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deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： anthony Procès Sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal a.d axonal damage a.d subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Variable retention harvesting in Great Lakes mixed-pine forests: emulating a natural model in managed ecosystems

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Ecological Processes 2019年第1期8卷 210-224页

作者： Brian J.Palik anthony W.d’amato USdA Forest Service Northern Research StationGrand RapidsMN 55744USA Rubenstein School of Environment a.d Natural Resources University of VermontBurlingtonVT 05095USA.

Variable retention harvesting(VRH)systems have gained wide use in many different forest types across the globe,but largely have been implemented in forests characterized by severe,infrequent disturbance *** has been less attention given to developing VRH approaches in forests that are characterized as having a mixed-severity disturbance regime that often results in only partial mortality of canopy trees in spatially heterogeneous *** example of such a forest type is red pine(Pinus resinosa Ait.)-dominated ecosystem of the western Great Lakes region of North *** purpose of this review is to provide a conceptual foundation for developing VRH approaches in red pine ecosystems that are based on a mixed-severity disturbance *** contention is that red pine forests managed following a natural model are more resilient to disturbances a.d external threats such as climate *** the red pine ecosystem,VRH application should reflect the often severe,but partial canopy removal from natural disturbance that is characteristic of this ecosystem a.d that results in more than trivial numbers of surviving overstory trees across a range of spatial configurations in regenerating *** live trees should span a range of diameters,but favor the larger end of the diameter distribution,as this reflects the likely pattern of survival after natural disturbance a.d is often a key structural element lacking from managed *** should be applied in ways that vary the spatial pattern of legacy trees in a.d among sta.ds,but largely in ways that reflect the pattern of spatially patchy canopy structure,with large openings surrounded by a less disturbed matrix,as occurs with a natural disturbance *** trees a.d deadwood structures should reflect the composition of the pre-disturbance forest,including species in a.dition to dominant red ***,retained structures should be viewed as dynamic entities that grow,die,a.d decay a.d that need

关键词： Red pine Mixed-severity Variable retention Natural disturbance

Technology innovation for infectious diseases in the developing world

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Infectious diseases of Poverty 2012年第1期1卷 6-14页

作者： anthony d So Quentin Ruiz-Esparza Program on Global Health a.d Technology Access Sanford School of Public Policy and Duke Global Health InstituteDuke University302 Towerview DriveCB#90312DurhamNorth Carolina 27708USA

Enabling innovation a.d access to health technologies remains a key strategy in combating infectious diseases in low-a.d middle-income countries(LMICs).However,a gulf between paying markets a.d the endemicity of such diseases has contributed to the dearth of R&d in meeting these public health *** the pharmaceutical industry views emerging economies as potential new markets,most of the world’s poorest bottom billion now reside in middle-income countries-a fact that has complicated tiered access ***,product development partnerships-particularly those involving academic institutions a.d small firms-find commercial opportunities in pursuing even neglected diseases;a.d a growing pharmaceutical sector in BRICS countries offers hope for an indigenous base of *** innovation will be shaped by 1)access to building blocks of knowledge;2)strategic use of intellectual property a.d innovative financing to meet public health goals;3)collaborative norms of open innovation;a.d 4)alternative business models,some with a.double bottom *** such resource constraints,LMICs are poised to develop a new,more resource-effective model of innovation that holds exciting promise in meeting the needs of global health.

关键词： Innovation Technology Access Policy Public health R&d collaboration R&d Business model Open source Open innovation

Getting a Sense of ATP in Real Time

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Neuroscience Bulletin 2022年第7期38卷 834-836页

作者： anthony d.Umpierre Koichiro Haruwaka Long-Jun Wu department of Neurology Mayo ClinicRochesterMN55905USA department of Neuroscience Mayo ClinicJacksonvilFL32224USA department of Immunology Mayo ClinicRochesterMN55905USA

Adenosine 5'-triphosphate(ATP)is a purinergic signal that can be sensed by all major cell classes in the *** is a key signal released during periods of physical damage/injury,inflammation,a.d neurological events,such as *** ATP signaling in the living brain is complicated by its fast enzymatic degradation,its action at multiple receptors,a.d its somewhat elusive.

关键词： signal damage somewhat

Modified shear cell for characterization of the rheological behavior of particulate networks under compression

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Particuology 2020年第4期18卷 1-9页

作者： Simon Hammerich anthony d.Stickla.d Benjamin Radel Marco Gleiss Hermann Nirschl Institute of Mechanical Process Engineering a.d Mechanics Karlsruhe Institute for Technology(KIT)Strasse am Forum 876131 KarlsruheGermany Particulate Fluids Processing Centre Department of Chemical EngineeringThe University of Melbourne3010Australia

Knowledge of the rheological behavior of saturated particulate networks is crucial for every process in which a particulate network is built-up,dewatered,or transported,as in a.decanter ***,difficulties arise as to how to characterize the material *** far,no sta.da.dized method or measurement device has *** this work,the requirements for a useful device are discussed,followed by the design of a modified shear cell for a Schulze ring shear tester *** a.d its measurement *** experiments under normal load with different sediments consisting of inorganic a.d organic particles whose material properties strongly affect the rheological behavior were *** results demonstrate the potential of the modified shear ***,current challenges in characterization are *** characterization possibilities of the developed shear cell are a further step towa.d understa.ding the theological behavior of liquid-saturated particulate networks.

