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Future for inertial-fusion energy in Europe:a roadmap

High Power Laser Science and Engineering 2023年第6期11卷 162-192页

作者： Dimitri Batani arnaud Colaitis Fabrizio Consoli Colin N.Danson Leonida Antonio Gizzi Javier Honrubia Thomas Kühl Sebastien Le Pape Jean-Luc Miquel Jose Manuel Perlado R.H.H.Scott Michael Tatarakis Vladimir Tikhonchuk Luca Volpe Centre Lasers Intenses et Applications(CELIA) Universitéde Bordeaux±CNRS±CEATalence cedexFrance ENEA Fusion and Technology for Nuclear Safety and Security DepartmentC.R.FrascatiFrascatiItaly AWE AldermastonReadingUK Centre for Inertial Fusion Studies Blackett LaboratoryImperial College LondonLondonUK Istituto Nazionale di Ottica Consiglio Nazionale delle Ricerche(CNR-INO)PisaItaly ETSIAE Universidad Politecnica de Madrid MadridSpain GSI-Helmholtzzentrum für Schwerionenforschung GmbH DarmstadtGermany Laboratoire pour l’Utilisation des Lasers Intenses(LULI) CNRS±Ecole PolytechniquePalaiseau cedexFrance ALP Le BarpFrance and CEA/DAMÎle de FranceBruyères le ChâtelArpajon cedexFrance Instituto Fusión NuclearªGuillermo Velardeº(IFN-GV) Universidad Politecnica de MadridMadridSpain Central Laser Facility STFC Rutherford Appleton LaboratoryHarwell OxfordOxfordshireUK Institute of Plasma Physics and Lasers University Research and Innovation CentreHellenic Mediterranean UniversityRethymnoCreteGreece Department of Electronic Engineering School of EngineeringHellenic Mediterranean UniversityChaniaCreteGreece Extreme Light Infrastructure ERIC ELI-Beamlines FacilityDolníBÏrežanyCzech Republic Centro de Laseres Pulsados(CLPU) Parque CientificoVillamayorSalamancaSpain

The recent achievement of fusion ignition with laser-driven technologies at the National Ignition Facility sets a historic accomplishment in fusion energy *** accomplishment paves the way for using laser inertial fusion as a viable approach for future energy *** has a unique opportunity to empower research in this field internationally,and the scientific community is eager to engage in this *** propose establishing a European programme on inertial-fusion energy with the mission to demonstrate laser-driven ignition in the direct-drive scheme and to develop pathway technologies for the commercial fusion *** proposed roadmap is based on four complementary axes:(ⅰ)the physics of laser-plasma interaction and burning plasmas;(ⅱ)high-energy high repetition rate laser technology;(ⅲ)fusion reactor technology and materials;and(ⅳ)reinforcement of the laser fusion community by international education and training *** foresee collaboration with universities,research centres and industry and establishing joint activities with the private sector involved in laser *** project aims to stimulate a broad range of high-profile industrial developments in laser,plasma and radiation technologies along with the expected high-level socio-economic impact.

关键词： education and training fusion reactor technology high-energy laser high repetition rate laser inertial confinement fusion laser-plasma interaction public-private partnership radiation resistant materials

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A Myosin XI Tail Domain Homologous to the Yeast Myosin Vacuole-Binding Domain Interacts with Plastids and Stromules in Nicotiana benthamiana

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Molecular Plant 2009年第6期2卷 1351-1358页

作者： Amir Sattarzadeh Johanna Krahmer arnaud D. Germain Maureen R. Hanson Department of Molecular Biology and Genetics Biotechnology Building Cornell University Ithaca NY 14853 USA

The actin cytoskeleton plays a role in mobility of many different organelles in plant cells, including chloroplasts, mitochondria, Golgi, and peroxisomes. While progress has been made in identifying the myosin motors involved in trafficking of various plant organelles, not all of the cargoes mobilized by different members of the myosin XI family have yet been identified. The involvement of myosins in chloroplast positioning and mitochondrial movement was demonstrated by expression of a virus-induced gene silencing （VIGS） construct in tobacco. When VIGS with two different conserved sequences from a myosin Xl motor was performed in plants with either GFP-labeled plastids or mitochondria, chloroplast positioning in the dark was abnormal, and mitochondrial movement ceased. Because these and prior obser- vations have implicated a role for myosins and the actin cytoskeleton in plastid and stromule movement, we searched for myosin tail domains that could associate with plastids and stromules. While a yellow fluorescent protein （YFP） fusion with the entire tail region of myosin XI-F was usually found only in the cytoplasm, we observed that an Arabidopsis or Nicotiana benthamiana YFP：：myosin XI-F tail domain homologous to the yeast myo2p vacuole-binding domain associated with plastids and stromules after transient expression in N. benthamiana. Taken together, these observations implicate myosin motor proteins in dynamics of plastids and stromules.

