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Microglia lactylation in relation to central nervous system diseases

Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui Yang Nan Mo le Tong Jianhong Dong Ziwei Fan Mengxian Jia Juanqing Yue Ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

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Free vibration and transient response of double curved beams connected by intermediate straight beams

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 37-62页

作者： R.A.JAFARI-TALOOKOLAEI H.GHANDVAR E.JUMAEV S.KHATIR T.CUONG-le School of Mechanical Engineering Babol Noshirvani University of Technology Department of Mechanical Engineering Faculty of Engineering New Uzbekistan University University of Business and Science Center for Engineering Application and Technology Solutions Ho Chi Minh City Open University

This paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP) materials. The strain potential and kinetic energies of each beam along with the work done by the external force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vector. The curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total matrices of the entire structure. Subsequently, the natural frequencies and transient response of the system are determined. The accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANSYS, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

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Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng le Wang Wenwu Zhang Gang Li Xing Cheng Peiqiang Su Yong Wan Xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

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Direct observation of photonic Landau levels and helical edge states in strained honeycomb lattices

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Light(Science & Applications) 2020年第1期9卷 627-636页

作者： Omar Jamadi Elena Rozas Grazia Salerno Marijana Milicevic Tomoki Ozawa Isabelle Sagnes aristide.le.aitre Luc le Gratiet Abdelmounaim Harouri Iacopo Carusotto Jacqueline Bloch Alberto Amo Universite de Lille CNRSUMR 8523—PhLAM—Physique des Lasers Atomes et Molecules59000 LilleFrance Depto.de Fisica de Materiales e Instituto Nicolas Cabrera Universidad Autonoma de Madrid(UAM)28049 MadridSpain Center for Nonlinear Phenomena and Complex Systems Universite Libre de BruxellesCP 231Campus PlaineB-1050 BrusselsBelgium Universite Paris-Saclay CNRSCentre de Nanosciences et de Nanotechnologies91120 PalaiseauFrance Interdisciplinary Theoretical and Mathematical Sciences Program(iTHEMS) RIKENWakoSaitama 351-0198Japan INO-CNR BEC Center and Dipartimento di Fisica Universita di Trento38123 PovoItaly

We report the realization of a synthetic magnetic field for photons and polaritons in a honeycomb lattice of coupled semiconductor micropillars.A strong synthetic field is induced in both the s and p orbital bands by engineering a uniaxial hopping gradient in the lattice,giving rise to the formation of Landau levels at the Dirac *** provide direct evidence of the sublattice symmetry breaking of the lowest-order Landau level wavefunction,a distinctive feature of synthetic magnetic *** realization implements helical edge states in the gap between n=0 and n=±1 Landau levels,experimentally demonstrating a novel way of engineering propagating edge states in photonic *** light of recent advances in the enhancement of polariton–polariton nonlinearities,the Landau levels reported here are promising for the study of the interplay between pseudomagnetism and interactions in a photonic system.

关键词： Landau helical realization

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Organic Iono-Electronics,a New Front for Semiconducting Polymers to Shine

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Accounts of Materials Research 2022年第7期3卷 669-671页

作者： aristide Gumyusenge Department of Materials Science&Engineering Massachusetts Institute of TechnologyCambridgeMassachusetts 02139United States

Structural tunability,low-cost solution processability,mechanical deformability,and biocompatibility were among several keywords that made organic semiconductors a popular class of materials.1 Here we are over three decades later with very few practical devices using organic semiconductors,and many wondering what is next for the field of organic electronics and whether organics were destined for nothing more than low-grade electronics and displays.

