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Creativity and innovation:A contribution of behavioral economics

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International Journal of Innovation Studies 2019年第1期3卷 12-21页

作者： Jose Chavaglia neto Jose antonio Filipe antonio Bento Caleiro Fundacao Getulio Vargas(EESP-FGV) Itapeva StreetSao Paulo01332-000Brazil Instituto Universitario de Lisboa(ISCTE-IUL) Information SciencesTechnologies and Architecture Research Center(ISTAR-IUL)Business Research Unit-IUL(BRU-IUL)Lisbon1649-026Portugal Departamento de Economia Universidade de EvoraLargo Dos Colegiais2Evora7002-554Portugal

Innovation in products and services is seen by scholars,by specialized media in management,and by some managers as the main currency in modern *** is because it allows high average market profits,fame for innovators,or brand growth,for ***,in practice,most managers still treat innovation as a secondary issue on their *** problem results from the inability of market professionals to analyze people inside and outside their *** is not possible to develop innovative products in a systematic way without treating this point ***,in this process,creativity is a necessary,but not necessarily sufficient,condition to be fulfilled and requires behavioral *** this context,it is believed that behavioral economics can make a sufficient contribution in the form of an analytical marketing tool by offering an analysis closer to human beings'reality,and,thus,allow a better understanding of people's behavior in the process of innovation in the market.

关键词： Behavioral economics Neuroeconomics Innovation Creativity

Polychromic carbon black: Laser galvanized multicolour fluorescence display

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Nano Research 2019年第4期12卷 733-740页

作者： Sharon Xiaodai Lim Kae Lin Wong Zheng Zhang antonio H. Castro neto Chorng-Haur Sow Department of Physics National University of Singapore 2 Science Drive 3 Singapore 117542 Singapore Department of Electrical and Electronic Engineering Universiti Tunku Abdul Rahman Sungai Long Campus Jalan Sungai Long Bandar Sungai Long Cheras Kajang 43000 Selangor Malaysia Institute of Materials Research Engineering A*Star (Agency for Science Technology and Research) 2 Fusionopolis Way Innovis Singapore 138634 Singapore Center for Advanced 2D Materials and Graphene Research Center National University of Singapore 6 Science Drive 2 Singapore 117546 Singapore

Recovered carbon black (rCB),a very economical and abundance source of material,is transformed into dazzling multicolour fluorescence and visual display for the first time by way of a scanning focused laser *** laser-initiated process is both straightforward and versatile,catering to both micro-and macro-scopic patterning with the sample in ambient or helium *** observed phenomenon is attributed to both chemical and structural induced colouration of rCB ***,carbon infusion of oxidised metal occurs when photothermal reaction takes place in *** laser modification with the sample in helium environment,the powder not only fluoresces due to sulphur impurities,control annealing of these powders results in formation of periodic arrangements of carbon *** periodicity of these arrangement falls within the range of visible wavelength,hence contributing to the visually observable rainbow coloured rCB *** patterned sample is also transferrable using PDMS *** in turn broadens the application of this material in flexible electronic devices/*** measurements show most significant enhancement under yellow light ***,in the presence of an applied potential,the fluorescence detected from the sample can easily be switched *** in all,we present a simple process to add multiple functionalities to a material that is both inexpensive and sustainable.

关键词： recovered carbon black laser modification fluorescence emission photocurrent flexible

Impacts of COVID-19 on children and adolescents:A systematic review analyzing its psychiatric effects

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World Journal of Psychiatry 2022年第11期12卷 1313-1322页

