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Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

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Cellular & Molecular Immunology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya Joséantonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez E Clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of Medical Biochemistry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biomedicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Medico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Emergencies Virgen del Rocío University HospitalSevilleSpain Intensive Care Unit Virgen del Rocío University HospitalSevilleSpain Department of Medicine University of SevilleSevilleSpain Cardiology and Cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumatology Unit Virgen del Rocío University HospitalSevilleSpain Internal Medicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain Neurology and Clinical Neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and Nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and Nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Investigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity *** cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease *** this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory ***,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 ***,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were *** findings contribute to a better understanding of the immunological sequelae of COVID-19.

关键词： SARS-CoV-2 COVID-19 Dendritic cell Long-COVID

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量子世界虚数不虚

环球科学 2023年第17期 70-75页

作者：马克-奥利维尔·勒努安东尼奥·阿辛米格尔·纳瓦斯库斯刘丰铭(翻译) 陈贺(翻译) 陆朝阳(审校) 不详

物理学家认为必然存在纯实数的量子理论,但去年一项巧妙的思想实验证实,虚数对于标准量子理论是不可或缺的。三年前,我们三人中的马克-奥利维尔·勒努(Marc-Olivier Renou)应安东尼奥·阿辛(antonio Acin)的邀请,前往西班牙巴塞罗那的... 详细信息

物理学家认为必然存在纯实数的量子理论,但去年一项巧妙的思想实验证实,虚数对于标准量子理论是不可或缺的。三年前,我们三人中的马克-奥利维尔·勒努(Marc-Olivier Renou)应安东尼奥·阿辛(antonio Acin)的邀请,前往西班牙巴塞罗那的光子科学研究中心。

关键词：科学研究中心量子理论安东尼奥虚数奥利维尔量子世界巴塞罗那物理学家

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发挥开发银行“看得见的手”的作用

金融博览 2020年第19期 34-35页

作者：雷吉斯·马罗唐斯特凡妮·格里菲斯-琼斯何塞·安东尼奥·奥坎波徐佳君法国开发署(AFD) 全球发展中心哥伦比亚大学北京大学新结构经济学研究院

危机屡见不鲜。在人类漫长的历史中.就曾因系统出现某些故障而引起经济海啸.这些故障起初并未引人注意.直到海啸巨浪漫过海岸。在最近的几次危机中.金融市场都是引发灾难的源头,实体经济因此遭受重创,虽最终都得以复苏,但损失甚为惨重.... 详细信息

危机屡见不鲜。在人类漫长的历史中.就曾因系统出现某些故障而引起经济海啸.这些故障起初并未引人注意.直到海啸巨浪漫过海岸。在最近的几次危机中.金融市场都是引发灾难的源头,实体经济因此遭受重创,虽最终都得以复苏,但损失甚为惨重.纠正措施只是恢复正轨的一种办法.但以往经济政策史上.

关键词：看得见的手纠正措施金融市场海啸实体经济经济政策史银行危机

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Pulmonary vein stenosis:Etiology,diagnosis and management

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World Journal of Cardiology 2016年第1期8卷 81-88页

作者： Pablo Pazos-López Cristina García-Rodríguez Alba Guitián-González Emilio Paredes-Galán María ángel De La Guarda álvarez-Moure Marta Rodríguez-álvarez José antonio Baz-Alonso Elvis Teijeira-Fernández Francisco Eugenio Calvo-Iglesias Andrés íniguez-Romo Department of Cardiology Complexo Hospitalario Universitario de Vigo Hospital álvaro Cunqueiro Department of Radiology Complexo Hospitalario Universitario de Vigo Hospital álvaro Cunqueiro Diagnostic Imaging Unit Galaria Empresa Pública de Servicios Sanitarios Hospital do Meixoeiro

Pulmonary vein stenosis(PVS) is rare condition characterized by a challenging diagnosis and unfavorable prognosis at advance stages. At present, injury from radiofrequency ablation for atrial fibrillation has become the main cause of the disease. PVS is characterized by a progressive lumen size reduction of one or more pulmonary veins that, when hemodynamically significant, may raise lobar capillary pressure leading to signs and symptoms such as shortness of breath, cough, and hemoptysis. Image techniques(transesophageal echocardiography, computed tomography, magnetic resonance and perfusion imaging) are essential to reach a final diagnosis and decide an appropriate therapy. In this regard, series from referral centers have shown that surgical and transcatheter interventions may improve prognosis. The purpose of this article is to review the etiology, assessment and management of PVS.

