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Intricacies during pregnancy with gestational diabetes mellitus

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World Journal of Clinical Cases 2025年第1期13卷 62-64页

作者： Richa Rattan Rimesh Pal Parul Chawla Gupta arvind kumar Morya Ripunjay Prasad Department of Endocrinology Post Graduate Institute of Medical Education and ResearchChandigarh 160012India Department of Ophthalmology Post Graduate Institute of Medical Education and ResearchChandigarh 160012PunjabIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Ophthalmology RP Eye InstituteDelhi 110001India

The study by Cao et al aimed to identify early second-trimester biomarkers that could predict gestational diabetes mellitus(GDM)development using advanced proteomic techniques,such as Isobaric tags for relative and absolute quantitation isobaric tags for relative and absolute quantitation and liquid chromatography-mass spectrometry liquid chromatography-mass *** analysis revealed 47 differentially expressed proteins in the GDM group,with retinol-binding protein 4 and angiopoietin-like 8 showing significantly elevated serum levels compared to *** these findings are promising,the study is limited by its small sample size(n=4 per group)and lacks essential details on the reproducibility and reliability of the protein quantification methods ***,the absence of experimental validation weakens the interpretation of the protein-protein interaction network identified through bioinformatics *** study's focus on second-trimester biomarkers raises concerns about whether this is a sufficiently early period to implement preventive interventions for *** GDM risk during the first trimester or pre-conceptional period may offer more clinical *** its limitations,the study presents valuable insights into potential GDM biomarkers,but larger,well-validated studies are needed to establish their predictive utility and generalizability.

关键词： Gestational diabetes mellitus Biomarkers Differentially expressed proteins Retinol-binding protein 4 Angiopoietin-like 8 Proteomics Lifestyle interventions Early prediction

Impedance and ferroelectric properties of Sr^(2+) modified PZT-PMN ceramics

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International Journal of Minerals,Metallurgy and Materials 2014年第6期21卷 595-603页

作者： arvind kumar S.K.mishra Research and Technology Development Centre Sharda University Dr. Harisingh Gour University

Sr^2＋ modified polycrystalline PZT-PMN ceramics were synthesized by a semi-wet route. Impedance spectroscopy studies indicate the bulk and grain boundary effects of PZT-PMN material along with the negative temperature coefficient of resistance. The bulk conductiv-ity exhibits an Arrhenius-type thermally activated hopping process which is supported by the AC conductivity behavior as a function of fre-quency and temperature. It is observed that the remnant polarization increases with an increase in the Sr2＋content in PZT-PMN.

关键词： piezoelectric ceramics ferroelectric materials ferroelectricity electrochemical properties strontium

Dielectric, piezoelectric, and ferroelectric properties of lanthanum-modified PZTFN ceramics

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International Journal of Minerals,Metallurgy and Materials 2014年第10期21卷 1019-1027页

作者： arvind kumar S.K.mishra Research and Technology Development Centre Sharda University Dr. Harisingh Gour University

Specimens of Pb1-1.5xLax（Zr0.53 Ti0.47）1-y-zFeyNb2O3 （x = 0, 0.004, 0.008, 0.012, and 0.016, y = z = 0.01）（PZTFN） ceramics were synthesized by a semi-wet route. In the present study, the effect of La doping was investigated on the structural, microstructural, dielectric, piezoelectric, and ferroelectric properties of the ceramics. The results show that, the tetragonal （space group P4mm） and rhombohedral （space group R3c） phases are observed to coexist in the sample at x = 0.012. Microstructural investigations of all the samples reveal that La doping inhibits grain growth. Doping of La into PZTFN improves the dielectric, ferroelectric, and piezoelectric properties of the ceramics. The hys- teresis loops of all specimens exhibit nonlinear behavior. The dielectric, piezoelectric and ferroelectric properties show a maximum response atx 〉 0.012, which corresponds to the morphotropic phase boundary （MPB）.

