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Contrast-enhanced ultrasound Liver Imaging Reporting and Data System:Lights and shadows in hepatocellular carcinoma and cholangiocellular carcinoma diagnosis

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World Journal of Gastroenterology 2022年第27期28卷 3488-3502页

作者： Gianpaolo Vidili Marco Arru Giuliana Solinas Diego Francesco Calvisi Pierluigi Meloni Assunta Sauchella Davide Turilli Claudio Fabio antonio Cossu giordano Madeddu Sergio Babudieri Maria Assunta Zocco Giovanni Iannetti Enza Di Lembo Alessandro Palmerio Delitala Roberto Manetti Department of Medical Surgical and Experimental SciencesUniversity of SassariSassari 07100Italy Department of Biomedical Sciences Public Health-Laboratory of BiostatisticsUniversity of SassariSassari 07100Italy Department of Internal Medicine and Gastroenterology Fondazione Policlinico Universitario A.Gemelli IRCCSCatholic UniversityRome 00168Italy Ultrasound Unit Ospedale S.SpiritoPescara 65123Italy

BACKGROUND Contrast-enhanced ultrasound(CEUS)is considered a secondary examination compared to computed tomography(CT)and magnetic resonance imaging(MRI)in the diagnosis of hepatocellular carcinoma(HCC),due to the risk of misdiagnosing intrahepatic cholangiocarcinoma(ICC).The introduction of CEUS Liver Imaging Reporting and Data System(CEUS LI-RADS)might overcome this *** though data from the literature seems promising,its reliability in real-life context has not been well-established *** To test the accuracy of CEUS LI-RADS for correctly diagnosing HCC and ICC in *** CEUS LI-RADS class was retrospectively assigned to 511 nodules identified in 269 patients suffering from liver *** diagnostic standard for all nodules was either biopsy(102 nodules)or CT/MRI(409 nodules).Common diagnostic accuracy indexes such as sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)were assessed for the following associations:CEUS LR-5 and HCC;CEUS LR-4 and 5 merged class and HCC;CEUS LR-M and ICC;and CEUS LR-3 and *** frequency of malignant lesions in CEUS LR-3 subgroups with different CEUS patterns was also ***-rater agreement for CEUS LI-RADS class assignment and for major CEUS pattern identification was *** CEUS LR-5 predicted HCC with a 67.6%sensitivity,97.7%specificity,and 99.3%PPV(P<0.001).The merging of LR-4 and 5 offered an improved 93.9%sensitivity in HCC diagnosis with a 94.3%specificity and 98.8%PPV(P<0.001).CEUS LR-M predicted ICC with a 91.3%sensitivity,96.7%specificity,and 99.6%NPV(P<0.001).CEUS LR-3 predominantly included benign lesions(only 28.8%of malignancies).In this class,the hypo-hypo pattern showed a much higher rate of malignant lesions(73.3%)than the iso-iso pattern(2.6%).Inter-rater agreement between internal raters for CEUS-LR class assignment was almost perfect(n=511,k=0.94,P<0.001),while the agreement among raters from separate centres was subst

关键词： Contrast-enhanced ultrasound Liver Imaging Reporting and Data System Hepatocellular carcinoma Intrahepatic cholangiocarcinoma Cirrhosis Contrast-enhanced ultrasound Liver

Sorbents with high efficiency for CO2 capture based on amines-supported carbon for biogas upgrading

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Journal of Environmental Sciences 2016年第10期28卷 138-150页

作者： Lidia Pino Cristina Italiano antonio Vita Concetto Fabiano Vincenzo Recupero CNR Institute of Aduanced Technology for Energy "Nicola giordano" Via S. Lucia 5 98126 Messina Italy

Sorbents for CO2 capture have been prepared by wet impregnation of a commercial active carbon （Ketjen-black, Akzo Nobel） with two CO2-philic compounds, polyethylenimine （PEI） and tetraethylenepentamine （TEPA）, respectively. The effects of amine amount （from 10 to 70 wt.%）, CO2 concentration in the feed, sorption temperature and gas hourly space velocity on the CO2 capture performance have been investigated. The sorption capacity has been evaluated using the breakthrough method, with a fixed bed reactor equipped with on line gas chromatograph. The samples have been characterized by N2 adsorption-desorption, scanning electron microscopy and energy dispersive X-ray （SEM/EDX）. A promising CO2 sorption capacity of 6.90 mmo1/gsorbent has been obtained with 70 wt.% of supported TEPA at 70℃ under a stream containing 80 vol% of CO2. Sorption tests, carried out with simulated biogas compositions （CH4/CO2 mixtures）, have revealed an appreciable CO2 separation selectivity; stable performance was maintained for 20 adsorption-desorption cycles.

