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Validation of Fujinon intelligent chromoendoscopy with high definition endoscopes in colonoscopy

World Journal of Gastroenterology 2009年第42期15卷 5266-5273页

作者： Adolfo Parra-Blanco Alejandro Jiménez Bjrn Rembacken Nicolás González David Nicolás-Pérez antonio Z gimeno-garcía Marta Carrillo-Palau Takahisa Matsuda Enrique Quintero Department of Gastroenterology University Hospital of the Canary Islandsc/Ofra s/nLa Laguna 38320TenerifeSpain Department of Gastroenterology Hospital Universitario Central de AsturiasCelestino Villamil s/n33006 OviedoPrincipado de AsturiasSpain Research Unit University Hospital of the Canary Islandsc/Ofra s/nLa Laguna 38320TenerifeSpain Centre for Digestive Diseases The General Infirmary at LeedsGreat George StLeedsLS1 3EXUnited Kingdom Department of Gastroenterology Hospital de Clínicas de MontevideoAvda.Italia s/nMontevideo 11600Uruguay Division of Endoscopy National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyo 104-0045Japan

AIM:To validate high definition endoscopes with Fujinon intelligent chromoendoscopy(FICE) in ***:The image quality of normal white light endoscopy(WLE),that of the 10 available FICE filters and that of a gold standard(0.2% indigo carmine dye) were ***:FICE-filter 4 [red,green,and blue(RGB) wavelengths of 520,500,and 405 nm,respectively] provided the best images for evaluating the vascular pattern compared to white *** mucosal surface was best assessed using filter ***,the views obtained were not rated significantly better than those observed with white *** "gold standard",indigo carmine(IC) dye,was found to be superior to both white light and filter *** 6(RGB wavelengths of 580,520,and 460 nm,respectively) allowed for exploration of the IC-stained *** assessing mucosal polyps,both FICE with magnification,and magnification following dye spraying were superior to the same techniques without magnification and to white light *** the presence of suboptimal bowel preparation,observation with the FICE mode was possible,and endoscopists considered it to be superior to observation with white ***:FICE-filter 4 with magnification improves the image quality of the colonic vascular patterns obtained with WLE.

关键词：内窥镜结肠镜内镜色素智能检查富士验证

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Endoscopic submucosal dissection training with pig models in a Western country

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World Journal of Gastroenterology 2010年第23期16卷 2895-2900页

作者： Adolfo Parra-Blanco María Rosa Arnau David Nicolás-Pérez antonio Z gimeno-garcía Nicolás González Juan A Díaz-Acosta Alejandro Jiménez Enrique Quintero Department of Gastroenterology University Hospital of the Canary Islands Ofra s/n Endoscopy Unit Department of GastroenterologyAsturias Central University HospitalCelestino Villamil s/n Research Animal Laboratory Ofra s/nLa Laguna University Department of Gastroenterology Montevideo Clinic HospitalAvda Italia s/n Research Unit University Hospital of the Canary IslandsOfra s/n

AIM:To test a strategy for endoscopic submucosal dissection(ESD) training in animal models designed to overcome the initial learning ***:ESD was attempted in ex vivo and in vivo pig *** ESD procedures were attempted in the esophagus(n=9) or the stomach(n=21).The ex vivo model was used until initial competence was *** the in vivo model,several ESD procedures were performed in up to 3 *** following variables were analyzed:specimen size,complete and en bloc resection rate,time for circumferential incision,time for submucosal dissection,total ESD duration,and ***:Complete resection was achieved in 28 cases(en bloc 27);2 could not be completed(one perforation,one technical diff iculty).The mean ± SD time for circumferential incision was 36.2±16.8 min(range:8-87 min),and the mean±SD time for submucosal dissection was 45.1±35.7 min(range:9-196 min).The mean±SD size of the resected specimens was 45.2±17.8 *** mean±SD total resection time was signif icantly increased for the gastric cases performed in the f irst half of the study(n=13) than in the second half(n=8)(98.9±62.4 min vs 61.7±17.6 min,P=0.04),although the specimen size did not ***:Training in animal models could help endoscopists overcome the learning curve before starting ESD in humans.

关键词： Endoscopic submucosal dissection Training Animal model

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The timing of bowel preparation before colonoscopy determines the quality of cleansing,and is a significant factor contributing to the detection of flat lesions:A randomized study

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World Journal of Gastroenterology 2006年第38期12卷 6161-6166页

作者： Adolfo Parra-Blanco David Nicolás-Pérez antonio gimeno-garcía Begoa Grosso Alejandro Jiménez Juan Ortega Enrique Quintero Department of Gastroenterology Hospital Universitario de Canarias La Laguna 38109 Santa Cruz de Tenerife Spain Research Unit Hospital Universitario de Canarias La Laguna 38109 Santa Cruz de Tenerife Spain

AIM: To compare the cleansing quality of polyethylene glycol electrolyte solution and sodium phosphate with different schedules of administration, and to evaluate whether the timing of the administration of bowel preparation affects the detection of polyps. METHODS: One hundred and seventy-seven consecutive outpatients scheduled for colonoscopy were randomized in one of four groups to receive polyethylene glycol electrolyte solution or oral sodium phosphate with two different timing schedules. Quality of cleansing, polyp detection, and tolerance were evaluated. RESULTS: Patients receiving polyethylene glycol or sodium phosphate on the same day as the colonoscopy, obtained good to excellent global cleansing scores more frequently than patients who received polyethylene glycol or sodium phosphate on the day prior to the procedure (P < 0.001). Flat lesions, but not flat adenomas, were more frequent in patients prepared on the same day (P = 0.02). CONCLUSION: The quality of colonic cleansing and the detection of flat lesions are significantly improved when the preparation is taken on the day of the colonoscopy.

