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Clinical and pathophysiological understanding of the hepatorenal syndrome:Still wrong or still not exactly right?

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World Journal of Clinical Cases 2023年第6期11卷 1261-1266页

作者： Benjamin Wilde Ali Canbay antonios Katsounas Department of Nephrology University of Duisburg-EssenUniversity Hospital EssenEssen 45147Germany Department of Medicine Ruhr University BochumBochum 44892Germany

The hepatorenal syndrome(HRS)is one major extrahepatic complication of endstage liver *** circulatory dysregulation is considered as primary etiology for HRS,cirrhosis-related(systemic)inflammation and/or cardial dysfunction may also play a key pathogenic role in HRS *** of other causes of acute kidney injury(AKI)is required for diagnosis of HRS-AKI by the definition of the International Club of ***,the pathophysiology of HRS is not understood completely and there are still limited therapeutic *** of renal dysfunction after liver transplantation indicates that HRS-AKI is a functional disorder caused by altered cellular *** interplay between systemic inflammation and the onset of kidneyrelated hypometabolism may have a key role and needs to be studied in *** minireview challenges simplified views of the HRS in the context of diagnostics and therapy stressing the need for further evidence to advance the knowledge on this syndrome.

关键词： Hepatorenal syndrome Liver disease Cirrhosis Inflammation Chronic kidney disease Acute kidney injury

Capturability of 3D RTPN guidance law against true-arbitrarily maneuvering target with maneuverability limitation

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Chinese Journal of Aeronautics 2022年第7期35卷 75-90页

作者： Kebo LI Zhihui BAI Hyo-Sang SHIN antonios TSOURDOS Min-Jea TAHK Department of Applied Mechanics College of Aerospace Science and EngineeringNational University of Defense TechnologyChangsha 410073China Institute of Aerospace Sciences SATMCranfield UniversityCranfield MK430ALUK Department of Aerospace Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea

The capturability of the Three-Dimensional(3D)Realistic True Proportional Navigation(RTPN)guidance law is thoroughly *** true-arbitrarily maneuvering target is considered,which maneuvers along an arbitrary direction in 3D space with an arbitrary but upperbounded *** whole nonlinear relative kinematics between the interceptor and target is taken into ***,the upper-bound of commanded acceleration of 3D RTPN is deduced,using a novel Lyapunov-like ***,the reasonable selection range of navigation gain of3D RTPN is analyzed,when the maneuver limitation of interceptor is *** that,a more realistic definition of capture is adopted,i.e.,the relative range is smaller than an acceptable miss-distance while the approaching speed is larger than a required impact *** previous researches which present Two-Dimensional(2D)capture regions,the inequality analysis technique is utilized to obtain the 3D capture region,where the three coordinates are the closing speed,transversal relative speed,and relative *** obtained capture region could be taken as a sufficient-but-unnecessary condition of *** new theoretical findings are all given in explicit expressions and are more general than previous results.

关键词： Capture region Lyapunov-like approach Maneuverability Limitation Realistic true proportional navigation True-arbitrarily maneuvering target

Electro-Hydrodynamic(EHD) Thrust Analysis in Wire-Cylinder Electrode Arrangement

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Plasma Science and Technology 2014年第4期16卷 363-369页

作者： Konstantinos N.KIOUSIS antonios X.MORONIS Wolf G.FRUH Heriot-Watt University Technological Educational Institute(TEI) of Athens

The thrust generation by electro-hydrodynamic （EHD） effect has been studied for a wire-cylinder arrangement under high DC voltage. Series of measurements have been conducted in order to determine the relationship between generated thrust and corona discharge current, as well as its dependence on geometrical characteristics of the electrodes, e.g. electrode gap, wire and cylinder radii. The experimental investigation has shown a linear relationship between the generated thrust and the discharge current, while parametric analysis showed that increased electrode gap and emitter radius reduces the thrust. On the other hand, large gaps favor the thrust per unit power ratio.

关键词： electro-hydrodynamic (EHD) effect thrust wire-cylinder electrodes

Perspectives on the prevention and treatment of infection for orthopedic tissue engineering applications

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Chinese Science Bulletin 2013年第35期58卷 4342-4348页

作者： SHAH Sarita R KASPER F Kurtis MIKOS antonios G Department of Bioengineering Rice University P.O. Box 1892 MS 142 Houston Texas 77251-1892 USA Department of Chemical and Biomolecular Engineering Rice University P.O. Box 1892 MS 142 Houston Texas 77251-1892 USA

The emergence of orthopedic tissue engineering devices as viable clinical solutions demands that the field address significant clinical complications associated with the implantation of foreign materials in the body,especially *** tissue engineering has focused on the development of methods to regenerate and repair,until recently there has been a relative dearth of literature regarding the intersection of tissue engineering and *** particular,local delivery of antimicrobials has long been of clinical interest,but only recently has that been translated into the realm of tissue *** this perspective,we briefly review major modes of local delivery for infection prevention and treatment and discuss possible strategies for preventing implant-associated infections.