关键词： ceramics lanthanum doping dielectric properties piezoelectricity ferroelectricity Rietveld refinement hysteresis loops

Effects of Sr^(2+) substitution on the structural, dielectric, and piezoelectric properties of PZT-PMN ceramics

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International Journal of Minerals,Metallurgy and Materials 2014年第2期21卷 175-180页

作者： arvind kumar S.K. mishra Research and Technology Development Centre Sharda University

This study described the structural, dielectric, and piezoelectric behavior of Pb1-xSrx[（Zr0.52Ti0.48）0.95（Mn1/3Nb2/3）0.05]O3 ceramics （PSZT-PMN, x=0, 0.025, 0.050, and 0.075）, prepared by a semi-wet route. X-ray diffraction, dielectric, and piezoelectric investigations were carried out to analyze the crystal structure. The relative dielectric constant and dielectric loss were both calculated as the functions of temperature. The room-temperature dielectric constant reaches a maximum for a Sr2＋-modified PZT-PMN ceramic with an x value of 0.050, which corresponds to the morphotropic phase boundary （MPB）. Raman spectroscopy studies also confirm the existence of this MPB for x=0.050. The piezoelectric strain coefficients （d33） value shows a maximum response for this composition. In addition, the phase transition temperature decreases significantly when the Sr2＋concentration increases in the PZT-PMN ceramics.

关键词： ceramic materials strontium substitution structural properties dielectric properties piezoelectricity

Underground mining of thick coal seams

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International Journal of Mining Science and Technology 2015年第6期25卷 885-896页

作者： kumar Rakesh Singh Arun kumar mishra arvind kumar Singh Rajendra Central Institute of Mining and Fuel Research (CIMFR under CSIR) Indian School of Mines (ISM)

This paper reviews underground mining methods for total thickness of a thick coal seam in single lift （TI＇rCSSL）. Review shows the required engineering for extraction of thick seams needs to be fitted with thickness of the seam, behavior of rock-mass and surrounding stress conditions for efficient mining. Variants of TI＇rCSSL are able to extract a maximum 10-12 m thickness only. An improvement in bending moment of the overlying coal band in longwall top coal caving （LTCC） provides better under-winning opportunity for the roof coal band. An acceptable limit of 25 MPa compressive strength of coal for the success of LTCC may be increased under favorable geo-technical conditions. Bord and pillar in India adopted induced caving of roof coal band for single lift depillaring of total thickness （SLDTr） of a compe- tent thick coal seam developed along floor. Case studies are given to arrest the adverse effects of extrac- tion height on pillars.

关键词： Thick coal seamSingle lift depillaring of total thicknessCSmIT)Extraction heightPillar instabilityCaving of coal

Depillaring of total thickness of a thick coal seam in single lift using cable bolts：A case study

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International Journal of Mining Science and Technology 2016年第2期26卷 223-233页

作者： kumar Rakesh mishra arvind kumar Singh Arun kumar Singh Amit kumar Ram Sahendr Singh Rajendr Central Institute of Mining and Fuel Research (under CSIR) Dhanbad 826015 India Indian School of Mines Dhanbad 826004 India

Explaining fundamentals of application of cable bolting for a thick seam depillaring,this paper summarizes the results of field studies conducted during adoption of this approach in more than fifteen panels of Madhusudanpur 7 pit and incline *** 7.0 m thick Kajora top coal seam of this mine is developed on pillars along the floor horizon to an average height of 3.0 m,leaving a coal band of around 4.0 m along the *** of procured core samples showed that roof strata are easily caveable with a caveability index value of around 2000 *** caveable overlying strata and shallow depth of cover alleviated most of the expected strata mechanics problems of the thick seam ***,extraction of total thickness at shallow cover caused differential-subsidence and cracks on the *** manifestations were immediately tackled to avoid creation of a breathing path for spontaneous heating in the extracted area.

