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Heat shock protein 20 promotes sirtuin 1-dependent cell proliferation in induced pluripotent stem cells

World Journal of Stem Cells 2021年第6期13卷 659-669页

作者： Mujib Ullah Nicole Pek Min Qian Gustavo Yannarelli asma akbar Institute for Immunity and Transplantation Stem Cell Biology and Regenerative MedicineSchool of MedicineStanford UniversityStanfordCA 94304United States Immunology and School of Medicine Stanford UniversityStanfordCA 94304United States Laboratorio de Regulación Génica y Células Madre Instituto de Medicina TraslacionalTrasplante y Bioingeniería(IMeTTyB)Universidad Favaloro-CONICETBuenos Aires 1078Argentina Institute for Molecular Medicine School of MedicineStanford UniversityStanfordCA 94304United States

BACKGROUND Heat shock proteins(HSPs)are molecular chaperones that protect cells against cellular stresses or ***,it has been increasingly recognized that they also play crucial roles in regulating fundamental cellular ***20 has been implicated in cell proliferation,but conflicting studies have shown that it can either promote or suppress *** underlying mechanisms by which HSP20 regulates cell proliferation and pluripotency remain *** the effect of HSP20 on cell proliferation has been recognized,its role in inducing pluripotency in human-induced pluripotent stem cells(iPSCs)has not been *** To evaluate the efficacy of HSP20 overexpression in human iPSCs and evaluate the ability to promote cell *** purpose of this study was to investigate whether overexpression of HSP20 in iPSCs can increase pluripotency and *** We used iPSCs,which retain their potential for cell ***20 overexpression effectively enhanced cell proliferation and *** of HSP20 in iPSCs was characterized by immunocytochemistry staining and realtime polymerase chain *** also used cell culture,cell counting,western blotting,and flow cytometry analyses to validate HSP20 overexpression and its *** This study demonstrated that overexpression of HSP20 can increase the pluripotency in ***,by overexpressing HSP20 in iPSCs,we showed that HSP20 upregulated proliferation markers,induced pluripotent genes,and drove cell proliferation in a sirtuin 1(SIRT1)-dependent *** data have practical applications in the field of stem cell-based therapies where the mass expansion of cells is needed to generate large quantities of stem cell-derived cells for transplantation *** We found that the overexpression of HSP20 enhanced the proliferation of iPSCs in a SIRT1-dependent ***,we established the distinct crosstalk between HSP20 and SIR

关键词： Heat shock proteins Stem cells Proliferation Induced pluripotent stem cells Sirtuin-1 Heat shock protein 20 Pluripotency

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Finite element model updating for structural damage detection using transmissibility data

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 87-101页

作者： Ahmad Izadi akbar Esfandiari Department of Maritime Engineering Amirkabir University of TechnologyTehran 15875-4413Iran

This paper presents a new finite element model updating method for estimating structural parameters and detecting structural damage location and severity based on the structural responses(output-only data).The method uses the sensitivity relation of transmissibility data through a least-squares algorithm and appropriate normalization of the extracted *** proposed transmissibility-based sensitivity equation produces a more significant number of equations than the sensitivity equations based on the frequency response function(FRF),which can estimate the structural parameters with higher *** abilities of the proposed method are assessed by using numerical data of a two-story two-bay frame model and a plate structure *** evaluating different damage cases,the number,location,and stiffness reduction of the damaged elements and the severity of the simulated damage have been accurately *** reliability and stability of the presented method against measurement and modeling errors are examined using error-contaminated *** parameter estimation results prove the method’s capabilities as an accurate model updating algorithm.

关键词： damage detection model updating output-only transmissibility sensitivity equation

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Therapeutic effects of Coriandrum sativum extracts:A review

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Asian Pacific Journal of Tropical Biomedicine 2024年第5期14卷 181-186页

作者： akbar Anaeigoudari Department of Physiology School of MedicineJiroft University of Medical SciencesJiroftIran

Medicinal plants,as a good therapeutic strategy,can be used to treat a wide spectrum of *** sativum(***)is a plant from Apiaceae *** reports indicate that *** has positive effects on anxiety,seizure,learning and memory ability,as well as *** annual plant can also treat colitis,increase appetite,reduce blood pressure,and attenuate myocardial ***,it improves liver and kidney function and diabetes mellitus and inhibits osteoclast *** beneficial effects of *** mainly are attributed to its antioxidant and anti-inflammatory *** present paper reviews the impacts of *** on different body *** was extracted by searching the Web of Science,PubMed,Scopus,and Google Scholar from January 2010 until the end of February 2024.

