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Clinical Validation of Cambridge Neuropsychological Test Automated Battery in a Norwegian Epilepsy Population

Journal of Behavioral and Brain science 2012年第1期2卷 108-116页

作者： Johan Torgersen Hans Flaatten Bernt A. Engelsen arne Gramstad Department of Anaesthesiology and Intensive Care Medicine Haukeland University Hospital Bergen Norway Department of Neurology Haukeland University Hospital Bergen Norway Department of Surgical sciences Section for Anaesthesiology and Intensive Care University of Bergen Bergen Norway Faculty of Psychology University of Bergen Bergen Norway

Introduction: Semi-automatic neuropsychological testing has gained a position both in clinical use and in research. Comparison studies with traditional neuropsychological tests are sparse and the role of such semi-automated testing is debated. To integrate semi-automated neuropsychological testing in the established clinical setting the tests must be validated in the patient groups addressed. The aim of this study was to validate Cambridge Neuropsychological Tests Automated Battery (CANTAB) in patients with epilepsy. Material and Methods: Patients scheduled for traditional neuropsychological testing with Category test (CT), Trail Making Test part B (TMT-B), WAIS-III and WMS-R were also asked to complete the CANTAB battery. Our hypothesis was that memory tests from CANTAB (DMS, PAL) would correlate with visual memory tests from WMS-R and that a test of executive functions from CANTAB (SOC) would correlate with functions tested with TMT-B, CT and WAIS-III. Results: scores from DMS correlated strongly with Visual Paired Associations 1 from WMS-R. From SOC results correlated both with Visual Paired Association 1 & 2, General Memory Index and Full scale IQ. Results from PAL correlated with several results from the traditional battery: Verbal, Visual and General Memory Index, Paired Associations, Visual Memory Span Backwards, TmtB and Visual IQ. Conclusion: Our results indicate that DMS primarily tests visual matching to sample. SOC tests executive functions and also depends on non-verbal IQ and memory. Numerous correlations between PAL and traditional tests illustrates that PAL is a complex task depending on several cognitive domains, but mainly memory.

关键词： CANTAB Validation Epilepsy WMS-R WAIS-III TMT-B CT

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Small intestine bleeding due to multifocal angiosarcoma

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World Journal of Gastroenterology 2012年第44期18卷 6494-6500页

作者： Luisa Zacarias Fhrding arne Macher Stefan Braunstein Wolfram Trudo Knoefel Stefan Andreas Topp Department of General Visceral and Pediatric SurgeryHeinrich-Heine-UniversityDüsseldorfMoorenstrasse 540225 DüsseldorfGermany Institute of Pathology Heinrich-Heine-UniversityDüsseldorfMoorenstrasse 540225 DüsseldorfGermany

We report a case of an 84-year-old male patient with primary small intestinal *** patient initially presented with anemia and *** endoscopy revealed no signs of upper or lower active gastrointestinal *** patient had been diagnosed 3 years previously with an aortic dilation,which was treated with a *** tomography suggested an aorto-intestinal fistula as the cause of the intestinal bleeding,leading to operative stent explantation and aortic ***,an aorto-intestinal fistula was not found,and the intestinal bleeding did not arrest *** constant need for blood transfusions made an exploratory laparotomy imperative,which showed multiple bleeding sites,predominately in the jejunal wall.A distal loop jejunostomy was conducted to contain the small intestinal bleeding and a segmental resection for histological evaluation was *** histological analysis revealed a lessdifferentiated tumor with characteristic CD31,cytokeratin,and vimentin expression,which led to the diagnosis of small intestinal ***,the infiltrated part of the jejunum was successfully resected in a subsequent operation,and adjuvant chemotherapy with paclitaxel was *** of the small intestine is an extremely rare malignant neoplasm that presents with bleeding and high *** diagnosis and treatment are essential to improve outcome.A small intestinal angiosarcoma is a challenging diagnosis to make because of its rarity,nonspecific symptoms of altered intestinal function,nonspecific abdominal pain,severe melena,and acute abdominal ***,a quick clinical and histological diagnosis and decisive measures including surgery and adjuvant chemotherapy should be the aim.

