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H pylori status and angiogenesis factors in human gastric carcinoma

World Journal of Gastroenterology 2006年第34期12卷 5465-5472页

作者： Anita Mangia annalisa Chiriatti Girolamo Ranieri Ines Abbate Maria Coviello Giovanni Simone Francesco Alfredo Zito Severino Montemurro Antonello Rucci Alfredo Di Leo Stefania Tommasi Pasquale Berloco Jian Ming Xu Angelo Paradiso Clinical Experimental Oncology Laboratory National Cancer Institute 70126 Bari Italy Interventional Radiology Unit National Cancer Institute 70126 Bari Italy Chemical-Clinical-Microbiology and Immunology Laboratory Unit National Cancer Institute70126 Bari Italy Histopathology Unit National Cancer Institute 70126 Bari Italy Gastroenterology Surgical Unit National Cancer Institute Bari Italy Department of Emergency and Organ Transplantation Section of Gastroenterology University of Bari Italy Laboratory of Biochemistry IRCCS 'Saverio de Bellis' Castellana Grotte (BA) Italy Department of Gastrointestinal Cancer Beijing 307 Hospital Cancer Center Beijing China

AIM： To investigate H pylori expression in gastric cancer patients in relation to primary tumor angiogenic markers, such as microvessel density （MVD）, thymidine phosphorylase （TP）, vascular endothelial growth factor receptor-1 （VEGF-R1）, p53 and circulating VEGF levels. METHODS： Angiogenic markers were analyzed immunohistochemically in 56 primary gastric cancers. H pylori cytotoxin （vacA） and the cytotoxin-associated gene （cagA） amplification were evaluated using PCR assay. Serum H pylori IgG antibodies and serum/plasma circulating VEGF levels were detected in 39 and 38 patients by ELISA, respectively. RESULTS： A total of 69% of patients were positive for circulating IgG antibodies against Hpylori. cagA-positive H pylor/strains were found in 41% of gastric patients. vacA was found in 50% of patients; s1 strains were more highly expressed among vacA-positive patients. The presence of the s1 strain was significantly associated with cagA （P = 0.0001）. MVD was significantly correlated with both tumor VEGF expression （r = 0.361, P = 0.009） and serum VEGF levels （r = -0.347, P = 0.041）.Conversely, neither VEGF-R1 expression nor MVD was related to p53 expression. However, H pylori was not related to any angiogenic markers except for the plasma VEGF level （P = 0.026）. CONCLUSION： H pylori antigen is related to higher plasma VEGF levels, but not to angiogenic characteristics. It can be hypothesized that the toxic effects of H pylori on angiogenesis occurs in early preclinical disease phase or in long-lasting aggressive infections, but only when high H pylori IgG levels are persistent.

关键词： H pylori Gastric carcinoma Angiogenesis

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Orthostatic hypotension,an often-neglected problem in community-dwelling older people:discrepancies between studies and real life

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Journal of Geriatric Cardiology 2018年第10期15卷 644-646页

作者： Sarah Damanti Dario Consormi annalisa Valentini Benedetta Cerasoli Martina Biotto Federica Conti Marta Clerici Pasqualina Iannuzzi Emanuela Manzo Paolo D Rossi Simona Ciccone Matteo Cesari Geriatric Unit Fondazione IRCCS Ca'Granda Ospedale Maggiore PoliclinicoMilanltaly Department of Clinical Sciences and Community Health University of MilanMilanItaly Unit of Epidemiology Fondazione IRCCS Ca'Granda Ospedale Maggiore PoliclinicoMilanltaly Fellowship in Geriatrics and Gerontology University of MilanMilanItaly

Orthostatic hypotension (OH)is a common condition in older *** to the 2011criteria,OH is defined by a sustained reduction of systolic blood pressure of 20 mmHg or a 10mmHg-fall of diastolic blood pressure,[1] Its prevalence increases with age and according to a recent systematic review the pooled prevalence in community dwelling older people is 22.2%.[2]Although OH is largely explained by concurrent clinical conditions (in particular, hypertension,diabetes,malnutrition,vascular encephalopa- thy,anemia,Parkinson's disease)[3],aging per se determines a series of physiological dysfunctions potentially representing its biological substratum (e.g.,reduction in barore- flex-mediated cardiovascular function,altered salt and water balance at renal level,impaired cardiac diastolic filling).It is also noteworthy that age-related changes in pharmacokinetic and pharmacodynamic mechanisms of drugs (especially in the context of polypharmacy)also increase the risk of OH.

