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光学相干断层扫描在监测光动力疗法治疗老年性黄斑变性中的应用

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世界核心医学期刊文摘（眼科学分册） 2005年第12期1卷 6-6页

作者： Salinas-Alamán A Garca-Layana A maldonado M.j 陈立军 Departament of Ophthalmology Clnica Universitaria de Navarra Avda. Po XII 36 31080 Pamplona Spain.Dr

PURPOSE: To evaluate the role of optical coherence tomography (OCT) in determining choroidal neovascularization (CNV) activity before and after photodynamic therapy (PDT)-in patients with age-related macular degeneration (ARMD). DESIGN: Prospective observational case series. METHODS: setting: Institutional study. patient population: Fiftythree patients (62 eyes) with ARMD. observation procedure: Prospective observational case study. main outcome measures: Presence or absence of leakage on fluorescein angiography, presence of intraretinal or sub-retinal fluid on OCT, and macular and choroidal neovascular complex thickness on OCT. RESULTS: The macular thickness decreased significantly after PDT (P=.001). However, no significant changes in CNVthickness were measured after PDT (P=.567). Once the diagnosis of ARMD was established before treatment, OCT had a sensitivity of 96.77% for detecting CNV activity. After treatment, OCT had a good sensitivity (95.65% ) and a moderate specificity (59.01% ) in determining CNV activity, which resulted in a diagnostic efficiency (proportion of correct results) of 82.95% . CONCLUSIONS:OCT appears to be useful for indicating CNV activity. Therefore, it may serve as a complementary technique for deciding the need for PDT and re-treatment in patients with ARMD.

关键词：老年性黄斑变性光动力疗法脉络膜新生血管荧光素渗漏补充诊断诊断效能血管造影复合体前瞻性观察特异度

光学相干断层成像监测病理性近视的光动力疗法

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世界核心医学期刊文摘（眼科学分册） 2006年第10期2卷 16-16页

作者： Garca-Layana A. Salinas-Alamán A. maldonado M.j. 王大江 Department of Ophthalmology Clinica Universitaria de NavarraAvda PoXII3631080 PamplonaSpain

Aim:To evaluate the role of optical coherence tomography(OCT)in determining choroidal neovascularisation(CNV)activity before and after photodynamic therapy(PDT)in patients with pathological ***:33 patients(33 eyes)with pathological myopia and being treated with PDT were *** 3 months all patients were evaluated and presence or absence of leakage on fluorescein angiography,presence of intraretinal or subretinal fluid on OCT,and macular and choroidal neovascular complex thickness on OCT,were determined at each ***:The macular thickness decreased significantly after PDT at 6 months(p=0.001)and at 12 months follow up(p=0.01).However,no significant changes in CNV thickness were measured after PDT at 6 months of follow up(p=0.418)and at 12 months of follow up(p=0.521).Once the diagnosis of CNV associated with pathological myopia was established,before treatment,OCT had a sensitivity of 96.96% for detecting CNV *** treatment,OCT had a good sensitivity(95.23%)and a moderate specificity(69,69%)in determining CNV activity,which resulted in a diagnostic efficiency(proportion of correct results)of 79.62%.Conclusions:OCT appears to be useful for indicating CNV ***,it may serve as a complementary technique for deciding the need for PDT and re-treatment in patients with pathological myopia.

关键词：病理性近视光动力疗法脉络膜新生血管视网膜下液荧光造影诊断效率辅助技术特异性

Cluster Analysis for Political Scientists

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Applied Mathematics 2014年第15期5卷 2408-2415页

作者： Dalson Britto Figueiredo Filho Enivaldo Carvalho da Rocha josé Alexandre da Silva júnior Ranulfo Paranhos Mariana Batista da Silva Bárbara Sofia Félix Duarte Department of Political Science Federal University of Pernambuco Recife Brazil Institute of Social Science Federal University of Alagoas Maceió Brazil

This paper provides an intuitive introduction to cluster analysis. Our targeting audience are both scholars and students in Political Science. Methodologically, we use basic simulation to illustrate the underlying logic of cluster analysis and we replicate data from Coppedge, Alvarez and maldonado (2008)?[1]?to classify political regimes according to Dahl’s (1971)?[2]?polyarchy dimensions: contestation and inclusiveness. With this paper, we hope to help novice scholars to understand and employ cluster analysis in Political Science empirical research.

关键词： Cluster Analysis Q Analysis Political Regimes

阿苯达唑对土源性蠕虫流行社区儿童遗传性过敏症患病率的影响:一项聚类随机试验

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世界核心医学期刊文摘（胃肠病学分册） 2006年第10期2卷 1-1页

作者： Cooper P.j. Chico M.E. Vaca M.G. 王晓君 Laboratorio de Investigaciones Hospital Pedro Vicente MaldonadoPichincha ProvinceEcuador.Dr

Background: Epidemiological studies have shown inverse associations between geohelminth (intestinal helminth) infection and atopy, leading to the suggestion that geohelminths might protect against allergy. Periodic deworming of school children with anthelmintics is a widely implemented intervention and has raised concerns that such programmes could increase allergy. We investigated the effect of repeated anthelmintic treatments with albendazole over 12 months on the prevalence of atopy and clinical indices of allergy. Methods: We did a cluster-randomised controlled trial in schoolchildren from 68 rural schools. Children were randomly assigned by school to either albendazole (34 schools, 1164 children) every 2 months for 12 months, or to no intervention (34 schools, 1209 children). The intervention schools received a total of seven albendazole treatments. The primary outcome was atopy at 12 months (allergen skin-test reactivity), and analysis was by intention-to-treat for whole-school analyses and per protocol for children. This study is registered as an International Standard Randomised Controlled Trial, number ISRCTN61195515. Findings: Data for analysis were available for all schools and from 67.4%(784 of 1164) and 70.1%(848 of 1209) of children in albendazole and no-treatment groups, respectively. Albendazole treatment caused large reductions in geohelminth prevalence over the study period (adjusted odds ratio 0.13, 95%CI 0.09-0.19, p < 0.001), but there was no evidence that treatment was associated with an increase in atopy prevalence (0.97, 0.68-1.39, p=0.862), or clinical allergy (wheeze, 1.07, 0.54-2.11, p=0.848) in the albendazole compared with the no-treatment group. Interpretation: We saw no increase in the prevalence of atopy or clinical allergy associated with albendazole treatment. Deworming programmes for schoolchildren are unlikely to be accompanied by an increase in allergy.

关键词：过敏症土源性蠕虫阿苯达唑社区儿童随机试验对抗作用肠道寄生虫在校儿童皮肤试验乡村学校