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世界核心医学期刊文摘（妇产科学分册） 2005年第3期1卷 42-43页

作者： judson P.l. jonson A.l. Paley P.j. 成健

Based on the reduced morbidity seen in our retrospective study, we undertook a prospective, randomized trial to determine whether transposition of the sartorius muscle improves postoperative morbidity in women with squamous cell carcinoma of the vulva undergoing inguinal- femoral lymphadenectomy. Patients with squamous carcinoma of the vulva requiring inguinal- femoral lymphadenectomywere randomized to undergo sartorius transposition or not. All patients received perioperative antibiotics, DVT prophylaxis, and closed suction surgical site drainage. Outcomes assessed include wound cellulitis, wound breakdown, lymphocyst formation, lymphedema, and/or rehospitalization. Cohorts were compared using Fisher’ s exact test. Baseline characteristics were compared using Student’ s t test or Fischer’ s exact test as appropriate. logistic regression was used to assess the impact of sartorius trans position, after adjusting for other factors. From june 1996 to December 2002, 61 patients underwent 99 inguinal- femoral lymphadenectomies, 28 with sartorius transposition, and 33 without. The mean (SD) age for controls and patients undergoing sartorius transpositionwas 63.5 (15.2) and 73.8 (13.7) years, respectively (P lly significant differences in BSA, tobacco use, co- morbid medical conditions, past surgical history, medication use, size of incision, duration of surgery, number of positive lymph nodes, pathologic stage, pathologic grade, pre- or postoperative hemoglobin, or length of hospitalization. Therewere no statistically significant differences in the incidence of wound cellulitis, wound breakdown, lymphedema, or rehospitalization. The incidence of lymphocyst formation was increased in the sartorius transposition group. After adjusting for age, however, the groups appeared similar. Sartorius transposition after inguinal- femoral lymphadenectomy does not reduce postoperative wound morbidity.

关键词：淋巴结切除术缝匠肌移位术随机研究淋巴囊肿淋巴水肿鳞癌患者前瞻性随机试验阳性淋巴结女性外阴

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肾损伤病人经导管主动脉瓣置换术前应用纳米氧化铁增强MR血管成像进行血管成像:迈向病人特殊护理的一步

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国际医学放射学杂志 2018年第2期 222-223页

作者： K.l.Nguyen j.M.Moriarty A.N.Plotnik O.Aksoy T.Yoshida R.j.Shemin 邹繁洁 Diagnostic Cardiovascular Imaging laboratory David Geffen School of Medicine at UCLA

摘要目的评估肾损伤病人经导管主动脉瓣置换术前应用纳米氧化铁增强MR血管成像(FE MRA)进行血管成像的可行性。材料与方法本研究经伦理委员会批准并符合

关键词：经导管主动脉瓣置换术血管成像肾损伤 MR 氧化铁

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超声触发微泡破裂增强肝细胞肝癌对经动脉放射栓塞治疗反应的随机临床试验

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国际医学放射学杂志 2021年第2期44卷 237-238页

作者： j.R.Eisenbrey F.Forsberg C.E.Wessner l.j.Delaney K.Bradigan S.Gummadi 朱海涛

摘要充满气体的微泡(MB)超声对比剂可在外部超声波作用下原位破裂。在临床前模型中,超声触发的MB破裂即UTMD,已被证实可以通过对血管内皮细胞的局部损伤增

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Novel polysaccharide-protein conjugates provide an immunogenic 13-valent pneumococcal conjugate vaccine for ***

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Synthetic and Systems Biotechnology 2017年第1期2卷 49-58页

作者： Allison E.B.Turner jonas E.Gerson Helen Y.So Daniel j.Krasznai Adrienne j.St.Hilaire Donald F.Gerson Vaccine Research and Development PnuVax Incorporated Headquarters134 Albert St.KingstonOntarioK7L 3V2Canada Vaccine Research and Development PnuVax Incorporated Laboratories6000 Royalmount Ave.MontrealQuebecH4P 2T1Canada

Pneumonia remains the single leading cause of childhood death *** the commercial availability of multiple pneumococcal conjugate vaccines(PCVs),high dosage cost and supply shortages prevent PCV delivery to much of the developing *** current work presents high-yield pneumococcal conjugates that are immunogenic in animals and suitable for use in human vaccine *** 13-valent pneumococcal conjugate vaccine(PCV-13)investigated in this research incorporated serotypes 1,3,4,5,6A,6B,7F,9V,14,18C,19A,19F,and *** polysaccharides(PnPSs)and CRM197 carrier protein were produced and purified in-house,and used to prepare PnPS-CRM conjugates using unique,cyanide-free,in vacuo glycation conjugation *** vitro characterization confirmed the generation of higher molecular weight PnPS-CRM conjugates low in free *** vivo animal studies were performed to compare PnuVax's PCV-13 to the commercially available PCV-13,Prevnar®13(Pfizer,USA).A boost dose was provided to all groups post-dose 1 at t?14 ***-dose 2 results at t?28 days showed that all 13 serotypes in PnuVax's PCV-13 were *** serotype IgG GMCs demonstrated that PnuVax's PCV-13 is immunogenic for all 13 serotypes,with 10 of the 13 serotypes statistically the same or higher than Prevnar®13 post-dose *** a result,the novel polysaccharideprotein conjugates developed in this work are highly promising for use in human PCV *** in vacuo conjugation technique applied in this work could also be readily adapted to develop many other conjugate vaccines.

