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南方金融 2002年第4期 42-44页

作者： arunkumar S Khobragade 康建明中国工商银行广东省分行

无论你问及世界各地的哪一位银行家,目前所面临的挑战是什么,他们的回答肯定是一致的,即技术进步、日益增长的收入要求以及全面提高经营的收益性.

关键词：银行业市场竞争电子商务服务质量

Sterols possess immunomodulatory property:Activity guided isolation and in vitro screening of phytoconstituents of Pongamia glabra and Ficus glomerata

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Chinese Herbal Medicines 2020年第3期12卷 310-315页

作者： Sanjeev Heroor arunkumar Beknal Nitin Mahurkar Suresh Hiremath Shivkumar Inamdar Department of Pharmacognosy HKES's MTR Institute of Pharmaceutical SciencesKalaburagi 585105India Deptartment of Pharmacology HKES's MTR Institute of Pharmaceutical SciencesKalaburagi 585105India

Objective:To isolate the phytoconstituents from the methanolic extracts of the stem bark of Pongamia glabra and Ficus glomerata,characterize spectroscopically and screen for in vitro immunomodulatory activity on human ***:A flavonoid(PGF)and an alkaloidal compound(PGA)from the extract of *** and a steroidal compound(FGS)and tannin fraction(FGT)from the extract of *** were isolated using column chromatography technique and were subjected for the spectroscopic(FT-Ir,1HNMr and LC-MS)and TLC studies to identify the *** isolated compounds were screened for in vitro immunomodulatory activity on human neutrophils using nitroblue tetrazolium(NBT)dye test,phagocytosis of Candida albicans and neutrophil locomotion and chemotaxis assay at the concentration range of 100,50,25,12.50 and 5.00μg/***:From the spectroscopic and TLC studies data,the isolated compounds were identified as glabrin(PGA),karanjin(PGF),β-sitosterol(FGS),and tannin fraction(FGT).The isolated compounds PGA,PGF,FGS,and FGT exhibited significant(Pro immunomodulatory activity in all the parameters ***:The steroidal compound,*** was found to be more immunopotent than all constituents alkaloid,flavonoid and ***,these constituents could be attributed to the immunomodulatory property of the plants.

关键词： activity guided isolation Ficus glomerate roxb. immunomodulation Pongamia glabra Vent.

Epidemiology and Sequelae of Workplace Hand Injuries at a Tertiary Trauma Care Centre

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Surgical Science 2014年第4期5卷 150-158页

作者： rohini Prasad Arivind Bhamidi arunkumar rajeswaran Subramaniam Muthukumar Porkodi Kothandaraman Meenatchi Sivaraj Department of Plastic Reconstructive and Hand Surgery Parvathy Hospital Chennai India

Aims & Objectives: To study the epidemiology of workplace hand injuries, to understand relation between mode of injury and prognosis, to investigate into the possible contributing factors and to study the Socio-economic impact. Design of Study: For the prospective study there were 2 sources of data: 1) Proforma which was filled by the hand surgeon and 2) A questionnaire that was filled up by safety officer. For the retrospective study case, sheets were retrieved from the Medical records section and a telephonic or personal interview was carried out by a single interviewer. Setting: Department of Plastic and reconstructive Surgery, Parvathy Hospital, Chennai, India. Patients: A total of 419 industrial injury patients treated from January 2008 to January 2013 were included in the study. Further follow-up regarding return to work and residual disability continues. Main Outcome Measures: Personal details (Age, Gender, Handedness, Work experience, Income). Type of injury, mode of injury, day and time of injury, treatment given, disability and number of working days lost were measured. results: Those workers who were experienced less than 6 months had more workplace injuries and the commonest contributing factor was co-workers carelessness followed by long working hours and faulty machinery. Maximum injuries occurred on Monday and morning shift. Conclusions: Constant supervision of trainees for 2 years, shorter working hours with regular breaks, regular health checkups for personnel, regular servicing of machines can prevent occurrence of hand injuries. Corrective surgery within 6 hours, systematic and protocol based physiotherapy and rehabilitation can reduce the economic loss and disability arising out of work place injuries.

关键词： Hand Injury Disability Prevention

Standardization of DNA Extraction Method from Mature Dried Leaves and ISSr-PCr Conditions for Melia dubia Cav. —A Fast Growing Multipurpose Tree Species

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American Journal of Plant Sciences 2016年第3期7卷 437-445页

作者： Swati rawat Geeta Joshi D. Annapurna A. N. arunkumar Nataraja N. Karaba Tree Improvement and Genetics Division Institute of Wood Science and Technology Bengaluru India Department of Crop Physiology University of Agricultural Sciences GKVK Bengaluru India

Melia dubia Cav. of family Meliaceae is a fast growing, high value tree species native to India. Isolating DNA from matured dried leaves of M. dubia was difficult due to accumulation of secondary metabolites, majorly polyphenolics, which resulted in dark brown to black colour of the pellet. In this study, a modified STE-(Sucrose, Tris-HCl and Ethylene Diamine Tetra Acetic Acid) CTAB (hexadecyltrimethylammonium bromide) method was standardized for removal of polyphenolics. The protocol developed yielded 200 - 1000 ng/μl of quality DNA without any impurities as evident by A260/280 ratio ranging from 1.75 - 2.0. It was also suitable for extracting quality DNA from other members of Meliaceae like Azadirachta indica and Melia azedarach. In downstream applications, the extracted DNA was used for PCr amplification by using ISSr and SSr markers. ISSr PCr conditions were optimized in a reaction volume of 25 μl, consisting of 30 ng of template DNA, 1.5 mM MgCl2, 200 μM of each of dNTPs and 2 U of Taq polymerase. The best amplification was observed and the same was applicable for SSr markers.