关键词： Coriandrum sativum Inflammation Antioxidant Oxidative stress Nervous system Liver

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A novel non-intrusive load monitoring technique using semi-supervised deep learning framework for smart grid

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Building Simulation 2024年第3期17卷 441-457页

作者： Mohammad Kaosain akbar Manar Amayri Nizar Bouguila Concordia Institute for Information Systems Engineering Concordia UniversityMontrealCanada

Non-intrusive load monitoring(NILM)is a technique which extracts individual appliance consumption and operation state change information from the aggregate power consumption made by a single residential or commercial *** plays a pivotal role in modernizing building energy management by disaggregating total energy consumption into individual appliance-level *** enables informed decision-making,energy optimization,and cost ***,NILM encounters substantial challenges like signal noise,data availability,and data privacy concerns,necessitating advanced algorithms and robust methodologies to ensure accurate and secure energy disaggregation in real-world *** learning techniques have recently shown some promising results in NILM research,but training these neural networks requires significant labeled *** initial sets of labeled data for the research by installing smart meters at the end of consumers’appliances is laborious and expensive and exposes users to severe privacy *** is also important to mention that most NILM research uses empirical observations instead of proper mathematical approaches to obtain the threshold value for determining appliance operation states(On/Off)from their respective energy consumption *** paper proposes a novel semi-supervised multilabel deep learning technique based on temporal convolutional network(TCN)and long short-term memory(LSTM)for classifying appliance operation states from labeled and unlabeled *** two thresholding techniques,namely Middle-Point Thresholding and Variance-Sensitive Thresholding,which are needed to derive the threshold values for determining appliance operation states,are also compared *** superiority of the proposed model,along with finding the appliance states through the Middle-Point Thresholding method,is demonstrated through 15%improved overall improved F1micro score and almost 26%improved Hamming loss,F1 and Specificity score for the p

关键词： semi-supervised learning non-intrusive load monitoring middle-point thresholding deep learning TCN LSTM

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Exergy Analysis of Charge and Discharge Processes of Thermal Energy Storage System with Various Phase Change Materials:A Comprehensive Comparison

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Journal of Thermal Science 2024年第2期33卷 509-521页

作者： Mojtaba TAHERI Fathollah POURFAYAZ Roghayeh HABIBI akbar MALEKI Department of Renewable Energies and Environment Faculty of New Sciences and TechnologiesUniversity of TehranTehran***Iran Faculty of Mechanical Engineering Shahrood University of TechnologyShahrood***Iran

Thermal energy storage(TES) is of great importance in solving the mismatch between energy production and *** this regard,choosing type of Phase Change Materials(PCMs) which are widely used to control heat in latent thermal energy storage systems,plays a vital role as a means of TES ***,this field suffers from lack of a comprehensive investigation on the impact of various PCMs in terms of *** address this issue,in this study,in addition to indicating the melting temperature and latent heat of various PCMs,the exergy destruction and exergy efficiency of each material are estimated and compared with each ***,in the present work the impact of PCMs mass and ambient temperature on the exergy efficiency is *** results proved that higher latent heat does not necessarily lead to higher exergy ***,to obtain a suitable exergy efficiency,the specific heat capacity and melting temperature of the PCMs must also be *** to the results,LiF-CaF_(2)(80.5%:19.5%,mass ratio) mixture led to better performance with satisfactory exergy efficiency(98.84%) and notably lower required mass compared to other ***,the highest and lowest exergy destruction are belonged to GR25 and LiF-CaF_(2)(80.5:19.5) mixture,respectively.