关键词： CO2 capturePEI-TEPA based sorbentsAmine efficiencyBiogasSeparation selectivity

Serotyping and genotyping ofEscherichia Coli strains from clinically healthy and colibacillosis affected flocks

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Serotyping and genotyping ofEscherichia Coli strains from cl...

Intestinal metastasis from breast cancer:Presentation,treatment and survival from a systematic literature review

The 15th World Veterinary Poultry Congress

作者： Elena Circella giordano Bruni Donato Pennelli Patrizia Battista Giancarlo Di Paola Silvia Tagliabue antonio Camarda Dipartimento di Sanità e Benessere degli Animali Sezione di Patologia AviareUniversità degli Studi di BariItaly. Dipartimento di Sanità e Benessere degli Animali Sezione di Patologia AviareUniversità degli Studi di BariItaly. Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna BresciaItaly Dipartimento di Sanità e Benessere degli Animali Sezione di Patologia AviareUniversità degli Studi di BariItaly. Dipartimento di Sanità e Benessere degli Animali Sezione di Patologia AviareUniversità degli Studi di BariItaly. Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna BresciaItaly Dipartimento di Sanità e Benessere degli Animali Sezione di Patologia AviareUniversità degli Studi di BariItaly

＜正＞112 Escherichia（E.）coli strains from laying hens of 23 different farms of Apulia were serotyped and tested for the presence of virulence *** particular,we tested for iss - increased serum survival protein, irp2 - iron-repressible protein,iucD - aerobactin,tsh - temperature-sensitive haemagglutinin,vat - vacuolating

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World Journal of Clinical Oncology 2021年第5期12卷 382-392页

作者： Elena Bolzacchini Olga Nigro Davide Inversini Monica giordano Giovanni Maconi Department of Oncology Ospedale Sant'AnnaASST LarianaComo 22100ItalyDepartment of Medicine and SurgeryUniversity of InsubriaVarese 21100Italy Department of Oncology Ospedale di Circolo ASST-Sette LaghiVarese 21100Italy Department of General Surgery Ospedale Sant'Antonio AbateASST LarianaCantu'22100Italy Department of Oncology Ospedale Sant'AnnaASST LarianaComo 22100Italy Department of Biomedical and Clinical Sciences Gastroenterology Unit"Luigi Sacco"University HospitalMilano 20157Italy

BACKGROUND Intestinal metastases from breast cancer(BC)arerare;available data depend mainly on case reports and case *** To conduct a review of the literature regarding presentation,diagnosis,treatment and survival of patients with intestinal metastasis from *** We identified all articles that described patients with intestinal metastasis(from duodenum to anum)from BC using MEDLINE(1975 to 2020)and EMBASE(1975 to 2020)electronic *** We found 96 cases of intestinal metastasis of *** involved large bowel(cecum,colon,sigmoid,rectum)(51%),small bowel(duodenum,jejunum,ileum)(49%),and anum(<1%).Median age of patients was *** most frequent histology was infiltrating lobular carcinoma followed by infiltrating ductal *** more than half of patients,the diagnosis was made after the diagnosis of BC(median:7.2 years)and in many cases of emergency,for bowel obstruction,bleeding or *** was achieved through endoscopy,radiological examination or *** most of the cases,patients underwent surgery with or without systemic *** of patients included in this review was available in less than 50%of patients and showed an overall median of 12 mo since diagnosis of the intestinal *** Although,intestinal metastases of BC are considered a rare condition,clinicians should consider the possibility of intestinal involvement in case of abdominal symptoms even in acute setting and many years after the diagnosis of BC,especially in patients with a histology of lobular carcinoma.

