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Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses

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Cancer Communications 2024年第2期44卷 287-293页

作者： Kouya Shiraishi atsushi Takahashi Yukihide Momozawa Yataro Daigo Syuzo Kaneko Takahisa Kawaguchi Hideo Kunitoh Shingo Matsumoto Hidehito Horinouchi Akiteru Goto Takayuki Honda Kimihiro Shimizu Masahiro Torasawa Daisuke Takayanagi Motonobu Saito Akira Saito Yuichiro Ohe Shun-ichi Watanabe Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara Sadaaki Takata Tomomi Aoi atsushi Takano Masashi Kobayashi Yohei Miyagi Kazumi Tanaka Hiroyuki Suzuki Daichi Maeda Takumi Yamaura Maiko Matsuda Yoko Shimada Takaaki Mizuno Hiromi Sakamoto Teruhiko Yoshida Yasushi Goto Tatsuya Yoshida Taiki Yamaji Makoto Sonobe Shinichi Toyooka Kazue Yoneda Katsuhiro Masago Fumihiro Tanaka Megumi Hara Nobuo Fuse Satoshi S.Nishizuka Noriko Motoi Norie Sawada Yuichiro Nishida Kazuki Kumada Kenji Takeuchi Kozo Tanno Yasushi Yatabe Kuniko Sunami Tomoyuki Hishida Yasunari Miyazaki Hidemi Ito Mitsuhiro Amemiya Hirohiko Totsuka Haruhiko Nakayama Tomoyuki Yokose Kazuyoshi Ishigaki Toshiteru Nagashima Yoichi Ohtaki Kazuhiro Imai Ken Takasawa Yoshihiro Minamiya Kazuma Kobayashi Kenichi Okubo Kenji Wakai atsushi Shimizu Masayuki Yamamoto Motoki Iwasaki Koichi Matsuda Johji Inazawa Yuichi Shiraishi Hiroyoshi Nishikawa Yoshinori Murakami Michiaki Kubo Fumihiko Matsuda Yoichiro Kamatani Ryuji Hamamoto Keitaro Matsuo Takashi Kohno Division of Genome Biology National Cancer Center Research InstituteTokyoJapan Department of Clinical Genomics National Cancer Center Research InstituteTokyoJapan Laboratory for Statistical Analysis Center for Integrative Medical SciencesRIKENYokohamaJapan Department of Genomic Medicine Research InstituteNational Cerebral and Cardiovascular CenterOsakaJapan Laboratory for Genotyping Development Center for Integrative Medical SciencesRIKENYokohamaJapan Center for Antibody and Vaccine Therapy Research HospitalInstitute of Medical ScienceThe University of TokyoTokyoJapan Department of Medical Oncology and Cancer Center and Center for Advanced Medicine against CancerShiga University of Medical ScienceOtsuJapan Division of Medical AI Research and Development National Cancer Center Research InstituteTokyoJapan Center for Genomic Medicine Graduate School of MedicineKyoto UniversityKyotoJapan Department of Medical Oncology Japanese Red Cross Medical CenterTokyoJapan Department of Thoracic Oncology National Cancer Center Hospital EastJapan Department of Thoracic Oncology National Cancer Center HospitalTokyoJapan Department of Cellular and Organ Pathology Graduate School of MedicineAkita UniversityAkitaJapan Department of Respiratory Medicine Tokyo Medical and Dental UniversityBunkyo-kuTokyoJapan Division of General Thoracic Surgery Department of SurgeryShinshu University School of MedicineMatsumotoNaganoJapan Department of General Surgical Science Division of General Thoracic SurgeryGunma University Graduate School of MedicineIntegrative Center of General SurgeryGunma University HospitalGunmaJapan Department of Gastrointestinal Tract Surgery Fukushima Medical University School of MedicineFukushimaJapan StaGen Co. LtdTokyoJapan Division of Thoracic Surgery National Cancer Center HospitalTokyoJapan Department of Thoracic Surgery National Cancer Center Hospital EastChibaJapan Division of Translational Informatics Exploratory Oncology Research and Clinical Trial Center(EPOC

Dear editor,Lung carcinoma is responsible for the highest fatal-ity rate among cancer-related deaths globally,with lung adenocarcinoma(LADC)emerging as the prevailing sub-type.

