检索结果-南通市图书馆

deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： anthony Procès Sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Technology innovation for infectious diseases in the developing world

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Infectious diseases of Poverty 2012年第1期1卷 6-14页

作者： anthony d So Quentin Ruiz-Esparza Program on Global Health and Technology Access Sanford School of Public Policy and Duke Global Health InstituteDuke University302 Towerview DriveCB#90312DurhamNorth Carolina 27708USA

Enabling innovation and access to health technologies remains a key strategy in combating infectious diseases in low-and middle-income countries(LMICs).However,a gulf between paying markets and the endemicity of such diseases has contributed to the dearth of R&d in meeting these public health *** the pharmaceutical industry views emerging economies as potential new markets,most of the world’s poorest bottom billion now reside in middle-income countries-a fact that has complicated tiered access ***,product development partnerships-particularly those involving academic institutions and small firms-find commercial opportunities in pursuing even neglected diseases;and a growing pharmaceutical sector in BRICS countries offers hope for an indigenous base of *** innovation will be shaped by 1)access to building blocks of knowledge;2)strategic use of intellectual property and innovative financing to meet public health goals;3)collaborative norms of open innovation;and 4)alternative business models,some with a double bottom *** such resource constraints,LMICs are poised to develop a new,more resource-effective model of innovation that holds exciting promise in meeting the needs of global health.

关键词： Innovation Technology Access Policy Public health R&d collaboration R&d Business model Open source Open innovation

Variable retention harvesting in Great Lakes mixed-pine forests: emulating a natural model in managed ecosystems

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ecological Processes 2019年第1期8卷 210-224页

作者： Brian J.Palik anthony W.d’Amato USdA Forest Service Northern Research StationGrand RapidsMN 55744USA Rubenstein School of Environment and Natural Resources University of VermontBurlingtonVT 05095USA.

Variable retention harvesting(VRH)systems have gained wide use in many different forest types across the globe,but largely have been implemented in forests characterized by severe,infrequent disturbance *** has been less attention given to developing VRH approaches in forests that are characterized as having a mixed-severity disturbance regime that often results in only partial mortality of canopy trees in spatially heterogeneous *** example of such a forest type is red pine(Pinus resinosa Ait.)-dominated ecosystem of the western Great Lakes region of North *** purpose of this review is to provide a conceptual foundation for developing VRH approaches in red pine ecosystems that are based on a mixed-severity disturbance *** contention is that red pine forests managed following a natural model are more resilient to disturbances and external threats such as climate *** the red pine ecosystem,VRH application should reflect the often severe,but partial canopy removal from natural disturbance that is characteristic of this ecosystem and that results in more than trivial numbers of surviving overstory trees across a range of spatial configurations in regenerating *** live trees should span a range of diameters,but favor the larger end of the diameter distribution,as this reflects the likely pattern of survival after natural disturbance and is often a key structural element lacking from managed *** should be applied in ways that vary the spatial pattern of legacy trees in and among stands,but largely in ways that reflect the pattern of spatially patchy canopy structure,with large openings surrounded by a less disturbed matrix,as occurs with a natural disturbance *** trees and deadwood structures should reflect the composition of the pre-disturbance forest,including species in addition to dominant red ***,retained structures should be viewed as dynamic entities that grow,die,and decay and that need

关键词： Red pine Mixed-severity Variable retention Natural disturbance

Getting a Sense of ATP in Real Time

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2022年第7期38卷 834-836页

作者： anthony d.Umpierre Koichiro Haruwaka Long-Jun Wu department of Neurology Mayo ClinicRochesterMN55905USA department of Neuroscience Mayo ClinicJacksonvilFL32224USA department of Immunology Mayo ClinicRochesterMN55905USA

Adenosine 5'-triphosphate(ATP)is a purinergic signal that can be sensed by all major cell classes in the *** is a key signal released during periods of physical damage/injury,inflammation,and neurological events,such as *** ATP signaling in the living brain is complicated by its fast enzymatic degradation,its action at multiple receptors,and its somewhat elusive.

关键词： signal damage somewhat

Modified shear cell for characterization of the rheological behavior of particulate networks under compression

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2020年第4期18卷 1-9页

作者： Simon Hammerich anthony d.Stickland Benjamin Radel Marco Gleiss Hermann Nirschl Institute of Mechanical Process Engineering and Mechanics Karlsruhe Institute for Technology(KIT)Strasse am Forum 876131 KarlsruheGermany Particulate Fluids Processing Centre Department of Chemical EngineeringThe University of Melbourne3010Australia

Knowledge of the rheological behavior of saturated particulate networks is crucial for every process in which a particulate network is built-up,dewatered,or transported,as in a decanter ***,difficulties arise as to how to characterize the material *** far,no standardized method or measurement device has *** this work,the requirements for a useful device are discussed,followed by the design of a modified shear cell for a Schulze ring shear tester *** and its measurement *** experiments under normal load with different sediments consisting of inorganic and organic particles whose material properties strongly affect the rheological behavior were *** results demonstrate the potential of the modified shear ***,current challenges in characterization are *** characterization possibilities of the developed shear cell are a further step toward understanding the theological behavior of liquid-saturated particulate networks.

