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Microwave Preparation of SiO2-B2O3-Na2O-K2O-CaO-Fe2O3-TiO2 Glass System

Journal of Chemistry and Chemical Engineering 2014年第4期8卷 349-357页

作者： ashis kumar manda Prasanta kumar Sinha Santanu Sen Sitendu Mondal Chandan Guha Ranjan Sen CSIR-Central Glass and Ceramic Research Institute Kolkata 700032 India Department of Chemical Engineering Jadavpur Unirversity Kolkata 700032 India

This study reports preparation of glass composition （54.50 wt.%） SiO2, （10.80 wt.%） B2O3, （14.20 wt.%） Na2O, （1.20 wt.%） K2O, （6.00 wt.%） CaO, （4.00 wt.%） Fe2O3 and （9.30 wt.%） TiO2 by melt quenching method using direct microwave heating and conventional resistive heating. Study of dielectric loss factor of the glass as function of temperature illustrated increasing loss factor above 370 ℃, 550 ℃, 650 ℃ and 900 ℃, indicating enhanced microwave absorption by the glass at above these temperatures. Chemical analysis results of both the glasses depicted more volatilization loss of volatile ingredients in conventional heating. The study of chemical durability was performed from leachate analysis describing less leaching of Na2O, K2O and other constituents from glass melted in microwave furnace. Glass transition temperatures （Tg） were found to be 576.3 ℃ and 569.5 ℃ for glass melted in conventional and microwave heating route, respectively. Laboratory experiment of glass melting utilizing microwave energy as an alternate heating source demonstrated 70%-75% electrical power saving.

关键词： Microwave heating energy efficient glass melting dielectric constant loss factor chemical durability.

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Effects of six compounds with different chemical structures on melanogenesis

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Chinese Journal of Natural Medicines 2018年第10期16卷 766-773页

作者： Rakotomalala manda Heriniaina DONG Jing Praveen kumar Kalavagunta WU Hua-Li YAN Dong-Sheng SHANG Jing State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China Jiangsu Key Laboratory of TCM Evaluation and Translational Research China Pharmaceutical UniversityNanjing 211198China School of Ophthalmology and Optometry Eye HospitalWenzhou Medical UniversityWenzhou 325035China State Key Laboratory of Ophthalmology Optometry and Visual ScienceWenzhou 325035China

Several chemical compounds can restore pigmentation in vitiligo through mechanisms that vary according to disease *** the present study,we investigated the melanogenic activity of six structurally distinct compounds,namely,scopoletin,kaempferol,chrysin,vitamin D_3,piperine,and *** determined their effectiveness,toxicity,and mechanism of action for stimulating pigmentation in B16F10 melanoma cells and in a zebrafish *** melanogenic activity of 6-benzylaminopurine,the compound identified as the most potent,was further verified by measuring green fluorescent protein concentration in tyrp1 a:eGFP(tyrosinase-related protein 1)zebrafish and mitfa:eGFP(microphthalmia associated transcription factor)zebrafish and antioxidative *** the tested compounds were found to enhance melanogenesis responses both in vivo and in vitro at their respective optimal concentration by increasing melanin content and expression of TYR and MITF.6-Benzyamino-purine showed the strongest re-pigmentation action at a concentration of 20μmol·L^(-1 )in vivo and 100μmol·L^(-1) in vitro,and up-regulated the strong fluorescence expression of green fluorescent protein in tyrp1 a:e GFP and mitfa:e GFP zebrafish in ***,its relative anti-oxidative activity was found to be very ***,our results indicated that 6-benzylaminopurine stimulated pigmentation through a direct mechanism,by increasing melanin content via positive regulation of tyrosinase activity in vitro,as well as up-regulating the expression of the green fluorescent protein in transgenic zebrafish in vivo.