关键词： Chloroplast biology cytoskeleton dynamics mitochondria gene silencing fluorescent protein.

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Structure of the Panzhihua intrusion and its Fe-Ti-V deposit,China

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Geoscience Frontiers 2013年第5期4卷 571-581页

作者： arnaud Pecher Nicholas Arndt Alexander Jean Arthur Bauville Clement Ganino Charlotte Athurion ISTerre Universite Joseph Fourier de GrenobleCNRS1381 rue de la Piscine38400 Saint Martin d'HeresFrance Geoazur Universite de Nice-Sophia AntipolisCNRS/IRDParc Valrose06108 NiceFrance

The Panzhihua intrusion in southwest China is part of the Emeishan large igneous province and host of a large Fe-Ti-V ore *** previous interpretations it was considered to be a layered,differentiated sill with the ore deposits at its *** structural and petrological data suggest instead that the intrusion has an open S-shape,with two near-concordant segments joined by a discordant dyke-like segment. During emplacement of the main intrusion,multiple generations of mafic dykes invaded carbonate wall rocks,producing a large contact *** the central segment,magmatic layering is oriented oblique to the walls of the *** layering cannot have formed by crystal settling or in-situ growth on the floor of the intrusion;instead we propose that it resulted from inward solidification of multiple,individually operating,convection *** formation was triggered by interaction of magma with carbonate wall rocks.

关键词： Fe-Ti-V deposit Intrusion Structure Skarn Tectonics

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The Mérieux Chinese Research Network in Wuhan: the 4th Chapter of a Success Story

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Virologica Sinica 2013年第3期28卷 127-128页

作者： arnaud Favry Jiali Si Institut Mérieux bioMérieux Beijing Office Wuhan Institute of Virology Chinese Academy of Sciences

On April 17-18th 2013, the 4th meeting of the Mérieux Chinese Research Network was held in Wuhan, an event organized by Institut Mérieux, together with the Wuhan Institute of Virology, Chinese Academy of Sciences, Huangzhong University of Science and Technology, and the Chinese Society for *** Mérieux Chinese Research Network connects a community of high level scientists with a portfolio of innovative projects,

关键词：中国科学技术大学武汉病毒研究所中国微生物学会故事网络梅科学院

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A data fusion-based framework to integrate multi-source VGI in an authoritative land use database

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International Journal of Digital Earth 2021年第4期14卷 480-509页

作者： Lanfa Liu Ana-Maria Olteanu-Raimond Laurence Jolivet arnaud-le Bris Linda See LASTIG Univ Gustave EiffelENSGIGNSaint-MandeFrance International Institute for Applied Systems Analysis(IIASA) LaxenburgAustria

Updating an authoritative Land Use and Land Cover(LULC)database requires many *** geographic information(VGI)involves citizens in the collection of data about their spatial *** is a growing interest in using existing VGI to update authoritative *** paper presents a framework aimed at integrating multi-source VGI based on a data fusion technique,in order to update an authoritative land use *** VGI data source is considered to be an independent source of information,which is fused together using Dempster-Shafer Theory(DST).The framework is tested in the updating of the authoritative land use data produced by the French National Mapping *** data sets were collected from several in-situ and remote campaigns run between 2018 and 2020 by contributors with varying *** data fusion approach achieved an overall accuracy of 85.6%for the 144 features having at least two contributions when the confidence threshold was set to *** the heterogeneity and limited amount of VGI used,the results are promising,with 99%of the LU polygons updated or *** results show the potential of using multi-source VGI to update or enrich authoritative LU data and potentially LULC data more generally。

关键词： Data fusion DempsterShafer Theory land use OCSGE volunteered geographic information

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PHProteomicDB:A Module for Two-dimensional Gel Electrophoresis Database Creation on Personal Web Sites

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Genomics, Proteomics & Bioinformatics 2006年第2期4卷 134-136页

作者： Pascal Pernet arnaud Bruneel Bruno Baudin Michel Vaubourdolle Service de Biochimie A Hpital Saint-Antoine 75012 Paris France.