作者： Italo Wanderson de Moura Gabriel Danielly Gonçalves Sombra Lima Jeully Pereira Pires Nélio Barreto Vieira Aloisio antonio Gomes de Matos Brasil Yara Talita Gomes Pereira Erika galvao de Oliveira HildsonLeandro de Menezes Nadia Nara Rolim Lima Alberto Olavo Advíncula Reis Ruan neto Pereira Alves Uanderson Pereira da Silva Jucier Gonçalves Junior Modesto Leite Rolim-neto School of Medicine Faculty of Medicine of Juazeiro do Norte-FMJ/IDOMEDJuazeiro do Norte 63040-360CearaBrazil School of Medicine Federal University of CaririBarbalha 63048-080CearaBrazil Mais Médicos Program Federal Government of Brazil-Ministry of HealthIguatu 63048-080CearaBrazil Julio Alves de Lira Hospital and Maternity Hospital HALHMBelo Jardim 55157-290PernambucoBrazil Nursing Department Doctor Leão Sampaio University Center-UNILEAOJuazeiro do Norte 63.041-140CearaBrazil Julio Alves de Lira Hospital and Maternity Hospital JALHMBelo Jardim 55157-290PernambucoBrazil Graduate Program(Post-Doctoral)in Neuro-Psychiatry UFPERecife 50670-901PernambucoBrazil Postgraduate Program(Master’s and Doctorate)in Public Health University of São Paulo-USPSão Paulo 01246-904São PauloBrazil School of Education USPSão Paulo 05508-040São PauloBrazil Internal Medicine-Division of Rheumathology at Hospital das Clínicas São Paulo UniversitySão Paulo 01246-903São PauloBrazil

OBJECTIVE To summarize the most relevant data from a systematic review on the impact of COVID-19 on children and adolescents,particularly analyzing its psychiatric *** This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses(PRISMA)guidelines and included experimental studies(randomized-individually or pooled-and non-randomized controlled trials),observational studies with a group for internal comparison(cohort studies-prospective and retrospective-and case-control)and qualitative studies in the period from 2021 to *** The search identified 325 articles;we removed 125 *** selected 200 manuscripts,chosen by title and selected *** excluded 50 records after screening titles and abstracts,as they did not meet the inclusion *** retrieved 150 records selected for a full *** excluded 90 text articles and we selected 25 records for the(n)***:Due to the short period of data collection,from 2021 to 2022,there is a possibility of lack of relevant studies related to the mental health care of children and *** addition,there is the possibility of publication bias,such as only significant findings being *** The impact of COVID-19 on the mental health of children and adolescents is of great concern to child and youth *** such as fear,anxiety,panic,depression,sleep and appetite disorders,as well as impairment in social interactions caused by psychic stress,are punctual markers of pain and psychic suffering,which have increasing impacts on the mental health panorama of children and adolescents globally,particularly in vulnerable and socially at-risk populations.

关键词： Child psychiatry Adolescent psychiatry Mental health COVID-19 Kids Teens

Successful expression and purification of dppd, using a codon optimized synthetic gene

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Open Journal of Immunology 2011年第1期1卷 1-7页

作者： Suely S. Kashino antonio Campos-neto The Forsyth Institute Global Infectious Disease Research Center Boston USA.

DPPD (Rv0061) is a difficult to express protein of Mycobacterium tuberculosis that elicits strong and specific delayed type hypersensitiv-ity reactions in humans infected with M. tuber-culosis. Therefore DPPD is a molecule that can improve the specificity of the tuberculin skin test, which is widely used as an aid for the di-agnosis of tuberculosis. However, a pitfall of our initial studies was that the DPPD molecule used to perform the skin tests was engineered as fu-sion molecule with another Mycobacterium protein. This approach was used because no expression of DPPD could be achieved either as a single molecule or as a fusion protein using a variety of commercially available expression systems. Here, we report the production and purification of rDPPD using a synthetic gene engineered to contain E. coli codon bias. The gene was cloned into pET14b expression vector, which was subsequently used to transform Rosetta 2(DE3)pLysS or BL-21(DE3)pLysS host cells. The recombinant protein was over-ex- pressed after induction with IPTG and its puri-fication was easily achieved at levels of 5 – 10 mg/l of bacterial broth cultures. The purified protein was confirmed to be DPPD by Mass Spectroscopy sequencing analysis. Moreover, purified rDPPD stimulated peripheral blood mononuclear cells of PPD positive blood do-nors to produce high levels of IFN-γ, thus con-firming that this molecule is biologically active. Because of the DPPD gene is restricted to the tuberculosis-complex organisms of Mycobacte-rium genus, this highly purified molecule should be useful for the identification of indi-viduals sensitized with tubercle