关键词： exergy analysis phase change materials thermal energy storage exergy efficiency

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Emerging Trends in Damage Tolerance Assessment:A Review of Smart Materials and Self-Repairable Structures

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Structural Durability & Health Monitoring 2024年第1期18卷 1-18页

作者： Ali akbar Firoozi Ali Asghar Firoozi Department of Civil Engineering Faculty of Engineering&TechnologyUniversity of BotswanaGaboroneUB0061Botswana Department of Civil Engineering University Kebangsaan Malaysia(UKM)Bangi43600Malaysia

The discipline of damage tolerance assessment has experienced significant advancements due to the emergence of smart materials and self-repairable *** review offers a comprehensive look into both traditional and innovative methodologies employed in damage tolerance *** a detailed exploration of damage tolerance concepts and their historical progression,the review juxtaposes the proven techniques of damage assessment with the cutting-edge innovations brought about by smart materials and self-repairable *** subsequent sections delve into the synergistic integration of smart materials with self-repairable structures,marking a pivotal stride in damage tolerance by establishing an autonomous system for immediate damage identification and *** holistic approach broadens the applicability of these technologies across diverse sectors yet brings forth unique challenges demanding further innovation and ***,the review examines future prospects that combine advanced manufacturing processes with data-centric methodologies,amplifying the capabilities of these‘intelligent’*** review culminates by highlighting the transformative potential of this union between smart materials and self-repairable structures,promoting a sustainable and efficient engineering paradigm.

关键词： Damage tolerance smart materials self-repairable structures structural health monitoring synergy autonomous system advanced manufacturing data-driven methodologies

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Influence of Various Earth-Retaining Walls on the Dynamic Response Comparison Based on 3D Modeling

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2835-2863页

作者： Muhammad akbar Huali Pan Jiangcheng Huang Bilal Ahmed Guoqiang Ou Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu610000China Institute of International Rivers and Eco-Security Yunnan UniversityKunming650500China Department of Structural Engineering Faculty of Civil EngineeringDoctoral SchoolAkademicka 2Silesian University of TechnologyGliwice44-100Poland

The present work aims to assess earthquake-induced earth-retaining(ER)wall *** study is on the dynamics analysis of various earth-retaining wall designs in hollow precast concrete panels,reinforcement concrete facing panels,and gravity-type earth-retaining *** finite element(FE)simulations utilized a 3D plane strain condition to model full-scale ER walls and numerous nonlinear dynamics *** seismic performance of differentmodels,which includes reinforcement concrete panels and gravity-type and hollowprecast concrete ER walls,was simulated and examined using the FE *** also displays comparative studies such as stress distribution,deflection of the wall,acceleration across the wall height,lateral wall displacement,lateral wall pressure,and backfill plastic *** components of the created ER walls were found throughout this research *** is a granular reinforcement backfill,while the other is a wall-facing panel and base *** dynamic response effects of varied earth-retaining walls have also been *** was discovered that the facing panel of the model significantly impacts the earthquake-induced displacement of ER *** proposed analytical model’s validity has been evaluated and compared with the reinforcement concrete facing panels,gravity-type ER wall,scientifically available data,and American Association of State Highway and Transportation Officials(AASHTO)guidelines results based on FE *** results of the observations indicate that the hollow prefabricated concrete ER wall is the most feasible option due to its lower displacement and high-stress distribution compared to the two *** methodology and results of this study establish standards for future analogous investigations and professionals,particularly in light of the increasing computational capabilities of desktop computers.

关键词： Seismic analysis finite element modeling earth-retaining ER walls dynamic response structural resilience

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Managing the surge:A comprehensive review of the entire disposal framework for retired lithium-ion batteries from electric vehicles

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Journal of Energy Chemistry 2024年第5期92卷 648-680页

作者： Ruohan Guo Feng Wang M.akbar Rhamdhani Yiming Xu Weixiang Shen Department of Engineering Technologies School of ScienceComputing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia Department of Chemistry and Biotechnology School of ScienceComputing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia Department Mechanical and Product Design Engineering School of EngineeringSwinburne University of TechnologyMelbourne VIC 3122Australia

