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The bad and the good of mesenchymal stem cells in cancer: Boosters of tumor growth and vehicles for targeted delivery of anticancer agents

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World Journal of Stem Cells 2010年第1期2卷 5-12页

作者： Umberto Galderisi antonio giordano Marco G Paggi Sbarro Institute for Cancer Research and Molecular Medicine Center for BiotechnologyTemple UniversityPhiladelphiaPA 19122United States Department of Experimental Medicine Biotechnology and Molecular Biology SectionSecond University of NaplesNaples 80138Italy Human Health Foundation Terni 05100Italy National Cancer Institute"Regina Elena" Rome 00144Italy

In cancer biology,mesenchymal stem cells(MSCs)display aspects that can appear *** one hand,these cells possess several features which give them the ability to specifically target and then sustain cancer cells in their ability to survive the multifaceted host response against *** the other hand,due to this excellent aptitude to home-in on tumor tissues,regardless their location in the host’s body,MSCs are considered to be extremely selective vehicles to reach cancer cells ***,MSC sustainment of cancer cell growth is a hot research ***,these cells are known to sustain tumor angiogenesis and metastasis formation,to create a microenvironment favorable for cancer cell growth and to down-modulate the immune system capabilities in the host *** the other hand,since scientists became able to take advantage of their extremely selective capability to target cancer cells,MSCs are now also thought of in a different ***,MSCs are now considered a promising vehicle for local expression or delivery of even particularly toxic anticancer agents,ranging from Herpes Simplex Virus to locally-acting antineoplastic *** this basis,investigation is now focused on how to impair the pro-neoplastic features of MSCs on one hand whilst taking advantage of their specific tropism toward cancer cells,on the *** with the two faces of Janus,this review will concisely explore the research activity in these two apparently conflicting fields.

关键词： Mesenchymal stem cells Cancer Cell therapy Angiogenesis Niche Immunomodulation

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Novel findings about management of gastric cancer: A summary from 10^(th) IGCC

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World Journal of Gastroenterology 2014年第27期20卷 8986-8992页

作者： Danila Penon Letizia Cito antonio giordano Department of Biochemistry and Medical Biotechnology University of Naples Federico Ⅱ 80131 Naples Italy Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione Giovanni Pascale" IRCCS 80131 Naples Italy Sbarro Institute for Cancer Research and Molecular Medicine Philadelphia PA 19122 United States Center of Biotechnology College of Science and Technology Temple University Philadelphia PA 19122 United States Department of Medicine Surgery and Neuroscience University of Siena 53100 Siena Italy

The Tenth International Gastric Cancer Congress(IGCC) was held in Verona, Italy, from June 19 to 22, 2013. The meeting enclosed various aspects of stomach tumor management, including both tightly clinical approaches, and topics more related to basic research. Moreover, an overview on gastrointestinal stromal tumors was provided too, although here not discussed. Here we will discuss some topics related to molecular biology of gastric cancer(GC), inherent to prognostic, diagnostic and therapeutic tools shown at the conference. Results about well known subjects, such as E-cadherin loss of expression/function, were presented. They revealed that other mutations of the gene were identified, showing a continuous research to improve diagnosis and prognosis of stomach tumor. Simultaneously, new possible molecular markers with an established role for other neoplasms, were discussed, such as mesothelin, stomatin-like protein 2 and Notch-1. Hence, a wide overview including both old and new diagnostic/prognostic tools was offered. Great attention was also dedicated to possible drugs to be used against GC. They included monoclonal antibodies, such as MS57-2.1, drugs used in other pathologies, such as maraviroc, and natural extracts from plants such as biflorin. We would like to contribute to summarize the most impressive studies presented at the IGCC, concerning novel findings about molecular biology of gastric cancer. Although further investigations will be necessary, it can be inferred that more and more tools were developed, so as to better face stomach neoplasms.

关键词： Gastric cancer Prognostic tools Markers Therapy

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Effects of Unsaturated Fatty Acid Esters of Testosterone on Neuronal, Behavioral and Hormonal Parameters in Male Rats Subjected to the Formalin Test

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Open Journal of Endocrine and Metabolic Diseases 2014年第6期4卷 167-179页

作者： Anna Petroni Paolo Fiorenzani Valentina Tomei antonio Garofalo Francesca Aiello Daniele Della Seta antonio giordano Stella Vodo Ilaria Ceccarelli Anna Maria Aloisi Department of Medicine Surgery and Neuroscience University of Siena Siena Italy Department of Pharmacological and Biomolecular Sciences University of Milan Milan Italy Department of Pharmacy and Health Nutrition Sciences University of Calabria Rende Italy