关键词： Pneumonia Vaccine development PCV Pneumococcal conjugate vaccine Polysaccharide Carrier protein In vacuo glycation

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Ⅳ期神经母细胞瘤患者的远期预后

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世界核心医学期刊文摘（儿科学分册） 2006年第9期2卷 22-23页

作者： Escobar M.A. Grosfeld j.l. Powell R.l. 刘凯 Department of Surgery Indiana University School of MedicineJWRiley Hospital for ChildrenIndianapolisIN 46202United States

Aim of Study: long-term outcome studies in survivors with stage IV neuroblastoma (NB) are sparse. This review evaluates late complications and long-term outcomes in stage IV NB survivors. Methods: A retrospective review of stage IV NB survivors was performed to analyze outcomes,including longterm morbidity,recurrence,and survival. Main Results: Of 153 patients with stage IV NB,52 (34% ) survived (male-female,26:26). Age at diagnosis was 29.1 ± 31.7 months in survivors. Eighteen were 1 year or younger and 34 were older than 1 year compared with 10 nonsurvivors 1 year or younger and 91 older than 1 year (P = 0.0003,Fisher’ s Exact test). Primary tumor sites were adrenal (35),retroperitoneal (11),mediastinal (3),pelvic (2),and no primary with tumor metastases identified (1). Ten survivors had favorable and 16 had unfavorable histology compared with 1 favorable and 18 unfavorable in nonsurvivors (P = 0.01). Four survivors had MYCN amplification (≥ 10 copies) and 2 deletions of 1p and 11q. Sites of metastasis in survivors and nonsurvivors were similar. Treatment in survivors included surgery in 51 (75% [39/51] complete tumor resection [CTR]); chemotherapy,50; radiation,17; stem cell transplantation,20; and bone marrow transplant,1. In nonsurvivors,13 (25% ) of 53 (Pll transplantation,and 12 bone marrow transplant. Six patients had tumor recurrence but survived (mean,9.3 ± 8.3 years; range,6 months-24 years). Recurrence was local (1),distant (2),and both (3) and was treated by resection,chemotherapy,and radiation. The mean age of survivors was 12.4 ± 8.3 years (range,2-34 years). In all stage IV cases,event-free survival was 30% and overall survival was 34% . long-term complications occurred in 23 (44% ) survivors,including endocrine disturbances (7),orthopedic (5),cataracts (2),adhesive bowel obstruction (2),hypertension (1),bronchiolitis (1),blindness (1),peripheral neuropathy (1),nonfunctioning kidney (1),cholelithiasis (1),and thyroid nodul

关键词：神经母细胞瘤存活者原发肿瘤肿瘤复发骨髓移植晚期并发症组织分型复发率细支气管炎生存者

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long-range optical trapping and binding of microparticles in hollow-core photonic crystal fibre

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light(Science & Applications) 2018年第1期7卷 865-871页

作者： Dmitry S.Bykov Shangran Xie Richard Zeltner Andrey Machnev Gordon K.l.Wong Tijmen G.Euser Philip St.j.Russell Max Planck Institute for the Science of light Staudtstr.291058 ErlangenGermany Department of Physics University of Erlangen-Nuremberg91058 ErlangenGermany NanoPhotonics Centre Cavendish LaboratoryUniversity of CambridgeCambridge CB30HEUK

Optically levitated micro-and nanoparticles offer an ideal playground for investigating photon–phonon interactions over macroscopic *** we report the observation of long-range optical binding of multiple levitated microparticles,mediated by intermodal scattering and interference inside the evacuated core of a hollow-core photonic crystal fibre(HC-PCF).Three polystyrene particles with a diameter of 1μm are stably bound together with an inter-particle distance of~40μm,or 50 times longer than the wavelength of the trapping *** levitated boundparticle array can be translated to-and-fro over centimetre distances along the *** evacuated to a gas pressure of 6 mbar,the collective mechanical modes of the bound-particle array are able to be *** measured interparticle distance at equilibrium and mechanical eigenfrequencies are supported by a novel analytical formalism modelling the dynamics of the binding *** HC-PCF system offers a unique platform for investigating the rich optomechanical dynamics of arrays of levitated particles in a well-isolated and protected environment.