关键词：组织工程感染骨科治疗预防应用工程设备工程规划

Inferior mesenteric arteriovenous fistula: Case report and world-literature review

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World Journal of Gastroenterology 2014年第25期20卷 8298-8303页

作者： antonios Athanasiou Adamantios Michalinos reas Alexrou Sotirios Georgopoulos Evangelos Felekouras First Department of Surgery Laikon University HospitalAthens 11527Greece

Arteriovenous fistulas between the inferior mesenteric artery and vein are rare, with only 26 primary and secondary cases described in the literature. Secondary fistulas occur following operations of the left hemicolon and manifest as abdominal pain, abdominal mass, gastrointestinal bleeding, colonic ischemia and portal hypertension. Symptom intensities are flow-dependent, and can range from minimal symptoms to severe heart failure due to left to right shunt. Diagnosis is usually established by radiological or intraoperative examination. Treatment options include embolization and/or surgical resection. Therapeutic decisions should be adapted to the unique characteristics of the fistula on an individual basis. A new case of a primary arteriovenous fistula is described and discussed along with a complete review of the literature. The patient in this report presented with signs and symptoms of colonic ischemia without portal hypertension. The optimal treatment for this pa-tient required a combination of embolization and surgical operation. The characteristics of these rare inferior mesenteric arteriovenous fistulas are examined and some considerations concerning diagnostic and therapeutic strategies that should be followed are presented.

关键词： Inferior mesenteric artery Arteriovenous fistula Colectomy Embolization Portal hypertension

Data-driven comparison of federated learning and model personalization for electric load forecasting

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Energy and AI 2023年第4期14卷 3-16页

作者： Fabian Widmer Severin Nowak Benjamin Bowler Patrick Huber antonios Papaemmanouil Lucerne University of Applied Science and Arts Institute of Electrical EngineeringCompetence Center Digital Energy and Electric PowerTechnikumsstrasse 216048HorwLucerneSwitzerland

Residential short-term electric load forecasting is essential in modern decentralized power *** forecasting methods mostly rely on neural networks and require access to private and sensitive electric load data for model *** neural network training aggregates all data on a centralized server to train one global ***,the aggregation of user data introduces security and data privacy *** contrast,this study investigates the modern neural network training methods of federated learning and model personalization as potential solutions to security and data privacy *** an extensive simulation approach,the investigated methods are compared to the conventional centralized method and a pre-trained baseline predictor to compare their respective *** study identifies that the underlying data structure of electric load data has a significant influence on the loss of a *** therefore conclude that a comparison of loss distributions will in fact be considered a comparison of data structures,rather than a comparison of the model *** an alternative method of comparison of loss values,this study develops the"differential comparison".The method allows for the isolated comparison of model loss differences by only comparing the losses of two models generated by the same data sample to build a distribution of *** differential comparison method was then used to identify model personalization as the best performing model training method for load forecasting among all analyzed methods,with a superior performance in 59.1%of all cases.

关键词： Federated learning Machine learning Model personalization Temporal convolutional network Electric load forecast Differential comparison

Conservation genetics of a resident population of Greylag Goose(Anser anser) at the southernmost limit of the species' distribution in Europe

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Avian Research 2019年第1期10卷 53-62页

作者： Anastasios Bounas Giorgos Catsadorakis Annita Logotheti Berend Voslamber antonios Magoulas Dimitris Tsaparis Molecular Ecology and Conservation Genetics Lab Department of Biological Applications and TechnologyUniversity of Ioannina Society for the Protection of Prespa Sovon Dutch Centre for Field Ornithology Institute of Marine Biology Biotechnology and Aquaculture(IMBBC)Hellenic Centre for Marine Research(HCMR)

