Calcium phosphate nanoparticles show an effective activation of the innate immune response in vitro and in vivo after functionalization with flagellin

作     者：Diana Kozlova Viktoriya Sokolova Maohua Zhong Ejuan Zhang Jingyi Yang Wei Li Yi Yang Jan Buer Astrid Maria Westendorf Matthias Epple Huimin Yan 

作者机构：Institute of Inorganic Chemistry and Center for Nanointegration Duisburg-Essen(CeNIDE)University of Duisburg-Essen Mucosal Immunity Research GroupState Key Laboratory of VirologyWuhan Institute of VirologyChinese Academy of Sciences Institute of Medical MicrobiologyUniversity Hospital EssenUniversity of Duisburg-Essen 

出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)

年 卷 期：2014年第29卷第1期

页      面：33-39页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：supported by the Deutsche Forschungsgemeinschaft(SFB/Transregio 60) the National Natural Science Foundation of China(no.81302609 and 81202312) 

主　　题：calcium phosphate nanoparticle immunostimulation innate immune system flagellin adjuvants 

摘      要：For subunit vaccines,adjuvants play a key role in shaping the magnitude,persistence and form of targeted antigen-specific immune *** is a potent immune activator by bridging innate inflammatory responses and adaptive immunity and an adjuvant candidate for clinical *** phosphate nanoparticles are efficient carriers for different biomolecules like DNA,RNA,peptides and ***-functionalized calcium phosphate nanoparticles were prepared and their immunostimulatory effect on the innate immune system,*** cytokine production,was *** induced the production of the proinflammatory cytokines IL-8 （Caco-2 cells） and IL-1β（bone marrow-derived macrophages; BMDM） in vitro and IL-6 in vivo after intraperitoneal injection in *** immunostimulation was more pronounced than with free flagellin.