关键词： Elderly Orthostatic hypotension Prevalence Real-life

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An effective strategy for cloning the mitochondrial citrate carrier: identification, characterization and tissue distribution in silver eel

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Advances in Bioscience and Biotechnology 2011年第3期2卷 157-162页

作者： Loredana Capobianco Domenico Iacopetta Chiara Carrisi Marianna Madeo Anna Rita cappello Vincenza Dolce 不详

A general and effective strategy to identify cDNA encoding for mitochondrial silver eel citrate carrier (CIC) has been developed. In particular using prim- ers directed towards the highly conserved signature motif of the ortholog citrate cDNA sequences, the full-length silver eel cDNA from liver was obtained. This is 1193 bp in length with 5’ and 3’ untranslated regions of 90 and 149 bp, respectively. The open rea- ding frame encodes a mature protein of 297 amino acids, preceded by a presequence of 20 amino acids. Additionally the mature CIC overexpressed in Es- cherichia coli and reconstituted into phospholipids vesicles showed the same substrate specificity of the native protein previously characterized in silver eel. The tissue distribution of silver eel CIC mRNAs was investigated and transcripts were detected at high levels in swim bladder whereas a weaker signal was found in brain, gill, intestine and liver.

关键词： Citrate Carrier Cloning Metabolite Transport Mitochondrial Carrier Family PCR Surfactant

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Sorafenib delivery nanoplatform based on superpara- magnetic iron oxide nanoparticles magnetically targets hepatocellular carcinoma

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Nano Research 2017年第7期10卷 2431-2448页

作者： Nicoletta Depalo Rosa Maria lacobazzi Gianpiero Valente Ilaria Arduino Silvia Villa Fabio Canepa Valentino Laquintana Elisabetta Fanizza Marinella Striccoli annalisa Cutrignelli Angela Lopedota Letizia Porcelli Amalia Azzariti Massimo Franco Maria Lucia Curri Nunzio Denora Istituto per i Processi Chimico-Fisici-CNR UOS Bari Via Orabona 4 70125 Bari Italy Istituto Tumori IRCCS Giovanni Paolo II viale O. Flacco 65 70124 Bari Italy Dipartimento di Chimica Universita degli Studi di Bad Aldo Moro Via Orabona70125 Bari Italy Dipartimento di Farmacia-Scienze del Farmaco Universita degli Studi di Bari Aldo Moro Via Orabona 4 70125 Bari Italy Dipartimento di Chimica e Chimica Industriale Universita di Genova Via Dodecaneso 31 16146 Genova Italy

Currently, sorafenib is the only systemic therapy capable of increasing overall survival of hepatocellular carcinoma patients. Unfortunately, its side effects, particularly its overall toxicity, limit the therapeutic response that can be achieved. Superparamagnetic iron oxide nanoparticles （SPIONs） are very attractive for drug delivery because they can be targeted to specific sites in the body through application of a magnetic field, thus improving intratumoral accumulation and reducing adverse effects. Here, nanoformulations based on polyethylene glycol modified phospholipid micelles, loaded with both SPIONs and sorafenib, were successfully prepared and thoroughly investigated by complementary techniques. This nanovector system provided effective drug delivery, had an average hydrodynamic diameter of about 125 nm, had good stability in aqueous medium, and allowed controlled drug loading. Magnetic analysis allowed accurate determination of the amount of SPIONs embedded in each micelle. An in vitro system was designed to test whether the SPION micelles can be efficiently held using a magnetic field under typical flow conditions found in the human liver. Human hepatocellular carcinoma （HepG2） cells were selected as an in vitro system to evaluate tumor cell targeting efficacy of the superparamagnetic micelles loaded with sorafenib. These experiments demonstrated that this delivery platform is able to enhance sorafenib＇s antitumor effectiveness by magnetic targeting. The magnetic nanovectors described here represent promising candidates for targeting specific hepatic tumor sites, where selective release of sorafenib can improve its efficacy and safety profile.

