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Overloading of differentiated Caco-2 cells during lipid transcytosis induces glycosylation mistakes in the Golgi complex

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BIOCELL 2021年第3期45卷 773-783页

作者： GALInA n.DEnISOVA IVAn D.DIMOV anna V.ZAITSEVA LInARD J.ARTIUX ALEXAnDER A.MIROnOV nATALIA R.KARELInA Department of Anatomy Saint Petersburg State Paediatric Medical UniversityPetersburg194100Russia Department of Biochemistry Saint Petersburg State Paediatric Medical UniversityPetersburg194100Russia Department of Heart and Vessel Surgery Saint Petersburg State Paediatric Medical UniversityPetersburg194100Russia The FIRC Institute of Molecular Oncology Milan20139Italy

Overloading the intestine enterocytes with lipids induced alteration of the Golgi complex(GC;Sesorova et al.,2020)and could cause glycosylation ***,using differentiated Caco-2 cells with the established 0[I]blood group phenotype(no expression of the blood antigens A and B[AgA,AgB]under normal conditions)as a model of human enterocytes we examined whether the overloading of these cells with lipids could cause errors in the Golgi-dependent *** demonstrated that under these conditions,there were alterations of the GC and the appearance of lipid droplets in the *** cells produced AgA and *** suggested that after overloading of enterocytes with lipids,AgA were mistakenly synthesized in individual enterocytes by the Golgi *** mistakes could explain why in the absence of AgA and AgB antibodies against them exist in the blood.

关键词： Golgi Blood group antigens Glycosylation errors Enterocyte Lipid transcytosis Caco-2 cells

Loop Structures and Barrier Elements from D. melanogaster 87А7 Heat Shock Locus

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Computational Molecular Bioscience 2016年第4期6卷 53-65页

作者： Mikhail V. Glazkov anna n. Shabarina Koltzov Institute of Developmental Biology Russian Academy of Sciences Moscow Russia

The three-dimensional organization of the genome is closely related to its functioning. Interactions between parts of the genome located at large distances from each other have been detected within the chromosomes of different organisms, which led to the discovery of topologically associated domains (TADs). Methods that reveal such interactions between chromosomal loci imply detection of both protein-protein and protein-DnA interactions. We investigated the possibility of involvement of the direct DnA-DnA interactions in the structural and functional organization of Drosophila melanogaster chromosomal 87A7 locus, containing genes hsp70Aa and hsp70Ab, with the sequence analysis method. Our results indicate that the functional organization of 87A7 locus may involve different elements: chromosomal DnA fragments that attach chromosomes to the nuclear envelope, short polypurine/polypyrimidine tracts, insulators and their proteins. The combination of interactions of these elements may cause different functional states of 87A7 locus.

关键词： hsp70 Genes DnA-DnA Interactions Insulators nuclear Envelope TADs

Poly(phenylene oxide) and Renewable Polyamide 11 Blends Compatibilized by Ethylene-n-Octene Copolymer

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Journal of Renewable Materials 2018年第7期6卷 772-783页

作者： Regina Jeziorska Agnieszka Abramowicz Agnieszka Szadkowska anna Pasnik Ewa Spasowka Department of Polymer Technology and Processing Industrial Chemistry Research InstituteRydygiera 801-793 WarsawPoland

Poly(phenylene oxide)/renewable polyamide 11 (PPO/PA11 20/80) blends toughened with glycidylmethacrylate grafted ethylene-n-octene copolymer (GEOC) were prepared in a co-rotating twin-screwextruder. The reaction between GEOC and PPO/PA11 blend was analyzed by gel content tests. Themorphology of PPO/PA11/GEOC blends was observed by scanning electron microscope. The SEMresults showed that PPO formed the continuous phase, though it is a minority component of blends. Withincreasing GEOC content from 5 to 15 wt% the morphology of the blends transformed from droplet-matrix toco-continuous structure, in which both PA11 and PPO phases are continuous. The blend with co-continuousmorphology had better mechanical properties than those with droplet-matrix morphology. The impactstrength of the PPO/PA11/GEOC blends was much higher compared to the one without GEOC as well asPA11 due to the compatibilizing effect, which was also proved by DSC analysis, rheological behavior (MFR,DMTA) and tensile properties.

