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Novel insights into m6A modification in circular RNA and implications for immunity

Cellular & Molecular Immunology 2020年第6期17卷 668-669页

作者： arumugam paramasivam Jayaseelan Vijayashree Priyadharsini Saveetha UniversityChennaiIndia

Chemical modifications play an important role in modifying and regulating the functions of coding and noncoding *** RNAs mainly include microRNAs(miRNAs),long noncoding RNAs(lncRNAs),and circular RNAs(circRNAs).A common feature of these noncoding RNAs is that they are all transcribed from the genome and can perform biological ***,the stable expression of noncoding RNAs in vivo makes them potential biomarkers for the diagnosis,prognosis,and clinical treatment of cancers and a variety of immunological diseases.

关键词： immunity diagnosis circular

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Dissecting the theranostic potential of exosomes in autoimmune disorders

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Cellular & Molecular Immunology 2019年第12期16卷 935-936页

作者： Vijayashree Priyadharsini Jayaseelan paramasivam arumugam Biomedical Research Unit and Laboratory Animal Centre-Dental Research Cell Saveetha Dental CollegeSaveetha Institute of Medical and Technical Sciences(SIMATS)Saveetha UniversityChennaiTamil Nadu 600077India

The biology of exosomes is a fascinating field of science that has attracted much attention from clinical researchers due to the plethora of associated *** biological cargoes serve as a hub of information about the health status of a cell or a group of *** reports on exosome-derived biomolecules in relation to diseases such as cancer,neurodegenerative diseases,and infectious diseases have spurred interest in exploring their role in the pathogenesis of other debilitating disease *** research into autoimmune disorders(ADs)in relation to exosome biology has identified novel therapeutic leads aiming to improve the life expectancy of individuals suffering from such disorders.1 One such important,notable contribution was recently shared by Guay et *** provided concreate evidence on the mechanism ofβcell apoptosis induced by the transfer of exosomal miRNAs derived from T cells,which eventually leads to type I diabetes *** crucial mediators of the process were T-lymphocyte-derived exosomes harboring miR-142-3p,miR-142-5p,and ***-miRs designed to block the interactions of miRNAs with their target genes insideβcells prevented the process of apoptosis,eventually rescuingβcells.2 Thus,targeting the mediators of crosstalk or blocking the function of exosomal miRNAs could serve as an interesting therapeutic strategy for type I diabetes mellitus(Fig.1).Consistent with the above report,this review highlights the contribution of exosomes to the development of autoimmune *** addition,this review also reveals the possible“theranostic”markers(therapeutic and diagnostic biomarkers)associated with ADs.

关键词： disorders autoimmune eventually

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Implications of m6A modification in autoimmune disorders

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Cellular & Molecular Immunology 2020年第5期17卷 550-551页

作者： arumugam paramasivam Jayaseelan Vijayashree Priyadharsini Subramanian Raghunandhakumar Saveetha UniversityChennaiIndia Centre for Biotechnology Anna UniversityChennaiIndia

N6-Methyladenosine(m6A)is the most common and abundant modification of RNA molecules,including mRNAs,microRNAs(miRNAs),and long noncoding RNAs(lncRNAs).1 The m6A modification is catalyzed and dynamically regulated by recently discovered enzymes termed“writers”(methyltransferases including METTL3,METTL14,and WTAP),“erasers”(demethylases including FTO and ALKBH5)and“readers”(m6A-binding proteins including YTHDC1,YTHDC2,YTHDF1,YTHDF2,and YTHDF3).These modifications were recently shown to be involved in the regulation of different biological processes.

关键词： autoimmune m6A modification

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Thymoquinone inhibits the migration of mouse neuroblastoma(Neuro-2a) cells by down-regulating MMP-2 and MMP-9

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Chinese Journal of Natural Medicines 2016年第12期14卷 904-912页

作者： arumugam paramasivam Subramanian Raghunandhakumar Jayaseelan Vijayashree Priyadharsini Gopalswamy Jayaraman Department of Genetics Dr. ALM Post Graduate Institute of Basic Medical Sciences University of Madras Sekkizhar campusTaramani Chennai-600113 India Department of Biochemistry University of Madras Guindy Campus Chennai-600025 India

Thymoquinone(TQ), an active component derived from the medial plant Nigella sativa, has been used for medical purposes for more than 2 000 years. Recent studies have reported that TQ blocked angiogenesis in animal model and reduced migration, adhesion, and invasion of glioblastoma cells. We have recently shown that TQ could exhibit a potent cytotoxic effect and induce apoptosis in mouse neuroblastoma(Neuro-2a) cells. In the present study, TQ treatment markedly decreased the adhesion and migration of Neuro-2a cells. TQ down-regulated MMP-2 and MMP-9 protein expression and m RNA levels and their activities. Furthermore, TQ significantly down-regulated the protein expression of transcription factor NF-κB(p65) but not significantly altered the expression of N-Myc. Taken together, our data indicated that TQ's inhibitory effect on the migration of Neuro-2a cells was mediated through the suppression of MMP-2 and MMP-9 expression, suggesting that TQ treatment can be a promising therapeutic strategy for human malignant neuroblastoma.

关键词： Thymoquinone Neuroblastoma Migration NF-κB MMP-2

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