关键词： materials nothing electronics

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Analysis of the Impacts of Work,Non-Work and Stress Issues on the Work Family Conflict in Ivorian Industrial Sector

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Journal of Systems Science and Information 2021年第2期9卷 131-153页

作者： aristide Gbame CHOKI Qiuhong ZHAO School of Economics and Management Beihang UniversityBeijing 100191China LIMAK AFRIKA Human Resources DepartmentKm 23 AbidjanCote d'Ivoire

This paper analyzes the perceptions that workers in the Ivorian industrial sector have as the interface between their professional and personal life,and the factors that facilitate or make it *** collected from 4 Ivorian industrial companies which represent a sample of 187 respondents according to the selection *** collected data make it possible to identify the factors which act on the labor conflict towards the family as well as the factors which act on the family conflict towards the work within the industrial sector in Cte d'*** results of the correlation coefficients show that the relationships between the proposed variables are significant and in the direction suggested for the most part,thus providing support for nine of the ten hypotheses affecting these *** to some results obtained,it was discovered that certain factors could be at the same time,factors of conflict and satisfaction,such as the commitment to work or the nature of the *** variables can simultaneously increase stress,and increase the self-esteem of the *** results of the analysis of the proposed model recommend the possibility that the data fit the model well,explaining the impacts of work,non-work and stressors on work-family *** indicates that the proposed model is adapted to the Ivorian context.

关键词： work-family conflict job performance non-work stress coefficient of correlation

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Landslide Susceptibility Mapping Using RBFN-Based Ensemble Machine learning Models

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 467-500页

作者： Landslide Susceptibility Mapping Using RBFN-Based Ensemble Machine learning Models Duc-Dam Nguyen Nguyen Viet Tiep Quynh-Anh Thi Bui Hiep Van le Indra Prakash Romulus Costache Manish Pandey Binh Thai Pham Faculty of Civil Engineering University of Transport TechnologyThanh XuanHa Noi100000Vietnam Faculty of Hydraulic Engineering Hanoi University of Civil EngineeringHa Noi100000Vietnam DDG(R)Geological Survey of India Gandhinagar382010India Research Institute of the University of Bucharest Bucharest050663Romania National Institute of Hydrology and Water Management Bucharest013686Romania Department of Civil Engineering Transilvania University of BrasovBrasov500152Romania Danube Delta National Institute for Research and Development Tulcea820112Romania Marwadi University Research Center(MURC) Marwadi UniversityRajkotGujaratBharat360003India Department of Civil Engineering Faculty of Engineering&TechnologyMarwadi UniversityRajkotGujaratBharat360003India

This study was aimed to prepare landslide susceptibility maps for the Pithoragarh district in Uttarakhand,India,using advanced ensemble models that combined Radial Basis Function Networks(RBFN)with three ensemble learning techniques:DAGGING(DG),MULTIBOOST(MB),and ADABOOST(AB).This combination resulted in three distinct ensemble models:DG-RBFN,MB-RBFN,and ***,a traditional weighted method,Information Value(IV),and a benchmark machine learning(ML)model,Multilayer Perceptron Neural Network(MLP),were employed for comparison and *** models were developed using ten landslide conditioning factors,which included slope,aspect,elevation,curvature,land cover,geomorphology,overburden depth,lithology,distance to rivers and distance to *** factors were instrumental in predicting the output variable,which was the probability of landslide *** analysis of the models’performance indicated that the DG-RBFN model,with an Area Under ROC Curve(AUC)of 0.931,outperformed the other *** AB-RBFN model achieved an AUC of 0.929,the MB-RBFN model had an AUC of 0.913,and the MLP model recorded an AUC of *** results suggest that the advanced ensemble ML model DG-RBFN was more accurate than traditional statistical model,single MLP model,and other ensemble models in preparing trustworthy landslide susceptibility maps,thereby enhancing land use planning and decision-making.

关键词： Landslide susceptibility map spatial analysis ensemble modelling information values(IV)

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Suspended sediment transport analysis in two Italian instrumented catchments

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Journal of Mountain Science 2016年第6期13卷 957-970页

作者： Adriana GARCIA-RAMA Stefano Giorgio PAGANO Francesco GENTIle Mario aristide leNZI Department of Land EnvironmentAgriculture and Forestry(TeSAF)University of PadovaAgripolis-Vialedell'Universita 16-35o20 Legnaro(PD)Italy Department of Agricultural and Environmental Science(DiSAAT) University of BariviaAmendola 165/A70126 BariItaly ApuliaBasin Authority SPper Casamassima km 370010 ValenzanoBariItaly

