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Virologica Sinica 2014年第1期29卷 33-39页

作者： Diana Kozlova Viktoriya Sokolova Maohua Zhong Ejuan Zhang Jingyi Yang Wei Li Yi Yang Jan Buer astrid maria westendorf Matthias Epple Huimin Yan Institute of Inorganic Chemistry and Center for Nanointegration Duisburg-Essen(CeNIDE) University of Duisburg-Essen Mucosal Immunity Research Group State Key Laboratory of VirologyWuhan Institute of VirologyChinese Academy of Sciences Institute of Medical Microbiology University Hospital EssenUniversity of Duisburg-Essen

For subunit vaccines,adjuvants play a key role in shaping the magnitude,persistence and form of targeted antigen-specific immune *** is a potent immune activator by bridging innate inflammatory responses and adaptive immunity and an adjuvant candidate for clinical *** phosphate nanoparticles are efficient carriers for different biomolecules like DNA,RNA,peptides and ***-functionalized calcium phosphate nanoparticles were prepared and their immunostimulatory effect on the innate immune system,*** cytokine production,was *** induced the production of the proinflammatory cytokines IL-8 （Caco-2 cells） and IL-1β（bone marrow-derived macrophages; BMDM） in vitro and IL-6 in vivo after intraperitoneal injection in *** immunostimulation was more pronounced than with free flagellin.

关键词： calcium phosphate nanoparticle immunostimulation innate immune system flagellin adjuvants

Enhanced history matching process by incorporation of saturation logs as model selection criteria

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Petroleum Exploration and Development 2023年第2期50卷 450-463页

作者： APONTE Jesus Manuel WEBBER Robert CENTENO maria astrid DHAKAL Hom Nath SAYED Mohamed Hassan MALAKOOTI Reza Faculty of Technology University of PortsmouthPortsmouth PO12UPUnited Kingdom CNOOC International Ltd Uxbridge UB81LUUnited Kingdom London South Bank University London SE10AAUnited Kingdom University of Southampton Southampton SO171BJUnited Kingdom Computer Modelling Group Ltd London OX108BAUnited Kingdom

This paper proposes a methodology for an alternative history matching process enhanced by the incorporation of a simplified binary interpretation of reservoir saturation logs(RST) as objective function. Incorporating fluids saturation logs during the history matching phase unlocks the possibility to adjust or select models that better represent the near wellbore waterfront movement, which is particularly important for uncertainty mitigation during future well interference assessments in water driven reservoirs. For the purposes of this study, a semi-synthetic open-source reservoir model was used as base case to evaluate the proposed methodology. The reservoir model represents a water driven, highly heterogenous sandstone reservoir from Namorado field in Brazil. To effectively compare the proposed methodology against the conventional methods, a commercial reservoir simulator was used in combination with a state-of-the-art benchmarking workflow based on the Big LoopTMapproach. A well-known group of binary metrics were evaluated to be used as the objective function, and the Matthew correlation coefficient(MCC) has been proved to offer the best results when using binary data from water saturation logs. History matching results obtained with the proposed methodology allowed the selection of a more reliable group of reservoir models,especially for cases with high heterogeneity. The methodology also offers additional information and understanding of sweep behaviour behind the well casing at specific production zones, thus revealing full model potential to define new wells and reservoir development opportunities.

关键词： geological modeling reservoir model objective function binary classification history matching saturation logs

Optimization of the future remnant liver:review of the current strategies in Europe

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Hepatobiliary Surgery and Nutrition 2021年第3期10卷 350-363页

作者： Riccardo Memeo maria Conticchio Emmanuel Deshayes Silvio Nadalin astrid Herrero Boris Guiu Fabrizio Panaro Division of Hepato-Pancreato-Biliary Surgery Department of Surgery“F.Miulli”General HospitalAcquaviva delle FontiBariItaly Policlinico di Bari Aldo Moro UniversityBariItaly Department of Nuclear Medicine Institute du Cancer de Montpellier(ICM)MontpellierFrance INSERM U1194 Montpellier Cancer Research InstituteMontpellier UniversityMontpellierFrance Department of General Visceral and Transplant SurgeryUniversity Hospital TübingenGermany Department of Surgery Division of HBP Surgery and Liver TransplantationSt-Eloi University HospitalMontpellierFrance Department of Radiology St-Eloi University HospitalMontpellierFrance

Liver resection still represent the treatment of choice for liver malignancies,but in some cases inadequate future remnant liver(FRL)can lead to post hepatectomy liver failure(PHLF)that still represents the most common cause of death after *** strategies in recent era have been developed in order to generate a compensatory hypertrophy of the FRL,reducing the risk of post hepatectomy liver *** vein embolization,portal vein ligation,and ALLPS are the most popular techniques historically adopted up to *** liver venous deprivation and the radio-embolization are the most recent promising *** even more precise tools to calculate the relationship among volume and function,such as scintigraphy with^(99m)Tc-mebrofenin(HBS),no consensus is still available to define which of the above mentioned augmentation strategy is more adequate in terms of kind of surgery,complexity of the pathology and quality of liver *** aim of this article is to analyse these different strategies to achieve sufficient FRL.