Anticipating the imminent surge of retired lithium-ion batteries(R-LIBs)from electric vehicles,the need for safe,cost-effective and environmentally friendly disposal technologies has *** paper seeks to offer a comprehensive overview of the entire disposal framework for R-LIBs,encompassing a broad spectrum of activities,including screening,repurposing and ***,we delve deeply into a thorough examination of current screening technologies,shifting the focus from a mere enumeration of screening methods to the exploration of the strategies for enhancing screening ***,we outline battery repurposing with associated key factors,summarizing stationary applications and sizing methods for R-LIBs in their second life.A particular light is shed on available reconditioning solutions,demonstrating their great potential in facilitating battery safety and lifetime in repurposing scenarios and identifying their techno-economic *** the realm of battery recycling,we present an extensive survey of pre-treatment options and subsequent material recovery ***,we introduce several global leading recyclers to illustrate their industrial processes and technical ***,relevant challenges and evolving trends are investigated in pursuit of a sustainable end-of-life management and disposal *** hope that this study can serve as a valuable resource for researchers,industry professionals and policymakers in this field,ultimately facilitating the adoption of proper disposal practices.

关键词： Lithium-ion battery Battery reproposing and recycling Miaieiials recovery technologies Techno-economic issues End-of-life management Disposal framework

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Effect of CO_(2)exposure on the mechanical strength of geopolymerstabilized sandy soils

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 670-681页

作者： Hamid Reza Razeghi Armin Geranghadr Fatemeh Safaee Pooria Ghadir akbar A.Javadi School of Civil Engineering Iran University of Science and TechnologyTehran***Iran Department of Engineering University of ExeterExeterEX44QFUK

In recent years,there has been growing interest in developing methods for mitigating greenhouse effect,as greenhouse gas emissions continue to contribute to global temperature *** the other hand,investigating geopolymers as environmentally friendly binders to mitigate the greenhouse effect using soil stabilization has been widely ***,the effect of CO_(2)exposure on the mechanical properties of geopolymer-stabilized soils is rarely *** this context,the effect of CO_(2)exposure on the mechanical and microstructural features of sandy soil stabilized with volcanic ash-based geopolymer was *** factors were concerned,for example the binder content,relative density,CO_(2)pressure,curing condition,curing time,and carbonate *** results showed that the compressive strength of the stabilized sandy soil specimens with 20%volcanic ash increased from 3 MPa to 11 *** was also observed that 100 kPa CO_(2)pressure was the optimal pressure for strength development among the other *** mechanical strength showed a direct relationship with binder content and carbonate ***,in the ambient curing(AC)condition,the mechanical strength and carbonate content increased with the curing ***,the required water for carbonation evaporated after 7 d of oven curing(OC)condition and as a result,the 14-d cured samples showed lower mechanical strength and carbonate content in comparison with 7-d cured ***,the rate of strength development was higher in OC cured samples than AC cured samples until 7 d due to higher geopolymerization and carbonation rate.

关键词： Soil stabilization CO_(2)effect Geopolymer

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Examining the Effect of Hydroalcoholic Extract of Dracaena cinnabari on Sex Hormones and Ovarian and Uterine Tissues of Rats

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 213-219页

作者： Elham Najafi Bahareh Babaei Hoolari akbar Karimi Aliasghar Pilehvarian Department of Cellular Biology Genesis Evolution-Develoment Isfahan Payame Noor University IsfahanIran Department of Anatomy School of MedicineTehran University of Medical SciencesTehranIran Department of Biology Group Faculty Member of Isfahan Payame Noor UniversityIsfahanIran

Introduction: Dracaena cinnabari is considered a rich source of phytochemicals used widely in traditional medicine. In the present study, the effect of D. cinnabari hydraulic extract on the reproductive system of female rats was investigated. Methods: The samples were randomly divided into four groups(six samples in each group), including three treatment groups and one control group, and all samples were kept at the same conditions. Hydraulic extract of D. cinnabari and injected intraperitoneally daily for 10 days, while physiological serum was used for injection in to the control group. After 10 days of injection, estrogen and progesterone levels were measured by enzyme immunoassay technique. After dissection, the ovaries and uterine tissues were isolated for histological examination, and tissue changes were carefully examined. Results: The results revealed that the levels of estrogen and progesterone in experimental Groups 2 and 3 had a significant increase(P < 0.001). Regarding tissue changes, a significant increase was observed in epithelial thickness(P < 0.001), number of corpus luteum(P < 0.01), and Graafian follicle(P < 0.01) in doses of 100 and 150 mg/kg. Conclusions: Based on the results, it seems that D. cinnabari extract has an effect on the ovarian follicles.

关键词： Dracaena cinnabari herbal medicine ovarian tissues reproductive sex hormones

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