’anatomie et de cytologie pathologiques Quimper France CHU Rennes France

Purpose: Although controversial, assessment of epidermal growth factor receptor (EGFR) expression is required for the approved indications of Cetuximab in metastatic colorectal cancer (mCRC). With the objective of improving patient selection, “ERBITUX-OUEST” study aimed at analyzing EGFR status in a large cohort of mCRC patients who received cetuximab without preliminary EGFR screening, and assessing the correlation between EGFR status and response to treatment retrospectively. Patients and methods: 332 patients treated with Irinotecan Cetuximab based regimen after progression on irinotecan or oxaliplatin therapy were included. EGFR status was assessed using three available immunohistochemistry (IHC) tests and in situ hybridization in case of negativity. Clinical outcomes of EGFR-positive and EGFR-non-detected (or considered as negative with at least one test) patients were compared. Results: Of the 332 samples centrally screened, 194 were classified as full-positive (i.e., EGFR-positive for all three tests), 86 as full-negative, and 52 as discordant. One third of the 131 negative samples with FDA approved test should be reclassified as positive with at least one of the two others tests. Regarding results from FDA approved test only, neither objective response rate (ORR), progression-free survival (PFS) nor overall survival (OS) differed significantly between EGFR-negative and EGFR-positive patients (P = 0.788, 0.326 and 0.888, respectively). Similarly, comparison of full-negative to other groups did not show any significant difference in terms of ORR (P = 0.507), PFS (P = 0.222) or OS (P = 0.686). Conclusion: These data strongly argue against mCRC patients selection for Cetuximab treatment based on EGFR expression as measured by currently available IHC technics.

关键词： Metastatic Colorectal Cancer Cetuximab EGFR Expression

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基于动态演变过程的城市河流修复:以艾尔河与伊萨尔河为例

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景观设计学（中英文） 2021年第4期9卷 10-27页

作者： G·马蒂亚斯·康道夫乔治·德贡布奥德·赞格拉夫-哈梅德冉玲于(译) 张晨希(译) 申瑞琪(译) 闫露(译) 加州大学伯克利分校环境设计学院捷克ADR建筑事务所德国慕尼黑工业大学生命科学学院策略性景观规划与管理系不详

过程修复的河流修复方法并非直接创造出复杂的河流形态,而是通过少量人工干预"促进"河流动态过程的发生,以促进其自愈。河流生态条件的改善实际上是借助洪水的冲击(水流的能量)和河岸植被的生长(太阳辐射的能量)来实现的。在日内瓦的艾... 详细信息

过程修复的河流修复方法并非直接创造出复杂的河流形态,而是通过少量人工干预"促进"河流动态过程的发生,以促进其自愈。河流生态条件的改善实际上是借助洪水的冲击(水流的能量)和河岸植被的生长(太阳辐射的能量)来实现的。在日内瓦的艾尔河上,通过"还水以自由",恢复了艾尔河被开凿为运河前的生态功能。在谷底挖掘出的沟渠网络允许河流自由地淹没土地、侵蚀河床与河岸,泥沙可在此淤积成堤坝,复杂的水生栖息地得以形成,丰富着河流生态系统的食物网。在沟渠网络之间突出的菱形岛屿随着河水流动而逐渐被侵蚀,最终演变成了复杂的河道形态。在慕尼黑伊萨尔河的修复策略中,利用粗泥沙将原有的固化驳岸替换为可侵蚀的河床和堤岸,预留出河流演变、侵蚀和淤积作用的空间,并重塑了8km长的可达河岸线。自修复策略实施以来,通过泥沙的自然输移过程形成了砾石滩,其形态又在洪水的冲击中发生着演变,孕育了多样的栖息地。这两个项目均满足了过程修复的4个评价指标—空间、能源、材料和时间—且都可展示出通过修复河流动态演变过程来修复城市河流,并实现生态和社会效益的可能性。

关键词：河流修复城市河流河流过程过程修复绩效评估艾尔河伊萨尔河

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