关键词： Mycobacterium tuberculosis DPPD Codon Bias

Ni/Carbon Hybrid Prepared by Hydrothermal Carbonization and Thermal Treatment as Support for PtRu Nanoparticles for Direct Methanol Fuel Cell

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Journal of Materials Science & Technology 2013年第8期29卷 747-751页

作者： Marcelo Marques Tusi Michele Brandalise Nataly Soares de Oliveira Polanco Olandir Vercino Correa antonio Carlos da Silva Juan Carlo Villalba Fauze Jaco Anaissi Almir Oliveira neto Estevam Vitorio Spinac Universidade Regional Integrada do Alto Uruguai e das Missoes-URI Av.Batista Bonoto Sobrinhos/nSao Vicente97700-000 SantiagoRSBrazil Instituto de Pesquisas Energticas e Nucleares-IPEN/CNEN-SP Av.Prof.Lineu Prestes2242Cidade Universitria05508-900 Sao PauloSPBrazil Universidade Estadual do Centro-Oeste-UNICENTRO R.Simeao Varela de S 03Vila Carli85040-080 GuarapuavaPRBrazil

Ni/Carbon was prepared in two steps： initially cellulose as carbon source and NiCl2·6H2O as catalyst of the carbonization process were submitted to hydrothermal treatment at 200 ℃ and further to thermal treatment at 900 ℃ under argon atmosphere. The obtained material contains Ni nanoparticles with face-centered cubic （fcc） structure dispersed on amorphous carbon with graphitic domains. PtRu/C electrocatalysts （carbon- supported PtRu nanoparticles） were prepared by an alcohol-reduction process using Ni/Carbon as support. The materials were characterized by thermogravimetric analysis, energy-dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction, transmission electron microscopy and tested as anodes in single direct methanol fuel cell （DMFC）. The performances of PtRu/C electrocatalysts using Ni/Carbon as support were superior to those obtained for PtRu/C using commercial carbon black Vulcan XC72 as support.

关键词： Cellulose Hydrothermal carbonization Alcohol-reduction process PtRu/C electrocatalysts Direct methanol fuel cell

Endoscopic ultrasound fine needle aspiration vs fine needle biopsy in solid lesions:A multi-center analysis

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World Journal of Clinical Cases 2021年第34期9卷 10507-10517页

作者： Diogo Turiani Hourneaux Moura Thomas R McCarty Pichamol Jirapinyo Igor Braga Ribeiro Galileu Ferreira Ayala Farias antonio Coutinho Madruga-neto Marvin Ryou Christopher C Thompson Gastrointestinal Endoscopy Unit University of Sao Paulo School of MedicineSão PauloSP 05403-010Brazil Division of Gastroenterology Hepatology and EndoscopyBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115United States Division of Gastrointestinal Endoscopy University of São Paulo Medical SchoolSão PauloSP 01246-903Brazil

BACKGROUND While endoscopic ultrasound(EUS)-guided fine needle aspiration(FNA)is considered a preferred technique for tissue sampling for solid lesions,fine needle biopsy(FNB)has recently been *** To compare the accuracy of FNB vs FNA in determining the diagnosis of solid *** A retrospective,multi-center study of EUS-guided tissue sampling using FNA vs FNB *** outcomes included diagnostic test characteristics(i.e.,sensitivity,specificity,accuracy),use of rapid on-site evaluation(ROSE),and adverse *** analyses were performed by type of lesion and diagnostic yield with or without ROSE.A multivariable logistic regression was also *** A total of 1168 patients with solid lesions(n=468 FNA;n=700 FNB)underwent EUS-guided *** age was 65.02±12.13 ***,sensitivity,specificity and accuracy were superior for FNB vs FNA(84.70%vs 74.53%;99.29%vs 96.62%;and 87.62%vs 81.55%,respectively;P0.05).Multivariate analysis showed no significant predictor for better *** subgroup analyses,FNB was superior to FNA for non-pancreatic lesions;however,there was no difference between the techniques among pancreatic *** adverse event was reported in each *** FNB is superior to FNA with equivalent diagnostic test characteristics compared to FNA+ROSE in the diagnosis of non-pancreatic solid *** results suggest that EUS-FNB may eliminate the need of ROSE and should be employed as a first-line method in the diagnosis of solid lesions.