关键词： Pulmonary vein stenosis Pulmonary vein stenosis etiology Pulmonary vein stenosis causes Pulmonary vein stenosis diagnosis Pulmonary vein stenosis management Pulmonary vein stenosis treatment

从公务员到自由职业者:葡萄牙公证员制度改革的实证分析

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国际行政科学评论（中文版） 2013年第2期 152-171页

作者：安东尼奥·F.塔瓦雷斯米格尔·A.罗德里格斯董志超潘陆山崔玲孙涛范围葡萄牙布拉加市米尼奥大学经济与管理学院公共政策与行政管理研究中心

20世纪80年代以来,市场机制作为替代方案被逐步引入到公共服务提供中来。本文研究的是一种特殊的公共服务职能——民法公证员——并试图从公证员这个角度来分析,由于选择了公务员地位的市场化道路,都有哪些因素导致了多元市场结构的形... 详细信息

20世纪80年代以来,市场机制作为替代方案被逐步引入到公共服务提供中来。本文研究的是一种特殊的公共服务职能——民法公证员——并试图从公证员这个角度来分析,由于选择了公务员地位的市场化道路,都有哪些因素导致了多元市场结构的形成。葡萄牙政府给予公证员成为自由职业者的选择并由司法管辖区规定其权利。这项改革完成后,不同的市场结构遍布于278个公证司法管辖区。我们的主要假设是,有着多元代理机构的市场,形成于公证员数量多到更加有利可图的地步,且法律行为具有财务上的可持续性,能够获利的司法管辖区。相反,垄断的形成则是明显缺乏市场机会和需求的结果。2010一2011年间,我们收集了有关公证员制度的官方统计数据以及每个司法管辖权的经济、人口统计数据。对于葡萄牙大陆278个公证管辖区内市场安排的关键假设的验证,我们使用的是多元逻辑回归分析法。对实践工作者的启示解除对公证员职业管制的趋势可能会继续席卷整个欧盟国家。葡萄牙的经验告诉我们,虽然公务员地位的变化还没有强加给所有公证员,但在财政限制和压力下,(行政机构的)私有化是一个不可避免的选择。

关键词：民法公证员解除管制政府管制法律职业私有化

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Ana滑坡（地中海西部Eivissa海峡的巴利阿里陆缘）的触发机制分析

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海洋地质 2009年第1期25卷 49-49页

作者： Sara Lafuerza Nabil Sultan Didier Leynaud Jaume Frigola Bernard Dennielou Hong- Viet Nguyen antonio Cattaneo Galderic Lastras Miquels Canals 杨丽娟（译）闫章存（校对）海洋地质研究中心西班牙海洋开发研究院法国不详

Ana滑坡位于Eivissa海峡（西地中海）巴利阿里陆缘沉积速率低的碳酸盐陆坡上，在这个地区还发现了其它一些具有相同滑动层位的滑坡，表明它们可能是在同一时期内被同样的机制触发的。在Ana滑坡的滑坡后壁区，地震反射剖面上识别出的无... 详细信息

Ana滑坡位于Eivissa海峡（西地中海）巴利阿里陆缘沉积速率低的碳酸盐陆坡上，在这个地区还发现了其它一些具有相同滑动层位的滑坡，表明它们可能是在同一时期内被同样的机制触发的。在Ana滑坡的滑坡后壁区，地震反射剖面上识别出的无声波反射带遮掩了滑坡下的层状相，这可能是有天然气存在的指示。此外，在滑坡后壁区出现的麻坑表明晚第四纪上部沉积层序中流体的排出作用与Ana滑坡的形成有密切关系。

关键词：机制分析西地中海滑坡触发陆缘海峡

热塑性淀粉和生物微粒子复合材料：膜的抗真菌和化学物理性质

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绿色包装 2020年第2期 72-72页

作者： Arash Moeini Salvatore Mallardo Alessio Cimmino Giovanni Dal Poggetto Marco Masi Mariaelena Di Biase Albert van Reenen Paola Lavermicocca Francesca Valerio antonio Evidente Mario Malinconico Gabriella Santagata

本研究通过外凝胶交联法制备了含有ungeremine (CTUn)的壳聚糖(C)三聚磷酸酯(T)亚微粒子,这种生物碱对造成烘焙产品变质的青霉菌尤其有效。制备了热塑性淀粉基聚合物材料(MBi),并获得了MBi/CTUn生物活性复合材料。结果表明,该膜具有一... 详细信息

本研究通过外凝胶交联法制备了含有ungeremine (CTUn)的壳聚糖(C)三聚磷酸酯(T)亚微粒子,这种生物碱对造成烘焙产品变质的青霉菌尤其有效。制备了热塑性淀粉基聚合物材料(MBi),并获得了MBi/CTUn生物活性复合材料。结果表明,该膜具有一定的生物活性。特别是对不同浓度的CTUn和不同p H值的膜进行了生物测定。CTUn颗粒影响MBi结晶(DSC分析),促进了MBi淀粉组分(TGA)的热降解。形态分析证实了亚微粒子在聚合物基体中的均匀分布。如预期的那样,水的渗透性略有增加,而氧的渗透性却降低了。拉伸试验表明,CTUn亚微粒子改善了膜的刚度和拉伸强度,但牺牲了延性。最后,MBi/CTUn生物复合材料在生物活性烘焙食品包装材料中具有很好的开发潜力。