关键词： Cable bolting Thick seam depillaring Extraction height Pillar stability Caveability index

Design,molecular docking,synthesis,characterization,biologi- cal activity evaluation (against MES model),in-silico biological activity spectrum (PASS analysis),toxicological and predicted oral rat LDso studies of novel sulphonamide derivatives

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Frontiers in Biology 2018年第6期13卷 425-451页

作者： Ajeet arvind kumar Arun K.mishra Drug Design Laboratory School of Pharmaceutical SciencesIFTM UniversityMoradabadUttar Pradeshlndia Department of Pharmaceutical Chemistry S.D.College of Pharmacy and Vocational StudiesMuzaffarnagarUttar PradeshIndia

Among the reported potential agents to treat the epilepsy, sulphonamides are important and their significance cannot be ignored. A series of substituted 4-amino-benzene sulfonamides were designed, keeping in view the structural requirement of pharmacophore. Lipinski rule of five has been calculated; failure to Lipinski rule was not observed. Docking was performed through AutoDock Vina. Molecules have been screened out through docking. Compounds were synthesized and characterized through IR, 1HNMR, 13C NMR, Mass and elemental analysis. The anticonvulsant activity of the synthesized compounds was assessed using the Maximal Electroshock Seizure (MES) model. In-silico biological activity spectrum, toxicological studies, predicted oral rats LD50 were performed. Docking studies showed good interaction with lyase (Oxo-acid) - human carbonic anhydrase-I (1AZM). The in-silico studies proved them to be with good drug-likeness properties, especially 4-(3-Acetyl-phenylamino)-methyl)-benzenesulfonamide (2g). These results revealed that the synthesized compounds (1a-1c, 2a-2q) exhibited promising anticonvulsant effect against MES model for inhibition of Lyase- Human Carbonic Anhydrase-I. After investigating all the results, the compound 4-(3-Acetyl-phenylamino)-methyl)-benzenesulfonamide (2g) is found to be best in the series. A comparatively good activity of compound 2g suggests us that sulphonamide can be leads to further optimization for building potent and chemically diversified anti-convulsant agents.

关键词： anticonvulsant sulfonamide docking in-silico studies

ηmesons in hot magnetized nuclear matter

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Chinese Physics C 2022年第2期46卷 160-177页

作者： Rajesh kumar arvind kumar Department of Physics Dr.B R Ambedkar National Institute of Technology JalandharJalandhar-144011PunjabIndia

ηN interactions are investigated in hot magnetized asymmetric nuclear matter using the chiral SU(3)model and chiral perturbation theory(ChPT).In the chiral modcl,thc in-medium properties of η-mesons are calcu-lated using medium modified scalar densities under the influence of an extermal magnetic ***,in a com-bined chiral model and ChPT approach,off-shell contributions of the ηN interactions are evaluated from the ChPTeffective ηN Lagrangian,and the in-medium effect of scalar densities are incorporated from the chiral SU(3)*** find that the magnetic field has a significant effect on the in-medium mass and optical potential of η mesons,andwe observe a deeper mass-shift in the combined chiral model and ChPT approach than in the solo chiral SU(3)*** both approaches,no additional mass-shift is observed due to the uncharged nature of η mesons in the presenceof a magnetic field.

关键词： hadron physics ηinteractions in-medium mesons

Charmonia and bottomonia in asymmetric magnetized hot nuclear matter

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Chinese Physics C 2019年第12期43卷 141-158页

作者： Rajesh kumar arvind kumar Department of Physics Dr.B R Ambedkar National Institute of Technology Jalandhar

We investigate the mass-shift of P-wave charmonium(χc0,χc1),and S and P-wave bottomonium(ηb,■,χb0,andχb1)states in magnetized hot asymmetric nuclear matter using the unification of QCD sum rules(QCDSR)and the chiral S U(3)*** QCDSR,we use two approaches,i.e.,the moment sum rule and the Borel sum *** magnetic field induced scalar gluon condensateand the twist-2 gluon operatorcalculated in the chiral S U(3)model are utilised in QCD sum rules to calculate the in-medium mass-shift of the above *** attractive mass-shift of these mesons is observed,which is more sensitive to magnetic field in the high density regime for charmonium,however less so for *** results may be helpful to understand the decay of higher quarkonium states to the lower quarkonium states in asymmetric heavy ion collision experiments.

关键词： heavy mesons hot and dense matter finite magnetic field QCD sum rules chiral model