关键词： Endoscopic ultrasound-guided tissue acquisition Fine needle aspiration Fine needle biopsy Solid lesions Endoscopic ultrasound Cancer

Modelling the test, trace and quarantine strategy to control the COVID-19 epidemic in the state of São Paulo, Brazil

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Infectious Disease Modelling 2021年第1期6卷 46-55页

作者： Marcos Amaku Dimas Tadeu Covas Francisco antonio Bezerra Coutinho Raymundo Soares Azevedo neto Claudio Struchiner Annelies Wilder-Smith Eduardo Massad School of Medicine University of Sao Paulo and LIM01-HCFMUSPSao PauloBrazil Instituto Butantan Sao PauloBrazil School of Applied Mathematics Fundacao Getulio VargasRio de JaneiroBrazil School of Veterinary Medicine University of Sao PauloSao PauloBrazil Department Public Health and Clinical Heidelberg Institute of Global HealthUniversity of HeidelbergGermany Medicine Epidemiology and Global HealthUmeåUniversitySE-90185UmeåSweden Department of Disease Control London School of Hygiene and TropicalMedicineUK

Testing for detecting the infection by SARS-CoV-2 is the bridge between the lockdown and the opening of *** this paper we modelled and simulated a test-trace-andquarantine strategy to control the COVID-19 outbreak in the State of São Paulo,*** State of São Paulo failed to adopt an effective social distancing strategy,reaching at most 59%in late March and started to relax the measures in late June,dropping to 41%in 08 ***,São Paulo relies heavily on a massive testing strategy in the attempt to control the *** alternative strategies combined with economic evaluations were *** strategy included indiscriminately testing the entire population of the State,reaching more than 40 million people at a maximum cost of 2.25 billion USD,that would reduce the total number of cases by the end of 2020 by 90%.The second strategy investigated testing only symptomatic cases and their immediate contacts e this strategy reached a maximum cost of 150 million USD but also reduced the number of cases by 90%.The conclusion is that if the State of São Paulo had decided to adopt the simulated strategy on April the 1st,it would have been possible to reduce the total number of cases by 90%at a cost of 2.25 billion US dollars for the indiscriminate strategy but at a much smaller cost of 125 million US dollars for the selective testing of symptomatic cases and their contacts.

关键词： COVID-19 SARS-CoV-2 Testing Cost-analysis Modelling

Methodology for ranking controllable parameters to enhance operation of a steam generator with a combined Artificial Neural Network and Design of Experiments approach

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能源与人工智能(英文) 2021年第1期3卷 9-21页

作者： Lara Werncke Vieira Augusto Delavald Marques Paulo Smith Schneider Antônio Joseda Silva neto Felipe antonio Chegury Viana Madhat Abdel-jawad Julian David Hunt Julio Cezar Mairesse Siluk Federal University of Rio Grande do Sul-UFRGS Porto AlegreBrazil State University of Rio de Janeiro-UERJ Nova FriburgoBrazil University of Central Florida OrlandoUCFUnited States Advanced Analysis Australia-AAA PerthAustralia International Institute for Applied Systems Analysis-IIASA ViennaAustria Federal University of Santa Maria-UFSM Santa MariaBrazil