关键词： optical scattering fibre

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Smelling fit： scent marking exposes parasitic infection status in the banded mongoose

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Current Zoology 2017年第3期63卷 237-247页

作者： jessica MITCHEll Michael A. CANT Emma I.K. VITIKAINEN Hazel j. NICHOlS School of Natural Sciences and Psychology Liverpool John Moores University Liverpool L3 AF UK Centrefor Ecology and Conservation University of Exeter Penryn Campus TRIO 9FE UK

Preference for uninfected mates is presumed beneficial as it minimizes one＇s risk of contracting an infection and infecting one＇s offspring. In avian systems, visual ornaments are often used to indi- cate parasite burdens and facilitate mate choice. However, in mammals, olfactory cues have been proposed to act as a mechanism allowing potential mates to be discriminated by infection status. The effect of infection upon mammalian mate choice is mainly studied in captive rodents where ex- perimental trials support preference for the odors of uninfected mates and some data suggest scent marking is reduced in individuals with high infection burdens. Nevertheless, whether such effects occur in nonmodel and wild systems remains poorly understood. Here, we investigate the interplay between parasite load （estimated using fecal egg counts） and scent marking behavior in a wild population of banded mongooses Mungos mungo. Focusing on a costly protozoan parasite of the genus Isospora and the nematode worm Toxocara, we first show that banded mongooses that engage in frequent, intensive scent marking have lower Isospora loads, suggesting marking behavior may be an indicator trait regarding infection status. We then use odor presentations to demonstrate that banded mongooses mark less in response to odors of opposite sexed individuals with high Isospora and Toxocara loads. As both of these parasites are known to have detrimental effects upon the health of preweaned young in other species, they would appear key targets to avoid during mate choice. Results provide support for scent as an important ornament and mechanism for advertising parasitic infection within wild mammals.

关键词： Isospora olfaction parasite scent scent preferences Toxocara.

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结合较小淋巴结的大小和轴向比来提高CT检出食管癌淋巴结转移的敏感性

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国际医学放射学杂志 2018年第2期 237-238页

作者： j.F.liu Z.Wang H.F Shao D.Qu j.liu l.B.Yao 王宗英 National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

摘要目的评价结合较小淋巴结(lN)的大小和轴向比提高CT对食管鳞状细胞癌(QSCC)局灶性淋巴结转移诊断敏感性的价值。方法回顾性分析204例QSCC病人多层螺

关键词：淋巴结敏感性 CT

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A Novel Bacillus thuringiensis strain llB6 and its new gene

A Novel Bacillus thuringiensis strain LLB6 and its new gene

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第十届全国杀虫微生物学术研讨会暨全国生物农药与化学生物学研究与产业化会议

作者： l.l. Zhang, C.Y. Guan, j. lin, l.lan Key laboratory of Biopesticide and Chemical Biology, Ministry of Education, Fujian Agricultural and Forestry University, Fuzhou 350002, People’s Republic of China

A novel Bacillus thuringiensis named llB6 was isolated in Wuyi Mountain of China, and it was characterized by scanning electron microscopy as a mixture of round and bipyramidal crystals. Bioassays indicated that llB6 was toxic Aedes albopictus (Diptera), a vector of dengue. Cry2 gene was detected by PCR with novel general and specific primers for cry and cyt genes encoding proteins active against mosquitoes and a new genenamed cry2Ac5 by the Bacillus

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金属硬掩膜打开工艺中的CD偏差负载控制

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功能材料与器件学报 2013年第6期19卷 308-311,307页

作者： D.j.Wang M.D.Hu j.Q.Zhou C.l.Zhang H.Y.Zhang X.P.Wang Semiconductor Manufacturing International Corporation

本文系统地研究了密集线条和孤立线条间CD(关键尺寸)刻蚀偏差参数对金属硬掩膜(MHM)刻蚀工艺的影响,涉及的范围有化学气体、源功率、压力、偏差功率以及ESC温度。特别是,如果正确地应用基于CH4的等离子固化光刻胶掩膜,发现它具有控制密... 详细信息

本文系统地研究了密集线条和孤立线条间CD(关键尺寸)刻蚀偏差参数对金属硬掩膜(MHM)刻蚀工艺的影响,涉及的范围有化学气体、源功率、压力、偏差功率以及ESC温度。特别是,如果正确地应用基于CH4的等离子固化光刻胶掩膜,发现它具有控制密集和ISO CD负载的特殊能力,且同时保持准确的密集CD。而且,在基于Cl2和基于HBr的BARC打开步骤之间,还看到刻蚀化学气体对CD负载的有重大影响。此外,也发现M-HM的应力和刻蚀后剖面影响CD负载性能。根据这些发现,成功地展示了改善钨触点和铜沟槽之间电气互连的解决方法。

关键词：化学刻蚀负载控制沟槽偏差比较聚合物隔离负载效应线条刻蚀工艺掩膜

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