关键词： Liver resection future remnant liver(FRL) liver failure liver volume liver function hypertrophy

NOD2-and disease-specific gene expression profiles of peripheral blood mononuclear cells from Crohn's disease patients

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World Journal of Gastroenterology 2018年第11期24卷 1196-1205页

作者： Holger Schufler maria Rohde Sarah Rohde astrid Huth Nicole Gittel Hannes Hollborn Dirk Koczan Ane Glass Georg Lamprecht Robert Jaster Department of Medicine II Division of GastroenterologyRostock University Medical CenterRostock 18057Germany Institute of Immunology Rostock University Medical CenterRostock 18057Germany Institute for Biostatistics and Informatics in Medicine and Ageing Research Rostock 18057Germany

AIM To investigate disease-specific gene expression profiles of peripheral blood mononuclear cells(PBMCs) from Crohn's disease(CD) patients in clinical *** Patients with CD in clinical remission or with very low disease activity according to the Crohn's disease activity index were genotyped regarding nucleotidebinding oligomerization domain 2(NOD2),and PBMCs from wild-type(WT)-NOD2 patients,patients with homozygous or heterozygous NOD2 mutations and healthy donors were isolated for further *** cells were cultured with vitamin D,peptidoglycan(PGN) and lipopolysaccharide(LPS) for defined periods of time before RNA was isolated and subjected to microarray analysis using Clariom S assays and quantitative realtime ***2-and disease-specific gene expression profiles were evaluated with repeated measure ANOVA by a general linear *** Employing microarray assays,a total of 267 genes were identified that were significantly up-or downregulated in PBMCs of WT-NOD2 patients,compared to healthy donors after challenge with vitamin D and/or a combination of LPS and PGN(P < 0.05;threshold:≥ 2-fold change).For further analysis by real-time PCR,genes with known impact on inflammation and immunity were selected that fulfilled predefined expression *** a larger cohort of patients and controls,a disease-associated expression pattern,with higher transcript levels in vitamin D-treated PBMCs from patients,was observed for three of these genes,CLEC5 A(P < 0.030),lysozyme(LYZ;P < 0.047) and TREM1(P < 0.023).Six genes were found to be expressed in a NOD2-dependent manner(CD101,P < 0.002;CLEC5 A,P < 0.020;CXCL5,P < 0.009;IL-24,P < 0.044;ITGB2,P < 0.041;LYZ,P < 0.042).Interestingly,the highest transcript levels were observed in patients with heterozygous NOD2 *** Our data identify CLEC5 A and LYZ as CD-and NOD2-associated genes of PBMCs and encourage further studies on their pathomechanistic roles.

关键词： Peripheral blood mononuclear cells Gene expression NOD2 Lysozyme Crohn's disease CLEC5A

以饱和度测井数据为油藏模型选择标准的改进历史拟合方法

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石油勘探与开发 2023年第2期50卷 398-408页

作者： APONTE Jesus Manuel WEBBER Robert CENTENO maria astrid DHAKAL Hom Nath SAYED Mohamed Hassan MALAKOOTI Reza 朴茨茅斯大学理工学院朴茨茅斯PO12UP英国中海油国际有限公司阿克斯布里奇UB81LU英国伦敦南岸大学伦敦SE10AA英国南安普顿大学南安普顿SO171BJ英国计算机建模集团有限公司伦敦OX108BA英国

提出了一种将储集层饱和度测井数据二元简化形式作为油藏模型选择标准的改进历史拟合方法,使用半合成开源油藏模型作为基础模型对提出的方法进行评估,并与常规方法进行了比较。历史拟合阶段引入流体饱和度测井数据,有助于调整或选择能... 详细信息

提出了一种将储集层饱和度测井数据二元简化形式作为油藏模型选择标准的改进历史拟合方法,使用半合成开源油藏模型作为基础模型对提出的方法进行评估,并与常规方法进行了比较。历史拟合阶段引入流体饱和度测井数据,有助于调整或选择能够更好地表征近井地带水驱前缘推进的模型,从而有效降低水驱油藏后续井间干扰评价的不确定性。研究表明,对含水饱和度测井数据进行二元分类时,马修斯相关系数作为分类指标的效果最佳。与常规方法相比,根据提出的方法可以选出一组更可靠的储集层(特别是强非均质性储集层)模型,选出的模型历史拟合效果更好,对近井地带含水饱和度、生产井及其不同层位含水率的拟合质量更好。

关键词：地质建模油藏模型目标函数二元分类历史拟合饱和度测井

Prognostic performance of an index based on lactic dehydrogenase and transaminases for patients with liver steatosis and COVID-19

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World Journal of Gastroenterology 2022年第37期28卷 5444-5456页