关键词： Gastrointestinal bleeding Small intestine Angiosarcoma Small intestinal neoplasm

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Fibroadhesive scarring of grafted collagen scaffolds interferes with implant–host neural tissue integration and bridging in experimental spinal cord injury

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Regenerative Biomaterials 2019年第2期6卷 75-87页

作者： Haktan Altinova Sebastian Hammes Moniek Palm Jose Gerardo-Nava Pascal Achenbach Ronald Deumens Emmanuel Hermans Tobias Fuhrmann arne Boecker Sabien Geraldine Antonia van Neerven Ahmet Bozkurt Joachim Weis Gary Anthony Brook Department of Neurosurgery RWTH Aachen University HospitalAachenGermany Institute of Neuropathology RWTH Aachen University HospitalAachenGermany Police Headquarters Berlin Medical CommissionBerlinGermany Institute of Neuroscience Universite Catholique de LouvainBrusselsBelgium Donnelly Centre for Cellular&Biomolecular Research University of TorontoTorontoCanada Department of Hand- Plastic and Reconstructive SurgeryBurn Centre Trauma CentreBG Trauma Centre LudwigshafenUniversity of HeidelbergLudwigshafenGermany Department of Plastic Reconstructive and Hand SurgeryBurn CentreRWTH Aachen University HospitalAachenGermany Department of Plastic AestheticHand and Burn SurgeryHelios University Hospital WuppertalUniversity Witten/HerdeckeWuppertalGermany

Severe traumatic spinal cord injury(scI)results in a devastating and permanent loss of function,and is currently an incurable *** is generally accepted that future intervention strategies will require combinational approaches,including bioengineered scaffolds,to support axon growth across tissue scarring and cystic ***,we demonstrated that implantation of a microporous type-I collagen scaffold into an experimental model of scI was capable of supporting functional recovery in the absence of extensive implant–host neural tissue ***,we demonstrate the reactive host cellular responses that may be detrimental to neural tissue integration after implantation of collagen scaffolds into unilateral resection injuries of the adult rat spinal *** demonstrated scattered fibroblast-like cell infiltration throughout the scaffolds as well as the presence of variable layers of densely packed cells,the fine processes of which extended along the graft–host *** reactive astroglial or regenerating axonal profiles could be seen traversing this *** encapsulation-type behaviour around bioengineered scaffolds impedes the integration of host neural tissues and reduces the intended bridging role of the *** of the cellular and molecular mechanisms underpinning this behaviour will be pivotal in the future design of collagen-based bridging scaffolds intended for regenerative medicine.

关键词： spinal cord injury CNS-scarring type-I collagen scaffold astrogliosis fibrosis encapsulation

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Redox-Dependent Regulation of the Stress-Induced Zinc-Finger Protein SAP12 in Arabidopsis thaliana

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Molecular Plant 2009年第2期2卷 357-367页

作者： Elke Stroeher Xin-Jia Wang Nils Roloff Peter Klein arne Husemann Karl-Josef Dietz Biochemistry and Physiology of Plants Bielefeld University 33501 Bielefeld Germany

The stress-associated protein SAP12 belongs to the stress-associated protein （SAP） family with 14 members in Arabidopsis thaliana. SAP12 contains two AN1 zinc fingers and was identified in diagonal 2D redox SDS-PAGE as a protein undergoing major redox-dependent conformational changes. Its transcript was strongly induced under cold and salt stress in a time-dependent manner similar to SAP10, with high levels after 6 h and decreasing levels after 24 and 48 h. The tran- script regulation resembled those of the stress marker peroxiredoxin PrxllD at 24 and 48 h. Recombinant SAP12 protein showed redox-dependent changes in quaternary structure as visualized by altered electrophoretic mobility in non-reducing SDS polyacrylamide gel electrophoresis. The oxidized oligomer was reduced by high dithiothreitol concentrations, and also by E. coli thioredoxin TrxA with low dithiothreitol （DTF） concentrations or NADPH plus NADPH-dependent thioredoxin reductase. From Western blots, the SAP12 protein amount was estimated to be in the range of 0.5 ngμg^-1 leaf protein. SAP12 protein decreased under salt and cold stress. These data suggest a redox state-linked function of SAP12 in plant cells particularly under cold and salt stress.