关键词： Compatibilization elastomer PPO/PA11 blends toughening

Electrical properties and microstructure formation of V/Al-based n-contacts on high Al mole fraction n-AlGan layers

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Photonics Research 2020年第8期8卷 1381-1387页

作者： LUCA SULMOnI FRAnK MEHnKE anna MOGILATEnKO MARTIn GUTTMAnn TIM WERnICKE MICHAEL KnEISSL Institut für Festkorperphysik Technische Universitat Berlin10623 BerlinGermany Ferdinand-Braun-Institut Leibniz-Institut fur Höchstfrequenztechnik12489 BerlinGermany Institut für Physik Humboldt Universität zu Berlin12489 BerlinGermany

The electrical and structural properties of V/Al-based n-contacts on n‐AlxGa1−xn with an Al mole fraction x ranging from x=0.75 to x=0.95 are *** n-contacts are obtained up to x=0.75 with a contact resistivity of 5.7×10^−4Ω·cm^2 whereas for higher Al mole fraction the IV characteristics are *** electron microscopy reveals a thin crystalline Aln layer formed at the metal/semiconductor interface upon thermal *** analysis confirmed an Al enrichment at the *** interfacial nitride-based layer in n-contacts on n‐Al0.9Ga0.1n is partly amorphous and heavily contaminated by *** role and resulting limitations of Al in the metal stack for n-contacts on n-AlGan with very high Al mole fraction are ***,ultraviolet C(UVC)LEDs grown on n‐Al0.87Ga0.13n and emitting at 232 nm are fabricated with an operating voltage of 7.3 V and an emission power of 120μW at 20 mA in cw operation.

关键词： AlGan fraction properties

Input database related uncertainty of Biome-BGCMuSo agroenvironmental model outputs

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International Journal of Digital Earth 2021年第11期14卷 1582-1601页

作者： nándor Fodor LászlóPásztor Brigitta Szabó annamária Laborczi Klára Pokovai Dóra Hidy Roland Hollós Erzsébet Kristóf anna Kis Laura Dobor AnikóKern Thomas Grünwald Zoltán Barcza Centre for Agricultural Research Agricultural InstituteMartonvásárHungary Centre for Agricultural Research Institute for Soil SciencesBudapestHungary Department of Meteorology Eötvös Loránd UniversityBudapestHungary Faculty of Science-Excellence Center Eötvös Loránd UniversityMartonvásárHungary Faculty of Forestry and Wood Sciences Czech University of Life Sciences PraguePraha-SuchdolCzech Republic Department of Geophysics and Space Science Eötvös Loránd UniversityBudapestHungary Institute of Hydrology and Meteorology Technische Universität DresdenTharandtGermany

Gridded model assessments require at least one climatic and one soil database for carrying out the *** are several parallel soil and climate database development projects that provide sufficient,albeit considerably different,observation based input data for crop model based impact *** input database related uncertainty of the Biome-BGCMuSo agro-environmental model outputs was investigated using three and four different gridded climatic and soil databases,respectively covering an area of nearly 100.000 km2 with 1104 grid ***,temporal,climate and soil database selection related variances were calculated and compared for four model outputs obtained from 30-year-long *** choice of the input database introduced model output variability that was comparable to the variability the year-to-year change of the weather or the spatial heterogeneity of the soil *** database selection could be a decisive factor in carbon sequestration related studies as the soil carbon stock change estimates may either suggest that the simulated ecosystem is a carbon sink or to the contrary a carbon source on the long *** evaluation of the input database quality seems to be an inevitable and highly relevant step towards more realistic plant production and carbon balance simulations.