Suspended sediment transport in streams is an effective indicator of soil erosion at the watershed scale. This process was studied using the data obtained from two continuous monitoring stations installed in Italian watersheds, the Rio Cordon and Torrente CarapeUe. The catchments have substantially different climatic, morphological and land use characteristics. The Rio Cordon, a small Alpine watershed, has been monitored since 1986, while in the Torrente Carapelle, a medium-size Mediterranean watershed, the monitoring station has provided data since 2007. Several flood events with suspended sediment transport were isolated in the two catchments, excluding those determined by snowmelt in the Rio Cordon as this process does not affect the Carapelle watershed. Analysis of the events showed different behavior in terms of hysteresis loop trends between water discharge （m3 S-1） and suspended sediment concentration （g 1-1） values, as the Rio Cordon confirms clockwise relationships most frequently, while counter-clockwise trends represent the majority of cases for the Carapelle Torrent. The different behavior of the two watersheds was further analyzed by evaluating relationships between the main hydrological parameters related to suspended sediment transport. Runoff controls the total sediment budget in both catchments. In contrast, it was noted that the runoff process does not interfere in the magnitude of the suspended sediment transport in the Rio Cordon catchment, while variations due to the larger size of the catchment area characterize the events in the Carapelle watershed. Lastly, a flow peak threshold that determines the advance or delay of the hydrograph peak with respect to the sedigraph peak was established for the Carapelle Torrent, while it was not reported in the Rio Cordon.

关键词： Suspended sediment transport Continuous monitoring Hysteresis analysis Flowpeak threshold: Soil erosion

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Emerging progress: photochemical transformation of nitroso compounds

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Science China Chemistry 2025年第1期 118-133页

作者： Ze-le Chen Qiang-Qiang Li Armido Studer Jun Xuan Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials School of Chemistry & Chemical Engineering Anhui University Organisch-Chemisches Institut Universitat Münster

Nitroso compounds have emerged as highly valuable reaction partners or reagents in organic synthesis due to their rich *** versatile profile of these compounds allows them to function as electrophiles, nucleophiles, diradicals, and radical acceptors in diverse transformations. In recent years, notable progress has been made in harnessing photochemical reactions with nitroso compounds to prepare N,O-containing structures using mild and eco-friendly conditions. Various nitroso compounds like nitrosoarenes, acyloxy nitroso compounds, N-nitrosoamines and nitrites have received significant attention for their ability to introduce NO moieties into complex molecules that are otherwise difficult to access. In this review, we provide an overview of the recent advancements in the visible light-induced conversion of nitroso compounds, with particular emphasis on their role as bifunctional reagents and acceptors of radicals, carbenes and nitrenes.

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Pick-up strategies for and electrical characterization of ZnO nanowires with a SEM-based nanomanipulator

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Nanotechnology and Precision Engineering 2023年第1期6卷 26-31页

作者： Mei Liu Lingdi Kong Weilin Su aristide Djoulde Kai Cheng Jinbo Chen Jinjun Rao Zhiming Wang Shanghai Key Laboratory of Intelligent Manufacturing and Robotics School of Mechatronic Engineering and AutomationShanghai UniversityShanghai 200444China Guangdong Key Laboratory of Fuel Cell Technology School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510640China

Because of their unique mechanical and electrical properties,zinc oxide(ZnO)nanowires are used widely in microscopic and nanoscopic devices and structures,but characterizing them remains *** this paper,two pick-up strategies are proposed for characterizing the electrical properties of ZnO nanowires using SEM equipped with a *** pick up nanowires efficiently,direct sampling is compared with electrification fusing,and experiments show that direct sampling is more stable while electrification fusing is more *** nanowires have cut-off properties,and good Schottky contact with the tungsten probes was *** piezoelectric experiments,the maximum piezoelectric voltage generated by an individual ZnO nanowire was 0.07 V,and its impedance decreased with increasing input signal frequency until it became *** work offers a technical reference for the pick-up and construction of nanomaterials and nanogeneration technology.

关键词： ZnO nanowires nanomanipulator picking up strategy piezoelectric properties electrical characterization

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