Background:Conservation of small and isolated populations can be challenging since they are prone to loss of genetic diversity due to random genetic drift and ***,information from the assessment of genetic diversity and structure are needed for conservation programs to determine the appropriate management strategy for the *** investigated the levels of genetic variability in a resident Greylag Goose(Anser anser) population,the southernmost breeding population of the species in Europe and the sole viable population of any goose species in ***:A fragment of mtDNA Control Region and a panel of 11 microsatellite markers were used to search for any signs of genetic impoverishment and population substructure and to reveal the underlying processes through the identification of possible past demographic ***:The population was found to be monomorphic in the amplified fragment of the mitochondrial Control Region,with all individuals sharing a single private *** showed a lack of any population substructure indicating a panmictic *** the population seems to have experienced a strong and recent genetic bottleneck and exhibits a small effective population size,we did not find evidence of either extremely low levels of genetic diversity or inbreeding ***:The recent demographic decline we detected and the combined influence of residency and anthropogenic factors have probably shaped the current genetic *** study population does not need emergency conservation actions but should be regarded as a discrete management *** management strategies should focus on population and genetic monitoring and preventing further abundance declines that would increase the risk of genetic impoverishment.

关键词： Conservation Genetic variability Inbreeding Isolation Management units Microsatellites mtDNA Nonmigratory population

Neutrophil extracellular traps contribute to the development of hepatocellular carcinoma in NASH by promoting Treg differentiation

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Hepatobiliary Surgery and Nutrition 2022年第3期11卷 415-418页

作者： Rallia-Iliana Velliou Ioannis Mitroulis antonios Chatzigeorgiou Department of Physiology Medical SchoolNational and Kapodistrian University of AthensAthensGreece First Department of Internal Medicine University Hospital of AlexandroupolisDemocritus University of ThraceAlexandroupolisGreece Institute for Clinical Chemistry and Laboratory Medicine University Hospital and Faculty of Medicine Carl Gustav Carus of TU DresdenDresdenGermany

Non-alcoholic fatty liver disease(NAFLD)is an umbrella term,describing a range of chronic liver disorders associated with fat deposition in hepatocytes,defined as steatosis,and it is mostly emerged in the presence of obesity,hyperlipidemia and insulin *** has been classified as the most frequent liver condition worldwide with more than 10%of NAFLD patients progressing to the inflammatory and fibrotic disorder of non-alcoholic steatohepatitis(NASH),which in turn can lead to end stage liver disease including hepatocellular carcinoma(HCC);the most frequent malignant liver tumor(1).During HCC development the immune system interacts with the tumour microenvironment and it can stimulate its growth by maintaining a chronic inflammatory milieu and the production of factors that favor tumor growth,survival,and *** phenomena may also take place and have significant implications in the transition from NASH to HCC(2).Although,it is well established that chronic inflammation within the hepatic microenvironment is of great significance in HCC development,the exact mechanisms leading to the transition from NASH to HCC are yet to be elucidated.

关键词： hepatocellular NAFLD inflammation

Macrophage polarization in response to wear particles in vitro

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Cellular & Molecular Immunology 2013年第6期10卷 471-482页

作者： Joseph K antonios Zhenyu Yao Chenguang Li Allison J Rao Stuart B Goodman Orthopaedic Research Laboratories Department of Orthopaedic Surgery Stanford University School of Medicine Stanford CA USA

Total joint replacement is a highly successful surgical procedure for treatment of patients with disabling arthritis and joint dysfunction. However, over time, with high levels of activity and usage of the joint, implant wear particles are generated from the articulating surfaces. These wear particles can lead to activation of an inflammatory reaction, and subsequent bone resorption around the implant （periprosthetic osteolysis）. Cells of the monocyte/macrophage lineage orchestrate this chronic inflammatory response, which is dominated by a pro-inflammatory （M 1） macrophage phenotype rather than an anti-inflammatory pro-tissue healing （M2） macrophage phenotype. While it has been shown that interleukin-4 （IL-4） selectively polarizes macrophages towards an M2 anti-inflammatory phenotype which promotes bone healing, rather than inflammation, little is known about the time course in which this occurs or conditions in which repolarization through I L-4 is most effective. The goal of this work was to study the time course of murine macrophage polarization and cytokine release in response to challenge with combinations of polymethyl methacrylate （PMMA） particles, lipopolysaccharide （LPS） and IL-4 in vitro. Treatment of particle-challenged monocyte/macrophages with IL-4 led to an initial suppression of pro-inflammatory cytokines and inducible nitric oxide synthase （iNOS） production and subsequent polarization into an M2 anti-inflammatory phenotype. This result was optimized when IL-4 was delivered before PMMA particle challenge, to an M 1 phenotype rather than to uncommitted （MO） macrophages. The effects of this polarization were sustained over a 5-day time course. Polarization of M1 macrophages into an M2 phenotype may be a strategy to mitigate wear particle associated periprosthetic osteolysis.

关键词： IL-4 macrophage polarization osteolysis PMMA particles total joint replacement