关键词： Input data gridded data soil parameters climatic parameters uncertainty propagation

Root structure syndromes of four families of monocots in the Middle Urals

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Plant Diversity 2023年第6期45卷 722-731页

作者： anna A.Betekhtina Daria E.Tukova Denis V.Veselkin Ural Federal University named After the First President of Russia B.n.Yeltsin 19 Mira StreetEkaterinburg 620002Russia Ural Branch of the Russian Academy of Sciences Institute of Plant and Animal Ecology8 Marta StreetEkaterinburg 620144Russia

The present article tests the following general assumption:plant taxa with different specializations towards mycorrhizal interactions should have different root *** of 61 species common in boreal zone were studied:16 species of Poaceae,24 species of Cyperaceae,14 species of Orchidaceae,and 7 species of *** a fixed material of 5 individuals of each species,the following was determined:number of orders of branching roots;transverse dimensions of root,stele and cortex;number of primary xylem vessels and exodermis layers;length of root hairs;abundance of *** of each family had well-defined *** of Orchidaceae and Iridaceae were thick with a large stele and developed *** had no branching roots and had long root *** Iridaceae,roots were branched,and root hairs were *** of Poaceae and Cyperaceae were thin with a relatively thin *** hairs were short in Poaceae and long in *** finding that root syndromes of four families of monocots differed is a new and unexpected *** high specificity of root syndromes in Cyperaceae,Iridaceae,Poaceae,and Orchidaceae indicates that species of these families use different strategies to obtain water and soil nutrients.

关键词： Monocots Poaceae Cyperaceae Orchidaceae Iridaceae Syndromes of roots structure

Geochemistry and mineralogy of platinum-group elements(PGE)in chromites from CentralnoyeⅠ,Polar Urals,Russia

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Geoscience Frontiers 2011年第1期2卷 81-85页

作者： Jan Paava Ilja Knésl anna Vymazalová Ivan Vavrín Ludmila Ivanovna Gurskaya Leonid Ruslanovich Kolbantsev Czech Geological Survey Geologicka 6152 00 Praha 5Czech Republic All Russia Geological Research Institute(VSEGEI) 74 Srechy Pr.199 106 St.PetersburgRussia

The Polar Urals region of northern Russia is well known for large chromium （Cr）-bearing massifs with major chromite orebodies, including the Centralnoye I deposit in the Ray-Iz ultramafic massif of the Ural ophiolite belt. new data on platinum （Pt）-group elements （PGE）, geochemistry and mineralogy of the host dunite shows that the deposit has anomalous iridium （Ir） values. These values indicate the predominance of ruthenium--osmium--iridium （Ru--Os--Ir）-bearing phases among the platinum-group mineral （PGM） assemblage that is typical of mantle-hosted chromite ores. Low Pt values in chromites and increased Pt values in host dunites might reflect the presence of cumulus PGM grains. The most abundant PGM found in the chromite is erlichmanite （up to 15 μm）. Less common are cuproiridsite （up to 5 μm）, irarsite （up to 4--5 μm）, and laurite （up to 4 μm）. The predominant sulfide is heazlewoodite, in intergrowth with ni--Fe alloys, sporadically with pentlandite, and rarely with pure nickel. Based on the average PGE values and esti- mated Cr-ore resources, the Centralnoye I deposit can be considered as an important resource of PGE.

关键词： Platinum-group elements Platinum-group minerals Chromite Ophiolites Centralnoye I deposit Polar Urals

Local administration of porcine immunomodulatory,chemotactic and angiogenic extracellular vesicles using engineered cardiac scaffolds for myocardial infarction

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Bioactive Materials 2021年第10期6卷 3314-3327页