关键词：结肠镜检查聚乙烯消化疾病病理

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The Role of the Solar Cycle in the Relationship Between the North Atlantic Oscillation and Northern Hemisphere Surface Temperatures

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Advances in Atmospheric Sciences 2007年第2期24卷 191-198页

作者： Laura DE LA TORRE Luis gimeno Juan antonio AEL Raquel NIETO Universidad de Vigo Facultad de Ciencias de Ourense 32004OurenseSpain

The North Atlantic Oscillation （NAO） is one of the leading modes of climate variability in the Northern Hemisphere. It has been shown that it clearly relates to changes in meteorological variables, such as surface temperature, at hemispherical scales. However, recent studies have revealed that the NAO spatial pattern also depends upon solar forcing. Therefore, its effects on meteorological variables must vary depending upon this factor. Moreover, it could be that the Sun affects climate through variability patterns, a hypothesis that is the focus of this study. We find that the relationship between the NAO/AO and hemispheric temperature varies depending upon solar activity. The results show a positive significant correlation only when solar activity is high. Also, the results support the idea that solar activity influences tropospheric climate fluctuations in the Northern Hemisphere via the fluctuations of the stratospheric polar vortex .

关键词： solar activity North Atlantic Oscillation Arctic Oscillation Northern Hemisphere surface temperature

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Recent advances in bird sperm morphometric analysis and its role in male gamete characterization and reproduction technologies

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Asian Journal of Andrology 2016年第6期18卷 882-888页

作者： Julian Santiago-Moreno Milagros Cristina Esteso Silvia Villaverde-Morcillo Adolfo Toledano-Diaz Cristina Castafio Rosario Velazquez antonio Lopez-Sebastian Agustin Lopez Goya Javier gimeno Martinez Department of Animal Reproduction INIA 28040 Madrid Spain Veterinary Clinical and Research Services Fieb Foundation 28760 Tres Cantos Madrid Spain FAUNIA 28032 Madrid Spain

Postcopulatory sexual selection through sperm competition may be an important evolutionary force affecting many reproductive traits, including sperm morphometrics. Environmental factors such as pollutants, pesticides, and climate change may affect different sperm traits, and thus reproduction, in sensitive bird species. Many sperm-handling processes used in assisted reproductive techniques may also affect the size of sperm cells. The accurately measured dimensions of sperm cell structures （especially the head） can thus be used as indicators of environmental influences, in improving our understanding of reproductive and evolutionary strategies, and for optimizing assisted reproductive techniques （e.g., sperm cryopreservation） for use with birds. Computer-assisted sperm morphometry analysis （CASA-Morph） provides an accurate and reliable method for assessing sperm morphometry, reducing the problem of subjectivity associated with human visual assessment. Computerized systems have been standardized for use with semen from different mammalian species. Avian spermatozoa, however, are filiform, limiting their analysis with such systems, which were developed to examine the approximately spherical heads of mammalian sperm cells. To help overcome this, the standardization of staining techniques to be used in compute^-assessed light microscopical methods is a priority. The present review discusses these points and describes the sperm morphometric characteristics of several wild and domestic bird species.

关键词： avian computer-assisted assay morphometry spermatozoa

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Narrow band imaging and white light endoscopy in the characterization of a polypectomy scar:A single-blind observational study

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World Journal of Gastroenterology 2018年第45期24卷 5179-5188页

作者： Fausto Riu Pons Montserrat Andreu Javier gimeno Beltran Marco antonioálvarez-Gonzalez Agustín Seoane Urgorri Josep Maria Dedeu Luis Barranco Priego Xavier Bessa Gastroenterology Department Hospital del MarBarcelona 08003Spain IMIM(Hospital del Mar Medical Research Institute) Barcelona 08003Spain Department of Medicine Autonomous University of BarcelonaBarcelona 08003Spain Pompeu Fabra University Barcelona 08003Spain Pathology Department Hospital del MarBarcelona 08003Spain.

AIM To assess the incremental benefit of narrow band imaging(NBI) and white light endoscopy(WLE), randomizing the initial technique for the detection of residual neoplasia at the polypectomy scar after an endoscopic piecemeal mucosal resection(EPMR).METHODS We conducted an observational study in an academic center to assess the incremental benefit of NBI and WLE randomly applied 1:1(NBI-WLE or WLE-NBI) in the follow-up of a post-EPMR scar by the same *** A total of 112 EPMR scars were included. The median baseline polyp size was 20 mm(interquartile range: 14-30). At first review, NBI and WLE showed good sensitivity(85.0% vs 78.9%), specificity(77.1% vs 84.2%) and overall accuracy(80.0% vs 82.5%). NBI after WLE(WLE-NBI group) improved accuracy, but this difference was not statistically significant [area under the curve(AUC): 86.8% vs 81.6%, P = 0.15]. WLE after NBI(NBI-WLE group) did not improve accuracy(AUC: 81.4% vs 81.1%, P = 0.9). Overall, recurrence was found in 39/112(34.8%) *** Although no statistically significant differences were found between the two techniques at the first postEPMR assessment, the use of NBI after WLE may improve residual neoplasia detection. Nevertheless, biopsy is still required in the first scar review.

关键词： Colonoscopy Narrow band imaging Endoscopic mucosal resection

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