Clinical and pathophysiological understanding of the hepatorenal syndrome:Still wrong or still not exactly right?

作     者：Benjamin Wilde Ali Canbay Antonios Katsounas 

作者机构：Department of NephrologyUniversity of Duisburg-EssenUniversity Hospital EssenEssen 45147Germany Department of MedicineRuhr University BochumBochum 44892Germany 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2023年第11卷第6期

页      面：1261-1266页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Hepatorenal syndrome Liver disease Cirrhosis Inflammation Chronic kidney disease Acute kidney injury 

摘      要：The hepatorenal syndrome(HRS)is one major extrahepatic complication of endstage liver *** circulatory dysregulation is considered as primary etiology for HRS,cirrhosis-related(systemic)inflammation and/or cardial dysfunction may also play a key pathogenic role in HRS *** of other causes of acute kidney injury(AKI)is required for diagnosis of HRS-AKI by the definition of the International Club of ***,the pathophysiology of HRS is not understood completely and there are still limited therapeutic *** of renal dysfunction after liver transplantation indicates that HRS-AKI is a functional disorder caused by altered cellular *** interplay between systemic inflammation and the onset of kidneyrelated hypometabolism may have a key role and needs to be studied in *** minireview challenges simplified views of the HRS in the context of diagnostics and therapy stressing the need for further evidence to advance the knowledge on this syndrome.