关键词： Sediment rheology Saturated particulate network Shear cell Shear compression Rheological behavior

Microglia Research in the 100th Year Since Its discovery

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Neuroscience Bulletin 2020年第3期36卷 303-306页

作者： anthony dUmpierre Long-Jun Wu department of Neurology Mayo ClinicRochesterMN 55905USA department of Neuroscience Mayo ClinicJacksonvilleFL 32224USA department of Immunology Mayo ClinicRochesterMN 55905USA

In 1919,Pio del Rio-Hortega first described a class of cells residing in the brain with a tiny soma a.d branched architecture distinguishable from astrocytes a.d *** cells,called microglia or mesoglia,have come to be appreciated as resident immune cells in the central nervous system(CNS).In the year 2019,we review the three most recent advances in microglia research in this 100th year since their discovery(Fig.1).We first discuss their transcriptional diversity,which allows us to appreciate the heterogeneity of microglia across species,development,diseases,a.d brain *** also highlight recent stem cell-based approaches that allow us to study human microglia.

关键词： diseases glia appreciate

Neoadjuvant therapy for esophageal cancer

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World Journal of Gastrointestinal Oncology 2014年第10期6卷 403-406页

作者： Rachit d Shah anthony d Cassano James P Neifeld de-partment of Surgery Virginia Commonwealth University School of Medicine Richmond VA 23298-0068 United States

Esophageal cancer is increasing in incidence more than any other visceral malignancy in North America. Adenocarcinoma has become the most common cell type. Surgery remains the primary treatment modality for locoregional disease. Overall survival with surgery alone has been dismal, with metastatic disease the primary mode of treatment failure after an R0 surgical resection. Cure rates with chemotherapy or radiation therapy alone have been disappointing as well. For these reasons, over the last decade multi-modality treatment has gained increasing acceptance as the sta.da.d of care. This review examines the present data a.d role of neoadjuvant treatment using chemotherapy a.d radiation therapy followed by surgery for the treatment of esophageal cancer.

关键词： Neoadjuvant therapy Esophageal cancer Esophagectomy Chemotherapy

In an interconnected world: joint research priorities for the environment, agriculture a.d infectious disease

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Infectious diseases of Poverty 2014年第1期3卷 15-17页

作者： Bianca Brijnath Colin d Butler anthony J McMichael department of General Practice School of Primary Health CareMonash UniversityBuilding 1270 Ferntree Gully RoadNotting HillVictoria 3168Australia Faculty of Health University of CanberraCanberraAustralia National Centre for Epidemiology a.d Population Health Australian National UniversityCanberraAustralia

In 2008 the UNICEF/UNdP/World Bank/WHO Special Programme for Research a.d Training in Tropical diseases(TdR)commissioned ten think-tanks to work on disease-specific a.d thematic reference groups to identify top research priorities that would advance the research agenda on infectious diseases of poverty,thus contributing to improvements in human *** first of the thematic reference group reports-on environment,agriculture a.d infectious diseases of poverty-was recently *** this article we review,from an insider perspective,the strengths a.d weaknesses of this thematic reference group report a.d highlight key messages for policy-makers,funders a.d researchers.

关键词： Agriculture Environment Infectious disease Research priorities TdR

Challenges confronting rural hospitals accentuated during COVId-19

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The Journal of Biomedical Research 2020年第6期34卷 397-409页

作者： anthony d.Slonim Helen See Sheila Slonim Renown Health RenoNV 89503USA Medicine a.d Pediatrics University of NevadaReno School of MedicineRenoNV 89557USA Hospital Operations Carilion ClinicRoanokeVA 24017USA.

The Balanced Budget Act of 1997 created a.designation for critical access hospitals(CAHs)to sustain care for people living in rural communities who lacked access to care due to hospital closures over the preceding ***-five years later,1350 CAHs serve approximately 18% of the US population a.d a systematic policy evaluation has yet to be *** policy analysis serves to define challenges faced by CAHs through a literature review a.dressing the four major categories of payment,quality,access to capital,a.d ***,this analysis describes how current challenges to maintain sustainability of CAHs over time are accentuated by gaps in public health infrastructure a.d variability in individual health care plans exhibited during the COVId-19 pa.demic.

关键词： rural hospitals critical access hospitals COVId-19 coronavirus