关键词： Sediment rheology Saturated particulate network Shear cell Shear compression Rheological behavior

Microglia Research in the 100th Year Since Its discovery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2020年第3期36卷 303-306页

作者： anthony dUmpierre Long-Jun Wu department of Neurology Mayo ClinicRochesterMN 55905USA department of Neuroscience Mayo ClinicJacksonvilleFL 32224USA department of Immunology Mayo ClinicRochesterMN 55905USA

In 1919,Pio del Rio-Hortega first described a class of cells residing in the brain with a tiny soma and branched architecture distinguishable from astrocytes and *** cells,called microglia or mesoglia,have come to be appreciated as resident immune cells in the central nervous system(CNS).In the year 2019,we review the three most recent advances in microglia research in this 100th year since their discovery(Fig.1).We first discuss their transcriptional diversity,which allows us to appreciate the heterogeneity of microglia across species,development,diseases,and brain *** also highlight recent stem cell-based approaches that allow us to study human microglia.

关键词： diseases glia appreciate

Neoadjuvant therapy for esophageal cancer

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2014年第10期6卷 403-406页

作者： Rachit d Shah anthony d Cassano James P Neifeld de-partment of Surgery Virginia Commonwealth University School of Medicine Richmond VA 23298-0068 United States

Esophageal cancer is increasing in incidence more than any other visceral malignancy in North America. Adenocarcinoma has become the most common cell type. Surgery remains the primary treatment modality for locoregional disease. Overall survival with surgery alone has been dismal, with metastatic disease the primary mode of treatment failure after an R0 surgical resection. Cure rates with chemotherapy or radiation therapy alone have been disappointing as well. For these reasons, over the last decade multi-modality treatment has gained increasing acceptance as the standard of care. This review examines the present data and role of neoadjuvant treatment using chemotherapy and radiation therapy followed by surgery for the treatment of esophageal cancer.

关键词： Neoadjuvant therapy Esophageal cancer Esophagectomy Chemotherapy

Applying plant-based irrigation scheduling to assess water use efficiency of cotton following a high-biomass rye cover crop

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cotton Research 2020年第2期3卷 134-145页

作者： MEEKS Calvin d SNIdER John L CULPEPPER Stanley hawkins Gary division of Plant Sciences University of MissouriPortagevilleMO 63873USA department of Crop and Soil Sciences University of GeorgiaTiftonGA 31793USA department of Crop and Soil Sciences University of GeorgiaWatkinsvilleGA 30677USA.

Background:This study addressed the potential of combining a high biomass rye winter cover crop with predawn leaf water potential(ΨPd)irrigation thresholds to increase agricultural water use efficiency(WUE)in *** this end,a study was conducted near Tifton,Georgia under a manually-controlled,variable-rate lateral irrigation system using a Scholander pressure chamber approach to measure leaf water potential and impose varying irrigation scheduling treatments during the growing season.ΨPdthresholds were-0.4 MPa(T1),-0.5 MPa(T2),and-0.7 MPa(T3).A winter rye cover crop or conventional tillage were utilized for T1-T3 as ***:Reductions in irrigation of up to 10%were noted in this study for the driest threshold(-0.7 MPa)with no reduction in lint yield relative to the-0.4 MPa and-0.5 MPa *** conditions during flowering(2014)limited plant growth and node production,hastened cutout,and decreased yield and WUE relative to ***:We conclude thatΨPdirrigation thresholds between-0.5 MPa and-0.7 MPa appear to be viable for use in aΨPdscheduling system with adequate yield and WUE for cotton production in the southeastern *** cover positively impacted water potential at certain points throughout the growing season but not yield or WUE indicating the potential for rye cover crops to improve water use efficiency should be tested under longer-term production scenarios.

关键词： Cotton Irrigation management Water use efficiency Cover crops Cotton sustainability

In an interconnected world: joint research priorities for the environment, agriculture and infectious disease

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Infectious diseases of Poverty 2014年第1期3卷 15-17页

作者： Bianca Brijnath Colin d Butler anthony J McMichael department of General Practice School of Primary Health CareMonash UniversityBuilding 1270 Ferntree Gully RoadNotting HillVictoria 3168Australia Faculty of Health University of CanberraCanberraAustralia National Centre for Epidemiology and Population Health Australian National UniversityCanberraAustralia

In 2008 the UNICEF/UNdP/World Bank/WHO Special Programme for Research and Training in Tropical diseases(TdR)commissioned ten think-tanks to work on disease-specific and thematic reference groups to identify top research priorities that would advance the research agenda on infectious diseases of poverty,thus contributing to improvements in human *** first of the thematic reference group reports-on environment,agriculture and infectious diseases of poverty-was recently *** this article we review,from an insider perspective,the strengths and weaknesses of this thematic reference group report and highlight key messages for policy-makers,funders and researchers.

关键词： Agriculture Environment Infectious disease Research priorities TdR