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Spermotrend Improves Semen Quality and Infertility in Men with Varicocele —Spermotrend and Male Infertility

Advances in Reproductive Sciences 2024年第2期12卷 83-97页

作者： Melida Aguilar Chamorro Sergio antonio vargas Collado David Marquez Soriano Clinica Seniors Managua Nicaragua Scientific Department Catalysis S.L. Madrid Spain

Background: Infertility affects 8% - 12% of couples globally, with approximately half of the cases reported in males. Oxidative stress is a common factor increased in the varicocele condition and particularly affects spermatozoa, due to their sensitivity to oxidative signals and testicular hypotrophy. The objective of this clinical trial is to study the effectiveness of Spermotrend in the improvement of sperm parameters in male infertility. Methods: A total of 170 males aged > 18 years with a diagnosis of infertility and varicocele were consecutively enrolled in a Phase II, open-label clinical trial. Spermotrend was administered 1 capsule (450 mg) orally every 8 hours for 6 months and was evaluated through semen analysis at 4 and 6 months of follow-up. Results: The trial results show a significant improvement following the administration of Spermotrend over 6 months in sperm concentration (44.1% at baseline vs. 64.1% at 6 months), sperm survival (28.2% with sperm survival ≥ 2 hours vs.56.5%), normalization of sperm morphology (31.2% vs. 72.9%). Varicocele condition decreased in all patients and, by the end of the study, 55.3% of patients had normal venous flow and dilation. Only 5.9% of the patients showed grade 2 varicocele at the end of the study, while 38.8% showed grade 1 varicocele, with no patients showing grade 3 varicocele. Regarding testicular hypotrophy, 90.6% of the patients completed the study with normalized testicular volume by recovering normal venous flow. Conclusion: A short-term course of Spermotrend may significantly improve sperm parameters associated with male infertility. Clinical Trial Registration: The clinical trial protocol was registered in the international clinical trial registry, ***, with the code: NCT05222841 on 15/06/2021.

关键词： Antioxidants Dietary Supplementation Male Infertility Spermatogenesis Varicocele Pygeum africanum

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Thinking outside the black box:are the brain endothelial cells the new main target in Alzheimer's disease?

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Neural Regeneration Research 2023年第12期18卷 2592-2598页

作者： Enrique Estudillo Adolfo López-Ornelas Alejandro Rodríguez-Oviedo Neptali Gutiérrez de la Cruz Marco antonio vargas-Hernández Adriana Jiménez Laboratorio de Reprogramación Celular Instituto Nacional de Neurología y Neurocirugía Manuel Velasco SuárezMexico CityMexico División de Investigación Hospital Juárez de MéxicoMexico CityMexico Hospital Nacional Homeopático Hospitales Federales de ReferenciaMexico CityMexico Facultad de Ciencias Universidad Nacional Autónoma de MéxicoMexico CityMexico Laboratorio de Morfología Escuela Militar de Graduados de SanidadSecretaría de la Defensa NacionalBatalla de CelayaLomas de SoteloMiguel HidalgoMexico CityMexico Escuela Militar de Graduados de Sanidad Secretaría de la Defensa NacionalBatalla de CelayaLomas de SoteloMiguel HidalgoMexico CityMexico

The blood-brain barrier is the interface through which the brain interacts with the milieu and consists mainly of a sophisticated network of brain endothelial cells that forms blood vessels and selectively moves molecules inside and outside the brain through multiple mechanisms of *** brain endothelial cell function is crucial for brain homeostasis,their role in neurodegenerative diseases has historically not been considered with the same importance as other brain cells such as microglia,astroglia,neurons,or even molecules such as amyloid beta,Tau,or ***'s disease is the most common neurodegenerative disease,and brain endothelial cell dysfunction has been reported by several ***,its impairment has barely been considered as a potential therapeutic *** we review the most recent advances in the relationship between Alzheimer's disease and brain endothelial cells commitment and analyze the possible mechanisms through which their alterations contribute to this neurodegenerative disease,highlighting their inflammatory phenotype and the possibility of an impaired secretory pattern of brain endothelial cells that could contribute to the progression of this ***,we discuss why shall brain endothelial cells be appreciated as a therapeutic target instead of solely an obstacle for delivering treatments to the injured brain in Alzheimer's disease.