关键词： abiotic/environmental stress cold acclimation cell signaling gene expression Arabidopsis A20 and AN1 Zinc finger domains redox regulation stress associated protein thioredoxin.

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Nutrient activation of Trichoderma fungal spores for improved biocontrol activity

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浙江大学学报（农业与生命科学版） 2004年第4期30卷 401-401页

作者： Linda Gordon Hjeljord arne Tronsmo Department of Chemistry Biotechnology and Food Sciences.Agricultural University of Norway N-1432 s Norway.Department of Chemistry Biotechnology and Food Sciences.Agricultural University of Norway N-1432 s Norway.

The effect of preliminary nutrient activation on the ability of conidia of the antagonist Trichoderma harzianum P1 (ThP1) to suppress Botrytis cinerea was investigated in laboratory, greenhouse and field trials. Preliminary nutrient activation at 21 ℃ accelerated subsequent germination of the antagonist at temperatures from 9 ℃ to 21 ℃; at ≥ 18 ℃ the germination time of preactivated ThP1 conidia did not differ significantly from that of B. cinerea. When coinoculated with B. cinerea, concentrated inocula of preactivated but ungerminated ThP1 conidia reduced in vitro germination of the pathogen by ≥ 87% at 12 ℃ to 25 ℃; initially-quiescent conidia achieved this level of suppression only at 25 ℃. Application of quiescent ThP1 conidia to detached strawberry flowers in moist chambers reduced infection by B. cinerea by ≥85% at 24 ℃, but only by 35% at 12 ℃. Preactivated conidia reduced infection by ≥60% at 12 ℃. Both quiescent and preactivated conidia significantly reduced latent infection in greenhouse-grown strawberries at a mean temperture of 19 ℃, while only preactivated conidia were effective in the field at a mean temperature of 14 ℃ on the day of treatment application. Trichoderma biocontrol isolates are most effective as highly concentrated inocula. Their antagonism to other fungi may be a result of pregermination respiration. In a nutrient-rich medium, almost all Trichoderma. atroviride P1 (P1) conidia initiated germination processes and increased respiration, even in dense suspensions. When 1×107 P1 conidia per mL were coinoculated with 1×105 B. cinerea conidia per mL, dissolved oxygen fell to <1% within 2 h and the pathogen failed to germinate. More dilute P1 suspensions consumed oxygen slowly enough to allow coinoculated B. cinerea to germinate. On nutrient-poor media, fewer P1 conidia initiated germination. Oxygen consumption by the inoculum and inhibition of B. cinerea were enhanced when P1 conidia were nutrient-activated before inoculation. Pregermination r

关键词：营养素活化木霉素真菌孢子生物防治

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Policies and Initiatives for Carbon Neutrality in Nordic Heating and Transport Systems

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Journal of Energy and Power Engineering 2013年第9期7卷 1745-1753页

作者： Qiuwei Wu Jakob Glarbo Moiler Jacob Ostergaard arne Hejde Nielsen CEE (Centre for Electric Power and Energy) Department of Electrical Engineering DTU (Technical University of Denmark) Copenhagen 2800 Denmark

Policies and initiatives promoting carbon neutrality in the Nordic heating and transport systems are presented. The focus within heating systems is the promotion of HPs （heat pumps） while the focus within transport systems is initiatives regarding EVs （electric vehicles）. It is found that the conversion to HPs in the Nordic region relies on both private economic and national economic incentives. Initiatives toward carbon neutrality in the transport system are mostly concentrated on research, development and demonstration for deployment of a large number of EVs. All Nordic countries have plans for the future heating and transport systems with the ambition of realizing carbon neutrality.

关键词： Policies and initiatives carbon neutrality heat pumps electric vehicles.