关键词： DNA Extraction Downstream Applications ISSr Mature Dried Leaves Melia dubia SSr

A general-purpose material property data extraction pipeline from large polymer corpora using natural language processing

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npj Computational Materials 2023年第1期9卷 1826-1837页

作者： Pranav Shetty arunkumar Chitteth rajan Chris Kuenneth Sonakshi Gupta Lakshmi Prerana Panchumarti Lauren Holm Chao Zhang rampi ramprasad School of Computational Science&Engineering AtlantaGAUSA School of Materials Science and Engineering Georgia Institute of Technology771 Ferst Drive NWAtlanta 30332 GAUSA Department of Metallurgy Engineering and Materials Science Indian Institute of TechnologyIndoreMadhya PradeshIndia

The ever-increasing number of materials science articles makes it hard to infer chemistry-structure-property relations from *** used natural language processing methods to automatically extract material property data from the abstracts of polymer *** a component of our pipeline,we trained MaterialsBErT,a language model,using 2.4 million materials science abstracts,which outperforms other baseline models in three out of five named entity recognition *** this pipeline,we obtained~300,000 material property records from~130,000 abstracts in 60 *** extracted data was analyzed for a diverse range of applications such as fuel cells,supercapacitors,and polymer solar cells to recover non-trivial *** data extracted through our pipeline is made available at *** which can be used to locate material property data recorded in *** work demonstrates the feasibility of an automatic pipeline that starts from published literature and ends with extracted material property information.

关键词： property insight pipeline

Interleukin-6 mediates neutrophil mobilization from bone marrow in pulmonary hypertension

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Cellular & Molecular Immunology 2021年第2期18卷 374-384页

作者： Jonathan Florentin Jingsi Zhao Yi-Yin Tai Sathish Babu Vasamsetti Scott P.O’Neil rahul Kumar Anagha arunkumar Annie Watson John Sembrat Grant C.Bullock Linda Sanders Biruk Kassa Mauricio rojas Brian B.Graham Stephen Y.Chan Partha Dutta Center for Pulmonary Vascular Biology and Medicine Pittsburgh HeartLungBloodand Vascular Medicine InstituteDivision of CardiologyDepartment of MedicineUniversity of Pittsburgh School of MedicineUniversity of Pittsburgh Medical CenterPittsburghPA15213USA Division of Pulmonary and Critical Care Medicine Zuckerberg San Francisco General Hospital and Trauma CenterUniversity of California San FranciscoBuilding 1002nd floor1001 Potrero AveSan FranciscoCAUSA Division of Pulmonary Allergy and Critical Care MedicineUniversity of PittsburghPittsburghPA15261USA Division of Hematopathology Pittsburgh HeartLungBloodand Vascular Medicine Institute University of Pittsburgh School of MedicineUniversity of Pittsburgh Medical CenterPittsburghPA15213USA Department of Medicine Anschutz Medical CampusBuilding RC29th floor12700 E 19th AveAuroraCO80045USA Department of Immunology University of Pittsburgh School of MedicinePittsburghPA15213USA

Myeloid cells,such as neutrophils,are produced in the bone marrow in high quantities and are important in the pathogenesis of vascular diseases such as pulmonary hypertension(PH).Although neutrophil recruitment into sites of inflammation has been well studied,the mechanisms of neutrophil egress from the bone marrow are not well *** computational flow cytometry,we observed increased neutrophils in the lungs of patients and mice with ***,we found elevated levels of IL-6 in the blood and lungs of patients and mice with *** observed that transgenic mice overexpressing Il-6 in the lungs displayed elevated neutrophil egress from the bone marrow and exaggerated neutrophil recruitment to the lungs,resulting in exacerbated pulmonary vascular remodeling,and dysfunctional ***,we found that IL-6-induced neutrophil egress from the bone marrow was dependent on interferon regulatory factor 4(IrF-4)-mediated CX3Cr1 expression in ***,Cx3cr1 genetic deficiency in hematopoietic cells in Il-6-transgenic mice significantly reduced neutrophil egress from bone marrow and decreased neutrophil counts in the lungs,thus ameliorating pulmonary remodeling and *** summary,these findings define a novel mechanism of IL-6-induced neutrophil egress from the bone marrow and reveal a new therapeutic target to curtail neutrophil-mediated inflammation in pulmonary vascular disease.