关键词： adenocarcinoma lung Lung

Ultrafast reorientation of the Néel vector in antiferromagnetic Dirac semimetals

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npj Computational Materials 2021年第1期7卷 1562-1568页

作者： atsushi Ono Sumio Ishihara Department of Physics Tohoku UniversitySendai 980-8578Japan

Antiferromagnets exhibit distinctive characteristics such as ultrafast dynamics and robustness against perturbative fields,thereby attracting considerable interest in fundamental physics and technological ***,it was revealed that the Néel vector can be switched by a current-induced staggered(Néel)spin-orbit torque in antiferromagnets with the parity-time symmetry,and furthermore,a nonsymmorphic symmetry enables the control of Dirac ***,the real-time dynamics of the magnetic and electronic structures remain largely ***,we propose a theory of the ultrafast dynamics in antiferromagnetic Dirac semimetals and show that the Néel vector is rotated in the picosecond timescale by the terahertz-pulse-induced Néel spin-orbit torque and other torques originating from magnetic *** reorientation accompanies the modulation of the mass of Dirac fermions and can be observed in real time by the magneto-optical *** results provide a theoretical basis for emerging ultrafast antiferromagnetic spintronics combined with the topological aspects of materials.

关键词： materials Dirac metals

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宋明理学的性说

杭州师范大学学报（社会科学版） 2024年第4期46卷 1-13页

作者： [日]小岛毅申绪璐(译) 东京大学人文社会系研究科日本东京113-8654 杭州师范大学哲学系浙江杭州311121

北宋王安石承继唐代韩愈彰显孟子、肯定孟子的性善说,与程颢、程颐开创的道学派学者具有共同的性论基础。与王安石、程颢强调伦理意义上的善恶只是已发阶段的概念不同,南宋朱熹依据张载的心统性情与程颐的性即理,建立性情二层构架。同时... 详细信息

北宋王安石承继唐代韩愈彰显孟子、肯定孟子的性善说,与程颢、程颐开创的道学派学者具有共同的性论基础。与王安石、程颢强调伦理意义上的善恶只是已发阶段的概念不同,南宋朱熹依据张载的心统性情与程颐的性即理,建立性情二层构架。同时,《大学》“身有所忿懥”的身、心理解反映了道学家不同的思想特色。有关性本善与无善无恶、尊德性与道问学的争论,反映了理学家不同的思想重点。尤其是尊德性与道问学对立的思想史叙事不断地再生产,直至今天仍保持着生命力。黄宗羲的《明儒学案》可为代表,这样的叙事非常稳妥,但也因此需要保持警惕。一方面这样的叙事容易忽略不同学者思想的丰富性,另一方面即使强调“朱陆和会”的学者也不可避免地局限在朱陆对立的理论前提。

关键词：性善论无善无恶朱熹王阳明陆九渊

Factors Influence Hanoians’ Choice of Non-Motorized Transport Mode to Access Bus Stations

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Accumulation of aberrant DNA methylation during colorectal cancer development

Journal of Transportation Technologies（交通科技期刊） 2024年第3期 372页

作者： Ngo Trung Phuong Masahiko Kikuchi Aya kojima Hisashi Kubota

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World Journal of Gastroenterology 2014年第4期20卷 978-987页

作者： Eiji Sakai atsushi Nakajima atsushi Kaneda Department of Gastroenterology Yokohama City University School of Medicine Genome Science Division Research Center for Advanced Science and Technology The University of Tokyo Department of Molecular Oncology Graduate School of Medicine Chiba University CREST Japan Science and Technology Agency