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看乐高如何玩转客户共创

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商业评论 2024年第1期 109-115页

作者：米凯拉·贝雷塔(Michela Beretta) 利努斯·达兰德(Linus Dahlander) 拉尔斯·弗雷泽里克森(Lars Frederiksen) 阿尔内·托马斯(arne Thomas) 石小竹丹麦奥胡斯大学(Aar-hus University) 欧洲管理技术学院(ESMT) 奥胡斯大学阿姆斯特丹商学院(Amsterdam Business school)

能从顾客创意中获得持续商业回报的企业可谓凤毛麟角.事实上,源自顾客的创意往往是一时新鲜,后续多半难以为继.然而,此类创意一旦成功,就能创造新的收入来源,大大超越内部产生的创意,并在顾客群体当中建立更高的忠诚度——这便解释了众...

能从顾客创意中获得持续商业回报的企业可谓凤毛麟角.事实上,源自顾客的创意往往是一时新鲜,后续多半难以为继.然而,此类创意一旦成功,就能创造新的收入来源,大大超越内部产生的创意,并在顾客群体当中建立更高的忠诚度——这便解释了众多企业领导者为何会孜孜以求地追寻这种创意路径.

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USING THE PROCESS OF DISTILLING DIALOGUES TO UNDERSTAND DIALOGUE SYSTEMS

USING THE PROCESS OF DISTILLING DIALOGUES TO UNDERSTAND DIAL...

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6～(th) International Conference on Spoken Language Processing

作者： Staffan Larsson Lena Santamarta arne Jnsson Department of Linguistics G(?teborg University Box 200 SE-405 30 G(?teborg Sweden Department of Computer and Information science Link(?ping University SE-581 83 Link(?ping Sweden Department of Computer and Information science Link(?ping University SE-581 83 Link(?ping Sweden

＜正＞ Distilled dialogues, i.e. re-written natural dialogues, are a useful complement to dialogues collected in Wizard of Oz-experiments or in natural settings for development of dialogue systems. However, the distillation process itself also provides insights on human-computer interaction and on properties of dialogue systems. In this paper we present the distillation process, including how the guidelines are developed, and experiences from utilising distillation.

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Improvement of warm formability of Al-Mg sheet alloys containing coarse second-phase particles

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中国科学:技术科学 2010年第4期40卷 434-434页

作者： arne K DAHLE Amit K GHOSH Materials Engineering University of Queensland Department of Materials science and Engineering University of Michigan

Several alloying elements involving Zr,Cu,Zn and sc were added to Al-Mg sheet alloys in order to obtain an excellent combination of high strength and good high-temperature *** examination showed that coarse intermetallic particles were formed in the microstructure and their amounts changed with variations of the alloying elements. During warm rolling of thermomechanical treatments prior to warm deformation,the coarse particles initiated cracks,decreasing the warm *** healing the crack damage and further improving the warm formability,a process of hot isothermal press was developed and optimized to the sheet *** this process,the biaxial stretch formability at 350°C was improved by 22%for an aluminum alloy containing a large amount of coarse particles.

关键词： aluminum alloy microstructure second-phase particle hot isothermal press high-temperature formability

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眶部骨膜下区疾病的高分辨磁共振影像学表现

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中华眼科杂志 2005年第1期4卷 68-71页

作者：周全黄力刘斯润 arne-Jrn Lemke 暨南大学附属第一医院影像中心广州510632 Department

眶部体积小、解剖复杂,具有精细功能,眼眶部疾病常会引起严重的临床问题[1].影像学检查对眶部疾病的诊断和鉴别诊断起重要作用.高分辨MRI(HR-MRI)对眶部软组织有良好分辨力,且无放射性损伤,已成为一种被广泛接受的眶部检查方法.眶部的... 详细信息

眶部体积小、解剖复杂,具有精细功能,眼眶部疾病常会引起严重的临床问题[1].影像学检查对眶部疾病的诊断和鉴别诊断起重要作用.高分辨MRI(HR-MRI)对眶部软组织有良好分辨力,且无放射性损伤,已成为一种被广泛接受的眶部检查方法.眶部的分区模式对于眶部疾病鉴别诊断起关键作用。

关键词：骨膜疾病磁共振影像诊断放射性损伤临床问题眼眶关键作用重要作用模式

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