Chronic diseases are often accompanied by inflammatory and degenerative processes. Estrogens have repeatedly been found to be involved in these processes. Testosterone (T) is the main precursor of estrogen in the brain and T replacement in chronic diseases has become important in recent years, prompting research on new T-conjugated molecules. We recently synthesized three new molecules including unsaturated fatty acid esters: T-linoleate (TL), T-oleate (TO) and T-eicosapentanoate (TEPA). These substances were s.c. administered for 7 days to intact male rats subjected to the formalin test (FT). Three other groups were included as comparisons: NAIVE, receiving no substance, OIL, treated with almond oil (vehicle), and TN, treated with T-undecanoate, a?saturated?fatty acid. Spontaneous behaviors and pain-induced responses were determined during the FT, hormones (T and dihydrotestosterone, DHT) were determined in blood, while estrogen receptors (ERα?and?β) were detected at the genomic and proteomic levels in the hippocampus, hypothalamus and spinal cord. In the hippocampus, ERα?and ERβ?mRNA levels were increased respectively by TN and TL treatments with respect to OIL, whereas the hypothalamus TO and TL caused a decrease of ERα?mRNA levels. At the proteomic level, TO, TL and TEPA decreased the levels of ERα?in the hypothalamus, whereas TEPA decreased ERβ?in the spinal cord, hippocampus and hypothalamus. There was no effect of treatment on the spontaneous behaviors, while the TO and TL groups showed lower pain-induced behaviors (paw jerk frequency and licking duration) than the OIL group. TN increased paw jerk frequency and decreased licking duration with respect to OIL. The treatments had no effect on T and DHT plasma levels. These results clearly indicate the possibility of pain and ER modulation by T-esters.

关键词： Testosterone CNS Fatty Acids Pain Estrogen Receptors

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Advances in gastric cancer prevention

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World Journal of Clinical Oncology 2012年第9期3卷 128-136页

作者： antonio giordano Letizia Cito INT-CROM "Pascale Foundation" National Cancer Institute-Cancer Research Center Human Pathology and Oncology Department University of Siena

Gastric cancer is a multifactorial neoplastic pathology numbering among its causes both environmental and genetic predisposing factors. It is mainly diffused in South America and South-East Asia, where it shows the highest morbility percentages and it is relatively scarcely diffused in Western countries and North America. Although molecular mechanisms leading to gastric cancer development are only partially known, three main causes are well characterized: Helicobacter pylori(H. pylori) infection, diet rich in salted and/or smoked food and red meat, and epithelial cadherin(E-cadherin) mutations. Unhealthy diet and H. pylori infection are able to induce in stomach cancer cells genotypic and phenotypic transformation, but their effects may be crossed by a diet rich in vegetables and fresh fruits. Various authors have recently focused their attention on the importance of a well balanced diet, suggesting a necessary dietary education starting from childhood. A constant surveillance will be necessary in people carrying E-cadherin mutations, since they are highly prone in developing gastric cancer, also within the inner stomach layers. Above all in the United States, several carriers decided to undergo a gastrectomy, preferring changing their lifestyle than living with the awareness of the development of a possible gastric cancer. This kind of choice is strictly personal, hence a decisioncannot be suggested within the clinical management. Here we summarize the key points of gastric cancer prevention analyzing possible strategies referred to the different predisposing factors. We will discuss about the effects of diet, H. pylori infection and E-cadherin mutations and how each of them can be handled.

关键词： Cancer Prevention Diet Vegetables Cell cycle Lifestyle Helicobacter pylori

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Ferrierite vs. γ-Al_2O_3: The superiority of zeolites in terms of water-resistance in vapour-phase dehydration of methanol to dimethyl ether

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Journal of Energy Chemistry 2019年第3期28卷 162-169页

作者： Enrico Catizzone Massimo Migliori antonio Purita Girolamo giordano Department of Environmental and Chemical Engineering University of Calabria

The catalytic conversion of methanol to dimethyl ether(DME) over a series of home-made FER-type zeolites having different acidities and commercial γ-Al_2O_3 has been studied with the aim to understand the impact of adding water in the reactant stream on the catalytic behavior on investigated materials. Cofeeding water with methanol, the alcohol conversion was slightly reduced over the investigated zeolites while the catalytic activity of γ-Al_2O_3, the traditional catalyst of MeOH-to-DME conversion, was strongly inhibited. It was also found that, for the investigated zeolites, both the amount and the initial deposition rate of the coke formed during the reaction were reduced when water was co-fed with methanol while no significant effects on both methanol conversion and DME selectivity were observed under the investigated conditions.

