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Silicon waveguide cantilever displacement sensor for potential application for on-chip high speed AFM

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Frontiers of Optoelectronics 2018年第1期11卷 53-59页

作者： Peng WANG aron michael Chee Yee KWOK School of Electrical Engineering and Telecommunications University of New South Wales Kensington NSW 2052 Australia

This paper reviews an initial achievement of our group toward the development of on-chip parallel high-speed atomic force microscopy（HS-AFM）.A novel AFM approach based on silicon waveguide cantilever displacement sensor is *** displacement sensing approach uniquely allows the use of nano-scale wide cantilever that has a high resonance frequency and low spring constant desired for on-chip parallel *** approach consists of low loss silicon waveguide with nano-gap,highly efficient misalignment tolerant coupler,novel high aspect ratio（HAR）sharp nano-tips that can be integrated with nano-scale wide cantilevers and electrostatically driven nano-cantilever *** simulation results show that the displacement sensor with optical power responsivity of 0.31%/nm and AFM cantilever with resonance frequency of 5.4 MHz and spring constant of 0.21 N/m are achievable with the proposed *** developed silicon waveguide fabrication method enables silicon waveguide with 6 and 7.5 dB/cm transmission loss for TE and TM modes,respectively,and formation of 13 nm wide nano-gaps between silicon *** coupler demonstrates misalignment tolerance of ±1.8 μm for 5μm spot size lensed fiber and coupling loss of 2.12 dB/facet for standard cleaved single mode fiber without compromising other *** nano-tips with apex radius as small as 2.5 nm and aspect ratio of more than 50 has been enabled by the development of novel HAR nanotip fabrication *** of the HAR tips onto an array of 460 nm wide cantilever beam has also been demonstrated.

关键词： atomic force microscopy (AFM) siliconwaveguide silicon coupler high aspect ratio (HAR) nanotips

Single and bundled carbon nanofibers as ultralightweight and flexible piezoresistive sensors

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npj Flexible Electronics 2020年第1期4卷 82-92页

作者： Debarun Sengupta Ssu-Han Chen aron michael Chee Yee Kwok Sean Lim Yutao Pei Ajay Giri Prakash Kottapalli Department of Advanced Production Engineering(APE) Engineering and Technology Institute Groningen(ENTEG)University of Groningen9747 AG GroningenThe Netherlands School of Electrical Engineering&Telecommunications The University of New South WalesSydneyNSW 2052Australia Mark Wainwright Analytical Center The University of New South WalesSydneyNSW 2052Australia MIT Sea Grant College Program Massachusetts Institute of Technology(MIT)77 Massachusetts AvenueNW98-151CambridgeMA 02139USA

This work demonstrates the application of electrospun single and bundled carbon nanofibers(CNFs)as piezoresistive sensing elements in flexible and ultralightweight ***,electrical,and nanomechanical characterizations were conducted on the CNFs to understand the effect of the critical synthesis parameter—the pyrolyzation temperature on the morphological,structural,and electrical *** mechanism of conductive path change under the influence of external stress was hypothesized to explain the piezoresistive behavior observed in the CNF ***-static tensile strain characterization of the CNF bundle-based flexible strain sensor showed a linear response with an average gauge factor of 11.14(for tensile strains up to 50%).Furthermore,conductive graphitic domain discontinuity model was invoked to explain the piezoresistivity originating in a single isolated electrospun ***,a single piezoresistive CNF was utilized as a sensing element in an NEMS flow sensor to demonstrate air flow sensing in the range of 5-35 m/s.

关键词： bundle fibers conductive

SARS-CoV-2 RBD and Its Variants Can Induce Platelet Activation and Clearance:Implications for Antibody Therapy and Vaccinations against COVID-19

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Research 2024年第3期2023卷 1-15页

作者： Xiaoying Ma Jady Liang Guangheng Zhu Preeti Bhoria aron A.Shoara Daniel T.MacKeigan Christopher J.Khoury Sladjana Slavkovicl Lisha Lin Danielle Karakas Ziyan Chen Viktor Prifti Zhenze Liu Chuanbin Shen Yuchong Li Cheng Zhang Jiayu Dou Zack Rousseau Jiamin Zhang Tiffany Ni Xi Lei Pingguo Chen Xiaoyu Wu Hamed Shaykhalishahi Samira Mubareka Kim AConnelly Haibo Zhang Ori Rotstein Heyu Ni Department of Laboratory Medicine and Pathobiology University of TorontoTorontoONCanada Department of Laboratory Medicine Keenan Research Centre for Biomedical Science of St.Michael’s HospitalTorontoONCanada Toronto Platelet Immunobiology Group TorontoONCanada Department of Physiology University of TorontoTorontoONCanada CCOA Therapeutics Inc. TorontoONCanada Canadian Blood Services Centre for Innovation TorontoONCanada The State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory DiseaseThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Department of Laboratory Medicine The Second Affliated Hospital of Guangzhou University of Chinese MedicineGuangzhouChina Advanced Pharmaceutics&Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoTorontoONCanada Department of Medical Microbiology and Infectious Disease Sunnybrook Health Science CentreToronto ONCanada Department of Medicine University of TorontoTorontoONCanada Division of Cardiology.St.michael's Hospital TorontoONCanada Department of Anesthesiology and Pain Medicine and Division of Critical Care Medicine University of TorontoTorontoONCanada interdepartmental Division of Critical Care Medicine University of TorontoTorontoONCanada Department of Surgery University of Toronto TorontoONCanada.