PHProteomicDB is a PHP-written module to help researchers in proteomics to share two-dimenslonal gel electrophoresis data using personal web sites. No technical or PHP knowledge is necessary except a few basics about web site management. PHProteomicDB has a user-friendly administration interface to enter and update data. It creates web pages on the fly displaying gel characteristics, gel pictures, and numbered gel spots with their related identifications pointing to their reference pages in protein databanks. The module is freely available at http：//***/***3？rub=Download.

关键词： proteome two-dimensional gel electrophoresis database web tool

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Experimental and Numerical Study of Mechanical Behaviour of Fired Clay Bricks after Exposure to High Temperatures

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Journal of Minerals and Materials Characterization and Engineering 2023年第5期11卷 143-160页

作者： Jean Calvin Bidoung Léon arnaud Mpoung Jean Aimé Mbey Jean Raymond Lucien Meva’a Laboratory of Civil Engineering and Mechanics National Advanced School of Engineering of Yaoundé University of Yaoundé 1 Yaoundé Cameroon Laboratory of Applied Inorganic Chemistry Department of Inorganic Chemistry University of Yaoundé 1 Yaoundé Cameroon

This paper reports the modeling of residual compressive strength of fired clay bricks submitted to elevated temperature. Five formulations were used and the explored temperatures were 95˚C, 200˚C, 550˚C, 700˚C and 950˚C. The stress–strain relationships and the mechanical properties (including Young’s modulus and compressive strength) were assessed using a uniaxial compressive strength machine. A proposed model equation was established and found satisfying. The elastic modulus was evaluated and tested with one existing model together with two proposed models. The proposed model was both satisfying and even more precise than the existing one. The overall results show that the effect of temperature on the mechanical properties of clays can be accurately described through the definition of thermal damage using elastic modulus.

关键词： Clay Bricks Modeling Stress-Strain Equations Compressive Strength Young’s Modulus

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关于大坝环境影响评价中气候变化风险分析的文献综述

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环境影响评价 2022年第5期44卷 I0003-I0010页

作者： Ana Rita arnaud Loza Teresa Fidélis 吴成志(译) 刘芷舟(译) 阿威罗大学环境与规划系阿威罗葡萄牙 GOVCOPP 阿威罗大学环境与规划系阿威罗葡萄牙三捷环境工程咨询(杭州)有限公司

气候变化是当前社会关注的一个问题,其后果在全球范围内的感知日渐强烈。除了国家领土和社区外,水坝等大型基础设施也可能容易受到气候变化的影响,且需要能够抵御相关影响。因此,在批准这些大型基础设施项目时,应对与其相关的气候变化... 详细信息

气候变化是当前社会关注的一个问题,其后果在全球范围内的感知日渐强烈。除了国家领土和社区外,水坝等大型基础设施也可能容易受到气候变化的影响,且需要能够抵御相关影响。因此,在批准这些大型基础设施项目时,应对与其相关的气候变化风险进行全面评估。一些国际指南建议将气候变化风险评估纳入环境影响评价(EIA)过程。若干国家相应更新的EIA法规也体现了这一点。基于对过去20年发表的科学文献的系统回顾,本文探讨了科学界如何将气候变化风险纳入大坝环境影响评价中。调查结果表明,EIA在应对气候变化风险方面的潜力得到了广泛认可。然而,针对风险评估分析如何被纳入大坝EIA当前实践的系统研究却很少。这一差距表明围绕该主题具有研究潜力和研究机会。

关键词：气候变化水坝环境影响评价

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Impact of sarcopenia on tumor response and survival outcomes in patients with hepatocellular carcinoma treated by trans-arterial (chemo)-embolization

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World Journal of Gastroenterology 2022年第36期28卷 5324-5337页

作者： Gael Roth Yann Teyssier Maxime Benhamou Mélodie Abousalihac Stefano Caruso Christian Sengel Olivier Seror Julien Ghelfi arnaud Seigneurin Nathalie Ganne-Carrie Elia Gigante Lorraine Blaise Olivier Sutter Thomas Decaens Jean-Charles Nault Univ.Grenoble-Alpes Grenoble 38058France Department of Hepatology Gastroenterology and Digestive OncologyCHU Grenoble AlpesGrenoble 38043France Institute for Advanced Biosciences INSERM U1209/CNRS UMR 5309Grenoble 38043France Department of Radiology CHU Grenoble AlpesGrenoble 38043France Department of Radiology CHU Avicenne-APHPBobigny 93000France Functional Genomics of Solid Tumors Laboratory Centre de Recherche des Cordeliers-INSERM UMR 1138InsermUniversitéParisParis 75006France Unitéde Formation et de Recherche SantéMédecine et Biologie Humaine UniversitéParis NordParis 93430France Service d'Epidémiologie et Evaluation Médicale CHU Grenoble AlpesGrenoble 38043France Department of Hepatology CHU Avicenne-APHPBobigny 93000France