The operation of complex systems can drift away from the initial design conditions,due to environmental condi-tions,equipment wear or specific *** generators are complex equipment and their proper opera-tion relies on the identification of their most relevant *** approach to rank the operational parameters of a subcritical steam generator of an actual 360 MW power plant is *** Artificial Neural Network-ANN delivers a model to estimate the steam generator efficiency,electric power generation and flue gas outlet temperature as a function of seven input *** ANN is trained with a two-year long database,with training errors of 0.2015 and 0.2741(mean absolute and square error)and validation errors of 0.32%and 2.350(mean percent and square error).That ANN model is explored by means of a combination of situations proposed by a Design of Experiment-DoE *** seven controlled parameters showed to be relevant to express both steam generator efficiency and electric power generation,while primary air flow rate and speed of the dynamic classifier can be neglected to calculate flue gas temperature as they are not statistically *** also shows the prominence of the primary air pressure in respect to the steam generator efficiency,electric power generation and the coal mass flow rate for the calculation of the flue gas outlet *** ANN and DoE combined methodology shows to be promising to enhance complex system efficiency and helpful whenever a biased behavior must be brought back to stable operation.

关键词： Coal-fired power plant Artificial Neural Network Design of Experiments Response surface methodology Steam generator

Areas with evidence of equity and their progress on mortality from tuberculosis in an endemic municipality of southeast Brazil

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Infectious Diseases of Poverty 2017年第1期6卷 1185-1195页

作者： Mellina YAMAMURA Marcelino SANTOS neto Francisco CHIARAVALLOTI neto Luiz Henrique ARROYO antonio Carlos Vieira RAMOS Ana Angelica Rego de QUEIROZ Aylana de Souza BELCHIOR Danielle Talita dos SANTOS Juliane de Almeida CRISPIM Ione Carvalho PINTO Severina Alice da Costa UCHOA Regina Celia FIORATI Ricardo Alexandre ARCENCIO School of Nursing of the University of Sao Paulo Ribeirao Preto Campus(EERP/USP)Ribeirao retoSPBrazil Federal University of Maranhao(UFMA) Sao LuísMABrazil School of Public Health of the University of Sao Paulo(FSP/USP) Sao PauloSPBrazil Federal University of Rio Grande do Norte(UFRN) NatalRNBrazil School of Medicine of the University of Sao Paulo Ribeirao Preto Campus(FMRP/USP)Ribeirao PretoSPBrazil

Background:In Brazil,people still fall ill and die from tuberculosis(TB),and this can be explained by the significant impasse in the equity of distribution of therapeutic resources to the population as a *** aim was to identify geographical areas which have shown progress in terms of equity(of income,schooling and urban occupancy)and test its effect on mortality from TB in a municipality of southeast ***:It is an ecological study considering TB as the basic cause for deaths registered between 2006 and 2013 on the Mortality Information System and other variables obtained through the Demographic Census of the Brazilian Institute of Geography and Statistics(2010).The geographical area for analysis comprised the areas of coverage of the health *** indicators have been constructed through the Principal Component Analysis(PCA).The cases were geocoded and the annual mortality rate from TB was calculated with smoothing using the local empirical Bayesian *** linear regression was then *** was confirmation of the existence of spatial dependence of residue through the application of the Global Moran I test,and application of the Models with Global Spatial Effects,to identify the best standard of spatial ***:The mortality rates ranged from 0.00 to 2.8 deaths per 100,000 people,per *** the PCA,three indicators were constructed,and designated as indicators of income,social inequality,and social *** multiple linear regression,the indicator of social equity was statistically significant(P<0.0001)but had a negative association,an adjusted R^(2)of 28.36%and with spatial dependence(Moran I=0.21,P=0.003455).The best model to deal with existing spatial dependence was the Spatial Lag ***:The better social conditions have shown progress in reducing mortality from TB,thereby reinforcing the achievement of Sustainable Development *** addition,cartography was also applied,which can be replicated

关键词： Tuberculosis Spatial analysis Mortality Cause of death