关键词： superparamagnetic ironoxide nanoparticles poly(ethylene glycol) (PEG)-modified phospholipidmicelles drug delivery magnetic targeting hepatocellular carcinoma sorafenib

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Coronary microvasculopathy in heart transplantation: Consequences and therapeutic implications

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World Journal of Transplantation 2014年第2期4卷 93-101页

作者： Alessandra Vecchiati Sara Tellatin annalisa Angelini Sabino Iliceto Francesco Tona Department of Cardiac Thoracic and Vascular SciencesPadova University Hospital35128 PadovaItaly

Despite the progress made in the prevention and treatment of rejection of the transplanted heart, cardiac allograft vasculopathy(CAV) remains the main cause of death in late survival transplanted patients. CAV consists of a progressive diffuse intimal hyperplasia and the proliferation of vascular smooth muscle cells, ending in wall thickening of epicardial vessels, intramyocardial arteries(50-20 μm), arterioles(20-10 μm), and capillaries(< 10 μm). The etiology of CAV remains unclear; both immunologic and non-immunologic mechanisms contribute to endothelial damage with a sustained inflammatory response. The immunological factors involved are Human Leukocyte Antigen compatibility between donor and recipient, alloreactive T cells and the humoral immune system. The non-immunological factors are older donor age, ischemia-reperfusion time, hyperlipidemia and CMV infections. Diagnostic techniques that are able to assess microvascular function are lacking. Intravascular ultrasound and fractional flow reserve, when performed during coronary angiography, are able to detect epicardial coronary artery disease but are not sensitive enough to assess microvascular changes. Some authors have proposed an index of microcircula-tory resistance during maximal hyperemia, which is calculated by dividing pressure by flow(distal pressure multiplied by the hyperemic mean transit time). Non-invasive methods to assess coronary physiology are stress echocardiography, coronary flow reserve by transthoracic Doppler echocardiography, single photon emission computed tomography, and perfusion cardiac magnetic resonance. In this review, we intend to analyze the mechanisms, consequences and therapeutic implications of microvascular dysfunction, including an extended citation of relevant literature data.

关键词： Heart transplantation Cardiac allograft vasculopathy Microvascular function Coronary flow reserve Endothelial dysfunction

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Endoscopic features of gastro-intestinal lymphomas: From diagnosis to follow-up

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World Journal of Gastroenterology 2014年第36期20卷 12993-13005页

作者： Calogero Vetro Alessandra Romano Irene Amico Concetta Conticello Giovanna Motta Amalia Figuera annalisa Chiarenza Cosimo Di Raimondo Giorgio Giulietti Giacomo Bonanno Giuseppe Alberto Palumbo Francesco Di Raimondo Division of Hematology AOU Policlinico-OVE University of Catania 95124 Catania Italy Department of Diagnostic and Interventional Radiology A.O. "Policlinico-Vittorio Emanuele" 95124 Catania Italy Division of Gastroenterology A.O. Policlinico-Vittorio Emanuele 95124 Catania Italy

Many progresses have been done in the management of gastrointestinal(GI) lymphomas during last decades, especially after the discovery of Helicobacter pylori-dependent lymphoma development. The stepwise implementation of new endoscopic techniques, by means of echoendoscopy or double-balloon enteroscopy, enabled us to more precisely describe the endoscopic features of GI lymphomas with substantial contribution in patient management and in tailoring the treatment strategy with organ preserving approaches. In this review, we describe the recent progresses in GI lymphoma management from disease diagnosis to follow-up with a specific focus on the endoscopic presentation according to the involved site and the lymphoma subtype. Additionally, new or emerging endoscopic technologies that have an impact on the management of gastrointestinal lymphomas are reported. We here discuss the two most common subtypes of GI lymphomas: the mucosaassociated lymphoid tissue and the diffuse large B cell lymphoma. A general outline on the state-of-the-art of the disease and on the role of endoscopy in both diagnosis and follow-up will be performed.

关键词： Non-Hodgkin lymphomas Endoscopy Gastrointestinal tract Endosonography B-cell lymphomas Marginal zone

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Estimation of Accumulated Degree Day Value of Six Landmarks within the Pupal Stage of Lucilia sericata

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Journal of Life Sciences 2015年第7期9卷 311-317页

作者： annalisa Grisendi Francesco Defilippo Fabio Gatti Michele Dottori Paolo Bonilauri University of Parma Via Farini 90 Parma 43121 Italy lstituto Zooprofilattico Lombardia e Emilia-Romagna Via Pitagora 2 Reggio Emilia 42124 Italy

The present paper investigates the pupal development times ofLucilia sericata which were studied in the laboratory at six different constant temperatures （20, 22, 24, 26, 28 ℃ each ± ℃）. Lower thresholds （tL） for development were estimated from the linear regression of the developmental rates on each temperature. These data have made it possible to calculate the ADD （Accumulated Degree-Days） necessary for L. sericata to complete the larval stage and to achieve adult emergence. The minimal duration of development from oviposition to adult emergence was found to be inversely related to temperature. Additionally, six landmarks in pupal development are showed and for each of the landmarks the ADD value was calculated for every rearing temperature involved. These data assist in calculating the duration of the pupal stage based on morphological characteristics and would be of great value for future forensic entomological casework.