关键词： Breast cancer Intestinal metastasis Diagnosis Treatment Small bowel Large bowel

Focal Thyroid Uptake during <sup>18</sup>F-Choline PET/CT: A Case Report

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Case Reports in Clinical Medicine 2015年第11期4卷 345-348页

作者： giordano Savelli Pietro Basile Alfredo Muni Claudio Bna Claudio Pizzocaro Renato Pagani Nuclear Medicine Fondazione Poliambulanza Istituto Ospedaliero Brescia Italy Nuclear Medicine SS. Antonio e Biagio Arrigo Alessandria Italy Radiology Fondazione Poliambulanza Istituto Ospedaliero Brescia Italy Renato Pagani Carlo Poma Hospital Mantua Italy

Here we report the case of a 60-year-old patient previously affected by prostate cancer treated with prostatectomy. After surgery, the patient was scheduled for routine follow up examinations including biochemical and imaging evaluations. PSA testing evidenced a light, continuous increase in the course of the last four sampling. This finding calls for a biochemical recurrence. Thus the patient underwent a 18F-Fluorocholine (FCH) PET/CT to detect the possible sites of the relapse. FCH PET/CT did not disclose any focal uptake suggesting a metastatic spread. However, one focal uptake was noticed in the lower pole of the right thyroid lobe, corresponding to a hypodense nodule. Therefore, the patient was studied with 99 mTc thyroid scan and neck ultrasound. Both examinations had findings suspicious of a neoplasm. The fine needle aspiration biopsy (FNAB) that was carried out to rule out a malignancy, gave a TIR2 result. FCH PET/CT may give thyroidal uptakes in benign lesions.

关键词： 18F-Choline PET/CT Prostate Cancer Thyroid Incidentaloma

Transcranial direct current stimulation in psychiatric disorders

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World Journal of Psychiatry 2015年第1期5卷 88-102页

作者： Gabriel Tortella Roberta Casati Luana V M Aparicio antonio Mantovani Natasha Senco giordano D’Urso Jerome Brunelin Fabiana Guarienti Priscila Mara Lorencini Selingardi Débora Muszkat Bernardo de Sampaio Pereira Junior Leandro Valiengo Adriano H Moffa Marcel Simis Lucas Borrione André R Brunoni Service of Interdisciplinary Neuromodulation Laboratory of Neurosciences (LIM-27)Department and Institute of PsychiatryUniversity of Sao Paulo Interdisciplinary Center for Applied Neuromodulation University HospitalUniversity of Sao Paulo Psychology Department Advanced School in NeuropsychologyUniversità degli Studi Milano Bicocca Department of Physiology Pharmacology and Neuroscience Sophie Davis School of Biomedical Education City University of New York (CUNY) Obsessive Compulsive Disorder Project (PROTOC) Department and Institute of PsychiatryUniversity of Sao Paulo Unit of Psychiatry Department of Neurosciences Reproductive and Odontostomatological Sciences University of Naples Federico II Université de Lyon Université Claude Bernard Lyon I Centre Hospitalier le Vinatier National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq) Department of Psychiatry Department and Institute of PsychiatryUniversity of Sao Paulo Santa Casa de Sao Paulo Medical School Institute of Physical Medicine and Rehabilitation Clinics Hospital of the University of Sao Paulo Medical School

The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation(t DCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally,we provide an overview of t DCS use in cognitive enhancement as well as a discussion regarding its clinical use and regulatory and ethical issues. Although many promising results regarding t DCS efficacy were described, the total number of studies is still low, highlighting the need of further studies aiming to replicate these findings in larger samples as to provide a definite picture regarding t DCS efficacy in psychiatry.

关键词： Non-invasive brain stimulation Transcranial direct current stimulation Psychiatry disorders Review

The Tianjin geothermal field (northeastern China): Geochemistry and implications for possible plugging phenomena

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Chinese Journal Of Geochemistry 2006年第B8期25卷 148-148页

作者： Angelo Minissale Daniele Borrini giordano Montegrossi Franco Tassi Orlando Vaselli antonio Delgado Huertas Wanqing CHENG Jincheng YANG Xuzhou CHENG CNR-Institute of Geosciences and Earth Resources Via G La Pira 4-50121 Florence Italy Department of Earth Sciences Via G La Pira 4-50121 Florence ltaly Estaciōn Experimental del Zaidin （CSIC） Prof. Albareda 1 18008 Granada Spain Tianjin Aode Renewable Energy Research Institute Tianjin 300381 China Institute of Nuclear and New Energy Technology Tsinghua University Beijing 100084 China