BACKGROUND At the diagnosis of hepatocellular carcinoma(HCC),more than 90%of HCC patients present cirrhosis,a clinical condition often associated to *** is an indirect marker of malnutrition assessable on computed tomography(CT).AIM To evaluate the prognostic value of sarcopenia in patients with HCC treated by trans-arterial(chemo)-*** Patients with HCC treated by a first session of trans-arterial(chemo)embolization and an available CT scan before treatment were *** was assessed using skeletal muscle index at baseline and at the first radiological *** response was recorded after the first session of treatment using *** Of 225 patients treated by trans-arterial bland embolization(n=71)or trans-arterial chemoembolization(n=154)for HCC between 2007 and 2013,Barcelona Clinic of Liver Cancer stage was A,B,and C in 27.5%,55%,and 16.8%of cases,*** was present in 57.7%of the *** with sarcopenia presented a higher rate of progressive disease(19%vs 8%,P=0.0236),a shorter progression-free survival(8.3 vs 13.2 mo,P=0.0035),and a shorter median overall survival(19.4 mo vs 35.5 mo,P=0.0149)compared with non-sarcopenic ***,patients whose sarcopenia appeared after first transarterial treatment had the worst prognosis(P=0.0004).CONCLUSION Sarcopenia is associated with tumor progression and poor survival outcomes after trans-arterial(chemo)-embolization for HCC.

关键词： Hepatocellular carcinoma Transarterial chemoembolization Bland embolization Sarcopenia Skeletal muscle index

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Pilot Study on the Intercalibration of a Categorisation System for FAIRer Digital Objects Related to Sensitive Data in the Life Sciences

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Data Intelligence 2022年第2期4卷 196-211页

作者： Christian Ohmann Romain David Mónica Cano Abadia Florence Bietrix Jan-Willem Boiten Steve Canham Maria Luisa Chiusano Walter Dastrù arnaud Laroquette Dario Longo Michaela Theresia Mayrhofer Maria Panagiotopoulou Audrey Richard Pablo Emilio Verde European Clinical Research Infrastructure Network (ECRIN) 2. European Research Infrastructure on Highly Pathogenic Agents (ERINHA AISBL) 3. Biobanking and Biomolecular Resources Research Infrastructure (BBMRI) 4. European Infrastructure for Translational Medicine (EATRIS) 5. European Advanced Translational Research Infrastructure (EATRIS)/Lygature European Marine Biological Resource Centre (EMBRC)—Department of Agricultural Sciences University Federico II of Naples via Università Department of Molecular Biotechnology and Health Sciences Molecular Imaging Center University of Torino European Marine Biological Resource Centre (EMBRC) 9. European Research Infrastructure for Biological and Biomedical Imaging (Euro-Bio Imaging) Coordination Centre for Clinical Trials Heinrich Heine University Düsseldorf Ringgold standard institution

Sharing sensitive data is a specific challenge for research infrastructures in the field of life sciences. For that reason a toolbox has been developed, providing resources for researchers who wish to share and use sensitive data, to support the workflows for handling these kinds of digital objects. Common and community approved annotations are required to be compliant with FAIR principles(Findability, Accessibility,Interoperability, Reusability). The toolbox makes use of a tagging(categorisation) system, allowing consistent labelling and categorisation of digital objects, in terms relevant to data sharing tasks and activities. A pilot study was performed within the Horizon 2020 project EOSC-Life, in which 2 experts from 6 life sciences research infrastructures were recruited to independently assign tags to the same set of 10 to 25 resources related to sensitive data management and data sharing(in total 110). Summary statistics of agreement and observer variation per research infrastructure are provided. The pilot study has shown that experts were able to attribute tags but in most cases with a considerable observer variation between experts. In the context of CWFR(Canonical Workflow Frameworks for Research), this indicates the necessity for careful definition,evaluation and validation of parameters and processes related to workflow descriptions. The results from this pilot study were used to tackle this issue by revising the categorisation system and providing an updated version.

关键词： Categorisation system CWFR EOSC-Life FAIR Life sciences Sensitive data Tagging Toolbox

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