关键词： dementia endothelial cells neurodegeneration neuroinflammation neuronal death paracellular transport transcellular transport

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Electrical Properties and Phase Behavior of Proton Conducting Nanocomposites Based on the Polymer System (1 - x)[PVOH + H3PO2+ H2O]·x(Nb2O5)

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American Journal of Analytical Chemistry 2014年第5期5卷 301-307页

作者： Angélica María Mazuera Rubén antonio vargas TFnoM Group Universidad del Valle Cali Colombia

In the present work, novel blend polymer electrolyte membranes using poly(vinyl alcohol) (PVA), doped with hypophosphorous acid (H3PO2) and reinforced with porous niobium oxide (Nb2O5) microparticles in different compositions were prepared by the solution-casting technique. Their phase behavior and ionic conductivity were studied by differential scanning calorimetric (DSC), thermogravimetric analysis (TGA) and impedance spectroscopy (IS) in the radio-frequency range. Using a constant H3PO2/PVA weigh ratio of 0.25, it was found that the water content in the blended hydrogel membranes increased with increasing the filler Nb2O5 content, thus increasing the electrical conductivity. However, the suitable weight ratio of Nb2O5:(H3PO2/PVA) for the blend performance (both mechanically and electrically) was x = 0.075, with a maximum ionic conductivity of 2.7?× 10﹣3 S·cm﹣1 at 120°C. For all blends prepared, the lost tangent plots show asymmetrical peaks, as a consequence of correlations in the mobile ion diffusion as a function of frequency. Although this “universal dynamic response” was observed at all temperatures, variations in the tan(δ) relaxation peaks indicate a decrease of ionic correlation when the temperature is increased. Both the dc conductivity and tan(δ) peaks frequency dependency are thermally activated, following an Arrhenius-type behavior with activation energy of the same order, indicating that the corresponding ionic processes have the same origin, i.e., proton jump among available sites in the polymer matrix. The additions of oxide particles to the membranes improve their thermal and electrical properties, attributed to an approximation effect.

关键词： Nanocomposite Polymer Blend Impedance Study DSC/TGA Ionic Conductivities Polymer Electrolytes Phase Behavior

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New Rotative Radiofrequency Technology: A Multicenter Retrospective Study on Efficacy and Safety

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Journal of Cosmetics, Dermatological Sciences and Applications 2024年第1期14卷 69-83页

作者： José antonio Ferrández Martínez Gregorio Viera Mármol Fabrizio Vignoli Joanet Perera Agustin Blanch Mara Suárez Alicia Robledo Jorge Reyna vargas Lamas Sinclair Barcelona Spain Studio Vignoli Bologna Italy Clinica Perla Medic Alicante Spain Dr. Agustin Blanch Clinica Barcelona Spain Intek Medical Technology S.L.U. Barcelona Spain

Background: Non-ablative radiofrequency (RF) technology is widely used for the treatment of signs of aging, skin laxity, localized fat and cellulite. However, many RF devices suffer from technical limitations that make the results highly dependent on the user’s experience or clinical limitations that compromise safety, efficacy and comfort. Objective: To evaluate the efficacy and safety of a novel semi-automatic non-ablative RF device for skin tightening, body shaping and cellulite reduction. Materials and methods: A retrospective multicenter study was performed using a novel rotative RF device with temperature and impedance control (Sculpt&Shape®, Sinclair, Spain). 58 subjects underwent a minimum of 4 treatments every 1-2 weeks. A total of 120 treatments (56.7% body and 43.3% facial) and 1034 sessions were performed. Efficacy was evaluated by 3 researchers using the Global Aesthetic Improvement Scale (GAIS) and anthropometric measurements were collected. Subject and practitioner satisfaction were recorded. Safety was evaluated by analyzing the perception of pain during the treatment and the side and adverse effects immediately after treatment and over the next 48 hours. Results: Between 25% and 50% improvement was achieved according to the GAIS. Statistically significant (p < 0.01) abdominal fold reduction of 5.1 mm and circumference reduction of 32.0 mm, 16.4 mm and 13.9 mm were recorded for the abdomen, legs and arms, respectively. 77.5% of subjects and 94.9% of practitioners were either satisfied or very satisfied. Minor adverse effects were found in 0.97% of the sessions. Conclusion: This novel semi-automatic rotative RF device has been found to provide treatments that are effective, safe and comfortable for both practitioners and subjects. .