Despite the recent advances in the therapeutic modalities,colorectal cancer(CRC)remains to be one of the most common causes of cancer-related *** arises through accumulation of multiple genetic and epigenetic alterations that transform normal colonic epithelium into *** crucial roles of epigenetic alterations,gene silencing by aberrant DNA methylation of promoter regions is one of the most important epigenetic *** comprehensive methylation analyses on genome-wide scale revealed that sporadic CRC can be classified into distinct *** epigenotype cooperates with specific genetic alterations,suggesting that they represent different molecular carcinogenic *** lesions of CRC,such as conventional and serrated adenomas,already show similar methylation accumulation to CRC,and can therefore be classified into those epigenotypes of *** addition,specific DNA methylation already occurs in the normal colonic mucosa,which might be utilized for prediction of the personal CRC *** methylation is suggested to occur at an earlier stage than carcinoma formation,and may predict the molecular basis for future development of ***,we review DNA methylation and CRC classification,and discuss the possible clinical usefulness of DNA methylation as biomarkers for the diagnosis,prediction of the prognosis and the response to therapy of CRC.

关键词： Colorectal cancer Colorectal adenoma Aberrant crypt foci Genetic mutation Epigenotype DNA methylation Colorectal carcinogenesis

BDNF pro-peptide：a novel synaptic modulator generated as an N-terminal fragment from the BDNF precursor by proteolytic processing

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Neural Regeneration Research 2017年第7期12卷 1024-1027页

作者： Toshiyuki Mizui Koji Ohira Masami kojima Biomedical Research Inst. (BMD) National Institute of Advanced Industrial Science and Technology (AIST) Osaka Japan Laboratory of Nutritional Brain Science Department of Food Science and Nutrition Mukogawa Women's University Hyogo Japan Core Research for Evolutional Science and Technology (CREST) Science and Technology Agency (JST) KawaguchiJapan Graduate School of Frontier Bioscience Osaka University Suita Japan

Most growth factors are initially synthesized as precursors and it was cleaved into bioactive mature domain and ***,compared with the expression and function of bioactive mature domain,the biological role of the pro-domain is poorly ***,we found that the pro-domain（or pro-peptide）of brain-derived neurotrophic factor（BDNF）,which is well-known neurotrophic factor in brain,has a potential ability to facilitate hippocampal long-term ***,a BDNF polymorphism Val66Met,which substitute valine into methionine at 66 amino acid,impacted the biological activity of the BDNF *** lastly discuss the possible roles of BDNF and its pro-peptide in the generation of neural stem cells and progress of ischemia.

关键词： BDNF growth factor neural stem cells ischemia peptide

Effect of in vitro interferon-beta administration on hepatitis C virus in peripheral blood mononuclear cells as a predictive marker of clinical response to interferon treatment for chronic hepatitis C

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World Journal of Gastroenterology 2004年第5期10卷 733-736页

作者： Kaori Mochizuki Tatehiro Kagawa Shinji Takashimizu Kazuya Kawazoe Sei-Ichiro kojima Naruhiko Nagata atsushi Nakano Yasuhiro Nishizaki Koichi Shiraishi Masaru Itakura Norihito Watanabe Tetsuya Mine Shohei Matsuzaki Department of Internal Medicine Division of GastroenterologyTokai University School of MedicineBohseidaiIsehara 259-1193Japan

AIM:To test whether in vitro incubation of peripheral blood mononuclear cells (PBMC) with interferon (IFN) could efficiently decrease hepatitis C virus-RNA (HCV-RNA) amount and to analyze whether this effect was associated with clinical response to ***:Twenty-seven patients with histologically proven chronic hepatitis C were given intravenous administration of 6 million units (MU) IFN-β daily for 6 weeks followed by three times weekly for 20 weeks. PBMC collected before IFN therapy were incubated with IFN-β and HCV-RNA in PMBC was semi-quantitatively ***: Twenty-five patients completed IFN *** patients (32%) had sustained loss of serum HCV-RNA with normal serum ALT levels after IFN therapy (complete responders).HCV-RNA in PBMC was detected in all patients,whereas it was not detected in PBMC from healthy *** vitro administration of IFN-β decreased the amount of HCV-RNA in PMBC in 18 patients (72%). Eight of these patients obtained complete response. On the other hand,none of the patients whose HCV-RNA in PBMC did not decrease by IFN-β was complete responders. Multiple logistic regression analysis revealed that the decrease of HCV-RNA amount in PBMC by IFN-β was the only independent predictor for complete response (P<0.05).CONCLUSION:The effect of in vitro IFN-β on HCV in PBMC reflects clinical response and would be taken into account as a predictive marker of IFN therapy for chronic hepatitis C.