The COVID-19 pandemic caused by SARS-CoV-2 virus is an ongoing global health *** cases of COVID-19 and the rare cases of COVID-19 vaccine-induced-thrombotic-thrombocytopenia(VITT)are both associated with thrombosis and thrombocytopenia;however,the underlying mechanisms remain inadequately *** infection and vaccination utilize the spike protein receptor-binding domain(RBD)of *** found that intravenous injection of recombinant RBD caused significant platelet clearance in *** investigation revealed the RBD could bind platelets,cause platelet activation,and potentiate platelet aggregation,which was exacerbated in the Delta and Kappa *** RBD–platelet interaction was partially dependent on theβ3 integrin as binding was significantly reduced inβ3−/−***,RBD binding to human and mouse platelets was significantly reduced with relatedαIIbβ3 antagonists and mutation of the RGD(arginine-glycine-aspartate)integrin binding motif to RGE(arginine-glycine-glutamate).We developed anti-RBD polyclonal and several monoclonal antibodies(mAbs)and identified 4F2 and 4H12 for their potent dual inhibition of RBD-induced platelet activation,aggregation,and clearance in vivo,and SARS-CoV-2 infection and replication in Vero E6 *** data show that the RBD can bind platelets partially thoughαIIbβ3 and induce platelet activation and clearance,which may contribute to thrombosis and thrombocytopenia observed in COVID-19 and *** newly developed mAbs 4F2 and 4H12 have potential not only for diagnosis of SARS-CoV-2 virus antigen but also importantly for therapy against COVID-19.

关键词： Antibody diagnosis vaccine

Prolonged impacts of COVID-19-associated cystitis:A study on longterm consequences

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World Journal of Clinical Cases 2023年第33期11卷 7987-7993页

作者： Sophie Wittenberg Jack Vercnocke michael Chancellor Sorabh Dhar aron Liaw Steven Lucas Nivedita Dhar Department of Urology Wayne State University School of MedicineDetroitMI 48201United States Department of Urology Beaumont HospitalRoyal OakMI 48067United States Infectious Disease Wayne State University School of MedicineDetroitMI 48201United States Infectious Disease John D.Dingell VA Medical CenterDetroitMI 48201United States Infectious Disease Detroit Medical CenterDetroitMI 48201United States Department of Urology John D.Dingell VA Medical CenterDetroitMI 48201United States Department of Urology Detroit Medical CenterDetroitMI 48201United States

BACKGROUND The Coronavirus Disease 2019(COVID-19)caused by the severe acute respiratory syndrome coronavirus 2 virus is an international health concern with substantial morbidity and ***-associated cystitis(CAC),presents as new onset or exacerbated urinary symptoms,resembling overactive bladder(OAB)*** To examines the long-term outcomes of patients with CAC in the context of Long *** A cohort of 350 patients admitted to Detroit Hospitals with COVID-19 between May and December 2020,displaying CAC symptoms following discharge,was prospectively *** urologic evaluations occurred at 10-14 wk and were repeated at 21-28 mo *** were managed conservatively,employing behavioral modifications and standard OAB *** completed surveys assessing urinary symptoms and quality of life(QoL)at both time *** primary outcome was the Urology Care Foundation Overactive Bladder Assessment *** 87%of the final cohort(n=310)reported symptom improvement at 21-28 mo *** with new onset CAC symptoms showed a median decrease of 9-10 points in OAB and QoL scores,while those with existing symptoms experienced a decrease of 6 ***,95.4%of patients with new onset symptoms reported symptom improvement at follow-up,contrasting with 60.7%among those with existing *** This study presents the first long-term follow-up of adult patients with CAC,revealing a promising prognosis with conservative management measures in the context of Long *** findings provide reassurance to patients regarding symptom resolution and underscore the need for further research into this evolving aspect of COVID-19's impact on urological health.

关键词： COVID associated cystitis COVID-19 Long COVID Overactive bladder