关键词： Ferrierite Zeolites Methanol dehydration Dimethyl ether Coke

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Phrenic nerve displacement by intrapericardial balloon inflation during epicardial ablation of ventricular tachycardia: Four case reports

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World Journal of Cardiology 2020年第1期12卷 55-66页

作者： Sergio Conti Vito Bonomo antonio Taormina Umberto giordano Giuseppe Sgarito Department of Cardiology ElectrophysiologyPalermo 90127Italy Faculty of Medicine University of Tor VergataRome 00133Italy Department of Cardiology University of PalermoPalermo 90127Italy Department of Cardiology University of MessinaMessina 98122Italy

BACKGROUND Phrenic nerve(PN)injury is one of the recognized possible complications following epicardial ablation of ventricular tachycardia(VT).High-output pacing is a widely used maneuver to establish a relationship between the PN and the ablation catheter *** absence of PN capture is usually considered an indication that it is safe to ablate,and that successful ablation may be performed at adjacent ***,PN capture may impact the procedural *** a few cases have been reported in the literature that avoid PN injury by using different *** SUMMARY Three patients with a previous history of myocarditis and one patient with ischemic cardiomyopathy underwent epicardial ablation for drug-refractory *** the procedure,transthoracic echocardiogram,coronary angiogram,and cardiac magnetic resonance imaging were performed on all *** general anesthesia,endo/epicardial three-dimensional anatomical and substrate maps of the left ventricle were *** radiofrequency delivery,the course of the PN was identified by provoking diaphragmatic stimulation with high-output pacing from the distal electrode of the ablation *** every case,a scar region with late potentials was mapped along the PN *** obtaining another epicardial access,a second introducer sheath was placed,and a vascular balloon catheter was inserted into the epicardial space and inflated with saline solution to separate the PN from the *** the absence of PN capture had been proven,radiofrequency was applied to aim for complete late potential elimination and avoid VT *** PN injury can occur as one of the complications following epicardial VT ablation procedures,and may prevent successful ablation of these *** displacement by using large balloon catheters into the epicardial space seems to be feasible and reproducible,avoid procedure-related morbidity,and improve ablation success when performed in selected cent

关键词： Catheter ablation Epicardial access Myocarditis Nonischemic cardiomyopathy Ventricular tachycardia Phrenic nerve Case series

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Hepatitis C virus infection and thyroid autoimmunedisorders:A model of interactions between the host and theenvironment

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World Journal of Hepatology 2016年第2期8卷 83-91页

作者： francesca pastore antonio martocchia manuela stefanelli pietro prunas stefania giordano lavinia toussan antonio devito paolo falaschi “Sapienza”University of Rome Faculty of Medicine and PsychologyS.Andrea Hospital00189 RomeItaly

The hepatitis C virus(HCV) infection is an important public health problem and it is associated with hepatic and extrahepatic manifestations. Autoimmune thyroid diseases are common in HCV infected patients and the standard interferon-based treatment is associated with an increase of the immune-mediated thyroid damage. Recent evidence in the literature analyzed critical points of the mechanisms of thyroid damage, focusing on the balance between the two sides of the interaction: The environment(virus infection with potential crossreaction) and the host(susceptibility genes with consistent immune response). The spectrum of antiviral treatment for chronic HCV infection is rapidly expanding for the development of dual o triple therapy. The availability of interferon-free combined treatment with direct antiviral agents for HCV is very promising, in order to ameliorate the patient compliance and to reduce the development of thyroid autoimmunity.

关键词： Hepatitis C virus Thyroid autoimmunity Interferon Antiviral agents Self-tolerance

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Markers of bile duct tumors

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World Journal of Gastrointestinal Oncology 2011年第4期3卷 49-59页

作者： Giulia Malaguarnera Maria giordano Isabella Paladina Alessandra Rando Mario Uccello Francesco Basile antonio Biondi Santo Carnazzo Innocenza Alessandria Clorinda Mazzarino Department of Biomedical Science University of Catania Departments of Senescence Urologicaland Neurological SciencesUniversity of Catania Department of General Surgery University Medical School of CataniaHospital Vittorio Emanuele Department of General Surgery University Medical School of Catania Department of Internal Medicine University Medical School of CataniaHospital Cannizzaro

Biliary tract carcinomas are relatively rare,representing less than 1%of ***,their incidence has increased in Japan and in industrialized countries like the *** tract tumors have a poor prognosis and a high mortality rate because they are usually detected late in the course of the disease;therapeutic treatment options are often limited and of minimal *** studies have shown the importance of serum and molecularmarkers in the diagnosis and follow up of biliary tract *** review aims to introduce the main features of the most important serum and molecular markers of biliary tree *** considerable tumor markers are cancer antigen 125,carbohydrate antigen 19-9,carcinoembryonic antigen,chromogranin A,mucin 1,mucin 5,alpha-fetoprotein,claudins and cytokeratins.

