检索结果-南通市图书馆

Multi-national observational study to assess quality of life and treatment preferences in patients with Crohn’s perianal fistulas

引用

World Journal of Gastrointestinal Surgery 2023年第11期15卷 2537-2552页

作者： Chitra Karki Amod Athavale Vijay Abilash Gary Hantsbarger Parnia Geransar Kate Lee Slobodan Milicevic Marko Perovic Leanne Raven Magdalena Sajak-Szczerba Abigail Silber annabelle yoon Phil Tozer Global Evidence and Outcomes-Gastroenterology Takeda Pharmaceuticals United StatesIncCambridgeMA 02139United States Trinity Partners LLCWalthamMA 02451-7528United States Observational Research Takeda Pharmaceuticals United StatesIncCambridgeMA 02139United States Medical Affairs Takeda Pharmaceuticals International Co.Opfikon 8152ZurichSwitzerland Research and Patient Programs Crohn’s and Colitis Canada600-60 St.Clair Avenue EastToronto M4T 1N5OntarioCanada Treasurer European Federation of Crohn’s&Ulcerative Colitis AssociationsBrussels B 1000Belgium Crohn’s and Colitis Australia Camberwell SouthVIC 3124Australia European Federation of Crohn’s&Ulcerative Colitis Associations Brussels B 1000Belgium Japan Medical Office Takeda Pharmaceutical Company LimitedTokyo 103-8668Japan Department of Colorectal Surgery St Mark’s Hospital and Academic InstituteLondon HA13UJUnited Kingdom

BACKGROUND Patients with Crohn’s disease(CD)are at risk of developing complications such as perianal *** with Crohn’s perianal fistulas(CPF)are affected by fecal incontinence(FI),bleeding,pain,swelling,and purulent perianal discharge,and METHODS This cross-sectional observational study was conducted in patients with CD aged 21-90 years via a web-enabled questionnaire in seven countries(April-August 2021).Patients were recruited into three cohorts:Cohort 1 included patients without perianal fistulas;cohort 2 included patients with perianal fistulas without fistula-related surgery;and cohort 3 included patients with perianal fistulas and fistula-related *** patient-reported outcome measures were used to assess quality of *** of treatment preferences were measured using a discrete choice experiment(DCE).RESULTS In total,929 patients were recruited(cohort 1,n=620;cohort 2,n=174;cohort 3,n=135).Short Inflammatory Bowel Disease Questionnaire scores were worse for patients with CPF(cohorts 2 and 3)than for those with CD without CPF(cohort 1):Mean score 3.8 and 3.7 vs 4.1,respectively,(P<0.001).Similarly,mean Revised FI and FI Quality of Life scores were worse for patients with CPF than for those with CD without *** of Life with Anal Fistula scores were similar in patients with CPF with or without CPF-related surgery(cohorts 2 and 3):Mean score 41 and 42,*** the DCE,postoperative discomfort and fistula healing rate were the most important treatment attributes influencing treatment choice:Mean relative importance 35.7 and 24.7,*** The burden of illness in CD is significantly higher for patients with CPF and patients rate lower postoperative discomfort and higher healing rates as the most desirable treatment attributes.

关键词： Burden of illness Crohn’s disease Discrete choice experiment Perianal fistulas Patient-reported outcomes Treatment preferences

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：