作者： Ricardo Ulises Macías-Rodríguez Alberto Adrián Solís-Ortega Victoria J Ornelas-Arroyo astrid Ruiz-Margáin maria Sarai González-Huezo Nestor A Urdiales-Morán Berenice M Román-Calleja Juan M Mayorquín-Aguilar JoséA González-Regueiro Alejandro Campos-Murguía Israel Vicente Toledo-Coronado Mónica Chapa-Ibargüengoitia Bernardo Valencia-Peña Carlos Fernando Martínez-Cabrera Nayelli C Flores-García Department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City 14080Mexico Department of Gastroenterology Centro Médico ISSEMYMToluca 52140Mexico Department of Radiology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City 14080Mexico

BACKGROUND Metabolic associated fatty liver disease(MAFLD)is associated with complications and mortality in patients with coronavirus disease 2019(COVID-19).However,there are no prognostic scores aimed to evaluate the risk of severe disease specifically in patients with MAFLD,despite its high *** dehydrogenase,aspartate aminotransferase and alanine aminotransferase have been used as markers of liver ***,we propose an index based on lactate dehydrogenase,aspartate aminotransferase and alanine aminotransferase for the prediction of complications and mortality in patients with MAFLD and *** To evaluate the prognostic performance of an index based on lactate dehydrogenase and transaminases(aspartate aminotransferase/alanine aminotransferase)in patients with COVID-19 and MAFLD[liver fibrosis and nutrition(LNF)-COVID-19 index].METHODS In this retrospective cohort study,two cohorts from two different tertiary centers were *** first was the derivation cohort to obtain the score cutoffs,and the second was the validation *** included hospitalized patients with severe COVID-19 and *** steatosis was evaluated by computed tomography *** under the receiver operating characteristic(ROC)curve analysis and survival analysis were *** In the derivation cohort,44.6%had MAFLD;ROC curve analysis yielded a LFN-COVID-19 index>1.67 as the best cutoff,with a sensitivity of 78%,specificity of 63%,negative predictive value of 91%and an area under the ROC curve of *** the multivariate analysis,the LFN-COVID-19 index>1.67 was independently associated with the development of acute kidney injury(odds ratio:1.8,95%confidence interval:1.3-2.5,P<0.001),orotracheal intubation(odds ratio:1.9,95%confidence interval:1.4-2.4,P<0.001),and death(odds ratio:2.86,95%confidence interval:1.6-4.5,P<0.001)in both *** LFN-COVID-19 index has a good performance to predict prognosis in patients with MAFLD and COVID-19,which

关键词： COVID-19 Metabolic associated fatty liver disease Lactate dehydrogenase Transaminases Prognosis Nonalcoholic fatty liver disease

Experimental evidence of Bloch surface waves on photonic crystals with thin-film LiNbO_3 as a top layer

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光子学研究：英文版 2017年第6期5卷 168-172页

作者： TATIANA KOVALEVICH DJAFFAR BELHARET LAURENT ROBERT MYUN-SIK KIM HANS PETER HERZIG THIERRY GROSJEAN maria-PILAR BERNAL Département d'Optique P.M.Duffieux Institut FEMTO-ST UMR 6174 CNRS Université Bourgogne Franche-Comté Optics & Photonics Technology Laboratory Ecole Polytechnique Fédérale de Lausanne (EPFL)

Strong nonlinear, electro-optical, and thermo-optical properties of lithium niobate(LN) have gained much attention. However, the implementation of LiNbO_3 in real devices is not a trivial task due to difficulties in manufacturing and handling thin-film LN. In this study, we investigate an optical device where the Bloch surface wave(BSW) propagates on the thin-film LN to unlock its properties. First, access to the LN film from air(or open space) is important to exploit its properties. Second, for sustaining the BSW, one-dimensional photonic crystal(1DPhC) is necessary to be fabricated under the thin-film LN. We consider two material platforms to realize such a device: bulk LN and commercial thin-film LN. Clear reflectance dips observed in far-field measurements demonstrate the propagation of BSWs on top of the LN surface of the designed 1DPhCs.

关键词： LN Li Experimental evidence of Bloch surface waves on photonic crystals with thin-film LiNbO3 as a top layer

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独特的设计

现代装饰（家居） 2015年第9期 124-131页

作者： Elena Sidorova Elizaveta Putjatina Semen Lavdanskiy maria Marwuk Evgeniy Tverdohlebov Cheburashkin Kirill Cheburashkina Elena Zolotuhin Leonard Burov Vsevolod Ratnikov Anton 56thStudio Jackkrit Anantakul Saran Yen Panya 苏怡文张晏维 Sebastian Errazuriz Raúl Hott Aij Kaldanova Benjamin Nordsmark Fajno Design Daniel Kamp James McNab Sam Griffin Samwoong Lee astrid Tolnov Elise Tessier Stone Designs 李薇范嘉苑

当我们走走停停，计总能更快地引起熟知的形状或品可以唤起我对平常的突脑的智慧，是为引更多的注意。

关键词：室内装饰设计方案设计风格设计师