关键词： Vitiligo Melanogenesis Tyrosinase MITF Zebrafish

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Mechanistic studies of PEG-asparaginase-induced liver injury and hepatic steatosis in mice

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Acta Pharmaceutica Sinica B 2021年第12期11卷 3779-3790页

作者： Gundala Venkata Naveen kumar Keito Hoshitsuki Sanjay Rathod manda J.Ramsey Lauren Kokai Erin E.Kershaw Wen Xie Christian A.Fernandez Department of Pharmaceutical Sciences and Center for Pharmacogenetics University of Pittsburgh School of PharmacyPittsburghPA 15261USA Division of General Internal Medicine University of Pittsburgh School of MedicinePittsburghPA 15261USA Department of Plastic Surgery University of Pittsburgh and the McGowan Institute for Regenerative MedicinePittsburghPA 15261USA University of Pittsburgh Division of EndocrinologyDepartment of MedicinePittsburghPA 15261USA

PEGylated-L-asparaginase(PEG-ASNase)is a chemotherapeutic agent used to treat pediatric acute lymphoblastic leukemia(ALL).Its use is avoided in adults due to its high risk of liver injury including hepatic steatosis,with obesity and older age considered risk factors of the *** study aims to elucidate the mechanism of PEG-ASNase-induced liver *** received 1500 U/kg of PEG-ASNase and were sacrificed 1,3,5,and 7 days after drug *** triglycerides were quantified,and plasma bilirubin,ALT,AST,and non-esterified fatty acids(NEFA)were *** mRNA and protein levels of genes involved in hepatic fatty acid synthesis,β-oxidation,very low-density lipoprotein(VLDL)secretion,and white adipose tissue(WAT)lipolysis were *** developed hepatic steatosis after PEG-ASNase,which associated with increases in bilirubin,ALT,and *** hepatic genes Ppara,Lcad/Mcad,Hadhb,Apob100,and Mttp were upregulated,and Srebp-1 c and Fas were downregulated after *** plasma NEFA,WAT loss,and adipose tissue lipolysis were also observed after ***,we found that PEG-ASNase-induced liver injury was exacerbated in obese and aged mice,consistent with clinical studies of ASNase-induced liver *** data suggest that PEG-ASNase-induced liver injury is due to drug-induced lipolysis and lipid redistribution to the liver.

关键词： Liver injury Leukemia Asparaginase Lipolysis Adverse drug reaction Adipose tissue Hepatic steatosis Amino acid response

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Chronic Dietary Administration of 2-Deoxy-D-Glucose Does Not Compromise Neurobehavioral Functions at Tumor Preventive Doses in Mice

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Journal of Behavioral and Brain Science 2015年第9期5卷 381-393页

作者： Saurabh Singh Mayank kumar Kailash manda Seenu Haridas Anant Narayan Bhatt Daman Saluja Bilikere S. Dwarakanath Division of Radiation Biosciences Institute of Nuclear Medicine and Allied Sciences Delhi India Medical Biotechnology Laboratory Dr. B.R. Ambedkar Center for Biomedical Research University of Delhi Delhi India

Beneficial effects of dietary energy restriction (DER), including extension of life-span, reduction in cancer risk, anti-cancer effects and decrease in age related neurodegenerative diseases have been well established. Given that DER is difficult to implement in humans due to practical constraints, development of energy restriction mimetics (ERMs) is considered as a suitable alternative. Our recent studies have established the anti-tumor effects of the dietary administration of the glycolytic inhibitor 2-deoxy-D-glucose, a potential ERM, an alternative to DER;without any adverse effects on general physiology. Since functioning of the brain is critically dependent on glucose, we investigated the effects of chronic dietary 2-DG administration on the behavioural outcome in mice. Our findings based on a battery of neuro-behavioural tests clearly suggest that the chronic dietary administration of 2-DG that appreciably impairs the process of tumorigenesis has no adverse effect on the cognitive, affective and sensory-motor functions. Together with the maintenance of normal physiology reported by us earlier, these observations strengthen the potential of dietary 2-DG as a safe cancer preventive strategy.

关键词： Glycolysis Energy Restriction Mimetics (ERMs) 2-Deoxy-D-Glucose (2-DG) Tumor Prevention Neuro-Behaviour

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