关键词： Rotative Radiofrequency RF Cellulite Skin Tightening Body Shaping

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Symptomatic changes in postmenopause with different methods of hormonal therapy

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Open Journal of Preventive Medicine 2011年第2期1卷 20-24页

作者： Marcelino Hernández-Valencia Nydia Cordova antonio vargas Lourdes Basurto Renata Saucedo Carlos vargas Miriam Ruiz Leticia Manuel-Apolinar Arturo Zárate 不详

Objective: The diversity of opinions on the adverse effects of medications used to treat postmenopausal symptoms has prompted the use of various routes and mechanisms of action that need to be explored because bioavailability of the medications can vary. In order to select the appropriate route of administration for hormonal therapy (HT), it is necessary to determine baseline therapeutic efficacy. Design: We designed a prospective, randomized study consisting of four groups of postmenopausal wo-men: group 1 received oral conjugated estrogens, group 2 received a synthethic steroid, group 3 received estradiol nasally in spray form, and group 4 used transdermal estradiol in the form of patches. Criteria used to evaluate effectiveness was the Greene scale, which evaluate six components. These criteria were applied to each patient before hormonal intervention and then each month for 6 months. Luteinizing hormone (LH), follicle stimulating horone (FSH) and estradiol concentration were determined by chemiluminescence. Student’s t-test was used for intra-group comparisons before and after treatment. Results: There was a significant decrease in the vasomotor and sexual component (p < 0.05) with the use of four HT types. For depression, a difference was observed with synthetic steroids and oral estrogens. Upon analyzing the somatic component there was a decrease in symptoms with nasal and transdermal routes. Psychological changes were observed with the use of oral synthethic steroids and transdermal patches. Anxiety component demonstrated differences with nasal spray and oral estrogens, although all HT forms in this component showed a pattern of irregular changes. Conclusions: Changes in the response could be due each route of administration and medication used. Absorption variability may exist, which has repercussions in the control of symptoms and should be taken into consideration when selecting the appropriate route of administration for patients beginning HT.

关键词： hormonal therapy transdermal estradiol tibolone oral estrogen nasal estradiol postmenopause

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“脸谱”的那张脸

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英语沙龙（高中） 2011年第1期 40-42页

作者： Jose antonio vargas CJ

马克·扎克伯格，超级社交网站Facebook的创始人兼CEO，哈佛大学计算机和心理学专业辍学生，被人们冠以“盖茨第二”的美誉。在《福布斯》杂志日前公布的全美400大富豪中，27岁的扎克伯格以69亿元身价名列第35名，是历来全球最年轻的自... 详细信息

马克·扎克伯格，超级社交网站Facebook的创始人兼CEO，哈佛大学计算机和心理学专业辍学生，被人们冠以“盖茨第二”的美誉。在《福布斯》杂志日前公布的全美400大富豪中，27岁的扎克伯格以69亿元身价名列第35名，是历来全球最年轻的自行创业亿万富豪。

关键词： Facebook 《福布斯》杂志脸谱亿万富豪心理学专业社交网站哈佛大学 CEO

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揭开“脸谱”,走近马克·扎克伯格

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新东方英语（中英文版） 2011年第3期 26-31页

作者： Jose antonio vargas 陈继龙

对于全世界各地的很多网民来说，马克·扎克伯格这个名字．弗采陌生。他是《时代》周刊评出的“2010年年度人物”，被《名利场》杂志称作‘哉们这个时代的新凯撒”。马克于2004年创建了“脸谱”网站（Faccbook），短短七年时间，这个当... 详细信息

对于全世界各地的很多网民来说，马克·扎克伯格这个名字．弗采陌生。他是《时代》周刊评出的“2010年年度人物”，被《名利场》杂志称作‘哉们这个时代的新凯撒”。马克于2004年创建了“脸谱”网站（Faccbook），短短七年时间，这个当年在大学宿舍里诞掌生的小网站已经一跃成为全球最大的社交网站。