关键词： Adult Antiviral Agents dosage Drug Resistance, Viral Female Hepacivirus Hepatitis C, Chronic Humans In Vitro Interferon-beta Leukocytes, Mononuclear Male Middle Aged Predictive Value of Tests RNA, Viral

Imbricate structure of the Otakeyama area, Okayama Permian Yoshii Group in the Prefecture, southwest Japan

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Frontiers of Earth Science 2015年第1期9卷 152-163页

作者： Tsuyoshi ITO atsushi MATSUOKA State Key Laboratory of Geo-processes and Mineral Resources China University of Geosciences Wuhan 430074 China Department of Geology Faculty of Science Niigata University Niigata 950-2181 Japan

The Yoshii Group of the Akiyoshi terrane is distributed over the Otakeyama area, Okayama Prefecture, southwest Japan. The Yoshii Group is composed of siliceous rocks and clastics, comprising chert-clastic sequences. The Yoshii Group is divided into four structural units （Units Ot 1, Ot 2, Ot 3, and Ot 4） in structurally ascending order. Lithological similarities and radiolarian age suggest that these units exhibit almost identical ocean plate stratigraphy. These units are structurally-repeated to form an imbricate structure. This structure was possibly formed by off-scrape accretion at a toe of an accretionary complex. Additionally, a review of previous studies indicates that an imbricate structure is common in the Akiyoshi terrane. The presence of an imbricate structure in the Akiyoshi terrane, Permian accretionary complex, indicates the possibility that a specific horizon of Permian pelagic sequences acted as a drcollement zone.

关键词： accretionary complex imbricate structure,Permian radiolafia Yoshii Group Okayama Prefecture,southwest Japan

Response of understory vegetation over 10 years after thinning in an old-growth cedar and cypress plantation overgrazed by sika deer in eastern Japan

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Forest Ecosystems 2017年第2期4卷 93-102页

作者： atsushi Tamura Masanobu Yamane Division of Forest Research and Nature Restoration Planning Kanagawa Prefecture Natural Environment Conservation Center 657 Nanasawa AtsugiKanagawa 243-072 Japan

Background： Forest management strategies such as thinning have long been used to enhance ecosystem functions, especially in *** in plantations with high deer density, however, may not yield a desired increase in understory vegetation because deer graze on germinating plants after ***, we examine the changes in understory vegetation after thinning in plantations that have been overgrazed by sika deer to provide insight into the effects of thinning on ecosystem functions such as soil conservation and biological ***： We conducted our survey in the Tanzawa Mountains of eastern *** surveyed the change in understory vegetation within and outside of three deer exclosures on a single slope with three levels of understory vegetation cover： sparse（1%, exclosure ＂US＂）, moderate（30%, exclosure ＂MM＂）, and dense（80%, exclosure ＂LD＂） over10 years after a 30% thinning of an old-growth cedar and cypress plantation which was overgrazed by sika ***： Understory vegetation cover, biomass and species richness increased within and outside the ＂US＂ and＂MM＂ exclosures after thinning, and biomass was greater within than outside the exclosures at 10 years after *** species dominated both ＂US＂ and ＂MM＂ exclosures before thinning, and trees and shrubs dominated within the exclosures over time after *** contrast, unpalatable, grazing-tolerant, perennial,and annual species increased outside the ＂US＂ and ＂MM＂ *** noticeable changes were observed within and outside the ＂LD＂ exclosure when compared with the ＂US＂ and ＂MM＂ ***： Our results suggest that thinning a stand by 30% based on volume resulted in an increase in understory vegetation cover mainly composed of both unpalatable and grazing-tolerant species in a plantation forest where understory vegetation is sparse or moderate and sika deer density is *** emphasize that establishing deer exclosures or controlling deer is essential to ma

关键词： Biomass Deer exclosure Grazing-tolerant species Understory cover Unpalatable species