关键词： Forensic science forensic entomology Lucilia sericata pupal landmarks accumulated degree day post-morteminterval.

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线条勾勒的艺术

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现代装饰（家居） 2015年第11期 148-149页

作者： Paolo cappello 李薇

线条,我们可以说它是简单的,一条长长的直线,一条弯弯的曲线,似乎再也简洁不过;但线条也是充满想象的,它可以无限延长,创造出无穷的可能;同时线条也是灵活多变的,可以自由地曲折,它就像一个百变的精灵,弯弯直直的线条似乎可以勾勒出我... 详细信息

线条,我们可以说它是简单的,一条长长的直线,一条弯弯的曲线,似乎再也简洁不过;但线条也是充满想象的,它可以无限延长,创造出无穷的可能;同时线条也是灵活多变的,可以自由地曲折,它就像一个百变的精灵,弯弯直直的线条似乎可以勾勒出我们能够想象到的任何图案。本期我们将和大家分享Paolo cappello设计的Tangles系列墙纸,该系列墙纸共有七个主题。

关键词：无限延长锦鲤一灵独特韵味简约风格

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Management of small hepatocellular carcinoma in cirrhosis:Focus on portal hypertension

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World Journal of Gastroenterology 2013年第8期19卷 1193-1199页

作者： Virginia Hernandez-Gea Fanny Turon annalisa Berzigotti Augusto Villanueva Hepatocellular Carcinoma Translational Research Laboratory Barcelona-Clinic Liver Cancer GroupInstitut d'Investigacions Biomediques August Pi i SunyerLiver UnitHospital Clinic08036 BarcelonaSpain Hepatic Hemodynamic Laboratory Liver UnitHospital ClinicUniversity of Barcelona08036 BarcelonaSpain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas Instituto Carlos Ⅲ08036 BarcelonaSpain

The incidence of hepatocellular carcinoma(HCC) is rising worldwide being currently the fifth most common cancer and third cause of cancer-related *** detection of HCC through surveillance programs have enabled the identification of small nodules with higher frequency,and nowadays account for 10%-15% of patients diagnosed in the West and almost 30% in *** with small HCC can be candidates for potential curative treatments:liver transplantation,surgical resection and percutaneous ablation,depending on the presence of portal hypertension and *** review will analyze recent advancements in the clinical management of these individuals,focusing on issues related to the role of portal hypertension,the debate between resection and ablative therapies and the future impact of molecular technologies.

关键词： Portal hypertension Hepatic venous pressure gradient Clinically significant portal hypertension Liver stiffness Liver cancer Hepatocellular carcinoma Resection Radiofrequency ablation Percutaneous ethanol injection

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Safety Food in Celiac Disease Patients: A Systematic Review

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Food and Nutrition Sciences 2013年第7期4卷 55-74页

作者： Mariarita Dessì annalisa Noce Sara Vergovich Gianluca Noce Nicola Di Daniele Laboratory Medicine Department University of Rome Tor Vergata Rome Italy Laboratory Medicine Department University of Rome Tor Vergata Rome Italy Laboratory Medicine Department University of Rome Tor Vergata Rome Italy Department of Neuroscience Division of Human Nutrition University of Rome Tor Vergata Rome Italy. Nephrology and Hypertension Unit Department of Medicine System University of Rome Tor Vergata Rome Italy

The prevalence of Celiac Disease (CD), an autoimmune enteropathy, characterized by chronic inflammation of the intestinal mucosa, atrophy of intestinal villi and several clinical manifestations has increased in recent years. Epidemiological studies have shown that CD is very common and affects about one in 250 people. The mechanism of the intestinal immune-mediated response is not completely clear, but involves an HLA-DQ2 or HLA-DQ8 restricted T-cell immune reaction in the lamina propria as well as an immune reaction in the intestinal epithelium. Subjects affected by CD cannot tolerate gluten protein, a mixture of storage proteins contained in several cereals (wheat, rye, barley and derivatives). Gluten free-diet remains the cornerstone treatment for celiac patients. Therefore the absence of gluten in natural and processed foods represents a key aspect of food safety of the gluten-free diet. In this review, we evaluate the main studies about the safety food in CD patients.

关键词： Celiac Disease Safety Food Gluten Protein Gluten Free-Diet

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