关键词： Bile duct tumors Cholangiocarcinoma Tumor markers Carbohydrate antigen 19-9 Chromogranin A

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欧洲精神病学协会精神分裂症认知功能损害评估指引(全译)

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中华精神科杂志 2024年第9期57卷 543-561页

作者：蒲城城于欣石川邓红刘莎刘哲宁刘登堂张天宏陆峰李晓白胡婉珩高天奇黄冰洁北京大学第六医院、北京大学精神卫生研究所、国家卫生健康委员会精神卫生学重点实验室(北京大学)、国家精神心理疾病临床医学研究中心(北京大学第六医院) 四川大学华西医院心理卫生中心山西医科大学第一医院精神卫生科中南大学湘雅二医院精神病学科、国家精神心理疾病临床研究中心、国家精神疾病医学中心上海交通大学医学院附属精神卫生中心同济大学附属同济医院精神医学中心中国医科大学附属第一医院精神科

背景既往研究显示精神分裂症患者存在广泛的认知功能损害。神经认知功能损害和社会认知功能损害被认为是精神分裂症导致严重功能残疾的原因。尽管认知功能对精神分裂症预后起关键作用,但无论是在科研研究中,还是临床实践中,相关评估都... 详细信息

背景既往研究显示精神分裂症患者存在广泛的认知功能损害。神经认知功能损害和社会认知功能损害被认为是精神分裂症导致严重功能残疾的原因。尽管认知功能对精神分裂症预后起关键作用,但无论是在科研研究中,还是临床实践中,相关评估都非常不足。方法本文对科学文献进行系统综述,详细阐述在科研研究和临床实践中对精神分裂症认知功能评估的若干推荐。结果专家共识和系统综述为精神分裂症认知功能的最佳评估提供了指导。基于遴选的证据,本欧洲精神病学协会精神分裂症认识功能损害评估指引(下文简称指引)建议,在精神分裂症的全病程以及精神病风险人群中进行神经认知功能和社会认知功能2个领域的全面且系统的评估。指引不仅建议使用知情者报告,也建议使用自我报告和基于访谈的认知功能评估工具。指引还系统地回顾了首次发作精神病患者和精神病高危人群的评估现状。结论对证据的全面审查和推荐建议可能有助于推动这一领域的发展,有利于进行更好的认知功能评估,并避免与其他精神病理学维度重叠。该指导性文件的传播可促进涉及精神分裂症认知功能评估的相关指南的制定,从而提高医疗质量并获得临床痊愈。

关键词：精神分裂症精神病学精神病理学认知功能损害全病程精神病患者自我报告临床实践

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CRT-D Upgrading in a Patient with Persistent Left Superior Vena Cava and Right Superior Vena Cava Atresia Using the Novel Active-Fixation Quadripolar Left Ventricular Lead

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World Journal of Cardiovascular Diseases 2018年第9期8卷 462-466页

作者： Sergio Conti antonio Taormina Vito Bonomo Umberto giordano Giuseppe Sgarito ARNAS Ospedale Civico Di Cristina Benfratelli Palermo Italy University of Tor Vergata Rome Italy University of Messina Messina Italy University of Palermo Palermo Italy

The persistence of left superior vena cava (PLSVC) is the most common congenital anomaly of the venous return system to the heart. Because of the increasing number of patients referred for cardiac resynchronization therapy (CRT) devices implantations, it is expected to encounter this venous anatomic variation. Left ventricular lead placement at an appropriate site is an integral and technically challenging part of successful CRT. In case of cardiac abnormalities could be difficult to achieve an optimal cardiac rhythm management devices implantation. Previous reports in patients with PLSVC highlighted the challenges to achieve an optimal cardiac rhythm device implantation. Recently, a new quadripolar active fixation left ventricular lead is available for CRT device implantation. Hereby we report a case of a device upgrading from dual-chamber pacemaker to CRT with defibrillator backup using the active fixation left ventricular quadripolar lead in a patient with PLSVC and right superior vena cava atresia.

关键词： Cardiac Resynchronization Therapy Anatomic Abnormalities Persistent Left Superior Vena Cava Right Vena Cava Atresia Active-Fixation Lead

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