关键词：热塑性淀粉粒子复合材料生物活性抗真菌

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天津滨海图书馆

建筑实践 2019年第11期 158-163页

作者： Maria López Calleja Kyo Suk Lee Sen Yang Marta Pozo Chi Li Ray Zhu Angel Sanchez Navarro Daehee Suk Guang Ruey Tan Xichen Sun Michael Zhang Mariya Gyaurova antonio Luca Coco Constanza Cuccato Matteo Artico Tomaso Maschietti 董天杰侯勇军韩宁安志红田轶凡黄轩孙科章夏磊刘磊高艳任艳琴陈旭陆伟伟吴书驰张明宇张明韩薇李薇薇韩海磊郭鹏张萌战长恒 MVRDV建筑规划事务所天津市城市规划设计研究院 MVRDV

天津滨海图书馆是MVRDV建筑规划事务所与天津市城市规划设计研究院共同设计建造的城市新型图书馆,是滨海文化中心的一部分,一期由五个文化场馆与一条文化走廊构成,分别由国内外知名建筑团队合作设计,包括MVRDV建筑师事务所、伯纳德·屈... 详细信息

天津滨海图书馆是MVRDV建筑规划事务所与天津市城市规划设计研究院共同设计建造的城市新型图书馆,是滨海文化中心的一部分,一期由五个文化场馆与一条文化走廊构成,分别由国内外知名建筑团队合作设计,包括MVRDV建筑师事务所、伯纳德·屈米建筑师事务所、GMP建筑师事务所、Bing Thom建筑师事务所、天津华汇工程建筑设计有限公司、天津市城市规划设计研究院及

关键词： MVRDV 研究院天津滨海图书馆天津市建筑设计院城市规划设计

Renal impairment and heart failure with preserved ejection fraction early post-myocardial infarction

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World Journal of Cardiology 2010年第1期2卷 13-18页

作者： Vinod Jorapur Gervasio A Lamas Zygmunt P Sadowski Harmony R Reynolds antonio C Carvalho Christopher E Buller James M Rankin Jean Renkin Philippe Gabriel Steg Harvey D White Carlos Vozzi Eduardo Balcells Michael Ragosta C Edwin Martin Vankeepuram S Srinivas William W Wharton III Staci Abramsky Ana C Mon Shari S Kronsberg Judith S Hochman Columbia University Division of Cardiology Mount Sinai Medical Center II Ischemic Heart Disease Department National Institute of Cardiology Leon Charney Division of Cardiology New York University School of Medicine Cardiology Division-Hospital Sao Paulo Federal University of Sao Paulo Division of Cardiology University of British Columbia Department of Cardiovascular Medicine Royal Perth Hospital Department of Cardiology UCL St Luc University Hospital INSERM U-698 Department of CardiologyHopital Bichat Cardiology Department Green Lane Cardiovascular ServiceAuckland City Hospital Interventional Cardiology Instituto de Intervenciones Cardiovasculares S.A. Cardiovascular Associates Wellmont Holston Valley Medical Center Cardiovascular Division University of Virginia Department of Medicine-Division of Cardiology York Hospital Division of Cardiology Montefiore Medical Center/Albert Einstein College of Medicine Research Department Asheville Cardiology AssociatesP.A. Maryland Medical Research Institute

AIM:To study if impaired renal function is associated with increased risk of peri-infarct heart failure (HF) in patients with preserved ejection fraction (EF).METHODS:Patients with occluded infarct-related arteries (IRAs) between 1 to 28 d after myocardial infarction (MI) were grouped into chronic kidney disease (CKD) stages based on estimated glomerular filtration rate (eGFR).Rates of early post-MI HF were compared among eGFR *** regression was used to explore independent predictors of ***:Reduced eGFR was present in 71.1% of 2160 patients,with significant renal impairment (eGFR < 60 mL/min every 1.73 m2) in 14.8%.The prevalence of HF was higher with worsening renal function:15.5%,17.8% and 29.4% in patients with CKD stages 1,2 and 3 or 4,respectively (P < 0.0001),despite a small absolute difference in mean EF across eGFR groups:48.2 ± 10.0,47.9 ± 11.3 and 46.2 ± 12.1,respectively (P=0.02).The prevalence of HF was again higher with worsening renal function among patients with preserved EF:10.1%,13.6% and 23.6% (P < 0.0001),but this relationship was not significant among patients with depressed EF:27.1%,26.2% and 37.9% (P= 0.071).Moreover,eGFR was an independent correlate of HF in patients with preserved EF (P=0.003) but not in patients with depressed EF (P=0.181).CONCLUSION:A significant proportion of post-MI patients with occluded IRAs have impaired renal *** renal function was associated with an increased rate of early post-MI HF,the association being strongest in patients with preserved *** findings have implications for management of peri-infarct HF.

关键词： Heart failure Myocardial infarction Kidney disease