关键词： neutrophil IL-6 pulmonary hypertension CX3Cr1 inflammation

Malignant peripheral nerve sheath tumor of proximal third tibia

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World Journal of Clinical Oncology 2015年第5期6卷 179-183页

作者： arunkumar rao Sachin B Ingle Pawan rajurkar Vishav Goyal Nikhil Dokrimare Department of Orthopedics Maharashtra Institute of Medical Sciences and ResearchMedical College Department of Pathology Secretary Research and Development and Institutional Review BoardMaharashtra Institute of Medical Sciences and ResearchMedical College

A 16-year-old man had aswelling over the anterior aspect of the proximal third of the tibia for 1 year, which was peanut size initially and progressively increased to its present size of 10 cm × 8 cm. He underwent fine needle aspiration cytology(FNAC) twice during this period and reported aspindle cell sarcoma. Malignant peripheral nerve sheath tumor(MPNST) is a malignancy of the connective tissue surrounding the nerves. Previously, MPNST was also known as neurofibrosarcoma, malignant schwannoma, andneurogenic sarcoma. We are reporting this case for its rarity and peculiar mode of presentation. FNAC/core biopsy can be used as an effective tool to achievethe correct pathological diagnosis.

关键词： Tibial malignant peripheral nerve sheath tumor Fine needle aspiration cytology Histopathology

Microwave-Assisted rapid Extracellular Biosynthesis of Silver Nanoparticles Using Carom Seed (Trachyspermum copticum) Extract and in Vitro Studies

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American Journal of Analytical Chemistry 2011年第4期2卷 475-483页

作者： Deshpande raghunandan Prashant arunkumar Borgaonkar Basawaraj Bendegumble Mahesh Dhondojirao Bedre Mantripragada Bhagawanraju Manjunath Sooganna Yalagatti Do Sung Huh Venkataramana Abbaraju 不详

Microwave-assisted rapid extracellular biosynthesis of silver nanoparticles was carried out by using carom seed (Trachyspermum copticum) extract as the reducing agent. The reaction mixture containing AgNO3 and carom seed extract when exposed to microwave irradiation resulted in reducing silver ions to bio-functionalized silver nanoparticles of size 6- 50 nm. The AgNP were characterized by UV-vis spectroscopy (UV-vis), X-ray diffraction (XrD), energy dispersive X-ray analysis (EDAX), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM) and atomic force microscopy (AFM). Themogravimetric analysis (TGA) and fourier transform infrared spectroscopy (FTIr) are used to understand the possible mechanism of biosynthesis. In this study, we have also investigated the antimicrobial and antioxidant activities of bio-functionalized AgNP. The antibacterial activity is investigated by measuring the zone of inhibition and antioxidant study is done using 1,1-diphenyl-2-picryl hydrazyl (DPPH) method.

关键词： Microwave Silver Nanoparticles Biosynthesis Carom Seed (Trachyspermum copticum) Antibacterial Activity Antioxidant Activity

Endoscopic submucosal dissection of gastric tumors: A systematic review and meta-analysis

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World Journal of Gastrointestinal Endoscopy 2016年第15期8卷 517-532页

作者： Emmanuel Akintoye Itegbemie Obaitan arunkumar Muthusamy Olalekan Akanbi Mayowa Olusunmade Diane Levine Department of Internal Medicine Wayne State University School of Medicine/Detroit Medical Center Department of Emergency Medicine Brigham and Women’s Hospital Department of Internal Medicine Presence Saint Joseph Hospital School of Public Health Harvard University

AIM: To systematically review the medical literature in order to evaluate the safety and efficacy of gastric endoscopic submucosal dissection(ESD).METHODS: We performed a comprehensive literature search of MEDLINE, Ovid, CINAHL, and Cochrane for studies reporting on the clinical efficacy and safety profile of gastric ***: Twenty-nine thousand five hundred and six tumors in 27155 patients(31% female) who underwent gastric ESD between 1999 and 2014 were included in this study. r0 resection rate was 90%(95%CI: 87%-92%) with significant between-study heterogeneity(P rtly explained by difference in region(P = 0.02) and sample size(P = 0.04). Endoscopic en bloc and curative resection rates were 94%(95%CI: 93%-96%) and 86%(95%CI: 83%-89%) respectively. The rate of immediate and delayed perforation rates were 2.7%(95%CI: 2.1%-3.3%) and 0.39%(95%CI: 0.06%-2.4%) respectively while rates of immediate and delayed major bleeding were 2.9%(95%CI: 1.3-6.6) and 3.6%(95%CI: 3.1%-4.3%). After an average follow-up of about 30 mo post-operative, the rate of tumor recurrence was 0.02%(95%CI: 0.001-1.4) among those with r0 resection and 7.7%(95%CI: 3.6%-16%) among those without r0 resection. Overall, irrespective of the resection status, recurrence rate was 0.75%(95%CI: 0.42%-1.3%).CONCLUSION: Our meta-analysis, the largest and most comprehensive assessment of gastric ESD till date, showed that gastric ESD is safe and effective for gastrictumors and warrants consideration as first line therapy when an expert operator is available.

关键词： Endoscopic submucosal dissection Gastric neoplasms Meta-analysis