关键词：马克脸谱《时代》周刊社交网站 2010年《名利场》年度人物大学宿舍

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The health care economic-industrial complex: Concepts and general characteristics

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Health 2013年第10期5卷 1607-1621页

作者： Carlos Augusto Grabois Gadelha Lais Silveira Costa Jose Manuel Santos de Varge Maldonado Pedro Ribeiro Barbosa Marco antonio vargas Science Technology and Strategic InputsMinistry of HealthBrasiliaBrazil Research Group Innovation in Health Care Oswaldo Cruz Foundation(Fiocruz)Rio de JaneiroBrazil Professional Master’s Degree Course in Politics and Management of Science Technology and Innovation in Health CareSergio Arouca School of Public HealthOswaldo Cruz FoundationRio de JaneiroBrazil Management and Institutional Development Oswaldo Cruz Foundation(Fiocruz)Rio de JaneiroBrazil Department of Economics Faculty of EconomicsUniversidade Federal FluminenseNiteroiBrazil

The strategic role of health care within the Brazilian development agenda has been increasingly recognized and institutionalized. Aside from its importance as a structural element of the Welfare State, health care plays a leading role in generating innovation. Despite this, the productive base of Brazil’s health care system is extremely fragile, jeopardizing both the universal provision of health care services and the country’s competitive insertion in the globalized environment. This suggests the need for a more systematic analysis of the complex relationships that exist between the technological and the social interests involved in the productive base of health care provision in Brazil. Therefore, the purpose of this article is to enhance our understanding of the productive base of health care, especially given its potential to contribute to a socially inclusive development model, which is the ultimate goal in Brazil.

关键词： Technological Development Policies Health Care Sector Economics Health Sciences Technology and Innovation Management Policies and Cooperation in Science Technology and Innovation

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Low Frequency Dispersion in Ionic Conduction of （1 -x）（Nal-4Agl）-xAl2O3

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材料科学与工程（中英文版） 2010年第4期4卷 71-76页

作者： Luis Alfredo Rodriguez Gonzalez Wilmer Buchelli Hernando Correa Jesus E. Diosa Ruben antonio vargas Zapata Grupo de Transiciones de Fase en Sistemas no Metalicos Universidaddel Valle A.A. 25360 Cali Colombia Instituto de Ciencia de Materiales de Madrid CSIC Cantoblanco 28049 Madrid Espana Laboratorio de Optoelectronica Universidad del Quindio Armenia Colombia

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Polyphenols as potential enhancers of stem cell therapy against neurodegeneration

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Neural Regeneration Research 2022年第10期17卷 2093-2101页

作者： Diana Rodríguez-Vera antonio Abad-García Nancy vargas-Mendoza Rodolfo Pinto-Almazán Eunice D.Farfán-García José A.Morales-González Marvin A.Soriano-Ursúa Sección de Estudios de Posgrado e Investigación.Escuela Superior de Medicina Instituto Politécnico NacionalMéxico CityMéxico Unidad de Investigación Hospital Regional de Alta Especialidad IxtapalucaCarretera Federal México-Puebla km 34.5State of MéxicoMéxico

The potential of polyphenols for treating chronic-degenerative diseases(particularly neurodegenerative diseases)is ***,the selection of the best polyphenol for each treatment,the mechanisms by which they act,and their efficacy are frequently *** this review,the basics and the advances in the field,as well as suggestions for using natural and synthetic polyphenols alone or in a combinatorial strategy with stem cell assays,are compiled and ***,stem cells exhibit several responses when polyphenols are added to their environment,which could provide us with knowledge for advancing the elucidation of the origin of *** also,polyphenols are being included in the innovative strategies of novel therapies for treating neurodegenerative diseases as well as metabolic diseases related to *** this regard,flavonoid compounds are suggested as the best natural polyphenols due to their several mechanisms for acting in ameliorative effects;but increasing reports are involving other *** if some facts limiting bioactivity prevent them from conventional use,some natural polyphenols and derivatives hold the promise for being improved compounds,judged by their induced *** current results suggest polyphenols as enhancers of stem cell therapy against the targeted diseases.

关键词： Alzheimer’s disease chronic degenerative diseases combinatorial therapy metabolism neurodegenerative diseases neuronal damage neuroprotection Parkinson’s disease polyphenols stem cell assays

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