Iatrogenic opioid dependence is endemic and legal: Genetic addiction risk score (GARS) with electrotherapy a paradigm shift in pain treatment programs

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Health 2013年第11期5卷 16-34页

作者： Kenneth Blum David Han Marlene Oscar-Berman Gary Reinl Nicholas DiNubile Margaret A. Madigan Anish Bajaj Bernard William Downs John giordano Wayne Westcott Leonard Smith Eric R. Braverman Kristina Dushaj Mary Hauser Thomas Simpatico Thomas McLaughlin Joan Borsten Debmayla Barh Center for Psychiatric Medicine North Andover USA Centre for Genomics and Applied Gene Technology Institute of Integrative Omics and Applied Biotechnology (IIOAB) Nonakuri Purba Medinipur India Department of Addiction Research & Therapy Malibu Beach Recovery Center Malibu Beach USA Department of Executive Health Path Research Foundation NY New York USA Department of Exercise Science Quincy College Quincy USA Department of Holistic Medicine and Pain Track National Institute for Holistic Addiction Studies North Miami Beach USA Department of Management Science and Statistics The University of Texas at San Antonio San Antonio USA Department of Molecular Nutrition Impact Genomics Inc. Austin USA Igene LLC Austin USA Department of Psychiatry Anatomy & Neurobiology Boston VA and Boston University School of Medicine Boston USA Department of Psychiatry College of Medicine & McKnight Brain Institute University of Florida Gainesville USA Department of Executive Health Path Research Foundation NY New York USA Department of Psychiatry College of Medicine & McKnight Brain Institute University of Florida Gainesville USA Electronic Waveform Lab Department of Pain Research Huntington Beach USA Department of Orthopedic Surgery Hospital of the University of Pennsylvania Philadelphia USA Department of Molecular Nutrition Impact Genomics Inc. Austin USA Department of Executive Health Path Research Foundation NY New York USA Department of Holistic Medicine and Pain Track National Institute for Holistic Addiction Studies North Miami Beach USA Dominion Diagnostics LLC North Kingstown USA Department of Psychiatry Human Integrated Services Unit of Vermont Center for Clinical & Translational Science University of Vermont College of Medicine Burlington USA Department of Addiction Research & Therapy Malibu Beach Recovery Center Malibu Beach USA Centre for Genomics and Applied Gene Technology Institute of Integrative Omics and Applied Biotechnology (IIOAB) Nonakuri Purba Me

The mounting endemic of prescription iatrogenic opioid dependence in pain patients provoked this treatise about an alternative method that can be used to treat pain, improve function and reduce the risk of opioid dependence. It is well known that as well as the side effects reported for chronic opioid therapy, genetically predisposed individuals are at risk for opioid dependence. We propose the use of the Genetic Addiction Risk Score (GARS) assessment to identify patients early in treatment who should avoid narcotic pain medications. Primarily, this review will be an exploration of the mechanisms of action of an electrotherapeutic alternative to narcotic treatment that can be used to augment tissue healing and reduce the pain associated with human injuries and neuropathies. This particular electrotherapeutic device was developed at the Electronic Waveform Laboratory in Huntington Beach, California and is called the H-Wave? device. The primary effect of the H-Wave?device is stimulation (HWDS) of small diameter fibers of “red-slow-twitch” skeletal muscle. Mechanisms of action of HWDS have been investigated in both animal and human studies. They include edema reduction, induction of nitric oxide dependent augmented microcirculation and angiogenesis, small muscle contraction that eliminates transcapillary fluid shifts, reducing the painful effects of tetanizing fatigue and gradual loading of healing injured muscle tissue that helps repair and remodeling. A recent metaanalysis found a moderate-to-strong-positive effect of the HWDS in providing pain relief, reducing the requirement for pain medication, with the most robust effect being increased functionality. We are proposing that GARS can be used to identify those at risk of developing opioid dependence and that the need for opioid analgesia can be reduced by use of this electro therapeutic alternative to opioid analgesia in the treatment of pain and injuries.

关键词： Microcirculation Angiogenesis Analgesic Therapy Electrical Device Stimulation Tissue Loading Remodeling Genetic Addiction Risk Score (GARS) Reward Deficiency Syndrome (RDS)