作者： Marta Monguió-Tortajada Cristina Prat-Vidal Miriam Moron-Font Marta Clos-Sansalvador Alexandra Calle Paloma Gastelurrutia Adriana Cserkoova anna Morancho Miguel Angel Ramírez anna Rosell Antoni Bayes-Genis Carolina Gàlvez-Montón Francesc E.Borràs Santiago Roura ICREC Research Program Health Science Research Institute Germans Trias i Pujol(IGTP)Can Ruti CampusBadalonaSpain REMAR-IVECAT Group Health Science Research Institute Germans Trias i Pujol(IGTP)Can Ruti CampusBadalonaSpain Department of Cell Biology Physiology and ImmunologyUniversitat Autónoma de Barcelona(UAB)BellaterraSpain CIBERCV Instituto de Salud Carlos IIIMadridSpain Institut d’InvestigacióBiomèdica de Bellvitge-IDIBELL L’Hospitalet de LlobregatSpain Departamento de Reproducción Animal Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA)MadridSpain neurovascular Research Laboratory Vall d’Hebron Research Institute(VHIR)UABBarcelonaSpain Cardiology Service Germans Trias i Pujol University HospitalBadalonaSpain Department of Medicine UABBarcelonaSpain nephrology Service Germans Trias i Pujol University HospitalBadalonaSpain Faculty of Medicine University of Vic-Central University of Catalonia(UVic-UCC)VicBarcelona08500Spain

The administration of extracellular vesicles(EV)from mesenchymal stromal cells(MSC)is a promising cell-free nanotherapy for tissue repair after myocardial infarction(MI).However,the optimal EV delivery strategy remains ***,we designed a novel MSC-EV delivery,using 3D scaffolds engineered from decellularised cardiac tissue as a cell-free product for cardiac *** from porcine cardiac adipose tissue-derived MSC(cATMSC)were purified by size exclusion chromatography(SEC),functionally analysed and loaded to ***-EV markedly reduced polyclonal proliferation and pro-inflammatory cytokines production(IFnγ,TnFα,IL12p40)of allogeneic ***,cATMSC-EV recruited outgrowth endothelial cells(OEC)and allogeneic MSC,and promoted *** labelled cATMSC-EV were mixed with peptide hydrogel,and were successfully retained in decellularised ***,cATMSC-EV-embedded pericardial scaffolds were administered in vivo over the ischemic myocardium in a pig model of *** days from implantation,the engineered scaffold efficiently integrated into the post-infarcted ***-EV were detected within the construct and MI core,and promoted an increase in vascular density and reduction in macrophage and T cell infiltration within the damaged *** confined administration of multifunctional MSC-EV within an engineered pericardial scaffold ensures local EV dosage and release,and generates a vascularised bioactive niche for cell recruitment,engraftment and modulation of short-term post-ischemic inflammation.

关键词： Exosomes Mesenchymal stem/stromal cells Migration Infiltration Cardiac tissue engineering

The impact of burning on lion Panthera leo habitat choice in an African savanna

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Current Zoology 2013年第3期59卷 335-339页

作者： Stephanie EBY anna MOSSER Ali SWAnSOn Craig PACKER Mark RITCHIE Department of Biology Syracuse University Syracuse NY 13210 USA Department of Ecology Evolution and Behavior University of Minnesota Saint Paul MN 55108 USA Department of Integrative Biology University of Guelph Guelph Ontario N 1G 2W1

Camivores play a central role in ecosystem processes by exerting top-down control, while fire exerts bottom-up con- trol in ecosystems throughout the world, yet, little is known about how fire affects short-term carnivore distributions across the landscape. Through the use of a long-term data set we investigated the distribution of lions, during the daytime, in relation to burned areas in Serengeti national Park, Tanzania. We found that lions avoid burned areas despite the fact that herbivores, their prey, are attracted to burned areas. Prey attraction, however, likely results from the reduction in cover caused by burning, that may thereby decrease lion hunting success. Lions also do not preferentially utilize the edges of burned areas over unburned areas de- spite the possibility that edges would combine the benefit of cover with proximity to abundant prey. Despite the fact that lions avoid burned areas, lion territory size and reproductive success were not affected by the proportion of the territory burned each year. Therefore, burning does not seem to reduce lion fitness perhaps because of the heterogeneity of burned areas across the landscape or because it is possible that when hunting at night lions visit burned areas despite their daytime avoidance of these ar- eas .

关键词： Fire Lions Savannas Habitat distribution Predator-prey interactions Protected area management